Information on EC 2.4.1.16 - chitin synthase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.4.1.16
-
RECOMMENDED NAME
GeneOntology No.
chitin synthase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + [4)-N-acetyl-beta-D-glucosaminyl-(1->]n = UDP + [4)-N-acetyl-beta-D-glucosaminyl-(1->]n+1
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Amino sugar and nucleotide sugar metabolism
-
-
chitin biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyltransferase
Converts UDP-N-acetyl-alpha-D-glucosamine into chitin and UDP.
CAS REGISTRY NUMBER
COMMENTARY hide
9030-18-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
IM-80
-
-
Manually annotated by BRENDA team
Apodachlya sp.
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
a haploid strain, gene BcChs6 or BC1G_15936.1
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Chlorovirus CVK2
-
-
-
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
EhCHS-1; EhCHS-2
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
isoform CHS1
-
-
Manually annotated by BRENDA team
strain GZ03643
-
-
Manually annotated by BRENDA team
strain GZ03643
-
-
Manually annotated by BRENDA team
chitin synthase 2; f. sp. lycopersici, myosin motor-like chitin synthase gene chsVb
UniProt
Manually annotated by BRENDA team
Kluyveromyces bulgaricus
ATCC 96631
-
-
Manually annotated by BRENDA team
LeChs1; an edible basidiomycetous mushroom, strain strain SB1226, gene Lechs1, isozyme LeChs1
UniProt
Manually annotated by BRENDA team
Lucilia sp.
-
-
-
Manually annotated by BRENDA team
isoform Chs7; isoform CHS7
UniProt
Manually annotated by BRENDA team
Mortierella candelabrum
-
-
-
Manually annotated by BRENDA team
Mortierella pusilla
-
-
-
Manually annotated by BRENDA team
isolate PHI26, gene chsVII
UniProt
Manually annotated by BRENDA team
isolate PHI26, gene chsVII
UniProt
Manually annotated by BRENDA team
an edible basidiomycetous mushroom, class IV chitin synthase isozyme, gene Pochs1
-
-
Manually annotated by BRENDA team
X2180 strains
-
-
Manually annotated by BRENDA team
strain Y3437, isozyme Chs2
UniProt
Manually annotated by BRENDA team
strain YPH499 and ECY38-38A, isozyme CHS2p encoded by gene CHS2; strain YPH499 and ECY38-38A, isozymes CHS1p and CHS3p encoded by genes CHS1 and CHS3
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
4 isozymes, CHS1-CHS4
-
-
Manually annotated by BRENDA team
4 isozymes, CHS1-CHS4
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
-
chitin production in arthropods is a complicated process and a series of biochemical pathways are involved in individual chitin polymer biosynthesis in which the terminal step is catalyzed by chitin synthase
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
6-O-dansyl-N-acetylglucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
?
show the reaction diagram
Kluyveromyces bulgaricus
-
-
-
-
?
acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
show the reaction diagram
Kluyveromyces bulgaricus
-
-
-
-
?
chitobiose + N-acetyl-D-glucosamine
UDP + 1,4-(N-acetyl-beta-D-glucosaminyl)x
show the reaction diagram
-
-
-
-
?
UDP-GlcNAc + GlcNAc
UDP + N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosamine
show the reaction diagram
-
-
-
?
UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
show the reaction diagram
UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosamine
UDP + 1,4-(N-acetyl-beta-D-glucosaminyl)2
show the reaction diagram
-
-
-
-
?
UDP-N-acetyl-D-glucosamine + [(1-4)-N-acetyl-beta-D-glucosaminyl-]n
UDP + [(1-4)-N-acetyl-beta-D-glucosaminyl-]n+1
show the reaction diagram
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
show the reaction diagram
UDP-N-acetyl-D-glucosamine + [4-N-acetyl-beta-D-glucosaminyl-(1-)]n
UDP + [4-N-acetyl-beta-D-glucosaminyl-(1-)]n+1
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDP-N-acetyl-alpha-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
show the reaction diagram
UDP-N-acetyl-D-glucosamine + [1,4-(N-acetyl-beta-D-glucosaminyl)]n
UDP + [1,4-(N-acetyl-beta-D-glucosaminyl)]n+1
show the reaction diagram
additional information
?
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R,3R,4R,5R)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine
-
IC50: 1.6 mM
(2R,3R,4R,5S)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine
-
IC50: 38 mM
(2S,3R,4R,5R)-2-[(1-ethylphosphonyl)-1,1-difluoromethyl]-3,4-dihydroxy-5-hydroxymethyl-pyrrolidine
-
IC50: 4.0 mM
1-(2,2-dibutyl-5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-3(2H)-yl)ethanone
-
0.25 mM, about 30% residual activity
1-Geranyl-2-methylbenzimidazole
-
weak
1-[2,2-dibutyl-5-(2-chlorophenyl)-1,3,4-oxadiazol-3(2H)-yl]ethanone
-
0.25 mM, about 10% residual activity
1-[2,2-dibutyl-5-(4-chlorophenyl)-1,3,4-oxadiazol-3(2H)-yl]ethanone
-
0.25 mM, about 30% residual activity
1-[2,2-dibutyl-N-[(2,6-difluorophenyl)carbonyl]-5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-3(2H)-yl]ethanone
-
0.25 mM, about 20% residual activity
1-[2,2-dibutyl-N-[(2-chlorophenyl)carbonyl]-5-(2,4-dichlorophenyl)-1,3,4-oxadiazol-3(2H)-yl]ethanone
-
0.25 mM, about 15% residual activity
1-[2,2-dibutyl-N-[(2-chlorophenyl)carbonyl]-5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-3(2H)-yl]ethanone
-
0.25 mM, about 25% residual activity
2,2'-methylenebis(3,4,6-trichlorophenol)
-
0.25 mM, 56% inhibition
2,3,5,6-Tetrachloro-4-methoxyphenol
-
0.25 mM, 48% inhibition
2,5-dideoxy-2,5-imino-D-glucitol
-
IC50: 5.7 mM
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N,N-dipropylacetamide
-
-
-
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-(2-nitrophenyl)acetamide
-
-
-
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-(3-nitrophenyl)acetamide
-
-
-
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-(4-(trifluoromethyl)phenyl)acetamide
-
-
-
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-(4-methoxyphenyl)acetamide
-
-
-
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-(4-nitrophenyl)acetamide
-
-
-
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-(ptolyl)acetamide
-
-
-
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-methyl-N-phenylacetamide
-
-
-
2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)-N-phenylacetamide
-
-
-
3,5-Dichloro-4-methoxybenzaldehyde
-
0.25 mM, 17% inhibition
3,5-Dichloro-4-methoxybenzyl alcohol
-
0.25 mM, 40% inhibition
3,5-Dichlorobenzyl alcohol
-
0.25 mM, 15% inhibition
3-(2-hydroxy-3-(methyl(2-oxo-2-(piperidin-1-yl)ethyl)amino)propyl)-1-methylquinazoline-2,4(1H,3H)-dione
-
-
-
5'-(N-succinyl)-5'-amino-5'-deoxyuridine
-
-
-
5'-(N-succinyl)-5'-amino-5'-deoxyuridine methyl ester
-
inhibits the yeast enzyme, and exhibits synergistic interaction with caspofungin against Candida albicans
-
5'-(N-succinylglycyl)-5'-amino-5'-deoxyuridine
-
-
-
5'-(N-succinylglycyl)-5'-amino-5'-deoxyuridine methyl ester
-
-
-
5'-deoxy-5'-(glycylamino)uridine
-
-
-
8,20-dihydroxy-9(11),13-abietadien-12-one
AMP
-
6.25 mM
amphotericin
-
noncompetitive
Amphotericin B methyl ester
-
-
Ba2+
-
10 mM, 61% inhibition
bis(5'-amino-5'-deoxyuridine) 2,2'-[(1,4-dioxobutane-1,4-diyl)diazanediyl]diacetate
-
50% inhibition at 3 mM
-
bis(5'-amino-5'-deoxyuridine) 4-[(carboxymethyl)amino]-4-oxobutanoate
-
-
-
bis(5'-amino-5'-deoxyuridine) succinate
-
-
-
c3',5'-AMP
-
2 mM, slight inhibition
Calcofluor white
-
noncompetitive
Captan
Cd2+
complete inhibition of wild-type and mutant enzymes
chitin oligosaccharides
-
slight
chitodextrins
-
-
-
Cl-
-
10 mM
Diflubenzuron
edifenphos
-
non-competitive
Filipin
-
weak
Hexachlorophene
-
inhibition can be reversed by lecithin
insecticidal benzoylphenyl ureas
-
-
-
K+
-
10 mM, 14% inhibition
kanakugiol
-
inhibition of chitin synthase 2 and antifungal activity of the lignan from the stem bark of Lindera erythrocarpa, overview
linderone
-
inhibition of chitin synthase 2 and antifungal activity of the lignan from the stem bark of Lindera erythrocarpa, overview
methyl 2-((2-(methyl(2-oxo-2H-chromen-4-yl)amino)ethoxy) (phenoxy)phosphorylamino)-3-phenylpropanoate}
-
-
-
methyl 2-((2-(methyl(2-oxo-2H-chromen-4-yl)amino)ethoxy) (phenoxy)phosphorylamino)acetate}
-
-
-
methyl 2-((2-(methyl(2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)propanoate}
-
-
-
methyl 2-((2-(methyl(6-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)-3-phenylpropanoate}
-
-
-
methyl 2-((2-(methyl(6-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)acetate}
-
-
-
methyl 2-((2-(methyl(6-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)propanoate}
-
-
-
methyl 2-((2-(methyl(6-tert-buty-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)-3-phenylpropanoate
-
a noncompetitive inhibitor against chitin synthase
-
methyl 2-((2-(methyl(6-tert-buty-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)acetate}
-
-
-
methyl 2-((2-(methyl(6-tert-buty-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)propanoate}
-
-
-
methyl 2-((2-(methyl(7-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)-3-phenylpropanoate}
-
-
-
methyl 2-((2-(methyl(7-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)-acetate}
-
-
-
methyl 2-((2-(methyl(7-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)propanoate}
-
-
-
methyl 2-((2-(methyl(8-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)-3-phenylpropanoate}
-
-
-
methyl 2-((2-(methyl(8-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)-acetate}
-
-
-
methyl 2-((2-(methyl(8-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)propanoate}
-
-
-
methyl 2-(2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamido)benzoate
-
-
-
methyl 3-methyl-2-((2-(methyl(2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)butanoate}
-
-
-
methyl 3-methyl-2-((2-(methyl(6-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)butanoate}
-
-
-
methyl 3-methyl-2-((2-(methyl(6-tert-buty-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)butanoate}
-
-
-
methyl 3-methyl-2-((2-(methyl(7-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)butanoate}
-
-
-
methyl 3-methyl-2-((2-(methyl(8-methyl-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)butanoate}
-
-
-
methyllinderone
-
inhibition of chitin synthase 2 and antifungal activity of the lignan from the stem bark of Lindera erythrocarpa, overview
N,N-dibenzyl-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl) (methyl) amino)acetamide
-
-
-
N,N-diethyl-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl) (methyl) amino)acetamide
-
-
-
N- benzyl-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl) amino)acetamide
-
-
-
N-(2-chlorophenyl)-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamide
-
-
-
N-(4-(cyanomethyl)phenyl)-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamide
-
-
-
N-(4-chlorobenzyl)-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamide
-
-
-
N-(4-chlorophenyl)-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl)amino)acetamide
-
-
-
N-(tert-butyl)-2-((2-hydroxy-3-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)propyl)(methyl) amino)acetamide
-
-
-
N-acetyl-D-glucosamine-N,N-diacetylchitobiose
-
-
-
NaCl
-
0.5 M, 86% inhibition of Chs1 and 29% inhibition of Chs2
Nikkomycin
nikkomycin X
-
-
nikkomycin Z
Nystatin
-
-
O-methyl pisiferic acid
oudemansin B
-
0.25 mM, 31% inhibition
Pentachlorophenol
-
0.25 mM, 67% inhibition
Polyoxin B
Polyoxin D
polyoxin L
Primulin
-
noncompetitive
SO42-
-
10 mM
strobilurin A
-
0.25 mM, 24% inhibition
strobilurin B
-
0.25 mM, 29% inhibition
terpenoyl benzimidazole
-
weak
UDPgalacturonic acid
-
1 mM, about 20% inhibition
UDPglucose
-
1 mM, about 20% inhibition
UDPglucuronic acid
-
1 mM, about 20% inhibition
UDPmannose
-
1 mM, about 20% inhibition
UDPxylose
-
1 mM, about 20% inhibition
UMP
-
6.25 mM
uracil polyoxin C methyl ester
[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid 2-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylcarbamoyloxy]-ethyl ester
-
1 mM, 32% inhibition, competitive. IC50: 2.2 mM
[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid 2-{2-[5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylcarbamoyloxy]-ethoxy}-ethyl ester
-
1 mM 45% inhibition. IC50: 11.8 mM
additional information
-
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
chitodextrin F1
-
5 mg/ml, 183% increase in activity
-
chitodextrin F2
-
5 mg/ml, 170% increase in activity
-
diacetylchitobiose
-
activates
Digitonin
GlcNAc
glucose
lysophosphatidylserine
-
required, phosphatidylserine and lysophosphatidylserine are the best activators
N-acetyl-alpha-D-glucosamine
-
stimulates CHS activity at 2.5 mM but inhibits enzyme activity at higher concentrations
N-acetyl-D-glucosamine
GlcNAc and 2-acylamido analogues of GlcNAc stimulate formation of chitin oligosaccharides by yeast chitin synthase, and GlcNAc is transferred to the 2-acylamido analogues. Synthesis of chitin oligosaccharides is strongly dependent on inclusion of GlcNAc in chitin synthase incubations. Formation of both chitin oligosaccharides and insoluble chitin is also stimulated by GlcNAc2
N-butanoyl-D-glucosamine
stimulates formation of both chitin oligosaccharides and insoluble chitin from the 2-acylamido analogues of UDP-N-acetyl-alpha-D-glucosamine
N-Glycolyl-D-glucosamine
stimulates formation of both chitin oligosaccharides and insoluble chitin from the 2-acylamido analogues of UDP-N-acetyl-alpha-D-glucosamine
N-propanoyl-D-glucosamine
stimulates formation of both chitin oligosaccharides and insoluble chitin from the 2-acylamido analogues of UDP-N-acetyl-alpha-D-glucosamine
-
Nystatin
-
0.05 mM, marked stimulation
papain
-
fairly good activator of Chs1, poor activator of Chs2
-
phosphatidylethanolamine
-
stimulates
phosphatidylinositol
-
stimulates
phosphatidylserine
Phospholipid
-
required, phosphatidylserine and lysophosphatidylserine are the best activators
Pronase
-
stimulates both Chs1 and Chs2
-
proteinase B
-
from Saccharomyces cerevisiae, stimulates Chs1, no effect on Chs2
-
proteinase K
-
stimulates both Chs1 and Chs2
-
Staphylococcus V8 protease
-
best activator of Chs2 in presence of Co2+, elicits little Mg2+-stimulatable activity
-
Trypsin
Apodachlya sp.
-
activates
-
UDP-N-acetyl-alpha-D-glucosamine
-
-
additional information
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.5
6-O-dansyl N-acetylglucosamine
Kluyveromyces bulgaricus
-
chitin synthetase II
0.0133 - 0.2
6-O-dansyl-N-acetylglucosamine
2.3
chitobiose
-
-
3.1
N-acetyl-D-glucosamine
-
reaction with UDP-N-acetyl-D-glucosamine
0.5 - 2.5
UDP-GlcNAc
3.86
UDP-N-acetyl-alpha-D-glucosamine
-
pH 7.5, 37°C
2.6
UDP-N-acetyl-D-glucosamine
-
reaction with chitobiose
1.5 - 3.1
UDP-N-acetylglucosamine
additional information
additional information
-
Michaelis-Menten kinetics
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0009
5-((2-amino-5-O-(aminocarbonyl)-2-deoxy-L-xylonoyl)amino)-1-(5-carboxy-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-1,5-dideoxy-beta-D-allofuranuronic acid
-
chitin synthetase 1
0.13
Amphotericin B
-
-
0.054
edifenphos
-
-
0.0085
Hexachlorophene
-
-
0.096
methyl 2-((2-(methyl(6-tert-buty-2-oxo-2H-chromen-4-yl)amino)ethoxy)(phenoxy)phosphorylamino)-3-phenylpropanoate
-
pH 7.5, 37°C
-
0.002
Nikkomycin
-
-
0.00014
nikkomycin X
-
chitin synthetase 1
0.0001 - 0.0068
nikkomycin Z
0.005
O-methyl pisiferic acid
versus UDP-N-acetyl-beta-D-glucosamine; versus UDP-N-acetyl-beta-D-glucosamine
0.00065
polyoxin
-
-
-
0.032
Polyoxin B
-
-
0.001 - 2.5
Polyoxin D
0.014
Primulin
-
-
0.19 - 2.2
UDP