Information on EC 2.4.1.159 - flavonol-3-O-glucoside L-rhamnosyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.4.1.159
-
RECOMMENDED NAME
GeneOntology No.
flavonol-3-O-glucoside L-rhamnosyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-beta-L-rhamnose + a flavonol 3-O-beta-D-glucoside = UDP + a flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside]
show the reaction diagram
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hexosyl group transfer
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-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of secondary metabolites
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Flavone and flavonol biosynthesis
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Metabolic pathways
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rutin biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
UDP-beta-L-rhamnose:flavonol-3-O-beta-D-glucoside 6''-O-L-rhamnosyltransferase (configuration-inverting)
A configuration-inverting rhamnosyltransferase that converts flavonol 3-O-glucosides to 3-O-rutinosides. Also acts, more slowly, on rutin, quercetin 3-O-galactoside and flavonol 3-O-rhamnosides.
CAS REGISTRY NUMBER
COMMENTARY hide
83380-89-6
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
tulip, cv. Apeldoorn
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
UDP-L-rhamnose + kaempferol
kaempferol-3-O-rhamnoside + UDP
show the reaction diagram
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-
-
-
?
UDP-L-rhamnose + quercetin
quercetin-3-O-rhamnoside + UDP
show the reaction diagram
-
-
-
-
?
UDPrhamnose + flavonol 3-O-diglycoside
UDP + flavonol 3-O-triglycoside
show the reaction diagram
-
-
-
?
UDPrhamnose + flavonol 3-O-glucoside
UDP + flavonol 3-O-rhamnosylglucoside
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
UDPrhamnose + flavonol 3-O-glucoside
UDP + flavonol 3-O-rhamnosylglucoside
show the reaction diagram
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involved in flavonoid metabolism, pathway of flavonol 3-O-triglycoside biosynthesis
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-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
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slight stimulation
additional information
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no activation by Ca2+, NH4+, Mn2+, Cl- or SO42-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
p-chloromercuribenzoate
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weak
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
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slight stimulation
dithioerythritol
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slight stimulation
glutathione
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slight stimulation
additional information
-
no stimulation by sucrose or bovine serum albumin
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40000
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gel filtration
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE