Reference on EC 2.3.3.13 - 2-isopropylmalate synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bode, R.; Birnbaum, D.
Some properties of the leucine-biosynthesizing enzymes from Candida maltosa
J. Basic Microbiol.
31
21-26
1991
Candida maltosa
-
Beltzer, J.P.; Morris, S.R.; Kohlhaw, G.B.
Yeast LEU4 encodes mitochondrial and nonmitochondrial forms of alpha-isopropylmalate synthase
J. Biol. Chem.
263
368-374
1988
Saccharomyces cerevisiae
Wiegel, J.
Leucine biosynthesis in Alcaligenes eutrophus H16: influence of amino acid additions on the formation of active alpha-isopropylmalate synthase and alpha-acetohydroxy acid synthase
Arch. Microbiol.
142
194-199
1985
Cupriavidus necator, Cupriavidus necator H 16
-
Allison, M.J.; Baetz, A.L.; Wiegel, J.
Alternative pathways for biosynthesis of leucine and other amino acids in Bacteroides ruminicola and Bacteroides fragilis
Appl. Environ. Microbiol.
48
1111-1117
1984
Bacteroides fragilis, Prevotella ruminicola, Prevotella ruminicola 23
Honda, H.; Kato, C.; Kudo, T.; Horikoshi, K.
Cloning of leucine genes of alkalophilic Bacillus No. 221 in E. coli and B. subtilis
J. Biochem.
95
1485-1490
1984
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) No. 221
Hampsey, D.M.; Lewin, A.S.; Kohlhaw, G.B.
Submitochondrial localization, cell-free synthesis, and mitochondrial import of 2-isopropylmalate synthase of yeast
Proc. Natl. Acad. Sci. USA
80
1270-1274
1983
Saccharomyces cerevisiae, Saccharomyces cerevisiae D273-10B
Wiegel, J.
alpha-Isopropylmalate synthase as a marker for the leucine biosynthetic pathway in several clostridia and in Bacteroides fragilis
Arch. Microbiol.
130
385-390
1981
Bacteroides fragilis, Clostridium formicaceticum, Clostridium kluyveri, Clostridium pasteurianum, Moorella thermoacetica
Hampsey, D.M.; Kohlhaw, G.B.
Inactivation of yeast alpha-isopropylmalate synthase by CoA. Antagonism between CoA and adenylates and the mechanism of CoA inactivation
J. Biol. Chem.
256
3791-3796
1981
Saccharomyces cerevisiae, Saccharomyces cerevisiae SK101
Roeder, P.R.; Kohlhaw, G.B.
alpha-Isopropylmalate synthase from yeast. A zinc metalloenzyme
Biochim. Biophys. Acta
613
482-487
1980
Saccharomyces cerevisiae
Wiegel, J.
Mn++-specific reactivation of EDTA inactivated alpha-isopropylmalate synthase from Alcaligenes eutrophus H 16
Biochem. Biophys. Res. Commun.
82
907-912
1978
Cupriavidus necator, Cupriavidus necator H 16
Wiegel, J.; Schlegel, H.G.
alpha-Isopropylmalate synthase from Alcaligenes eutrophus H 16 I. Purification and general properties
Arch. Microbiol.
112
239-246
1977
Cupriavidus necator, Cupriavidus necator H 16
Wiegel, J.; Schlegel, H.G.
alpha-Isopropylmalate synthase from Alcaligenes eutrophus H 16. II. Substrate specificity and kinetics
Arch. Microbiol.
112
247-254
1977
Cupriavidus necator, Cupriavidus necator H 16
Wiegel, J.; Schlegel, H.G.
alpha-Isopropylmalate synthase from Alcaligenes eutrophus H 16. III. Endproduct inhibition and its relief by valine and isoleucine
Arch. Microbiol.
114
203-210
1977
Cupriavidus necator
Tracy, J.W.; Kohlhaw, G.B.
Evidence for two distinct CoA binding sites on yeast alpha-isopropylmalate synthase
J. Biol. Chem.
252
4085-4091
1977
Saccharomyces cerevisiae
Ulm, E.H.; Boehme, R.; Kohlhaw, G.
alpha-Isopropylmalate synthase from yeast: purification, kinetic studies and effect of ligands on stability
J. Bacteriol.
110
1118-1126
1972
Saccharomyces cerevisiae, Saccharomyces cerevisiae 60615
Leary, T.R.; Kohlhaw, G.B.
alpha-Isopropylmalate synthase from Salmonella typhimurium
J. Biol. Chem.
247
1089-1095
1972
Salmonella enterica subsp. enterica serovar Typhimurium
Bartholomew, J.C.; Calvo, J.M.
alpha-Isopropylmalate synthase from Salmonella typhimurium. Carboxypeptidase digestion studies of parent and feedback-insensitive enzymes
Biochim. Biophys. Acta
250
568-576
1971
Salmonella enterica subsp. enterica serovar Typhimurium
Hill, F.; Schlegel, H.G.
The alpha-isopropylmalate synthetase of Hydrogenomonas H 16
Arch. Mikrobiol.
68
1-17
1969
Hydrogenomonas sp., Hydrogenomonas sp. H16
Kohlhaw, G.; Leary, T.R.; Umbarger, H.E.
alpha-Isopropylmalate synthase from Salmonella typhimurium. Purification and properties
J. Biol. Chem.
244
2218-2225
1969
Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium CV-19
Webster, R.E.; Gross, S.R.
The alpha-isopropylmalate synthetase of Neurospora crassa. I. The kinetics and end product control of alpha-isopropylmalate synthetase function
Biochemistry
4
2309-2318
1965
Neurospora crassa
-
Teng-Leary, E.; Kohlhaw, G.B.
Mechanism of feedback inhibition by leucine. Binding of leucine to wild-type and feedback-resistant alpha-isopropylmalate synthases and its structural consequences
Biochemistry
12
2980-2986
1973
Salmonella enterica subsp. enterica serovar Typhimurium
Yoshikawa, S.; Oguri, I.; Kondo, K.; Fukuzawa, M.; Shimosaka, M.; Okazaki, M.
Enhanced formation of isoamyl alcohol in Zygosaccharomyces rouxii due to elimination of feedback inhibition of alpha-isopropylmalate synthase
FEMS Microbiol. Lett.
127
139-143
1995
Zygosaccharomyces rouxii
Azuma, T.; Nakanishi, T.
Enzymatic background for the reversion or stabilization of an L-leucine producing strain of Corynebacterium glutamicum
Agric. Biol. Chem.
52
1525-1528
1988
Corynebacterium glutamicum
-
Cavalieri, D.; Casalone, E.; Bendoni, B.; Fia, G.; Polsinelli, M.; Barberio, C.
Trifluoroleucine resistance and regulation of alpha-isopropyl malate synthase in Saccharomyces cerevisiae
Mol. Gen. Genet.
261
152-160
1999
Saccharomyces cerevisiae
Hagelstein, P.; Schultz, G.
Leucine synthesis in spinach chloroplasts: partial characterization of 2-isopropylmalate synthase
Biol. Chem. Hoppe-Seyler
374
1105-1108
1993
Spinacia oleracea
Kohlhaw, G.B.
Alpha-isopropylmalate synthase from yeast
Methods Enzymol.
166
414-423
1988
Saccharomyces cerevisiae
Stieglitz, B.I.; Calvo, J.M.
Distribution of the isopropylmalate pathway to leucine among diverse bacteria
J. Bacteriol.
118
935-941
1974
Alcaligenes viscolactis, Bacillus subtilis, Bradyrhizobium japonicum, Cereibacter sphaeroides, Chromatium sp., Chromatium sp. D, Escherichia coli, Escherichia coli B / ATCC 11303, Hydrogenomonas sp., Klebsiella aerogenes, Methylorubrum extorquens, Micrococcus luteus, Micrococcus sp., Paenibacillus polymyxa, Proteus vulgaris, Pseudomonas aeruginosa, Pseudomonas fluorescens, Rhodococcus opacus, Salmonella enterica subsp. enterica serovar Typhimurium
Casalone, E.; Barberio, C.; Cavalieri, D.; Polsinelli, M.
Identification by functional analysis of the gene encoding a-isopropylmalate synthase II (LEU9) in Saccharomyces cerevisiae
Yeast
16
539-545
2000
Saccharomyces cerevisiae
Chanchaem, W.; Palittapongarnpim, P.
A variable number of tandem repeats result in polymorphic alpha -isopropylmalate synthase in Mycobacterium tuberculosis
Tuberculosis
82
1-6
2002
Mycobacterium tuberculosis
Junk, D.J.; Mourad, G.S.
Isolation and expression analysis of the isopropylmalate synthase gene family of Arabidopsis thaliana
J. Exp. Bot.
53
2453-2454
2002
Arabidopsis thaliana (Q9C550), Arabidopsis thaliana (Q9FG67), Arabidopsis thaliana (Q9FN52), Arabidopsis thaliana, Arabidopsis thaliana IMS 2 (Q9FN52), Arabidopsis thaliana IMS 3 (Q9FG67), Arabidopsis thaliana IMS 1 (Q9C550)
Koon, N.; Squire, C.J.; Baker, E.N.
Crystallization and preliminary X-ray analysis of alpha-isopropylmalate synthase from Mycobacterium tuberculosis
Acta Crystallogr. Sect. D
60
1167-1169
2004
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
de Carvalho, L.P.S.; Argyrou, A.; Blanchard, J.S.
Slow-onset feedback inhibition: Inhibition of Mycobacterium tuberculosis alpha-isopropylmalate synthase by L-leucine
J. Am. Chem. Soc.
127
10004-10005
2005
Mycobacterium tuberculosis
de Carvalho, L.P.; Blanchard, J.S.
Kinetic analysis of the effects of monovalent cations and divalent metals on the activity of Mycobacterium tuberculosis alpha-isopropylmalate synthase
Arch. Biochem. Biophys.
451
141-148
2006
Mycobacterium tuberculosis
de Carvalho, L.P.; Blanchard, J.S.
Kinetic and chemical mechanism of alpha-isopropylmalate synthase from Mycobacterium tuberculosis
Biochemistry
45
8988-8999
2006
Mycobacterium tuberculosis
Oba, T.; Nomiyama, S.; Hirakawa, H.; Tashiro, K.; Kuhara, S.
Asp578 in LEU4p is one of the key residues for leucine feedback inhibition release in sake yeast
Biosci. Biotechnol. Biochem.
69
1270-1273
2005
Saccharomyces cerevisiae
Li, F.; Hagemeier, C.H.; Seedorf, H.; Gottschalk, G.; Thauer, R.K.
Re-citrate synthase from Clostridium kluyveri is phylogenetically related to homocitrate synthase and isopropylmalate synthase rather than to Si-citrate synthase
J. Bacteriol.
189
4299-4304
2007
Clostridium kluyveri, Desulfovibrio desulfuricans, Desulfovibrio vulgaris
Field, B.; Furniss, C.; Wilkinson, A.; Mithen, R.
Expression of a Brassica isopropylmalate synthase gene in Arabidopsis perturbs both glucosinolate and amino acid metabolism
Plant Mol. Biol.
60
717-727
2006
Brassica insularis (Q30DX9)
de Kraker, J.W.; Luck, K.; Textor, S.; Tokuhisa, J.G.; Gershenzon, J.
Two Arabidopsis genes (IPMS1 and IPMS2) encode isopropylmalate synthase, the branchpoint step in the biosynthesis of leucine
Plant Physiol.
143
970-986
2007
Arabidopsis thaliana, Arabidopsis thaliana (Q9C550), Arabidopsis thaliana (Q9LPR4)
Singh, K.; Bhakuni, V.
Cation induced differential effect on structural and functional properties of Mycobacterium tuberculosis alpha -isopropylmalate synthase
BMC Struct. Biol.
7
39
2007
Mycobacterium tuberculosis
Chanchaem, W.; Palittapongarnpim, P.
The significance and effect of tandem repeats within the Mycobacterium tuberculosis leuA gene on alpha-isopropylmalate synthase
FEMS Microbiol. Lett.
286
166-170
2008
Mycobacterium tuberculosis
Huisman, F.H.; Hunter, M.F.; Devenish, S.R.; Gerrard, J.A.; Parker, E.J.
The C-terminal regulatory domain is required for catalysis by Neisseria meningitidis alpha-isopropylmalate synthase
Biochem. Biophys. Res. Commun.
393
168-173
2010
Neisseria meningitidis (Q9JZG1), Neisseria meningitidis
de Carvalho, L.P.; Frantom, P.A.; Argyrou, A.; Blanchard, J.S.
Kinetic evidence for interdomain communication in the allosteric regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis
Biochemistry
48
1996-2004
2009
Mycobacterium tuberculosis (P9WQB3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WQB3)
Frantom, P.A.; Zhang, H.M.; Emmett, M.R.; Marshall, A.G.; Blanchard, J.S.
Mapping of the allosteric network in the regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis by the feedback inhibitor L-leucine: solution-phase H/D exchange monitored by FT-ICR mass spectrometry
Biochemistry
48
7457-7464
2009
Mycobacterium tuberculosis
Yindeeyoungyeon, W.; Likitvivatanavong, S.; Palittapongarnpim, P.
Characterization of alpha-isopropylmalate synthases containing different copy numbers of tandem repeats in Mycobacterium tuberculosis
BMC Microbiol.
9
122
2009
Mycobacterium tuberculosis (P9WQB3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WQB3)
Frantom, P.A.
Structural and functional characterization of alpha-isopropylmalate synthase and citramalate synthase, members of the LeuA dimer superfamily
Arch. Biochem. Biophys.
519
202-209
2012
Mycobacterium tuberculosis
Huisman, F.H.; Koon, N.; Bulloch, E.M.; Baker, H.M.; Baker, E.N.; Squire, C.J.; Parker, E.J.
Removal of the C-terminal regulatory domain of alpha-isopropylmalate synthase disrupts functional substrate binding
Biochemistry
51
2289-2297
2012
Mycobacterium tuberculosis (P9WQB3), Mycobacterium tuberculosis, Neisseria meningitidis (Q9JZG1), Neisseria meningitidis, Mycobacterium tuberculosis H37Rv (P9WQB3)
Casey, A.K.; Baugh, J.; Frantom, P.A.
The slow-onset nature of allosteric inhibition in alpha-isopropylmalate synthase from Mycobacterium tuberculosis is mediated by a flexible loop
Biochemistry
51
4773-4775
2012
Mycobacterium tuberculosis
Larson, E.M.; Idnurm, A.
Two origins for the gene encoding alpha-isopropylmalate synthase in fungi
PLoS ONE
5
e11605
2010
Phycomyces blakesleeanus, Phycomyces blakesleeanus NRRL1555 and UBC21
Kumar, G.; Frantom, P.A.
Evolutionarily distinct versions of the multidomain enzyme alpha-isopropylmalate synthase share discrete mechanisms of V-type allosteric regulation
Biochemistry
53
4847-4856
2014
Methanocaldococcus jannaschii (Q58595), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q58595)
Huisman, F.H.; Squire, C.J.; Parker, E.J.
Amino-acid substitutions at the domain interface affect substrate and allosteric inhibitor binding in alpha-isopropylmalate synthase from Mycobacterium tuberculosis
Biochem. Biophys. Res. Commun.
433
249-254
2013
Mycobacterium tuberculosis (P9WQB3)
Casey, A.K.; Schwalm, E.L.; Hays, B.N.; Frantom, P.A.
V-type allosteric inhibition is described by a shift in the rate-determining step for alpha-isopropylmalate synthase from Mycobacterium tuberculosis
Biochemistry
52
6737-6739
2013
Mycobacterium tuberculosis
Casey, A.K.; Hicks, M.A.; Johnson, J.L.; Babbitt, P.C.; Frantom, P.A.
Mechanistic and bioinformatic investigation of a conserved active site helix in alpha-isopropylmalate synthase from Mycobacterium tuberculosis, a member of the DRE-TIM metallolyase superfamily
Biochemistry
53
2915-2925
2014
Methanocaldococcus jannaschii
Frantom, P.A.; Birman, Y.; Hays, B.N.; Casey, A.K.
An evolutionarily conserved alternate metal ligand is important for activity in alpha-isopropylmalate synthase from Mycobacterium tuberculosis
Biochim. Biophys. Acta
1844
1784-1789
2014
Mycobacterium tuberculosis
Lopez, G.; Quezada, H.; Duhne, M.; Gonzalez, J.; Lezama, M.; El-Hafidi, M.; Colon, M.; Martinez de la Escalera, X.; Flores-Villegas, M.C.; Scazzocchio, C.; DeLuna, A.; Gonzalez, A.
Diversification of paralogous alpha-isopropylmalate synthases by modulation of feedback control and hetero-oligomerization in Saccharomyces cerevisiae
Eukaryot. Cell
14
564-577
2015
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Hunter, M.F.; Parker, E.J.
Modifying the determinants of alpha-ketoacid substrate selectivity in Mycobacterium tuberculosis alpha-isopropylmalate synthase
FEBS Lett.
588
1603-1607
2014
Mycobacterium tuberculosis (P9WQB3)
Zhang, Z.; Wu, J.; Lin, W.; Wang, J.; Yan, H.; Zhao, W.; Ma, J.; Ding, J.; Zhang, P.; Zhao, G.P.
Subdomain II of alpha-isopropylmalate synthase is essential for activity: inferring a mechanism of feedback inhibition
J. Biol. Chem.
289
27966-27978
2014
Leptospira biflexa (B0SN40)
Ning, J.; Moghe, G.D.; Leong, B.; Kim, J.; Ofner, I.; Wang, Z.; Adams, C.; Jones, A.D.; Zamir, D.; Last, R.L.
A feedback-insensitive isopropylmalate synthase affects acylsugar composition in cultivated and wild tomato
Plant Physiol.
169
1821-1835
2015
Solanum pennellii (A0A0G2T6D7), Solanum pennellii, Solanum lycopersicum (K4C627), Solanum lycopersicum (K4CJ56), Solanum lycopersicum
Yoshida, A.; Kosono, S.; Nishiyama, M.
Characterization of two 2-isopropylmalate synthase homologs from Thermus thermophilus HB27
Biochem. Biophys. Res. Commun.
501
465-470
2018
Thermus thermophilus (Q72JC9)
Pandey, P.; Lynn, A.M.; Bandyopadhyay, P.
Identification of inhibitors against alpha-isopropylmalate synthase of Mycobacterium tuberculosis using docking-MM/PBSA hybrid approach
Bioinformation
13
144-148
2017
Mycobacterium tuberculosis (P9WQB3), Mycobacterium tuberculosis ATCC 25618 (P9WQB3)
Yoshida, A.; Yoshida, M.; Kuzuyama, T.; Nishiyama, M.; Kosono, S.
Protein acetylation on 2-isopropylmalate synthase from Thermus thermophilus HB27
Extremophiles
23
377-388
2019
Thermus thermophilus (Q72JC9)
Abe, T.; Toyokawa, Y.; Sugimoto, Y.; Azuma, H.; Tsukahara, K.; Nasuno, R.; Watanabe, D.; Tsukahara, M.; Takagi, H.
Characterization of a new Saccharomyces cerevisiae isolated from Hibiscus flower and its mutant with L-leucine accumulation for awamori brewing
Front. Genet.
10
490
2019
Saccharomyces cerevisiae, Saccharomyces cerevisiae HC02-5-2
Schaufelberger, M.; Galbier, F.; Herger, A.; de Brito Francisco, R.; Roffler, S.; Clement, G.; Diet, A.; Hoertensteiner, S.; Wicker, T.; Ringli, C.
Mutations in the Arabidopsis ROL17/isopropylmalate synthase 1 locus alter amino acid content, modify the TOR network, and suppress the root hair cell development mutant lrx1
J. Exp. Bot.
70
2313-2323
2019
Arabidopsis thaliana (Q9LPR4), Arabidopsis thaliana
He, Y.; Cheng, J.; He, Y.; Yang, B.; Cheng, Y.; Yang, C.; Zhang, H.; Wang, Z.
Influence of isopropylmalate synthase OsIPMS1 on seed vigour associated with amino acid and energy metabolism in rice
Plant Biotechnol. J.
17
322-337
2019
Oryza sativa Japonica Group (Q2QXY9), Oryza sativa Japonica Group (Q2RAP8)
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