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Disease on EC 2.4.1.144 - beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
Altered ?1,6-GlcNAc and bisecting GlcNAc-branched N-glycan on integrin ?1 are associated with early spontaneous miscarriage in humans.
Alzheimer Disease
GLP-1 receptor agonists downregulate aberrant GnT-III expression in Alzheimer's disease models through the Akt/GSK-3?/?-catenin signaling.
MicroRNA-23b attenuates tau pathology and inhibits oxidative stress by targeting GnT-III in Alzheimer's disease.
beta-1,4-mannosyl-glycoprotein 4-beta-n-acetylglucosaminyltransferase deficiency
Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.
Blast Crisis
Changes of beta-1,4-N-acetylglucosaminyltransferase III (GnT-III) in patients with leukaemia.
High expression of UDP-N-acetylglucosamine: beta-D mannoside beta-1,4-N-acetylglucosaminyltransferase III (GnT-III) in chronic myelogenous leukemia in blast crisis.
Breast Neoplasms
Expression of N-Acetylglucosaminyltransferase III Suppresses ?2,3-Sialylation, and Its Distinctive Functions in Cell Migration Are Attributed to ?2,6-Sialylation Levels.
Carcinogenesis
?4-integrin/PI3K Signaling Promotes Tumor Progression through Galectin-3-N-glycan Complex.
Expression of N-acetylglucosaminyltransferase III in hepatic nodules during rat liver carcinogenesis promoted by orotic acid.
Expression of N-acetylglucosaminyltransferase III in hepatic nodules generated by different models of rat liver carcinogenesis.
Carcinoma
Alteration in N -acetylglucosaminyltransferase activities and glycan structure in tissue and bile glycoproteins from extrahepatic bile duct carcinoma.
Changes in N-acetylglucosaminyltransferase III, IV and V in renal cell carcinoma.
N-acetylglucosaminyltransferase III expression is regulated by cell-cell adhesion via the E-cadherin-catenin-actin complex.
The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer.
Carcinoma, Ductal
N-Acetylglucosaminyltransferase III (GnT-III) but not N-Acetylgalactosaminyltransferase-6 and 8 are Differentially Expressed in Invasive and In Situ Ductal Carcinoma of the Breast.
Carcinoma, Hepatocellular
Bisecting GlcNAc structures act as negative sorting signals for cell surface glycoproteins in forskolin-treated rat hepatoma cells.
Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the golgi apparatus.
Determination of N-acetylglucosaminyltransferases III, IV and V in normal and hepatoma tissues of rats.
Determination of UDP-N-acetylglucosamine: beta-D-mannoside-1,4-N-acetylglucosaminyltransferase-III in patients sera with chronic hepatitis and liver cirrhosis using a monoclonal antibody.
Elevated expression of bisecting N-acetylglucosaminyltransferase-III gene in a human fetal hepatocyte cell line by hepatitis B virus.
Expression of bisecting N-acetylglucosaminyltransferase-III in human hepatocarcinoma tissues, fetal liver tissues, and hepatoma cell lines of Hep3B and HepG2.
Expression of N-acetylglucosaminyltransferase III in hepatic nodules during rat liver carcinogenesis promoted by orotic acid.
Expression of N-Acetylglucosaminyltransferase III Suppresses ?2,3-Sialylation, and Its Distinctive Functions in Cell Migration Are Attributed to ?2,6-Sialylation Levels.
High expression of an N-acetylglucosaminyltransferase III in 3'-methyl DAB-induced hepatoma and ascites hepatoma.
N-acetylglucosaminyltransferase III and V messenger RNA levels in LEC rats during hepatocarcinogenesis.
N-acetylglucosaminyltransferase III in human serum, and liver and hepatoma tissues: increased activity in liver cirrhosis and hepatoma patients.
Reduced N-acetylglucosaminyltransferase III expression via Smad3 and Erk signaling in TGF-?1-induced HCC EMT model.
Serum N-acetylglucosaminyltransferase III activities in hepatocellular carcinoma.
Transfection of N-acetylglucosaminyltransferase III gene suppresses expression of hepatitis B virus in a human hepatoma cell line, HB611.
Carcinoma, Intraductal, Noninfiltrating
N-Acetylglucosaminyltransferase III (GnT-III) but not N-Acetylgalactosaminyltransferase-6 and 8 are Differentially Expressed in Invasive and In Situ Ductal Carcinoma of the Breast.
Carcinoma, Ovarian Epithelial
The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer.
Carcinoma, Renal Cell
Changes in N-acetylglucosaminyltransferase III, IV and V in renal cell carcinoma.
Choriocarcinoma
Unusually high expression of N-acetylglucosaminyltransferase-IVa in human choriocarcinoma cell lines: a possible enzymatic basis of the formation of abnormal biantennary sugar chain.
Colitis
Modulation of N-glycosylation by mesalamine facilitates membranous E-cadherin expression in colon epithelial cells.
Colonic Neoplasms
Cell cycle-dependent regulation of N-acetylglucosaminyltransferase-III in a human colon cancer cell line, Colo201.
Glioma
Expression of N-Acetylglucosaminyltransferase III Suppresses ?2,3-Sialylation, and Its Distinctive Functions in Cell Migration Are Attributed to ?2,6-Sialylation Levels.
Hematologic Diseases
High expression of UDP-N-acetylglucosamine: beta-D mannoside beta-1,4-N-acetylglucosaminyltransferase III (GnT-III) in chronic myelogenous leukemia in blast crisis.
Hematologic Neoplasms
High expression of UDP-N-acetylglucosamine: beta-D mannoside beta-1,4-N-acetylglucosaminyltransferase III (GnT-III) in chronic myelogenous leukemia in blast crisis.
Hepatitis B
Elevated expression of bisecting N-acetylglucosaminyltransferase-III gene in a human fetal hepatocyte cell line by hepatitis B virus.
Remodeling of cell surface glycoproteins by N-acetylglucosaminyltransferase III gene transfection: modulation of metastatic potentials and down regulation of hepatitis B virus replication.
Selective suppression of N-acetylglucosaminyltransferase III activity in a human hepatoblastoma cell line transfected with hepatitis B virus.
The hepatitis B virus X protein inhibits secretion of apolipoprotein B by enhancing the expression of N-acetylglucosaminyltransferase III.
Transfection of N-acetylglucosaminyltransferase III gene suppresses expression of hepatitis B virus in a human hepatoma cell line, HB611.
Hepatitis, Chronic
N-acetylglucosaminyltransferase III and V messenger RNA levels in LEC rats during hepatocarcinogenesis.
Serum N-acetylglucosaminyltransferase III activities in hepatocellular carcinoma.
Hepatoblastoma
Selective suppression of N-acetylglucosaminyltransferase III activity in a human hepatoblastoma cell line transfected with hepatitis B virus.
Infections
Elevated expression of bisecting N-acetylglucosaminyltransferase-III gene in a human fetal hepatocyte cell line by hepatitis B virus.
Sensitivity to human serum of gammaretroviruses produced from pig endothelial cells transduced with glycosyltransferase genes.
Serum N-acetylglucosaminyltransferase III activities in hepatocellular carcinoma.
Leukemia
Sensitivity to human serum of gammaretroviruses produced from pig endothelial cells transduced with glycosyltransferase genes.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
High expression of UDP-N-acetylglucosamine: beta-D mannoside beta-1,4-N-acetylglucosaminyltransferase III (GnT-III) in chronic myelogenous leukemia in blast crisis.
Liver Cirrhosis
Elevated expression of bisecting N-acetylglucosaminyltransferase-III gene in a human fetal hepatocyte cell line by hepatitis B virus.
N-acetylglucosaminyltransferase III in human serum, and liver and hepatoma tissues: increased activity in liver cirrhosis and hepatoma patients.
Serum N-acetylglucosaminyltransferase III activities in hepatocellular carcinoma.
Liver Neoplasms
mRNA expression of three glycosyltransferases in human hepatoma tissues.
Lymphatic Metastasis
N-acetylglucosaminyltransferase III and V messenger RNA levels in LEC rats during hepatocarcinogenesis.
Lymphoma
N-acetylglucosaminyltransferase III, IV and V activities in Novikoff ascites tumour cells, mouse lymphoma cells and hen oviduct. Application of a sensitive and specific assay by use of high-performance liquid chromatography.
Melanoma
Aberrant glycosylation of E-cadherin enhances cell-cell binding to suppress metastasis.
Implication of N-acetylglucosaminyltransferases III and V in cancer: gene regulation and signaling mechanism.
Introduction of bisecting GlcNAc in N-glycans of adenylyl cyclase III enhances its activity.
Overexpression of N-acetylglucosaminyltransferases III and V in human melanoma cells. Implications for MCAM N-glycosylation.
Remodeling of glycoconjugates on CD44 enhances cell adhesion to hyaluronate, tumor growth and metastasis in B16 melanoma cells expressing beta1,4-N-acetylglucosaminyltransferase III.
Suppression of lung metastasis of B16 mouse melanoma by N-acetylglucosaminyltransferase III gene transfection.
The glycomic effect of N-acetylglucosaminyltransferase III overexpression in metastatic melanoma cells. GnT-III modifies highly branched N-glycans.
[Suppression of lung metastasis of B16 mouse melanoma cells by introduction of N-acetylglucosaminyltransferase III gene]
Melanoma, Experimental
Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration.
Remodeling of glycoconjugates on CD44 enhances cell adhesion to hyaluronate, tumor growth and metastasis in B16 melanoma cells expressing beta1,4-N-acetylglucosaminyltransferase III.
Multiple Myeloma
Changes of beta-1,4-N-acetylglucosaminyltransferase III (GnT-III) in patients with leukaemia.
High expression of UDP-N-acetylglucosamine: beta-D mannoside beta-1,4-N-acetylglucosaminyltransferase III (GnT-III) in chronic myelogenous leukemia in blast crisis.
Neoplasm Metastasis
Aberrant glycosylation of E-cadherin enhances cell-cell binding to suppress metastasis.
Altered ?1,6-GlcNAc and bisecting GlcNAc-branched N-glycan on integrin ?1 are associated with early spontaneous miscarriage in humans.
Downregulated N-acetylglucosaminyltransferase III is involved in attenuating trophoblast migration and invasion under hypoxia-reoxygenation condition.
Expression of N-Acetylglucosaminyltransferase III Promotes Trophoblast Invasion and Migration in Early Human Placenta.
Expression of N-Acetylglucosaminyltransferase III Suppresses ?2,3-Sialylation, and Its Distinctive Functions in Cell Migration Are Attributed to ?2,6-Sialylation Levels.
Glycans and cancer: role of N-glycans in cancer biomarker, progression and metastasis, and therapeutics.
Implication of N-acetylglucosaminyltransferases III and V in cancer: gene regulation and signaling mechanism.
Loss and recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation is a mechanism involved in epithelial-mesenchymal-epithelial transitions.
N-acetylglucosaminyltransferase III and V messenger RNA levels in LEC rats during hepatocarcinogenesis.
N-acetylglucosaminyltransferase III antagonizes the effect of N-acetylglucosaminyltransferase V on alpha3beta1 integrin-mediated cell migration.
Potential of N-glycan in cell adhesion and migration as either a positive or negative regulator.
Remodeling of glycoconjugates on CD44 enhances cell adhesion to hyaluronate, tumor growth and metastasis in B16 melanoma cells expressing beta1,4-N-acetylglucosaminyltransferase III.
Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor ?1 (TGF-?1) in epithelial cell lines.
Suppression of lung metastasis of B16 mouse melanoma by N-acetylglucosaminyltransferase III gene transfection.
TGF-?1 Causes EMT by regulating N-Acetyl Glucosaminyl Transferases via Downregulation of Non Muscle Myosin II-A through JNK/P38/PI3K pathway in lung cancer.
The Role of N-acetylglucosaminyltransferase III and V in the Post-Transcriptional Modifications of E-cadherin.
[Suppression of lung metastasis of B16 mouse melanoma cells by introduction of N-acetylglucosaminyltransferase III gene]
Neoplasms
?4-integrin/PI3K Signaling Promotes Tumor Progression through Galectin-3-N-glycan Complex.
A glycomic approach to hepatic tumors in N-acetylglucosaminyltransferase III (GnT-III) transgenic mice induced by diethylnitrosamine (DEN): identification of haptoglobin as a target molecule of GnT-III.
All-trans-retinoic acid modulates ICAM-1 N-glycan composition by influencing GnT-III levels and inhibits cell adhesion and trans-endothelial migration.
Alteration in N -acetylglucosaminyltransferase activities and glycan structure in tissue and bile glycoproteins from extrahepatic bile duct carcinoma.
Altered glycosylation of proteins produced by malignant cells, and application for the diagnosis and immunotherapy of tumours.
Changes of beta-1,4-N-acetylglucosaminyltransferase III (GnT-III) in patients with leukaemia.
Downregulated N-acetylglucosaminyltransferase III is involved in attenuating trophoblast migration and invasion under hypoxia-reoxygenation condition.
E-cadherin and adherens-junctions stability in gastric carcinoma: Functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V.
Expression of N-Acetylglucosaminyltransferase III Promotes Trophoblast Invasion and Migration in Early Human Placenta.
Expression of N-Acetylglucosaminyltransferase III Suppresses ?2,3-Sialylation, and Its Distinctive Functions in Cell Migration Are Attributed to ?2,6-Sialylation Levels.
Glycans and cancer: role of N-glycans in cancer biomarker, progression and metastasis, and therapeutics.
Implication of N-acetylglucosaminyltransferases III and V in cancer: gene regulation and signaling mechanism.
Modulation of N-glycosylation by mesalamine facilitates membranous E-cadherin expression in colon epithelial cells.
N-Acetylglucosaminyltransferase III (GnT-III) but not N-Acetylgalactosaminyltransferase-6 and 8 are Differentially Expressed in Invasive and In Situ Ductal Carcinoma of the Breast.
N-acetylglucosaminyltransferase III and V messenger RNA levels in LEC rats during hepatocarcinogenesis.
N-acetylglucosaminyltransferase III, IV and V activities in Novikoff ascites tumour cells, mouse lymphoma cells and hen oviduct. Application of a sensitive and specific assay by use of high-performance liquid chromatography.
New evidence for an extra-hepatic role of N-acetylglucosaminyltransferase III in the progression of diethylnitrosamine-induced liver tumors in mice.
Potential of N-glycan in cell adhesion and migration as either a positive or negative regulator.
Reduced hepatocyte proliferation is the basis of retarded liver tumor progression and liver regeneration in mice lacking N-acetylglucosaminyltransferase III.
Reduced N-acetylglucosaminyltransferase III expression via Smad3 and Erk signaling in TGF-?1-induced HCC EMT model.
Remodeling of glycoconjugates on CD44 enhances cell adhesion to hyaluronate, tumor growth and metastasis in B16 melanoma cells expressing beta1,4-N-acetylglucosaminyltransferase III.
Roles of N-acetylglucosaminyltransferase III in epithelial-to-mesenchymal transition induced by transforming growth factor ?1 (TGF-?1) in epithelial cell lines.
The glycomic effect of N-acetylglucosaminyltransferase III overexpression in metastatic melanoma cells. GnT-III modifies highly branched N-glycans.
The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer.
Transfection of 2,6 and 2,3-sialyltransferase genes and GlcNAc-transferase genes into human glioma cell line U-373 MG affects glycoconjugate expression and enhances cell death.
True significance of N-acetylglucosaminyltransferases GnT-III, V and ?1,6 fucosyltransferase in epithelial-mesenchymal transition and cancer.
Neuroblastoma
Introduction of bisecting GlcNAc in N-glycans of adenylyl cyclase III enhances its activity.
N-acetylglucosaminyltransferase III antagonizes the effect of N-acetylglucosaminyltransferase V on alpha3beta1 integrin-mediated cell migration.
Protective effect of N-glycan bisecting GlcNAc residues on {beta}-amyloid production in Alzheimer's disease.
Obesity
Hyperexpression of N-acetylglucosaminyltransferase-III in liver tissues of transgenic mice causes fatty body and obesity through severe accumulation of Apo A-I and Apo B.
Ovarian Neoplasms
Expression of N-Acetylglucosaminyltransferase III Suppresses ?2,3-Sialylation, and Its Distinctive Functions in Cell Migration Are Attributed to ?2,6-Sialylation Levels.
Glycomic analysis of membrane glycoproteins with bisecting glycosylation from ovarian cancer tissues reveals novel structures and functions.
The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer.
Pheochromocytoma
Beta1,4-N-Acetylglucosaminyltransferase III down-regulates neurite outgrowth induced by costimulation of epidermal growth factor and integrins through the Ras/ERK signaling pathway in PC12 cells.
Overexpression of N-acetylglucosaminyltransferase III disrupts the tyrosine phosphorylation of Trk with resultant signaling dysfunction in PC12 cells treated with nerve growth factor.
Pre-Eclampsia
Downregulated N-acetylglucosaminyltransferase III is involved in attenuating trophoblast migration and invasion under hypoxia-reoxygenation condition.
Prion Diseases
Glycosylation differences between the normal and pathogenic prion protein isoforms.
Starvation
beta1,4-N-Acetylglucosaminyltransferase III potentiates beta1 integrin-mediated neuritogenesis induced by serum deprivation in Neuro2a cells.
Stomach Neoplasms
E-cadherin and adherens-junctions stability in gastric carcinoma: Functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V.
Expression of N-Acetylglucosaminyltransferase III Suppresses ?2,3-Sialylation, and Its Distinctive Functions in Cell Migration Are Attributed to ?2,6-Sialylation Levels.