Information on EC 2.3.1.B40 - caliceamicin oktaketide synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Micromonospora echinospora

EC NUMBER
COMMENTARY hide
2.3.1.B40
-
RECOMMENDED NAME
GeneOntology No.
caliceamicin oktaketide synthase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
8 malonyl-CoA + NADPH + H+ = 8 CoA + (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid + 8 CO2 + NADP+ + H2O
show the reaction diagram
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
malonyl-CoA:malonyl-CoA C-malonyltransferase (hexadecahexaenoic acid-forming)
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
polyketide is an authentic product of CalE8 and may be a key precursor to the enediyne core of calicheamicin
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
8 malonyl-CoA + NADPH + H+
8 CoA + (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid + NADP+ + H2O + CO2
show the reaction diagram
-
the enzyme-bound product (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid is a native intermediate in the biosynthesis of calicheamicin
-
?
additional information
?
-
a strong correlation between light exposure and the chain length of PKS-bound truncation products is observed, with shorter polyketides favored during light-exposed induction
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
8 malonyl-CoA + NADPH + H+
8 CoA + (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid + NADP+ + H2O + CO2
show the reaction diagram
Q8KNG1
-
the enzyme-bound product (4E,6E,8E,10E,12E,14E)-3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoic acid is a native intermediate in the biosynthesis of calicheamicin
-
?
additional information
?
-
Q8KNG1
a strong correlation between light exposure and the chain length of PKS-bound truncation products is observed, with shorter polyketides favored during light-exposed induction
-
-
-
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli