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Disease on EC 2.3.2.26 - HECT-type E3 ubiquitin transferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans.
Acquired Immunodeficiency Syndrome
Distinguishing the optimal binding mechanism of an E3 ubiquitin ligase: Covalent versus noncovalent inhibition.
Acute Kidney Injury
cMet agonistic antibody prevents acute kidney injury to chronic kidney disease transition by suppressing Smurf1 and activating Smad7.
Adenocarcinoma
Nedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis.
The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer.
Adenocarcinoma of Lung
ALCAP2 inhibits lung adenocarcinoma cell proliferation, migration and invasion via the ubiquitination of ?-catenin by upregulating the E3 ligase NEDD4L.
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53.
Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2.
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
Ubiquitination of heat shock protein 27 is mediated by its interaction with Smad ubiquitination regulatory factor 2 in A549 cells.
Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma.
Adenoma
NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor.
NEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling.
Adenoviridae Infections
CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys.
Amyotrophic Lateral Sclerosis
Regionally different immunoreactivity for Smurf2 and pSmad2/3 in TDP-43-positive inclusions of amyotrophic lateral sclerosis.
Anemia, Sickle Cell
PPAR? increases HUWE1 to attenuate NF-?B/p65 and sickle cell disease with pulmonary hypertension.
Aneurysm
Salvia miltiorrhiza-Derived Sal-miR-58 Induces Autophagy and Attenuates Inflammation in Vascular Smooth Muscle Cells.
Angelman Syndrome
A placebo-controlled trial of folic acid and betaine in identical twins with Angelman syndrome.
Administration of CoQ10 analogue ameliorates dysfunction of the mitochondrial respiratory chain in a mouse model of Angelman syndrome.
Cognitive and adaptive behavior profiles of children with Angelman syndrome.
De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome.
Denaturing high-performance liquid chromatography for the detection of mutations and polymorphisms in UBE3A.
E3 Ubiquitin Ligases in Neurological Diseases: Focus on Gigaxonin and Autophagy.
Genomic organization of the UBE3A/E6-AP gene and related pseudogenes.
Human disorders of ubiquitination and proteasomal degradation.
LRSAM1 E3 ubiquitin ligase promotes proteasomal clearance of E6-AP protein.
Molecular Evolution, Neurodevelopmental Roles and Clinical Significance of HECT-Type UBE3 E3 Ubiquitin Ligases.
Multiple regions of E6AP (UBE3A) contribute to interaction with papillomavirus E6 proteins and the activation of ubiquitin ligase activity.
Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.
Mutation screening of the UBE3A/E6-AP gene in autistic disorder.
Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome.
The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily.
The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/?-catenin pathway by inhibiting the proteasome.
The E6-Ap ubiquitin-protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region.
The human E6-AP gene (UBE3A) encodes three potential protein isoforms generated by differential splicing.
The Ubiquitin Ligase E6-AP Is Induced and Recruited to Aggresomes in Response to Proteasome Inhibition and May Be Involved in the Ubiquitination of Hsp70-bound Misfolded Proteins.
UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27.
Anhedonia
Nedd4l downregulation of NRG1 in the mPFC induces depression-like behaviour in CSDS mice.
Appendicitis
Association Between NEDD4L Variation and the Genetic Risk of Acute Appendicitis: A Multi-institutional Genome-Wide Association Study.
NEDD4L Polymorphism and Acute Appendicitis and the Need for a Deeper Dive.
Arrhythmias, Cardiac
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Asthma
Association analysis of UBE3C polymorphisms in Korean aspirin-intolerant asthmatic patients.
UBE3C genetic variations as potent markers of nasal polyps in Korean asthma patients.
Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma.
Ataxia Telangiectasia
Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response.
Transcriptional and Posttranslational Regulation of Nucleotide Excision Repair: The Guardian of the Genome against Ultraviolet Radiation.
Atherosclerosis
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Nedd4 Deficiency in Vascular Smooth Muscle Promotes Vascular Calcification by Stabilizing pSmad1.
Atrial Fibrillation
Identification of Co-expressed Genes Between Atrial Fibrillation and Stroke.
Bacterial Infections
HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection.
HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection.
The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.
Bone Diseases
Value of Osteoblast-Derived Exosomes in Bone Diseases.
Bone Diseases, Metabolic
Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation.
Bone Resorption
PMEPA1 and NEDD4 control the proton production of osteoclasts by regulating vesicular trafficking.
Brain Ischemia
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.
Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke.
Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion.
Brain Neoplasms
The N-Myc-DLL3 Cascade Is Suppressed by the Ubiquitin Ligase Huwe1 to Inhibit Proliferation and Promote Neurogenesis in the Developing Brain.
Ubiquitination by HUWE1 in tumorigenesis and beyond.
Breast Neoplasms
A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1.
A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.
Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer.
Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p.
Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4-1 and NRDP1, in primary breast cancer.
Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner.
Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.
Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis.
ER re-expression and re-sensitization to endocrine therapies in ER-negative breast cancers.
HUWE1 interacts with BRCA1 and promotes its degradation in the ubiquitin-proteasome pathway.
Identification of a new natural biflavonoids against breast cancer cells induced ferroptosis via the mitochondrial pathway.
Inverse association between MDM2 and HUWE1 protein expression levels in human breast cancer and liposarcoma.
Isoform-specific degradation of PR-B by E6-AP is critical for normal mammary gland development.
Liganded ER? Stimulates the E3 Ubiquitin Ligase Activity of UBE3C to Facilitate Cell Proliferation.
Metastatic heterogeneity of breast cancer cells is associated with expression of a heterogeneous TGF?-activating miR424-503 gene cluster.
MiR-153 promotes breast cancer cell apoptosis by targeting HECTD3.
NEDD4 expression is associated with breast cancer progression and is predictive of a poor prognosis.
NEDD4 Family of E3 Ubiquitin Ligases in Breast Cancer: Spotlight on SMURFs, WWPs and NEDD4.
NEDD4 Plays Roles in the Maintenance of Breast Cancer Stem Cell Characteristics.
NEDD4-induced degradative ubiquitination of phosphatidylinositol 4-phosphate 5-kinase ? and its implication in breast cancer cell proliferation.
Oncogenic function of p34SEI-1 via NEDD4?1?mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway.
Oncogenic UBE3C promotes breast cancer progression by activating Wnt/?-catenin signaling.
Overexpression of ligase defective E6-associated protein, E6-AP, results in mammary tumorigenesis.
PRRG4 promotes breast cancer metastasis through the recruitment of NEDD4 and downregulation of Robo1.
PTEN and NEDD4 in Human Breast Carcinoma.
Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression.
Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness.
SMURF1 facilitates estrogen receptor ? signaling in breast cancer cells.
SMURF1 plays a role in EGF-induced breast cancer cell migration and invasion.
Smurf2 E3 ubiquitin ligase modulates proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner.
Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.
SND1 acts downstream of TGF?1 and upstream of Smurf1 to promote breast cancer metastasis.
The expression and clinical significance of HERC4 in breast cancer.
The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8.
The miR-106b-25 cluster mediates breast tumor initiation through activation of NOTCH1 via direct repression of NEDD4L.
The Nedd4-like family of E3 ubiquitin ligases and cancer.
The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2.
The PIAS3-Smurf2 sumoylation pathway suppresses breast cancer organoid invasiveness.
The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.
Transcriptome-wide analysis and modelling of prognostic alternative splicing signatures in invasive breast cancer: a prospective clinical study.
USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis.
[Expression of E3 ligase HERC4 in breast cancer and its clinical implications].
Brucellosis
Brucella infection inhibits macrophages apoptosis via Nedd4-dependent degradation of calpain2.
Carcinogenesis
A cell-based high-throughput screening method based on a ubiquitin-reference technique for identifying modulators of E3 ligases.
A conformational switch regulates the ubiquitin ligase HUWE1.
A genome-wide association study to identify genetic susceptibility loci that modify ductal and lobular postmenopausal breast cancer risk associated with menopausal hormone therapy use: a two-stage design with replication.
A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1.
A Variant Smurf2 Protects Mice Against Colitis-Associated Colon Cancer by Inducing Transforming Growth Factor ? Signaling.
Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer.
ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance.
Bortezomib prevents oncogenesis and bone metastasis of prostate cancer by inhibiting WWP1, Smurf1 and Smurf2.
Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner.
Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p.
CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation.
Decreased expression of e6-associated protein in breast and prostate carcinomas.
DNA methylation-mediated downregulation of PTPN3 attenuates to boost TGF-? signaling in osteosarcoma cells.
Downregulation of Nedd4L predicts poor prognosis, promotes tumor growth and inhibits MAPK/ERK signal pathway in hepatocellular carcinoma.
Exploring the Roles of HERC2 and the NEDD4L HECT E3 Ubiquitin Ligase Subfamily in p53 Signaling and the DNA Damage Response.
FOSL1 promotes tumorigenesis in colorectal carcinoma by mediating the FBXL2/Wnt/?-catenin axis via Smurf1.
Generation of Smurf2 Conditional Knockout Mice.
Generation of SMURF2 knockout human cells using the CRISPR/Cas9 system.
H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis.
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53.
IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way.
Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?
Low density lipoprotein receptor class A domain containing 4 (LDLRAD4) promotes tumorigenesis of hepatic cancer cells.
Meta-analysis of gene expression alterations and clinical significance of the HECT domain-containing ubiquitin ligase HUWE1 in cancer.
MicroRNA-125a inhibits tumorigenesis by targeting Smurf1 in colorectal carcinoma.
MiR-542-5p is a negative prognostic factor and promotes osteosarcoma tumorigenesis by targeting HUWE1.
miR-93 promotes TGF-?-induced epithelial-to-mesenchymal transition through downregulation of NEDD4L in lung cancer cells.
NEDD4 E3 ligase: Functions and mechanism in human cancer.
NEDD4 triggers FOXA1 ubiquitination and promotes colon cancer progression under microRNA-340-5p suppression and ATF1 upregulation.
Nedd4, a human ubiquitin ligase, affects actin cytoskeleton in yeast cells.
Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer.
Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer.
Oncogenic Mutation of AIMP2/p38 Inhibits Its Tumor-Suppressive Interaction with Smurf2.
Overexpression of ligase defective E6-associated protein, E6-AP, results in mammary tumorigenesis.
Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.
Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas.
RNF43 interacts with NEDL1 and regulates p53-mediated transcription.
SCF?-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway.
Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1.
Smurf1 controls S phase progression and tumorigenesis through Wee1 degradation.
Smurf1 regulation of DAB2IP controls cell proliferation and migration.
Smurf1-positive expression indicates favorable survival for resected non-small cell lung cancer patients.
Smurf2 as a novel mitotic regulator: From the spindle assembly checkpoint to tumorigenesis.
SMURF2 prevents detrimental changes to chromatin, protecting human dermal fibroblasts from chromosomal instability and tumorigenesis.
Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.
Structure of the HECT domain of human WWP2.
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.
The dual function steroid receptor coactivator/ubiquitin protein-ligase integrator E6-AP is overexpressed in mouse mammary tumorigenesis.
The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer.
The Emerging Roles of the HERC Ubiquitin Ligases in Cancer.
The HECT family of E3 ubiquitin ligases: multiple players in cancer development.
The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase.
Transcription alterations of members of the ubiquitin-proteasome network in prostate carcinoma.
Ubiquitin ligase E6-AP and its role in human disease.
Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex.
Ubiquitination by HUWE1 in tumorigenesis and beyond.
Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.
USF2 inhibits the transcriptional activity of Smurf1 and Smurf2 to promote breast cancer tumorigenesis.
[Expression of E3 ligase HERC4 in breast cancer and its clinical implications].
Carcinoma
Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4-1 and NRDP1, in primary breast cancer.
Decreased expression of e6-associated protein in breast and prostate carcinomas.
Deletion of SMURF 1 represses ovarian cancer invasion and EMT by modulating the DAB2IP/AKT/Skp2 feedback loop.
Enhanced immortalization, HUWE1 mutations and other biological drivers of breast invasive carcinoma in Black/African American patients.
Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomas.
HERC4 Is Overexpressed in Hepatocellular Carcinoma and Contributes to the Proliferation and Migration of Hepatocellular Carcinoma Cells.
High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma.
HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.
Involvement of general control nonderepressible kinase 2 in cancer cell apoptosis by posttranslational mechanisms.
Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?
Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy.
Oncogenic Role of the E3 Ubiquitin Ligase NEDD4-1, a PTEN Negative Regulator, in Non-Small-Cell Lung Carcinomas.
Pan-cancer Analysis of NEDD4L and Its Tumor Suppressor Effects in Clear Cell Renal Cell Carcinoma.
PTEN and NEDD4 in Human Breast Carcinoma.
Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression.
SMURF1 silencing diminishes a CD44-high cancer stem cell-like population in head and neck squamous cell carcinoma.
SMURF1, a promoter of tumor cell progression?
Suppression of human tumor cell proliferation by Smurf2-induced senescence.
The E3 ligase HECTD3 promotes esophageal squamous cell carcinoma (ESCC) growth and cell survival through targeting and inhibiting caspase-9 activation.
The E3 ubiquitin ligase NEDD4 induces endocytosis and lysosomal sorting of connexin 43 to promote loss of gap junctions.
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
The Nedd4-like family of E3 ubiquitin ligases and cancer.
UBE3C Promotes Growth and Metastasis of Renal Cell Carcinoma via Activating Wnt/?-Catenin Pathway.
Ubiquitin ligase SMURF1 functions as a prognostic marker and promotes growth and metastasis of clear cell renal cell carcinoma.
Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells.
Upregulation of microRNA?194?5p inhibits hypopharyngeal carcinoma cell proliferation, migration and invasion by targeting SMURF1 via the mTOR signaling pathway.
Whole-exome sequencing identifies mutated PCK2 and HUWE1 associated with carcinoma cell proliferation in a hepatocellular carcinoma patient.
Carcinoma, Basal Cell
Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells.
Carcinoma, Ductal
Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression.
Carcinoma, Hepatocellular
CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and ?TrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular carcinoma cells.
CUL4B, NEDD4, and UGT1As involve in the TGF-? signalling in hepatocellular carcinoma.
Downregulation of Nedd4L predicts poor prognosis, promotes tumor growth and inhibits MAPK/ERK signal pathway in hepatocellular carcinoma.
HERC4 Is Overexpressed in Hepatocellular Carcinoma and Contributes to the Proliferation and Migration of Hepatocellular Carcinoma Cells.
MiR-542-3p inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting UBE3C.
NEDD4 Depletion Inhibits Hepatocellular Carcinoma Growth via Targeting PTEN.
NEDD4 Induces K48-Linked Degradative Ubiquitination of Hepatitis B Virus X Protein and Inhibits HBV-Associated HCC Progression.
NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma.
NEDD4 promotes cell growth and motility in hepatocellular carcinoma.
The ménage à trois of autophagy, lipid droplets and liver disease.
Ubiquitination of UVRAG by SMURF1 promotes autophagosome maturation and inhibits hepatocellular carcinoma growth.
Whole-exome sequencing identifies mutated PCK2 and HUWE1 associated with carcinoma cell proliferation in a hepatocellular carcinoma patient.
 CUL4B, NEDD4, and UGT1As involve in the TGF-? signalling in hepatocellular carcinoma.
Carcinoma, Non-Small-Cell Lung
Decreased expression of NEDD4L contributes to NSCLC progression and metastasis.
Erratum to: Identification of the NEDD4L Gene as a Prognostic Marker by Integrated Microarray Analysis of Copy Number and Gene Expression Profiling in Non-small Cell Lung Cancer.
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53.
Identification of the NEDD4L Gene as a Prognostic Marker by Integrated Microarray Analysis of Copy Number and Gene Expression Profiling in Non-small Cell Lung Cancer.
Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival.
Oncogenic Role of the E3 Ubiquitin Ligase NEDD4-1, a PTEN Negative Regulator, in Non-Small-Cell Lung Carcinomas.
Smurf1-positive expression indicates favorable survival for resected non-small cell lung cancer patients.
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
Carcinoma, Ovarian Epithelial
Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue.
Carcinoma, Renal Cell
Integrated bioinformatics analysis of the NEDD4 family reveals a prognostic value of NEDD4L in clear-cell renal cell cancer.
Pan-cancer Analysis of NEDD4L and Its Tumor Suppressor Effects in Clear Cell Renal Cell Carcinoma.
SMURF1, a promoter of tumor cell progression?
UBE3C Promotes Growth and Metastasis of Renal Cell Carcinoma via Activating Wnt/?-Catenin Pathway.
Ubiquitin ligase SMURF1 functions as a prognostic marker and promotes growth and metastasis of clear cell renal cell carcinoma.
Carcinoma, Squamous Cell
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53.
SMURF1 silencing diminishes a CD44-high cancer stem cell-like population in head and neck squamous cell carcinoma.
Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells.
Cardiomegaly
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
HECT (Homologous to the E6-AP Carboxyl Terminus)-Type Ubiquitin E3 Ligase ITCH Attenuates Cardiac Hypertrophy by Suppressing the Wnt/?-Catenin Signaling Pathway.
The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice.
Cardiomyopathy, Dilated
Genomic analysis of an infant with intractable diarrhea and dilated cardiomyopathy.
Cardiotoxicity
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
HECT-Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin-Interacting Protein and Ameliorates Reactive Oxygen Species-Induced Cardiotoxicity.
Cardiovascular Diseases
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Genetic variation in NEDD4L, an epithelial sodium channel regulator, is associated with cardiovascular disease and cardiovascular death.
Cerebral Infarction
Smurf2 exerts neuroprotective effects on cerebral ischemic injury.
Cervical Intraepithelial Neoplasia
Detection of E6-AP as a potential therapeutic target in cervical specimen of HPV-infected women.
Charcot-Marie-Tooth Disease
SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease.
SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation.
Cleft Palate
A novel missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria and cleft palate.
Author Correction: A missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria, and cleft palate.
Familial NEDD4L variant in periventricular nodular heterotopia and in a fetus with hypokinesia and flexion contractures.
Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.
Recurrent NEDD4L Variant in Periventricular Nodular Heterotopia, Polymicrogyria and Syndactyly.
Cockayne Syndrome
Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1.
Colitis, Ulcerative
Emerging views of mitophagy in immunity and autoimmune diseases.
Colitis-Associated Neoplasms
A Variant Smurf2 Protects Mice Against Colitis-Associated Colon Cancer by Inducing Transforming Growth Factor ? Signaling.
Colonic Neoplasms
CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation.
IRAK2 counterbalances oncogenic Smurf1 in colon cancer cells by dictating ER stress.
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.
NEDD4 triggers FOXA1 ubiquitination and promotes colon cancer progression under microRNA-340-5p suppression and ATF1 upregulation.
Reversible regulation of SATB1 ubiquitination by USP47 and SMURF2 mediates colon cancer cell proliferation and tumor progression.
Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation.
SMURF1, a promoter of tumor cell progression?
Colorectal Neoplasms
E3 ubiquitin ligase SMURF2 prevents colorectal cancer by reducing the stability of the YY1 protein and inhibiting the SENP1/c-myc axis.
E3 ubiquitin ligase Smurf2: a prognostic factor in microsatellite stable colorectal cancer.
Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomas.
FOSL1 promotes tumorigenesis in colorectal carcinoma by mediating the FBXL2/Wnt/?-catenin axis via Smurf1.
Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.
HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.
Intestinal knockout of Nedd4 enhances growth of Apc(min) tumors.
IRAK2 counterbalances oncogenic Smurf1 in colon cancer cells by dictating ER stress.
Low Expression of Smurf1 Enhances the Chemosensitivity of Human Colorectal Cancer to Gemcitabine and Cisplatin in Patient-Derived Xenograft Models.
Meta-analysis of gene expression alterations and clinical significance of the HECT domain-containing ubiquitin ligase HUWE1 in cancer.
MicroRNA-125a inhibits tumorigenesis by targeting Smurf1 in colorectal carcinoma.
Nedd4 E3 ubiquitin ligase promotes cell proliferation and autophagy.
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.
NEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling.
STK35 Is Ubiquitinated by NEDD4L and Promotes Glycolysis and Inhibits Apoptosis Through Regulating the AKT Signaling Pathway, Influencing Chemoresistance of Colorectal Cancer.
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.
The ubiquitination ligase SMURF2 reduces aerobic glycolysis and colorectal cancer cell proliferation by promoting ChREBP ubiquitination and degradation.
Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.
Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.
Contracture
Familial NEDD4L variant in periventricular nodular heterotopia and in a fetus with hypokinesia and flexion contractures.
COVID-19
Inhibition of HECT E3 ligases as potential therapy for COVID-19.
Crohn Disease
Emerging views of mitophagy in immunity and autoimmune diseases.
Cystic Fibrosis
Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease.
Role of the ubiquitin system in regulating ion transport.
The Ubiquitin Ligase E6-AP Is Induced and Recruited to Aggresomes in Response to Proteasome Inhibition and May Be Involved in the Ubiquitination of Hsp70-bound Misfolded Proteins.
Deafness
Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes.
Dehydration
Alpha Enolase 1 Ubiquitination and Degradation Mediated by Ehrlichia chaffeensis TRP120 Disrupts Glycolytic Flux and Promotes Infection.
Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease.
Diabetes Mellitus, Type 2
Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome.
Diabetic Nephropathies
Association of UBE3C Variants with Reduced Kidney Function in Patients with Diabetic Kidney Disease.
Diminution of microRNA-98 alleviates renal fibrosis in diabetic nephropathy by elevating Nedd4L and inactivating TGF-?/Smad2/3 pathway.
Molecular mechanism of smurf2 in regulating the expression of SnoN in diabetic nephropathy.
Dyslexia
Genetic risk variants for dyslexia on chromosome 18 in a German cohort.
Ehrlichiosis
Alpha Enolase 1 Ubiquitination and Degradation Mediated by Ehrlichia chaffeensis TRP120 Disrupts Glycolytic Flux and Promotes Infection.
Ehrlichia chaffeensis TRP120 Binds a G+C-Rich Motif in Host Cell DNA and Exhibits Eukaryotic Transciptional Activator Function.
Molecular basis of antibody mediated immunity against Ehrlichia chaffeensis involves species-specific linear epitopes in tandem repeat proteins.
Encephalitis, Japanese
E3 Ubiquitin Ligase Nedd4 Promotes Japanese Encephalitis Virus Replication by Suppressing Autophagy in Human Neuroblastoma Cells.
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Encephalomyelitis
Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.
Encephalomyelitis, Autoimmune, Experimental
Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.
Endometrial Neoplasms
NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling.
Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer.
Endometriosis
SMURF1-mediated ubiquitylation of SHP-1 promotes cell proliferation and invasion of endometrial stromal cells in endometriosis.
Epilepsy
De novo 2q36.3q37.1 deletion encompassing TRIP12 and NPPC yields distinct phenotypes.
Genetic diagnoses in epilepsy: The impact of dynamic exome analysis in a pediatric cohort.
Novel de novo TRIP12 mutation reveals variable phenotypic presentation while emphasizing core features of TRIP12 variations.
Esophageal Squamous Cell Carcinoma
High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma.
The E3 ligase HECTD3 promotes esophageal squamous cell carcinoma (ESCC) growth and cell survival through targeting and inhibiting caspase-9 activation.
The Nedd4-like family of E3 ubiquitin ligases and cancer.
Essential Hypertension
?-Kinase 2 is a novel candidate gene for inherited hypertension in Dahl rats.
Association of NEDD4L ubiquitin ligase with essential hypertension.
Common variant of human NEDD4L activates a cryptic splice site to form a frameshifted transcript.
Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension.
Gender difference in association of NEDD4L gene variants among southern Han Chinese with essential hypertension - a population-based case-control study.
Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study.
NEDD4L in essential hypertension.
Two polymorphisms in NEDD4L gene and essential hypertension in Chinese Hans - a population-based case-control study.
Fatty Liver
Increase of E3 ubiquitin ligase NEDD4 expression leads to degradation of its target proteins PTEN/IGF1R during the formation of goose fatty liver.
Protective Effect of SMAD-Specific E3 Ubiquitin Protein Ligase 1 in Alcoholic Steatohepatitis in Mice.
Smurf1 aggravates non-alcoholic fatty liver disease by stabilizing SREBP-1c in an E3 activity-independent manner.
The ménage à trois of autophagy, lipid droplets and liver disease.
Fatty Liver, Alcoholic
Protective Effect of SMAD-Specific E3 Ubiquitin Protein Ligase 1 in Alcoholic Steatohepatitis in Mice.
Fibroadenoma
Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression.
Frontotemporal Dementia
VCP/p97 increases BMP signaling by accelerating ubiquitin ligase Smurf1 degradation.
Gallbladder Neoplasms
Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer.
Glioblastoma
A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis.
Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation.
SMURF1, a promoter of tumor cell progression?
Glioma
Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells.
Down-regulation of Nedd4L is Associated with the Aggressive Progression and Worse Prognosis of Malignant Glioma.
IGF-1-enhanced miR-513a-5p signaling desensitizes glioma cells to temozolomide by targeting the NEDD4L-inhibited Wnt/?-catenin pathway.
NEDD4-1 regulates migration and invasion of glioma cells through CNrasGEF ubiquitination in vitro.
Partners of wild type Grb7 and a mutant lacking its calmodulin-binding domain.
Regulation of glioma migration and invasion via modification of Rap2a activity by the ubiquitin ligase Nedd4-1.
Suppression of the Smurf1 Expression Inhibits Tumor Progression in Gliomas.
The N-Myc-DLL3 Cascade Is Suppressed by the Ubiquitin Ligase Huwe1 to Inhibit Proliferation and Promote Neurogenesis in the Developing Brain.
Ubiquitin-protein ligase E3C promotes glioma progression by mediating the ubiquitination and degrading of Annexin A7.
Ubiquitination Destabilizes Protein Sphingosine Kinase 2 to Regulate Glioma Malignancy.
Gram-Negative Bacterial Infections
E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation.
Hearing Loss
De novo 2q36.3q37.1 deletion encompassing TRIP12 and NPPC yields distinct phenotypes.
Heart Diseases
Microarray analysis and functional characterization revealed NEDD4-mediated cardiomyocyte autophagy induced by angiotensin II.
The Role of HECT-Type E3 Ligase in the Development of Cardiac Disease.
Heart Failure
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Heart Valve Diseases
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
hect-type e3 ubiquitin transferase deficiency
E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3.
E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity.
E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation.
Generation of Smurf2 Conditional Knockout Mice.
Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3-H19 Cascade.
Nedd4 Deficiency in Vascular Smooth Muscle Promotes Vascular Calcification by Stabilizing pSmad1.
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.
Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes.
Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.
Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1.
Hemangioma, Cavernous, Central Nervous System
Cerebral Cavernous Malformation 2 Protein Promotes Smad Ubiquitin Regulatory Factor 1-mediated RhoA Degradation in Endothelial Cells.
Hepatitis B
Functional characterization of the putative hepatitis B virus core protein late domain using retrovirus chimeras.
NEDD4 Induces K48-Linked Degradative Ubiquitination of Hepatitis B Virus X Protein and Inhibits HBV-Associated HCC Progression.
{gamma}2-Adaptin, a Novel Ubiquitin-interacting Adaptor, and Nedd4 Ubiquitin Ligase Control Hepatitis B Virus Maturation.
Hepatitis C
Hepatitis C virus/human interactome identifies SMURF2 and the viral protease as critical elements for the control of TGF-? signaling.
Hepatitis, Alcoholic
Protective Effect of SMAD-Specific E3 Ubiquitin Protein Ligase 1 in Alcoholic Steatohepatitis in Mice.
Herpes Simplex
Herpes simplex virus type 2 tegument protein UL56 relocalizes ubiquitin ligase Nedd4 and has a role in transport and/or release of virions.
Herpes simplex virus type 2 UL56 interacts with the ubiquitin ligase Nedd4 and increases its ubiquitination.
Herpesviruses possess conserved proteins for interaction with Nedd4 family ubiquitin E3 ligases.
Image-based genome-wide siRNA screen identifies selective autophagy factors.
Hyperaldosteronism
High Frequency of Variants of Candidate Genes in Black Africans with Low Renin-Resistant Hypertension.
Hypersensitivity
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability.
Hypertension
A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension.
A functional variant of NEDD4L is associated with obesity and related phenotypes in a Han population of Southern China.
A variant in the NEDD4L gene associates with hypertension in chronic kidney disease in the southeastern Han Chinese population.
Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.
DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells.
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface.
Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension.
Further evidence of a quantitative trait locus on chromosome 18 influencing postural change in systolic blood pressure: the Hypertension Genetic Epidemiology Network (HyperGEN) Study.
Gender difference in association of NEDD4L gene variants among southern Han Chinese with essential hypertension - a population-based case-control study.
Genetic variation and association analyses of NEDD4 gene in Kazak Chinese patients with hypertension.
Genetic variation in NEDD4L, salt sensitivity, and hypertension: human NEDD4L rs4149601 G allele generates evolutionary new isoform I with C2 domain.
Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study.
Genetic variations in the sodium balance-regulating genes ENaC, NEDD4L, NDFIP2 and USP2 influence blood pressure and hypertension.
Inhibition of the epithelial Na+ channel by interaction of Nedd4 with a PY motif deleted in Liddle's syndrome.
MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension.
MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1.
Multiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4.
Novel SNPs of WNK1 and AKR1C3 are associated with preeclampsia.
Polymorphism in NEDD4L is associated with increased salt sensitivity, reduced levels of P-renin and increased levels of Nt-proANP.
Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension.
Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension.
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels.
Transcriptional diversity and expression of NEDD4L gene in distal nephron.
Two polymorphisms in NEDD4L gene and essential hypertension in Chinese Hans - a population-based case-control study.
Hypertension, Pulmonary
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
PPAR? increases HUWE1 to attenuate NF-?B/p65 and sickle cell disease with pulmonary hypertension.
Hypertrophy, Right Ventricular
MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1.
Hypokinesia
Familial NEDD4L variant in periventricular nodular heterotopia and in a fetus with hypokinesia and flexion contractures.
Hypospadias
Downregulation of MicroRNA-494 inhibits the TGF-?1/Smads signaling pathway and prevents the development of hypospadias through upregulating Nedd4L.
Hypotension, Orthostatic
A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension.
Association of NEDD4L ubiquitin ligase with essential hypertension.
Infarction, Middle Cerebral Artery
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.
Infections
A capsid-encoded PPxY-motif facilitates adenovirus entry.
Alpha Enolase 1 Ubiquitination and Degradation Mediated by Ehrlichia chaffeensis TRP120 Disrupts Glycolytic Flux and Promotes Infection.
BEI Inactivated Vaccine Induces Innate and Adaptive Responses and Elicits Partial Protection upon Reassortant Betanodavirus Infection in Senegalese Sole.
DDIT3 Targets Innate Immunity via the DDIT3-OTUD1-MAVS Pathway To Promote Bovine Viral Diarrhea Virus Replication.
E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3.
E3 Ubiquitin Ligase Nedd4 Promotes Japanese Encephalitis Virus Replication by Suppressing Autophagy in Human Neuroblastoma Cells.
Ehrlichia chaffeensis Tandem Repeat Effector Targets Differentially Influence Infection.
Ehrlichia chaffeensis TRP120 Activates Canonical Notch Signaling To Downregulate TLR2/4 Expression and Promote Intracellular Survival.
Ehrlichia chaffeensis TRP120 Binds a G+C-Rich Motif in Host Cell DNA and Exhibits Eukaryotic Transciptional Activator Function.
Ehrlichia chaffeensis TRP120 Effector Targets and Recruits Host Polycomb Group Proteins for Degradation To Promote Intracellular Infection.
Ehrlichia chaffeensis TRP120 Moonlights as a HECT E3 Ligase Involved in Self- and Host Ubiquitination To Influence Protein Interactions and Stability for Intracellular Survival.
Ehrlichia chaffeensis TRP120-mediated ubiquitination and proteasomal degradation of tumor suppressor FBW7 increases oncoprotein stability and promotes infection.
HECT E3 Ubiquitin Ligase Nedd4 Is Required for Antifungal Innate Immunity.
HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection.
Huwe1, a novel cellular interactor of Gag-Pol through integrase binding, negatively influences HIV-1 infectivity.
Identifying potential drug targets and candidate drugs for COVID-19: biological networks and structural modeling approaches.
Molecular basis of antibody mediated immunity against Ehrlichia chaffeensis involves species-specific linear epitopes in tandem repeat proteins.
NEDD4 Induces K48-Linked Degradative Ubiquitination of Hepatitis B Virus X Protein and Inhibits HBV-Associated HCC Progression.
Nedd4-Mediated Increase in HIV-1 Gag and Env Proteins and Immunity following DNA-Vaccination of BALB/c Mice.
Proteomics analysis of EV71-infected cells reveals the involvement of host protein NEDD4L in EV71 replication.
Smurf2 alters BPV1 trafficking and decreases infection.
Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA.
The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice.
The Salmonella Effector Protein SopA Modulates Innate Immune Responses by Targeting TRIM E3 Ligase Family Members.
The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.
Infertility, Female
X-Linked Huwe1 Is Essential for Oocyte Maturation and Preimplantation Embryo Development.
Inflammatory Bowel Diseases
Emerging views of mitophagy in immunity and autoimmune diseases.
Influenza, Human
E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3.
Human microRNA-30 inhibits influenza virus infection by suppressing the expression of SOCS1, SOCS3, and NEDD4.
Insulin Resistance
Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome.
Nedd4 Haploinsufficient Mice Display Moderate Insulin Resistance, Enhanced Lipolysis, and Protection against High-fat Diet Induced Obesity.
Intellectual Disability
Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE.
Case Report: Whole Exome Sequencing Revealed Disease-Causing Variants in Two Genes in a Patient With Autism Spectrum Disorder, Intellectual Disability, Hyperactivity, Sleep and Gastrointestinal Disturbances.
Copy-Number Gains of HUWE1 Due to Replication- and Recombination-Based Rearrangements.
De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability.
Erratum to: Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features.
Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features.
HUWE1 mutation explains phenotypic severity in a case of familial idiopathic intellectual disability.
HUWE1 variants cause dominant X-linked intellectual disability: a clinical study of 21 patients.
Identification of new TRIP12 variants and detailed clinical evaluation of individuals with non-syndromic intellectual disability with or without autism.
Increased p53 signaling impairs neural differentiation in HUWE1-promoted intellectual disabilities.
Novel microduplications at Xp11.22 including HUWE1: clinical and molecular insights into these genomic rearrangements associated with intellectual disability.
Regulation of turnover of tumor suppressor p53 and cell growth by E6-AP, a ubiquitin protein ligase mutated in Angelman mental retardation syndrome.
Roles of the HUWE1 ubiquitin ligase in nervous system development, function and disease.
Submicroscopic duplications of the hydroxysteroid dehydrogenase HSD17B10 and the E3 ubiquitin ligase HUWE1 are associated with mental retardation.
The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily.
The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development.
Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/?-catenin pathway in a Drosophila model for intellectual disability.
Xp11.22 Microduplications Including HUWE1: Case Report and Literature Review.
[Intellectual disability due to heterozygous c.40C>T variant of TRIP12 gene in a patient].
Intervertebral Disc Degeneration
Ectopic expression of Smurf2 and acceleration of age-related intervertebral disc degeneration in a mouse model.
TGF-? Initiates ?-Catenin-Mediated CTGF Secretory Pathway in Old Bovine Nucleus Pulposus Cells: A Potential Mechanism for Intervertebral Disc Degeneration.
Ischemic Stroke
Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity.
Differential regulation of Nedd4 ubiquitin ligases and their adaptor protein Ndfip1 in a rat model of ischemic stroke.
Keloid
A Role for the E3 Ubiquitin Ligase NEDD4 in Keloid Pathogenesis.
Admixture mapping identifies a locus at 15q21.2-22.3 associated with keloid formation in African Americans.
Association study confirmed susceptibility loci with keloid in the Chinese Han population.
NEDD4 Is Involved in Inflammation Development during Keloid Formation.
NEDD4 single nucleotide polymorphism rs2271289 is associated with keloids in Chinese Han population.
NEDD4-1 and PTEN expression in keloid scarring.
Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 (NEDD4) Gene Polymorphism Contributes to Keloid Development in Egyptian Population.
Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production.
STAT3 operates as a novel transcription factor that regulates NEDD4 in Keloid.
The Ubiquitin Proteasome System and Skin Fibrosis.
Language Development Disorders
Erratum to: Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features.
Haploinsufficiency of the E3 ubiquitin-protein ligase gene TRIP12 causes intellectual disability with or without autism spectrum disorders, speech delay, and dysmorphic features.
Novel de novo TRIP12 mutation reveals variable phenotypic presentation while emphasizing core features of TRIP12 variations.
Learning Disabilities
Identification of new TRIP12 variants and detailed clinical evaluation of individuals with non-syndromic intellectual disability with or without autism.
Leukemia
HUWE1 cooperates with RAS activation to control leukemia cell proliferation and human hematopoietic stem cells differentiation fate.
Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding.
Leukemia, Myeloid
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.
Leukemia, Myeloid, Acute
RNA-Seq analysis identifies aberrant RNA splicing of TRIP12 in acute myeloid leukemia patients at remission.
Leukemia, T-Cell
PPPYVEPTAP motif is the late domain of human T-cell leukemia virus type 1 Gag and mediates its functional interaction with cellular proteins Nedd4 and Tsg101 [corrected].
Regulation of human T-cell leukemia virus type 1 (HTLV-1) budding by ubiquitin ligase Nedd4.
Liddle Syndrome
Solution structure of a Nedd4 WW domain-ENaC peptide complex.
Liposarcoma
Inverse association between MDM2 and HUWE1 protein expression levels in human breast cancer and liposarcoma.
Listeriosis
The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.
Liver Cirrhosis
Abnormal expression of Smurf2 during the process of rat liver fibrosis.
Smad ubiquitination regulatory factor 2 expression is enhanced in hypertrophic scar fibroblasts from burned children.
Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition.
Liver Cirrhosis, Biliary
Emerging views of mitophagy in immunity and autoimmune diseases.
Liver Diseases
Smurf1 aggravates non-alcoholic fatty liver disease by stabilizing SREBP-1c in an E3 activity-independent manner.
The ménage à trois of autophagy, lipid droplets and liver disease.
Liver Failure
Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration.
Liver Neoplasms
Impaired phosphorylation and ubiquitination by P70 S6 kinase (P70S6K) and Smad ubiquitination regulatory factor 1 (Smurf1) promotes Tribbles homolog 2 (TRIB2) stability and carcinogenic property in liver cancer.
NEDD4 promotes cell growth and motility in hepatocellular carcinoma.
Reciprocal regulation between ?TrCP and Smurf1 suppresses proliferative capacity of liver cancer cells.
TRIB2 inhibits Wnt/?-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, ?-TrCP, COP1 and Smurf1, in liver cancer cells.
Ubiquitin E3 ligase SCF(?-TRCP) regulates TRIB2 stability in liver cancer cells.
[Regulation of Smad ubiquitination regulatory factor 1 expression by NF-?B].
Lung Diseases
Deletion of the ubiquitin ligase Nedd4L in lung epithelia causes cystic fibrosis-like disease.
Ubiquitination of heat shock protein 27 is mediated by its interaction with Smad ubiquitination regulatory factor 2 in A549 cells.
Lung Neoplasms
An outlined review for the role of Nedd4-1 and Nedd4-2 in lung disorders.
Decreased expression of NEDD4L contributes to NSCLC progression and metastasis.
Erratum to: Identification of the NEDD4L Gene as a Prognostic Marker by Integrated Microarray Analysis of Copy Number and Gene Expression Profiling in Non-small Cell Lung Cancer.
Exosomes Derived From Macrophages Enhance Aerobic Glycolysis and Chemoresistance in Lung Cancer by Stabilizing c-Myc via the Inhibition of NEDD4L.
Expression of HERC4 in Lung Cancer and its Correlation with Clinicopathological Parameters.
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53.
HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.
Identification of the NEDD4L Gene as a Prognostic Marker by Integrated Microarray Analysis of Copy Number and Gene Expression Profiling in Non-small Cell Lung Cancer.
LIMCH1 suppress the growth of lung cancer by interacting with HUWE1 to sustain p53 stability.
Meta-analysis of gene expression alterations and clinical significance of the HECT domain-containing ubiquitin ligase HUWE1 in cancer.
MiR-195 and miR-497 suppress tumorigenesis in lung cancer by inhibiting SMURF2-induced TGF-? receptor I ubiquitination.
miR-93 promotes TGF-?-induced epithelial-to-mesenchymal transition through downregulation of NEDD4L in lung cancer cells.
Nitidine chloride suppresses NEDD4 expression in lung cancer cells.
Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival.
Oncogenic Role of the E3 Ubiquitin Ligase NEDD4-1, a PTEN Negative Regulator, in Non-Small-Cell Lung Carcinomas.
Phosphatase and tensin homolog deleted on chromosome 10 degradation induced by NEDD4 promotes acquired erlotinib resistance in non-small-cell lung cancer.
Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKI?.
Smurf1 ubiquitin ligase targets Kruppel-like factor KLF2 for ubiquitination and degradation in human lung cancer H1299 cells.
Smurf1-positive expression indicates favorable survival for resected non-small cell lung cancer patients.
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
The Emerging Roles of the HERC Ubiquitin Ligases in Cancer.
Ubiquitin ligase SMURF2 enhances epidermal growth factor receptor stability and tyrosine-kinase inhibitor resistance.
Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex.
Lupus Erythematosus, Systemic
Emerging views of mitophagy in immunity and autoimmune diseases.
Lymphatic Metastasis
Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient.
High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma.
NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma.
Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue.
Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma.
Lymphoma
Characterization of ARF-BP1/HUWE1 Interactions with CTCF, MYC, ARF and p53 in MYC-Driven B Cell Neoplasms.
Knockdown of long noncoding RNA XIST mitigates the apoptosis and inflammatory injury of microglia cells after spinal cord injury through miR-27a/Smurf1 axis.
Lymphoma, B-Cell
Knockdown of long noncoding RNA XIST mitigates the apoptosis and inflammatory injury of microglia cells after spinal cord injury through miR-27a/Smurf1 axis.
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.
Smurf2 suppresses B-cell proliferation and lymphomagenesis by mediating ubiquitination and degradation of YY1.
Medulloblastoma
Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors.
Melanoma
Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma.
Emerging views of mitophagy in immunity and autoimmune diseases.
Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells.
NEDD4 Negatively Regulates GITR via Ubiquitination in Immune Microenvironment of Melanoma.
NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway.
Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma.
Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.
The Anti-proliferative Response of Indole-3-carbinol in human melanoma cells is Triggered by an Interaction with NEDD4-1 and Disruption of Wild-type PTEN Degradation.
Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells.
Ubiquitylation of a melanosomal protein by HECT-E3 ligases serves as sorting signal for lysosomal degradation.
Metabolic Syndrome
Gender flip-flop association between genetic variations of NEDD4L and metabolic syndrome in the Kazakh general population.
Mouth Neoplasms
E3 Ubiquitin Ligases as Molecular Targets in Human Oral Cancers.
Multiple Myeloma
Targeting of the E3 ubiquitin-protein ligase HUWE1 impairs DNA repair capacity and tumor growth in preclinical multiple myeloma models.
The E3 ligase HUWE1 inhibition as a therapeutic strategy to target MYC in multiple myeloma.
The NEDD4-1 E3 ubiquitin ligase: A potential molecular target for bortezomib sensitivity in multiple myeloma.
The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice.
Multiple Sclerosis
Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.
Multiple System Atrophy
Epigenetic modulation of AREL1 and increased HLA expression in brains of multiple system atrophy patients.
Mumps
Angiomotin-Like 1 Links Paramyxovirus M Proteins to NEDD4 Family Ubiquitin Ligases.
Muscular Atrophy
Long noncoding RNA SMUL suppresses SMURF2 production-mediated muscle atrophy via nonsense-mediated mRNA decay.
Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice.
PDLIM7 is a novel target of the ubiquitin ligase Nedd4-1 in skeletal muscle.
The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice.
Muscular Diseases
VCP/p97 increases BMP signaling by accelerating ubiquitin ligase Smurf1 degradation.
Myocardial Infarction
E3 Ubiquitin ligase NEDD4 family?regulatory network in cardiovascular disease.
Myocardial Ischemia
Characterization of novel lncRNAs in upper thoracic spinal cords of rats with myocardial ischemia-reperfusion injuries.
Heart ischemia results in connexin43 ubiquitination localized at the intercalated discs.
Myotonic Dystrophy
Abnormal splicing of NEDD4 in myotonic dystrophy type 2: possible link to statin adverse reactions.
Nasal Polyps
UBE3C genetic variations as potent markers of nasal polyps in Korean asthma patients.
Nasopharyngeal Carcinoma
Haplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population.
NEDD4 is involved in acquisition of epithelial-mesenchymal transition in cisplatin-resistant nasopharyngeal carcinoma cells.
Paeoniflorin exhibits antitumor effects in nasopharyngeal carcinoma cells through downregulation of NEDD4.
Neoplasm Metastasis
A novel small-form NEDD4 regulates cell invasiveness and apoptosis to promote tumor metastasis.
An outlined review for the role of Nedd4-1 and Nedd4-2 in lung disorders.
Bortezomib prevents oncogenesis and bone metastasis of prostate cancer by inhibiting WWP1, Smurf1 and Smurf2.
Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity.
Decreased expression of NEDD4L contributes to NSCLC progression and metastasis.
Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient.
Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomas.
High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma.
miR-15b promotes epithelial-mesenchymal transition by inhibiting SMURF2 in pancreatic cancer.
MiR-542-3p inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting UBE3C.
miR-93 promotes TGF-?-induced epithelial-to-mesenchymal transition through downregulation of NEDD4L in lung cancer cells.
NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma.
NEDD4 triggers FOXA1 ubiquitination and promotes colon cancer progression under microRNA-340-5p suppression and ATF1 upregulation.
Nedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis.
Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue.
Oncogenic UBE3C promotes breast cancer progression by activating Wnt/?-catenin signaling.
PRRG4 promotes breast cancer metastasis through the recruitment of NEDD4 and downregulation of Robo1.
RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis.
SMAD specific E3 ubiquitin protein ligase 1 promotes ovarian cancer cell migration and invasion via the activation of the RhoA/ROCK signaling pathway.
Smad Ubiquitination Regulatory Factor 1 (Smurf1) Promotes Thyroid Cancer Cell Proliferation and Migration via Ubiquitin-Dependent Degradation of Kisspeptin-1.
Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness.
SMURF1 promotes the proliferation, migration and invasion of gastric cancer cells.
Smurf1 regulation of DAB2IP controls cell proliferation and migration.
SMURF1, a promoter of tumor cell progression?
Smurf1-positive expression indicates favorable survival for resected non-small cell lung cancer patients.
Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.
SND1 acts downstream of TGF?1 and upstream of Smurf1 to promote breast cancer metastasis.
Structure of the HECT domain of human WWP2.
The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer.
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways.
The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2.
UBE3C Promotes Growth and Metastasis of Renal Cell Carcinoma via Activating Wnt/?-Catenin Pathway.
Ubiquitin ligase SMURF1 functions as a prognostic marker and promotes growth and metastasis of clear cell renal cell carcinoma.
Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells.
Ubiquitination by HUWE1 in tumorigenesis and beyond.
Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma.
WW domain-mediated regulation and activation of E3 ubiquitin ligase Suppressor of Deltex.
Neoplasms
A conformational switch regulates the ubiquitin ligase HUWE1.
A miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1.
A novel small-form NEDD4 regulates cell invasiveness and apoptosis to promote tumor metastasis.
A Potential Role for HUWE1 in Modulating Cisplatin Sensitivity.
A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks.
A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20.
A Variant Smurf2 Protects Mice Against Colitis-Associated Colon Cancer by Inducing Transforming Growth Factor ? Signaling.
Allosteric auto-inhibition and activation of the Nedd4 family E3 ligase Itch.
Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer.
An endogenous retrovirus mediating deletion of alpha beta T cells?
Artemisitene suppresses tumorigenesis by inducing DNA damage through deregulating c-Myc-topoisomerase pathway.
Association of Bovine Papillomavirus Type 1 E6 oncoprotein with the focal adhesion protein paxillin through a conserved protein interaction motif.
ATG101 Degradation by HUWE1-Mediated Ubiquitination Impairs Autophagy and Reduces Survival in Cancer Cells.
ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance.
Bortezomib attenuates renal interstitial fibrosis in kidney transplantation via regulating the EMT induced by TNF-?-Smurf1-Akt-mTOR-P70S6K pathway.
Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis.
Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner.
Circulating essential metals and lung cancer: Risk assessment and potential molecular effects.
CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation.
Clinical significance of the ubiquitin ligase E3C in hepatocellular carcinoma revealed by exome sequencing.
Clinicopathological and prognostic correlations of HER3 expression and its degradation regulators, NEDD4-1 and NRDP1, in primary breast cancer.
CNF1-induced ubiquitylation and proteasome destruction of activated RhoA is impaired in Smurf1-/- cells.
Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases.
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells.
Copper Promotes Tumorigenesis by Activating the PDK1-AKT Oncogenic Pathway in a Copper Transporter 1 Dependent Manner.
CRL4BRBBP7 targets HUWE1 for ubiquitination and proteasomal degradation.
Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity.
Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway.
Curcumin exerts its tumor suppressive function via inhibition of NEDD4 oncoprotein in glioma cancer cells.
Decreased expression of NEDD4L contributes to NSCLC progression and metastasis.
Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient.
Degradation of hDlg and MAGIs by human papillomavirus E6 is E6-AP-independent.
Deletion of SMURF 1 represses ovarian cancer invasion and EMT by modulating the DAB2IP/AKT/Skp2 feedback loop.
Derangements in HUWE1/c-MYC pathway confer sensitivity to the BET bromodomain inhibitor GS-626510 in uterine cervical carcinoma.
Detection of E6-AP as a potential therapeutic target in cervical specimen of HPV-infected women.
Direct regulation of Chk1 protein stability by E3 ubiquitin ligase HUWE1.
Divergent viral superantigens delete V beta 5+ T lymphocytes.
DNA damage-induced activation of CUL4B targets HUWE1 for proteasomal degradation.
Down-regulation of HECTD3 by HER2 inhibition makes serous ovarian cancer cells sensitive to platinum treatment.
Downregulation of Nedd4L predicts poor prognosis, promotes tumor growth and inhibits MAPK/ERK signal pathway in hepatocellular carcinoma.
Downregulation of Smurf2 ubiquitin ligase in pancreatic cancer cells reversed TGF-?-induced tumor formation.
Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis.
E3 ubiquitin ligase SMURF2 prevents colorectal cancer by reducing the stability of the YY1 protein and inhibiting the SENP1/c-myc axis.
E3 ubiquitin ligase Smurf2: a prognostic factor in microsatellite stable colorectal cancer.
E3 Ubiquitin Ligase TRIP12: Regulation, Structure, and Physiopathological Functions.
E6-associated protein (E6-AP) is a dual function coactivator of steroid hormone receptors.
Effect of SMURF2 targeting on susceptibility to MEK inhibitors in melanoma.
Ehrlichia chaffeensis TRP120-mediated ubiquitination and proteasomal degradation of tumor suppressor FBW7 increases oncoprotein stability and promotes infection.
Emerging views of mitophagy in immunity and autoimmune diseases.
Endogenous superantigen expression is controlled by mouse mammary tumor proviral loci.
Estradiol promotes rapid degradation of HER3 in ER-positive breast cancer cell line MCF-7.
Exosomal hsa-miR199a-3p Promotes Proliferation and Migration in Neuroblastoma.
Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomas.
Generation of SMURF2 knockout human cells using the CRISPR/Cas9 system.
Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53.
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
HECT ubiquitin ligase Smurf1 targets the tumor suppressor ING2 for ubiquitination and degradation.
HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.
HERC4 exerts an anti-tumor role through destabilizing the oncoprotein Smo.
HERC4 Is Overexpressed in Hepatocellular Carcinoma and Contributes to the Proliferation and Migration of Hepatocellular Carcinoma Cells.
High-level expression of the Smad ubiquitin ligase Smurf2 correlates with poor prognosis in patients with esophageal squamous cell carcinoma.
Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes.
HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53.
HUWE1 cooperates with RAS activation to control leukemia cell proliferation and human hematopoietic stem cells differentiation fate.
HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.
HUWE1 plays important role in mouse preimplantation embryo development and the dysregulation is associated with poor embryo development in humans.
Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3-H19 Cascade.
HUWE1 ubiquitylates and degrades the RAC activator TIAM1 promoting cell-cell adhesion disassembly, migration, and invasion.
HUWE1 upregulation has tumor suppressive effect in human prostate cancer cell lines through c-Myc.
Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma.
Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.
Impact of E6-associated protein on the proliferation and invasion of prostate cancer cells in bone metastasis.
Impeded Nedd4-1-mediated Ras degradation underlies Ras-driven tumorigenesis.
Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells.
Integrated bioinformatics analysis of the NEDD4 family reveals a prognostic value of NEDD4L in clear-cell renal cell cancer.
Integrated molecular analysis to investigate the role of microRNAs in pancreatic tumour growth and progression.
Interaction of the E6 protein of human papillomavirus with cellular proteins.
Intestinal knockout of Nedd4 enhances growth of Apc(min) tumors.
IRAK2 counterbalances oncogenic Smurf1 in colon cancer cells by dictating ER stress.
Itch: a HECT-type E3 ligase regulating immunity, skin and cancer.
Knockdown of long noncoding RNA XIST mitigates the apoptosis and inflammatory injury of microglia cells after spinal cord injury through miR-27a/Smurf1 axis.
KRAS Protein Stability Is Regulated through SMURF2: UBCH5 Complex-Mediated ?-TrCP1 Degradation.
LIMCH1 suppress the growth of lung cancer by interacting with HUWE1 to sustain p53 stability.
Low Expression of Smurf1 Enhances the Chemosensitivity of Human Colorectal Cancer to Gemcitabine and Cisplatin in Patient-Derived Xenograft Models.
LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13.
Meta-analysis of gene expression alterations and clinical significance of the HECT domain-containing ubiquitin ligase HUWE1 in cancer.
MicroRNA-125a inhibits tumorigenesis by targeting Smurf1 in colorectal carcinoma.
MicroRNA-27 Inhibits Autophagy and Promotes Proliferation of Multiple Myeloma Cells by Targeting the NEDD4/Notch1 Axis.
MicroRNA-424 regulates cisplatin resistance of gastric cancer by targeting SMURF1 based on GEO database and primary validation in human gastric cancer tissues.
MicroRNA-497 inhibition of ovarian cancer cell migration and invasion through targeting of SMAD specific E3 ubiquitin protein ligase 1.
MiR-153 promotes breast cancer cell apoptosis by targeting HECTD3.
MiR-195 and miR-497 suppress tumorigenesis in lung cancer by inhibiting SMURF2-induced TGF-? receptor I ubiquitination.
MiR-542-3p inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting UBE3C.
Molecular functions of NEDD4 E3 ubiquitin ligases in cancer.
Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells.
Multiple regions of E6AP (UBE3A) contribute to interaction with papillomavirus E6 proteins and the activation of ubiquitin ligase activity.
NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor.
NEDD4 Depletion Inhibits Hepatocellular Carcinoma Growth via Targeting PTEN.
NEDD4 E3 ligase: Functions and mechanism in human cancer.
NEDD4 Family of E3 Ubiquitin Ligases in Breast Cancer: Spotlight on SMURFs, WWPs and NEDD4.
NEDD4 Induces K48-Linked Degradative Ubiquitination of Hepatitis B Virus X Protein and Inhibits HBV-Associated HCC Progression.
NEDD4 is involved in acquisition of epithelial-mesenchymal transition in cisplatin-resistant nasopharyngeal carcinoma cells.
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway.
NEDD4 Negatively Regulates GITR via Ubiquitination in Immune Microenvironment of Melanoma.
NEDD4 promotes cell growth and migration via PTEN/PI3K/AKT signaling in hepatocellular carcinoma.
NEDD4 promotes cell growth and motility in hepatocellular carcinoma.
NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway.
NEDD4 triggers FOXA1 ubiquitination and promotes colon cancer progression under microRNA-340-5p suppression and ATF1 upregulation.
NEDD4 ubiquitin ligase is a putative oncogene in endometrial cancer that activates IGF-1R/PI3K/Akt signaling.
Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma.
NEDD4-1 and PTEN expression in keloid scarring.
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.
NEDD4: a promising target for cancer therapy.
NEDD4: The founding member of a family of ubiquitin-protein ligases.
NEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter.
Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue.
NEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling.
Neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) regulates hydrogen peroxide-induced cell proliferation and death through inhibition of Hippo signaling.
Nitidine chloride suppresses NEDD4 expression in lung cancer cells.
NMR uncovers direct interaction between human NEDD4-1 and p34(SEI-1).
Oncogenic function of p34SEI-1 via NEDD4?1?mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway.
Oncogenic Role of the E3 Ubiquitin Ligase NEDD4-1, a PTEN Negative Regulator, in Non-Small-Cell Lung Carcinomas.
Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation.
Oncogenic UBE3C promotes breast cancer progression by activating Wnt/?-catenin signaling.
Overexpression of ligase defective E6-associated protein, E6-AP, results in mammary tumorigenesis.
Pan-cancer Analysis of NEDD4L and Its Tumor Suppressor Effects in Clear Cell Renal Cell Carcinoma.
Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage.
Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response.
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.
Proteogenomics analysis unveils a TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas.
PTEN is a protein tyrosine phosphatase for IRS1.
Quantitative Lys-?-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1.
R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc.
RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress Tumorigenesis.
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation.
Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2.
Regulation of Krüppel-like factor 8 by the NEDD4 E3 ubiquitin ligase.
Regulation of turnover of tumor suppressor p53 and cell growth by E6-AP, a ubiquitin protein ligase mutated in Angelman mental retardation syndrome.
Reversible regulation of SATB1 ubiquitination by USP47 and SMURF2 mediates colon cancer cell proliferation and tumor progression.
Role of altered expression of Nedd4L in the pathogenesis of systemic malignancies.
SAG/RBX2 is a novel substrate of NEDD4-1 E3 ubiquitin ligase and mediates NEDD4-1 induced chemosensitization.
SCF?-TRCP-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway.
Shh signaling protects Atoh1 from degradation mediated by the E3 ubiquitin ligase Huwe1 in neural precursors.
SIMPLE interacts with NEDD4 and TSG101: evidence for a role in lysosomal sorting and implications for Charcot-Marie-Tooth disease.
SMAD specific E3 ubiquitin protein ligase 1 promotes ovarian cancer cell migration and invasion via the activation of the RhoA/ROCK signaling pathway.
Smad Ubiquitination Regulatory Factor 1 (Smurf1) Promotes Thyroid Cancer Cell Proliferation and Migration via Ubiquitin-Dependent Degradation of Kisspeptin-1.
SMURF1 amplification promotes invasiveness in pancreatic cancer.
SMURF1 promotes the proliferation, migration and invasion of gastric cancer cells.
Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility.
SMURF1 silencing diminishes a CD44-high cancer stem cell-like population in head and neck squamous cell carcinoma.
SMURF1, a promoter of tumor cell progression?
Smurf1-positive expression indicates favorable survival for resected non-small cell lung cancer patients.
Smurf1: a link between cell polarity and ubiquitination.
Smurf2 E3 ubiquitin ligase modulates proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner.
Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.
SMURF2 prevents detrimental changes to chromatin, protecting human dermal fibroblasts from chromosomal instability and tumorigenesis.
Smurf2 regulates stability and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin.
Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.
Smurf2-Mediated Stabilization of DNA Topoisomerase II? Controls Genomic Integrity.
SMURF2-mediated ubiquitin signaling plays an essential role in the regulation of PARP1 PARylating activity, molecular interactions, and functions in mammalian cells.
Somatic mutations in early onset luminal breast cancer.
Specific recognition of four-way DNA junctions by the C-terminal zinc-binding domain of HPV oncoprotein E6.
Structural insights into a HECT-type E3 ligase AREL1 and its ubiquitination activities in vitro.
Suppression of human tumor cell proliferation by Smurf2-induced senescence.
Suppression of the Smurf1 Expression Inhibits Tumor Progression in Gliomas.
Systems biology approach to identification of biomarkers for metastatic progression in gastric cancer.
Targeting DNA damage response in head and neck cancers through abrogation of cell cycle checkpoints.
Targeting of the E3 ubiquitin-protein ligase HUWE1 impairs DNA repair capacity and tumor growth in preclinical multiple myeloma models.
The Anti-proliferative Response of Indole-3-carbinol in human melanoma cells is Triggered by an Interaction with NEDD4-1 and Disruption of Wild-type PTEN Degradation.
The anticancer effects of curcumin via targeting the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway.
The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/?-catenin pathway by inhibiting the proteasome.
The correlation between NEDD4L and HIF-1? levels as a gastric cancer prognostic marker.
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis.
The dual function steroid receptor coactivator/ubiquitin protein-ligase integrator E6-AP is overexpressed in mouse mammary tumorigenesis.
The E3 ligase HECTD3 promotes esophageal squamous cell carcinoma (ESCC) growth and cell survival through targeting and inhibiting caspase-9 activation.
The E3 ligase HUWE1 mediates TGFBR2 ubiquitination and promotes gastric cancer cell proliferation, migration, and invasion.
The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer.
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling.
The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer.
The Effects of WW2/WW3 Domains of Smurf2 Molecule on CD4+CD25+/CD4+ Proportion in Spleen of 4T1 Tumor Bearing BALB/c Mice.
The Emerging Roles of the HERC Ubiquitin Ligases in Cancer.
The Epstein-Barr virus protein, latent membrane protein 2A, co-opts tyrosine kinases used by the T cell receptor.
The expression and clinical significance of HERC4 in breast cancer.
The HECT E3 Ligase E6AP/UBE3A as a Therapeutic Target in Cancer and Neurological Disorders.
The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8.
The HECTD3 E3 ubiquitin ligase suppresses cisplatin-induced apoptosis via stabilizing MALT1.
The Iron-Regulated Metastasis Suppressor NDRG1 Targets NEDD4L, PTEN, and SMAD4 and Inhibits the PI3K and Ras Signaling Pathways.
The Long Non-Coding RNA MIR503HG Enhances Proliferation of Human ALK-Negative Anaplastic Large-Cell Lymphoma.
The many substrates and functions of NEDD4-1.
The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase.
The NEDD4-1 E3 ubiquitin ligase: A potential molecular target for bortezomib sensitivity in multiple myeloma.
The Nedd4-like family of E3 ubiquitin ligases and cancer.
The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and mesenchymal traits through ZEB1/2.
The oncogenic role of human papillomavirus proteins.
The role of E3 ubiquitin ligase HECTD3 in cancer and beyond.
The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma.
The roles of E6-AP and MDM2 in p53 regulation in human papillomavirus-positive cervical cancer cells.
The structure and regulation of the E3 ubiquitin ligase HUWE1 and its biological functions in cancer.
The study on copy number alteration of clear cell renal cancer in Chinese population.
The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.
The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice.
Tobramycin suppresses HUWE1 degradation to control MCL-1 stability during tumour development.
Transcription alterations of members of the ubiquitin-proteasome network in prostate carcinoma.
TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects.
Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation.
Tudor tells about new twists in the story tale of SMURFs.
Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.
Tumor Necrosis Factor Promotes Runx2 Degradation through Up-regulation of Smurf1 and Smurf2 in Osteoblasts.
Tumor necrosis factor-? enhances the transcription of Smad ubiquitination regulatory factor 1 in an activating protein-1- and Runx2-dependent manner.
Tumor necrosis factor-receptor-associated factor-4 is a positive regulator of transforming growth factor-beta signaling that affects neural crest formation.
Tumour suppressive function of HUWE1 in thyroid cancer.
UBE3C Promotes Growth and Metastasis of Renal Cell Carcinoma via Activating Wnt/?-Catenin Pathway.
UBE3C promotes proliferation and inhibits apoptosis by activating the ?-catenin signaling via degradation of AXIN1 in gastric cancer.
Ubiquitin ligase SMURF1 functions as a prognostic marker and promotes growth and metastasis of clear cell renal cell carcinoma.
Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins.
Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells.
Ubiquitin-protein ligase E3C promotes glioma progression by mediating the ubiquitination and degrading of Annexin A7.
Ubiquitination and the ubiquitin - proteasome system in the pathogenesis and treatment of squamous head and neck carcinoma.
Ubiquitination by HUWE1 in tumorigenesis and beyond.
Ubiquitination Destabilizes Protein Sphingosine Kinase 2 to Regulate Glioma Malignancy.
Ubiquitination of tumor necrosis factor receptor-associated factor 4 (TRAF4) by Smad ubiquitination regulatory factor 1 (Smurf1) regulates motility of breast epithelial and cancer cells.
Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.
Upregulation of Neural Precursor Cell Expressed Developmentally Downregulated 4-1 is Associated with Poor Prognosis and Chemoresistance in Lung Adenocarcinoma.
Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone.
WW domain-mediated regulation and activation of E3 ubiquitin ligase Suppressor of Deltex.
X-Linked Huwe1 Is Essential for Oocyte Maturation and Preimplantation Embryo Development.
Nervous System Diseases
Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2.
The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily.
The HECT E3 Ligase E6AP/UBE3A as a Therapeutic Target in Cancer and Neurological Disorders.
Ubiquitin ligase E6-AP and its role in human disease.
Neuroblastoma
A novel HECT-type E3 ubiquitin protein ligase NEDL1 enhances the p53-mediated apoptotic cell death in its catalytic activity-independent manner.
E3 Ubiquitin Ligase Nedd4 Promotes Japanese Encephalitis Virus Replication by Suppressing Autophagy in Human Neuroblastoma Cells.
Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc.
Nedd4 Binding Protein 1 (N4BP1) and TNFAIP3 Interacting Protein 1 (TNIP1) control MHC-1 display in neuroblastoma.
The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway.
The histone deacetylase SIRT2 stabilizes Myc oncoproteins.
Ubiquitination of RhoA by Smurf1 promotes neurite outgrowth.
Neurodegenerative Diseases
Administration of CoQ10 analogue ameliorates dysfunction of the mitochondrial respiratory chain in a mouse model of Angelman syndrome.
Overexpression of Sirtuin 1 protein in neurons prevents and reverses experimental diabetic neuropathy.
Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke.
The Ubiquitin Ligase E6-AP Is Induced and Recruited to Aggresomes in Response to Proteasome Inhibition and May Be Involved in the Ubiquitination of Hsp70-bound Misfolded Proteins.
Upregulation of the E3 ligase NEDD4-1 by Oxidative Stress Degrades IGF-1 Receptor Protein in Neurodegeneration.
Neuroinflammatory Diseases
Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation.
The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice.
The Role of Smurf1 in Neuronal Necroptosis after Lipopolysaccharide-Induced Neuroinflammation.
Nevus
Pathobiological properties of the ubiquitin ligase Nedd4L in melanoma.
Non-alcoholic Fatty Liver Disease
Non-proteolytic ubiquitin modification of PPAR? by Smurf1 protects the liver from steatosis.
Smurf1 aggravates non-alcoholic fatty liver disease by stabilizing SREBP-1c in an E3 activity-independent manner.
The ménage à trois of autophagy, lipid droplets and liver disease.
Obesity
A functional variant of NEDD4L is associated with obesity and related phenotypes in a Han population of Southern China.
An investigation of obesity susceptibility genes in Northern Han Chinese by targeted resequencing.
Nedd4 Haploinsufficient Mice Display Moderate Insulin Resistance, Enhanced Lipolysis, and Protection against High-fat Diet Induced Obesity.
The impacts of the interaction of genetic variation, CYP11?2 and NEDD4L, with sodium intake on pediatric obesity with gender difference: a 3-year panel study.
[Association of the rs4149601 polymorphism of NEDD4L gene with obesity in Xinjiang Kazakh population].
Osteitis Deformans
VCP/p97 increases BMP signaling by accelerating ubiquitin ligase Smurf1 degradation.
Osteoarthritis
Long noncoding RNA LINC00671 exacerbates osteoarthritis by promoting ONECUT2-mediated Smurf2 expression and extracellular matrix degradation.
Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin.
SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis.
Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.
Osteonecrosis
microRNA-148a-3p in extracellular vesicles derived from bone marrow mesenchymal stem cells suppresses SMURF1 to prevent osteonecrosis of femoral head.
Osteoporosis
Fragile Bones Secondary to SMURF1 Gene Duplication.
Inhibition of osteoblastic Smurf1 promotes bone formation in mouse models of distinctive age-related osteoporosis.
Overexpression of miR-195-5p reduces osteoporosis through activating BMP-2/SMAD/Akt/RUNX2 pathway via targeting SMURF1.
Selective compounds enhance osteoblastic activity by targeting HECT domain of ubiquitin ligase Smurf1.
Silencing long noncoding RNA colon cancer-associated transcript-1 upregulates microRNA-34a-5p to promote proliferation and differentiation of osteoblasts in osteoporosis.
SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts.
Osteosarcoma
DNA methylation-mediated downregulation of PTPN3 attenuates to boost TGF-? signaling in osteosarcoma cells.
MiR-542-5p is a negative prognostic factor and promotes osteosarcoma tumorigenesis by targeting HUWE1.
Phospho-Smad1 modulation by Nedd4 E3 ligase in BMP/TGF? signaling.
RLIM interacts with Smurf2 and promotes TGF-? induced U2OS cell migration.
Screening and Interaction Analysis of Key Genes in miR-542-3p Over- Expressed Osteosarcoma Cells by Bioinformatics.
Ovarian Neoplasms
DDB2 modulates TGF-? signal transduction in human ovarian cancer cells by downregulating NEDD4L.
Deletion of SMURF 1 represses ovarian cancer invasion and EMT by modulating the DAB2IP/AKT/Skp2 feedback loop.
Down-regulation of HECTD3 by HER2 inhibition makes serous ovarian cancer cells sensitive to platinum treatment.
Huwe1 Sustains Normal Ovarian Epithelial Cell Transformation and Tumor Growth through the Histone H1.3-H19 Cascade.
MicroRNA-497 inhibition of ovarian cancer cell migration and invasion through targeting of SMAD specific E3 ubiquitin protein ligase 1.
Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue.
The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency.
Pancreatic Neoplasms
Downregulation of Smurf2 ubiquitin ligase in pancreatic cancer cells reversed TGF-?-induced tumor formation.
Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.
miR-15b promotes epithelial-mesenchymal transition by inhibiting SMURF2 in pancreatic cancer.
NEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter.
SMURF1 amplification promotes invasiveness in pancreatic cancer.
The E3 ubiquitin ligase NEDD4 is translationally upregulated and facilitates pancreatic cancer.
The effects of curcumin on proliferation, apoptosis, invasion, and NEDD4 expression in pancreatic cancer.
The histone deacetylase SIRT2 stabilizes Myc oncoproteins.
The Nedd4-like family of E3 ubiquitin ligases and cancer.
Papilloma
Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation.
Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases.
Paramyxoviridae Infections
Emerging views of mitophagy in immunity and autoimmune diseases.
Parkinson Disease
E3 Ubiquitin Ligases in Neurological Diseases: Focus on Gigaxonin and Autophagy.
Enhanced ubiquitin-dependent degradation by Nedd4 protects against ?-synuclein accumulation and toxicity in animal models of Parkinson's disease.
Loss of NEDD4 contributes to RTP801 elevation and neuron toxicity: implications for Parkinson's disease.
Reynosin protects against neuronal toxicity in dopamine-induced SH-SY5Y cells and 6-hydroxydopamine-lesioned rats as models of Parkinson's disease: Reciprocal up-regulation of E6-AP and down-regulation of ?-synuclein.
Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway.
Parkinsonian Disorders
Emerging views of mitophagy in immunity and autoimmune diseases.
Human disorders of ubiquitination and proteasomal degradation.
Pediatric Obesity
The impacts of the interaction of genetic variation, CYP11?2 and NEDD4L, with sodium intake on pediatric obesity with gender difference: a 3-year panel study.
Peripheral Nervous System Diseases
Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli.
Periventricular Nodular Heterotopia
A novel missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria and cleft palate.
Admixed phenotype of NEDD4L associated periventricular nodular heterotopia: A case report.
Author Correction: A missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria, and cleft palate.
Familial NEDD4L variant in periventricular nodular heterotopia and in a fetus with hypokinesia and flexion contractures.
Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.
Recurrent NEDD4L Variant in Periventricular Nodular Heterotopia, Polymicrogyria and Syndactyly.
[Clinical and genetic analysis of a patient with periventricular nodular heterotopia 7 caused by NEDD4L gene variant].
Pituitary Neoplasms
Correlation of NEDD4-1 and PTEN expression with the invasive capacity of pituitary adenomas.
Pneumonia
Genetic determinants of susceptibility to silver nanoparticle-induced acute lung inflammation in mice.
Polycythemia
Human disorders of ubiquitination and proteasomal degradation.
Polyendocrinopathies, Autoimmune
Human disorders of ubiquitination and proteasomal degradation.
Polymicrogyria
A novel missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria and cleft palate.
Author Correction: A missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria, and cleft palate.
Recurrent NEDD4L Variant in Periventricular Nodular Heterotopia, Polymicrogyria and Syndactyly.
Pre-Eclampsia
Novel SNPs of WNK1 and AKR1C3 are associated with preeclampsia.
Progeria
Smurf2 regulates stability and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin.
Prostatic Hyperplasia
Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia.
Prostatic Neoplasms
A Feedback Loop between the Androgen Receptor and a NEDD4-binding Protein, PMEPA1, in Prostate Cancer Cells.
Androgens differentially regulate the expression of NEDD4L transcripts in LNCaP human prostate cancer cells.
Bortezomib prevents oncogenesis and bone metastasis of prostate cancer by inhibiting WWP1, Smurf1 and Smurf2.
Diosgenin inhibits the expression of NEDD4 in prostate cancer cells.
E3 ubiquitin protein ligase, E6-associated protein (E6-AP) regulates PI3K-Akt signaling and prostate cell growth.
HUWE1 upregulation has tumor suppressive effect in human prostate cancer cell lines through c-Myc.
IMP3 accelerates the progression of prostate cancer through inhibiting PTEN expression in a SMURF1-dependent way.
Impact of E6-associated protein on the proliferation and invasion of prostate cancer cells in bone metastasis.
LncRNA SNHG3 sponges miR-577 to up-regulate SMURF1 expression in prostate cancer.
Meta-analysis of gene expression alterations and clinical significance of the HECT domain-containing ubiquitin ligase HUWE1 in cancer.
Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity.
Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia.
R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc.
Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN.
The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling.
Pseudohypoaldosteronism
Molecular pathogenesis of renal pseudohypoaldosteronism type 1.
Pseudohypoaldosteronism type 1 and the genes encoding prostasin, alpha-spectrin, and Nedd4.
Psoriasis
E3 ubiquitin ligase NEDD4L negatively regulates keratinocyte hyperplasia by promoting GP130 degradation.
Pulmonary Arterial Hypertension
MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension.
MicroRNA-424(322) as a new marker of disease progression in pulmonary arterial hypertension and its role in right ventricular hypertrophy by targeting SMURF1.
Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension.
Pulmonary Disease, Chronic Obstructive
Atrophy and hypertrophy signaling in the diaphragm of patients with COPD.
Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks.
Cellular Markers of Muscle Atrophy in Chronic Obstructive Pulmonary Disease (COPD).
Pulmonary Edema
MicroRNA 16 modulates epithelial sodium channel in human alveolar epithelial cells.
Pulmonary Fibrosis
NADPH oxidase DUOX1 sustains TGF-?1 signalling and promotes lung fibrosis.
The effects of miR-27a-3p-mediated Smurf2 on bleomycin A5-induced pulmonary fibrosis in rats.
Rabies
ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response.
Renal Insufficiency, Chronic
A variant in the NEDD4L gene associates with hypertension in chronic kidney disease in the southeastern Han Chinese population.
cMet agonistic antibody prevents acute kidney injury to chronic kidney disease transition by suppressing Smurf1 and activating Smad7.
Reperfusion Injury
Associations between Huwe1 and autophagy in rat cerebral neuron oxygen?glucose deprivation and reperfusion injury.
Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells.
Inhibition of Smurf2 translation by miR-322/503 protects from ischemia reperfusion injury by modulating EZH2/Akt/GSK3? signaling.
Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion.
RNA Virus Infections
Induction of OTUD1 by RNA viruses potently inhibits innate immune responses by promoting degradation of the MAVS/TRAF3/TRAF6 signalosome.
Sarcoma
miR-4319 inhibited the development of thyroid cancer by modulating FUS-stabilized SMURF1.
Suppression of human tumor cell proliferation by Smurf2-induced senescence.
Sarcoma, Avian
An LYPSL late domain in the Gag protein contributes to the efficient release and replication of Rous sarcoma virus.
Avian sarcoma virus and human immunodeficiency virus, type 1 use different subsets of ESCRT proteins to facilitate the budding process.
Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells.
Role of Nedd4 and ubiquitination of Rous sarcoma virus Gag in budding of virus-like particles from cells.
The functionally exchangeable L domains in RSV and HIV-1 Gag direct particle release through pathways linked by Tsg101.
Tsg101 can replace Nedd4 function in ASV Gag release but not membrane targeting.
Seizures
A novel missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria and cleft palate.
The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily.
Sepsis
E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation.
Silicosis
MiR-411-3p alleviates Silica-induced pulmonary fibrosis by regulating Smurf2/TGF-? signaling.
Skin Diseases
NEDD4 Is Involved in Inflammation Development during Keloid Formation.
Spasms, Infantile
A novel missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria and cleft palate.
Spinal Cord Injuries
microRNA-125b and its downstream Smurf1/KLF2/ATF2 axis as important promoters on neurological function recovery in rats with spinal cord injury.
Up-regulation of Smurf1 after spinal cord injury in adult rats.
Spinocerebellar Ataxias
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.
Pentanucleotide repeat-primed PCR for genetic diagnosis of spinocerebellar ataxia type 31.
Squamous Cell Carcinoma of Head and Neck
SMURF1 silencing diminishes a CD44-high cancer stem cell-like population in head and neck squamous cell carcinoma.
TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects.
Starvation
Hepatic PPAR? function is controlled by polyubiquitination and proteasome-mediated degradation via the coordinated actions of PAQR3 and HUWE1.
Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.
The HECT E3 ubiquitin ligase NEDD4 interacts with and ubiquitylates SQSTM1 for inclusion body autophagy.
The ubiquitin-protein ligase Nedd4 targets Notch1 in skeletal muscle and distinguishes the subset of atrophies caused by reduced muscle tension.
ULK1 ubiquitylation is regulated by phosphorylation on its carboxy terminus.
Stomach Neoplasms
Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient.
Expression of NEDD4-1, a PTEN regulator, in gastric and colorectal carcinomas.
LINC00355 induces gastric cancer proliferation and invasion through promoting ubiquitination of P53.
MicroRNA-424 regulates cisplatin resistance of gastric cancer by targeting SMURF1 based on GEO database and primary validation in human gastric cancer tissues.
miR-1254 inhibits cell proliferation, migration, and invasion by down-regulating Smurf1 in gastric cancer.
SMURF1 promotes the proliferation, migration and invasion of gastric cancer cells.
The correlation between NEDD4L and HIF-1? levels as a gastric cancer prognostic marker.
The E3 ligase HUWE1 mediates TGFBR2 ubiquitination and promotes gastric cancer cell proliferation, migration, and invasion.
The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
UBE3C promotes proliferation and inhibits apoptosis by activating the ?-catenin signaling via degradation of AXIN1 in gastric cancer.
Stroke
Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity.
Deletion of ubiquitin ligase Nedd4l exacerbates ischemic brain damage.
Identification of Co-expressed Genes Between Atrial Fibrillation and Stroke.
Syndactyly
A novel missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria and cleft palate.
Familial NEDD4L variant in periventricular nodular heterotopia and in a fetus with hypokinesia and flexion contractures.
Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia.
Recurrent NEDD4L Variant in Periventricular Nodular Heterotopia, Polymicrogyria and Syndactyly.
Thyroid Neoplasms
miR-4319 inhibited the development of thyroid cancer by modulating FUS-stabilized SMURF1.
REG? potentiates TGF-?/Smad signal dependent epithelial-mesenchymal transition in thyroid cancer cells.
Smad Ubiquitination Regulatory Factor 1 (Smurf1) Promotes Thyroid Cancer Cell Proliferation and Migration via Ubiquitin-Dependent Degradation of Kisspeptin-1.
Tumour suppressive function of HUWE1 in thyroid cancer.
Trauma, Nervous System
Up-regulation of Smurf1 after spinal cord injury in adult rats.
Triple Negative Breast Neoplasms
Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: involvement of the RB-microRNA axis.
MiR-153 promotes breast cancer cell apoptosis by targeting HECTD3.
The miR-106b-25 cluster mediates breast tumor initiation through activation of NOTCH1 via direct repression of NEDD4L.
Transcriptome-wide analysis and modelling of prognostic alternative splicing signatures in invasive breast cancer: a prospective clinical study.
Tuberculosis
The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.
The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.
Tuberculosis, Meningeal
The impact of common Smurf1 gene variants on the risk, clinical characteristics and short-term prognosis of tuberculous meningitis.
Tuberculosis, Pulmonary
The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense.
Ureteral Obstruction
Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis.
HUWE1 promotes EGFR ubiquitination and degradation to protect against renal tubulointerstitial fibrosis.
Urinary Bladder Neoplasms
Inhibition of NEDD4 inhibits cell growth and invasion and induces cell apoptosis in bladder cancer cells.
The Nedd4-like family of E3 ubiquitin ligases and cancer.
Uterine Cervical Neoplasms
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells.
Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53.
The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase.
The roles of E6-AP and MDM2 in p53 regulation in human papillomavirus-positive cervical cancer cells.
Tristetraprolin and E6-AP: Killing the messenger in cervical cancer.
[RNA interference of HERC4 inhibits proliferation, apoptosis and migration of cervical cancer Hela cells].
Vascular Calcification
Nedd4 Deficiency in Vascular Smooth Muscle Promotes Vascular Calcification by Stabilizing pSmad1.
Vesicular Stomatitis
Budding of PPxY-containing rhabdoviruses is not dependent on host proteins TGS101 and VPS4A.
ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response.
Smurf1 restricts the antiviral function mediated by USP25 through promoting its ubiquitination and degradation.
Virus Diseases
Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity.
E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3.
E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3.
E3 Ubiquitin Ligase Nedd4 Promotes Japanese Encephalitis Virus Replication by Suppressing Autophagy in Human Neuroblastoma Cells.
Human microRNA-30 inhibits influenza virus infection by suppressing the expression of SOCS1, SOCS3, and NEDD4.
Huwe1, a novel cellular interactor of Gag-Pol through integrase binding, negatively influences HIV-1 infectivity.
Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense.
The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.
von Hippel-Lindau Disease
Human disorders of ubiquitination and proteasomal degradation.
Wolfram Syndrome
The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum.
Xeroderma Pigmentosum
Transcriptional and Posttranslational Regulation of Nucleotide Excision Repair: The Guardian of the Genome against Ultraviolet Radiation.