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Information on EC 2.3.2.6 - lysine/arginine leucyltransferase

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.2 Aminoacyltransferases
                2.3.2.6 lysine/arginine leucyltransferase
IUBMB Comments
Requires a univalent cation. The enzyme participates in the N-end rule protein degradation pathway in certain bacteria, by attaching the primary destabilizing residue L-leucine to the N-termini of proteins that have an N-terminal L-arginine or L-lysine residue. Once modified, the proteins are recognized by EC 3.4.21.92, the ClpAP/ClpS endopeptidase system. The enzyme also transfers L-phenylalanine in vitro, but this has not been observed in vivo . cf. EC 2.3.2.29, aspartate/glutamate leucyltransferase, and EC 2.3.2.8, arginyltransferase.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
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N-terminal L-lysyl-[protein]
=
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N-terminal L-leucyl-L-lysyl-[protein]
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N-terminal L-arginyl-[protein]
=
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N-terminal L-leucyl-L-arginyl-[protein]
Synonyms
l/f-transferase, l/f transferase, leucyl/phenylalanyl-trna-protein transferase, aminoacyl transferase, lf-transferase, leucyl/phenylalanyl-trna protein transferase, l/f-trna-protein transferase, leucyltransferase, leucyl/phenylalanyl trna protein transferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-leucyl-tRNALeu + N-terminal L-arginyl-[protein] = tRNALeu + N-terminal L-leucyl-L-arginyl-[protein]
show the reaction diagram
(2)
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L-leucyl-tRNALeu + N-terminal L-lysyl-[protein] = tRNALeu + N-terminal L-leucyl-L-lysyl-[protein]
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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