Information on EC 2.3.1.B39 - brefelding oktaketide synthase

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The expected taxonomic range for this enzyme is: Eupenicillium brefeldianum

EC NUMBER
COMMENTARY hide
2.3.1.B39
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RECOMMENDED NAME
GeneOntology No.
brefelding oktaketide synthase
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SYSTEMATIC NAME
IUBMB Comments
malonyl-CoA:malonyl-CoA C-malonyltransferase (okta- and nonaketide-forming)
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
8 malonyl-CoA + 4 NADPH + 16 H+
8 CoA + (2E,4E,10E)-15-hydroxyhexadeca-2,4,10-trienoic acid + 8 CO2 + 4 NADP+ + 6 H2O
show the reaction diagram
9 malonyl-CoA + 5 NADPH + 19 H+
9 CoA + (4E,6Z,12E)-17-hydroxyoctadeca-4,6,12-trienoic acid + 9 CO2 + 5 NADP+ + 7 H2O
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
8 malonyl-CoA + 4 NADPH + 16 H+
8 CoA + (2E,4E,10E)-15-hydroxyhexadeca-2,4,10-trienoic acid + 8 CO2 + 4 NADP+ + 6 H2O
show the reaction diagram
9 malonyl-CoA + 5 NADPH + 19 H+
9 CoA + (4E,6Z,12E)-17-hydroxyoctadeca-4,6,12-trienoic acid + 9 CO2 + 5 NADP+ + 7 H2O
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
NADPH
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in the absence of the reducing cofactor NADPH, the reductive domains are inactive and yield an unreduced polyketide product
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Saccharomyces cerevisiae
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