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Reference on EC 2.3.1.85 - fatty-acid synthase system

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vagelos, R.P.
Acyl group transfer (acyl carrier protein)
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
8
155-199
1973
Columba sp., Rattus norvegicus
-
Manually annotated by BRENDA team
Rangan, V.S.; Smith, S.
Alteration of the substrate specificity of the malonyl-CoA/acetyl-CoA:acyl carrier protein S-acyltransferase domain of the multifunctional fatty acid synthase by mutation of a single arginine residue
J. Biol. Chem.
272
11975-11978
1997
Rattus norvegicus
Manually annotated by BRENDA team
Rangan, V.S.; Joshi, A.K.; Smith, S.
Fatty acid synthase dimers containing catalytically active beta-ketoacyl synthase or malonyl/acetyltransferase domains in only one subunit can support fatty acid synthesis at the acyl carrier protein domains of both subunits
J. Biol. Chem.
273
34949-34953
1998
Rattus norvegicus
Manually annotated by BRENDA team
Puri, R.N.; Porter, J.W.
Isolation and partial purification of elastase-released peptide domains that contain the partial activities of pigeon liver fatty acid synthetase
Biochem. Biophys. Res. Commun.
107
1212-1218
1982
Columba sp.
Manually annotated by BRENDA team
Jenik, R.A.; Porter, J.W.
Red blood cell fatty acid synthetase. Nonidentity with the enzyme from liver
Int. J. Biochem.
10
609-617
1979
Rattus norvegicus
Manually annotated by BRENDA team
Stoops, J.K.; Ross, P.; Arslanian, M.J.; Aune, K.C.; Wakil, S.J.
Physicochemical studies of the rat liver and adipose fatty acid synthetases
J. Biol. Chem.
254
7418-7426
1979
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
McCarthy, A.D.; Hardie, D.G.
The multifunctional polypeptide chains of rabbit-mammary fatty-acid synthase. Stoichiometry of active sites and active-site mapping using limited proteolysis
Eur. J. Biochem.
130
185-193
1983
Oryctolagus cuniculus
Manually annotated by BRENDA team
Katiyar, S.S.; Pan, D.; Porter, J.W.
Role of cysteine and 4-phosphopantetheine in the inactivation of pigeon liver fatty acid synthetase by S-(4-bromo-2,3-dioxobutyl)-coenzyme A
Biochem. Biophys. Res. Commun.
104
517-522
1982
Columba sp.
Manually annotated by BRENDA team
Katiyar, S.S.; Pan, D.; Porter, J.W.
Inactivation of 3-oxoacyl synthetase activity of pigeon liver fatty acid synthetase by S-(4-bromo-2,3-dioxobutyl)-coenzyme A
Eur. J. Biochem.
130
177-184
1983
Columba sp.
Manually annotated by BRENDA team
Wakil, S.J.; Stoops, J.K.; Joshi, V.C.
Fatty acid synthesis and its regulation
Annu. Rev. Biochem.
52
537-579
1983
Anser sp., Bos taurus, Canis lupus familiaris, Gallus gallus, Columba sp., Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Muesing, R.A.; Porter, J.W.
Fatty acid synthase from pigeon liver
Methods Enzymol.
35
45-49
1975
Gallus gallus, Columba sp., Rattus norvegicus
Manually annotated by BRENDA team
Podack, E.R.; Saathoff, G.; Seubert, W.
On the mechanism and control of the malonyl-CoA-dependent chain elongation of fatty acids. The malonyl-transfer reaction
Eur. J. Biochem.
50
237-243
1974
Rattus norvegicus
Manually annotated by BRENDA team
Stoops, J.K.; Wakil, S.J.
Animal fatty acid synthetase. A novel arrangement of the beta-ketoacyl synthetase sites comprising domains of the two subunits
J. Biol. Chem.
256
5128-5133
1981
Gallus gallus
Manually annotated by BRENDA team
Mikkelsen, J.; Hoejrup, P.; Hansen, H.F.; Hansen, J.K.; Knudsen, J.
Evidence that the medium-chain acyltransferase of lactating-goat mammary-gland fatty acid synthetase is identical with the acetyl/malonyltransferase
Biochem. J.
227
981-985
1985
Capra hircus
Manually annotated by BRENDA team
Wong, H.; Mattick, J.S.; Wakil, S.J.
The architecture of the animal fatty acid synthetase. III. Isolation and characterization of beta-ketoacyl reductase
J. Biol. Chem.
258
15305-15311
1983
Gallus gallus
Manually annotated by BRENDA team
Tsukamoto, Y.; Wong, H.; Mattick, J.S.; Wakil, S.J.
The architecture of the animal fatty acid synthetase complex. IV. Mapping of active centers and model for the mechanism of action
J. Biol. Chem.
258
15312-15322
1983
Gallus gallus
Manually annotated by BRENDA team
Chirala, S.S.; Huang, W.Y.; Jayakumar, A.; Sakai, K.; Wakil, S.J.
Animal fatty acid synthase: Functional mapping and cloning and expression of the domain I constituent activities
Proc. Natl. Acad. Sci. USA
94
5588-5593
1997
Gallus gallus
Manually annotated by BRENDA team
Foretz, M.; Foufelle, F.; Ferre, P.
Polyunsaturated fatty acids inhibit fatty acid synthase and spot-14-protein gene expression in cultured rat hepatocytes by a peroxidative mechanism
Biochem. J.
341
371-376
1999
Rattus norvegicus
-
Manually annotated by BRENDA team
Jayakumar, A.; Huang, W.Y.; Raetz, B.; Chirala, S.S.; Wakil, S.J.
Cloning and expression of the multifunctional human fatty acid synthase and its subdomains in Escherichia coli
Proc. Natl. Acad. Sci. USA
93
14509-14514
1996
Homo sapiens
Manually annotated by BRENDA team
Jayakumar, A.; Tai, M.H.; Huang, W.Y.; Al-Feel, W.; Hsu, M.; Abu-Elheiga, L.; Chirala, S.S.; Wakil, S.J.
Human fatty acid synthase: properties and molecular cloning
Proc. Natl. Acad. Sci. USA
92
8695-8699
1995
Homo sapiens
Manually annotated by BRENDA team
Joshi, A.K.; Rangan, V.S.; Smith, S.
Differential affinity labelling of the two subunits of the homodimeric animal fatty acid synthase allows isolation of heterodimers consisting of subunits that have been independently modified
J. Biol. Chem.
273
4937-4943
1998
Rattus norvegicus
Manually annotated by BRENDA team
Park, Y.D.; Wu, B.N.; Tian, W.X.; Zhou, H.M.
Effects of osmolytes on unfolding of chicken liver fatty acid synthase
Biochemistry (Moscow)
67
914-917
2002
Gallus gallus
Manually annotated by BRENDA team
Simpson, K.J.; Venkatesan, S.; Peters, T.J.
Fatty acid synthesis by rat liver after chronic ethanol feeding with a low-fat diet
Clin. Sci.
87
441-446
1994
Rattus norvegicus
Manually annotated by BRENDA team
Shi, Y.; Luo, W.; Tian, W.X.; Zhang, T.; Zhou, H.M.
Inactivation and conformational changes of fatty acid synthase from chicken liver during unfolding by sodium dodecyl sulfate
Int. J. Biochem. Cell Biol.
30
1319-1330
1998
Gallus gallus
Manually annotated by BRENDA team
Stuible, H.P.; Meurer, G.; Schweizer, E.
Heterologous expression and biochemical characterization of two functionally different type I fatty acid synthases from Brevibacterium ammoniagenes
Eur. J. Biochem.
247
268-273
1997
Corynebacterium ammoniagenes
Manually annotated by BRENDA team
Stuible, H.P.; Wagner, C.; Andreou, J.; Guter, G.; Haselmann, J.; Schweizer, E.
Identification and functional differentiation of two type I fatty acid synthases in Brevibacterium ammoniagenes
J. Bacteriol.
178
4787-4793
1996
Corynebacterium ammoniagenes
Manually annotated by BRENDA team
Wagle, S.; Bui, A.; Ballard, P.L.; Shuman, H.; Gonzales, J.; Gonzales, L.W.
Hormonal regulation and cellular localization of fatty acid synthase in human fetal lung
Am. J. Physiol.
277
L381-L390
1999
Homo sapiens
Manually annotated by BRENDA team
Wang, F.; Wang, X.; Liu, Y.; Tian, W.X.; Zhou, H.M.
Inhibitive effect of zinc ion on fatty acid synthase from chicken liver
Int. J. Biochem. Cell Biol.
35
391-400
2003
Gallus gallus
Manually annotated by BRENDA team
Witkowski, A.; Joshi, S.; Smith, S.
Fatty acid synthase: in vitro complementation of inactive mutants
Biochemistry
35
10569-10575
1996
Rattus norvegicus
Manually annotated by BRENDA team
Wu, B.N.; Park, Y.D.; Tian, W.X.; Zhou, H.M.
Unfolding and inactivation of fatty acid synthase from chicken liver during urea denaturation
Biochim. Biophys. Acta
1549
112-121
2001
Gallus gallus
Manually annotated by BRENDA team
Ide, T.; Ashakumary, L.; Takahashi, Y.; Kushiro, M.; Fukuda, N.; Sugano, M.
Sesamin, a sesame lignan, decreases fatty acid synthesis in rat liver accompanying the down-regulation of sterol regulatory element binding protein-1
Biochim. Biophys. Acta
1534
1-13
2001
Rattus norvegicus
Manually annotated by BRENDA team
Yu, X.X.; Lewin, D.A.; Forrest, W.; Adams, S.H.
Cold elicits the simultaneous induction of fatty acid synthesis and beta-oxidation in murine brown adipose tissue: prediction from differential gene expression and confirmation in vivo
FASEB J.
16
155-168
2002
Mus musculus, Mus musculus FVB-N
Manually annotated by BRENDA team
Swinnen, J.V.; Van Veldhoven, P.P.; Timmermans, L.; De Schrijver, E.; Brusselmans, K.; Vanderhoydonc, F.; Van de Sande, T.; Heemers, H.; Heyns, W.; Verhoeven, G.
Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains
Biochem. Biophys. Res. Commun.
302
898-903
2003
Homo sapiens
Manually annotated by BRENDA team
Schmid, B.; Rippmann, J.F.; Tadayyon, M.; Hamilton, B.S.
Inhibition of fatty acid synthase prevents preadipocyte differentiation
Biochem. Biophys. Res. Commun.
328
1073-1082
2005
Mus musculus
Manually annotated by BRENDA team
Rendina, A.R.; Cheng, D.
Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates
Biochem. J.
388
895-903
2005
Rattus norvegicus
Manually annotated by BRENDA team
Wang, X.; Song, K.S.; Guo, Q.X.; Tian, W.X.
The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase
Biochem. Pharmacol.
66
2039-2047
2003
Gallus gallus
Manually annotated by BRENDA team
Witkowski, A.; Joshi, A.K.; Smith, S.
Characterization of the beta-carbon processing reactions of the mammalian cytosolic fatty acid synthase: role of the central core
Biochemistry
43
10458-10466
2004
Rattus norvegicus
Manually annotated by BRENDA team
Zhang, R.; Xiao, W.; Wang, X.; Wu, X.; Tian, W.
Novel inhibitors of fatty acid synthase from green tea with high activity and new reacting site
Biotechnol. Appl. Biochem.
43
1-7
2005
Anas platyrhynchos, Gallus gallus
Manually annotated by BRENDA team
Lu, S.; Archer, M.C.
Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer
Carcinogenesis
26
153-157
2005
Rattus norvegicus
Manually annotated by BRENDA team
Joshi, A.K.; Rangan, V.S.; Witkowski, A.; Smith, S.
Engineering of an active animal fatty acid synthase dimer with only one competent subunit
Chem. Biol.
10
169-173
2003
Rattus norvegicus
Manually annotated by BRENDA team
Rohrbach, K.W.; Han, S.; Gan, J.; O'Tanyi, E.J.; Zhang, H.; Chi, C.L.; Taub, R.; Largent, B.L.; Cheng, D.
Disconnection between the early onset anorectic effects by C75 and hypothalamic fatty acid synthase inhibition in rodents
Eur. J. Pharmacol.
511
31-41
2005
Rattus norvegicus
Manually annotated by BRENDA team
Li, B.H.; Tian, W.X.
Inhibitory effects of flavonoids on animal fatty acid synthase
J. Biochem.
135
85-91
2004
Anas platyrhynchos
Manually annotated by BRENDA team
Kim, H.; Choi, S.; Lee, H.J.; Lee, J.H.; Choi, H.
Suppression of fatty acid synthase by dietary polyunsaturated fatty acids is mediated by fat itself, not by peroxidative mechanism
J. Biochem. Mol. Biol.
36
258-264
2003
Rattus norvegicus
Manually annotated by BRENDA team
Li, B.H.; Tian, W.X.
Presence of fatty acid synthase inhibitors in the rhizome of Alpinia officinarum hance
J. Enzyme Inhib. Med. Chem.
18
349-356
2003
Gallus gallus
Manually annotated by BRENDA team
Asturias, F.J.; Chadick, J.Z.; Cheung, I.K.; Stark, H.; Witkowski, A.; Joshi, A.K.; Smith, S.
Structure and molecular organization of mammalian fatty acid synthase
Nat. Struct. Mol. Biol.
12
225-232
2005
Rattus norvegicus
Manually annotated by BRENDA team
Agostini, M.; Silva, S.D.; Zecchin, K.G.; Coletta, R.D.; Jorge, J.; Loda, M.; Graner, E.
Fatty acid synthase is required for the proliferation of human oral squamous carcinoma cells
Oral Oncol.
40
728-735
2004
Homo sapiens
Manually annotated by BRENDA team
Chirala, S.S.; Chang, H.; Matzuk, M.; Abu-Elheiga, L.; Mao, J.; Mahon, K.; Finegold, M.; Wakil, S.J.
Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero
Proc. Natl. Acad. Sci. USA
100
6358-6363
2003
Mus musculus
Manually annotated by BRENDA team
Chakravarty, B.; Gu, Z.; Chirala, S.S.; Wakil, S.J.; Quiocho, F.A.
Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain
Proc. Natl. Acad. Sci. USA
101
15567-15572
2004
Homo sapiens (P49327)
Manually annotated by BRENDA team
Pflug, B.R.; Pecher, S.M.; Brink, A.W.; Nelson, J.B.; Foster, B.A.
Increased fatty acid synthase expression and activity during progression of prostate cancer in the TRAMP model
Prostate
57
245-254
2003
Mus musculus
Manually annotated by BRENDA team
Carlisle-Moore, L.; Gordon, C.R.; Machutta, C.A.; Miller, W.T.; Tonge, P.J.
Substrate recognition by the human fatty-acid synthase
J. Biol. Chem.
280
42612-42618
2005
Homo sapiens
Manually annotated by BRENDA team
Asturias, F.J.
Mammalian fatty acid synthase: X-ray structure of a molecular assembly line
ACS Chem. Biol.
1
135-138
2006
Homo sapiens
Manually annotated by BRENDA team
Consolazio, A.; Alo, P.L.; Rivera, M.; Iacopini, F.; Paoluzi, O.A.; Crispino, P.; Pica, R.; Paoluzi, P.
Overexpression of fatty acid synthase in ulcerative colitis
Am. J. Clin. Pathol.
126
113-118
2006
Homo sapiens
Manually annotated by BRENDA team
Ngo, S.C.; Zimhony, O.; Chung, W.J.; Sayahi, H.; Jacobs, W.R.; Welch, J.T.
Inhibition of isolated Mycobacterium tuberculosis fatty acid synthase I by pyrazinamide analogs
Antimicrob. Agents Chemother.
51
2430-2435
2007
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Na, M.; Jang, J.; Min, B.S.; Lee, S.J.; Lee, M.S.; Kim, B.Y.; Oh, W.K.; Ahn, J.S.
Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma
Bioorg. Med. Chem. Lett.
16
4738-4742
2006
Gallus gallus
Manually annotated by BRENDA team
Najjar, S.M.; Yang, Y.; Fernstroem, M.A.; Lee, S.J.; Deangelis, A.M.; Rjaily, G.A.; Al-Share, Q.Y.; Dai, T.; Miller, T.A.; Ratnam, S.; Ruch, R.J.; Smith, S.; Lin, S.H.; Beauchemin, N.; Oyarce, A.M.
Insulin acutely decreases hepatic fatty acid synthase activity
Cell Metab.
2
43-53
2005
Mus musculus
Manually annotated by BRENDA team
Lupu, R.; Menendez, J.A.
Pharmacological inhibitors of fatty acid synthase (FASN)-catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?
Curr. Pharm. Biotechnol.
7
483-494
2006
Homo sapiens
Manually annotated by BRENDA team
Li, B.H.; Ma, X.F.; Wang, Y.; Tian, W.X.
Structure-activity relationship of polyphenols that inhibit fatty acid synthase
J. Biochem.
138
679-685
2005
Anas platyrhynchos
Manually annotated by BRENDA team
Molle, V.; Brown, A.K.; Besra, G.S.; Cozzone, A.J.; Kremer, L.
The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation
J. Biol. Chem.
281
30094-30103
2006
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Du, Y.T.; Wang, X.; Wu, X.D.; Tian, W.X.
Keemun black tea extract contains potent fatty acid synthase inhibitors and reduces food intake and body weight of rats via oral administration
J. Enzyme Inhib. Med. Chem.
20
349-356
2005
Rattus norvegicus
Manually annotated by BRENDA team
Wang, Y.; Zhang, S.Y.; Ma, X.F.; Tian, W.X.
Potent inhibition of fatty acid synthase by parasitic loranthus [Taxillus chinensis (dc.) danser] and its constituent avicularin
J. Enzyme Inhib. Med. Chem.
21
87-93
2006
Anas platyrhynchos
Manually annotated by BRENDA team
Matsukuma, K.E.; Bennett, M.K.; Huang, J.; Wang, L.; Gil, G.; Osborne, T.F.
Coordinated control of bile acids and lipogenesis through FXR-dependent regulation of fatty acid synthase
J. Lipid Res.
47
2754-2761
2006
Mus musculus
Manually annotated by BRENDA team
van de Sande, T.; Roskams, T.; Lerut, E.; Joniau, S.; Van Poppel, H.; Verhoeven, G.; Swinnen, J.V.
High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB
J. Pathol.
206
214-219
2005
Homo sapiens
Manually annotated by BRENDA team
Wang, H.Q.; Altomare, D.A.; Skele, K.L.; Poulikakos, P.I.; Kuhajda, F.P.; Di Cristofano, A.; Testa, J.R.
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
Oncogene
24
3574-3582
2005
Homo sapiens
Manually annotated by BRENDA team
Schmidt, L.J.; Ballman, K.V.; Tindall, D.J.
Inhibition of fatty acid synthase activity in prostate cancer cells by dutasteride
Prostate
67
1111-1120
2007
Homo sapiens
Manually annotated by BRENDA team
Maier, T.; Jenni, S.; Ban, N.
Architecture of mammalian fatty acid synthase at 4.5 A resolution
Science
311
1258-1262
2006
Sus scrofa
Manually annotated by BRENDA team
Grunt, T.W.; Wagner, R.; Grusch, M.; Berger, W.; Singer, C.F.; Marian, B.; Zielinski, C.C.; Lupu, R.
Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells
Biochem. Biophys. Res. Commun.
385
454-459
2009
Homo sapiens
Manually annotated by BRENDA team
Kim, K.J.; Kim, H.Y.; Cho, H.K.; Kim, K.H.; Cheong, J.
The SDF-1alpha/CXCR4 axis induces the expression of fatty acid synthase via sterol regulatory element binding protein-1 activation in cancer cells
Carcinogenesis
31
679-686
2010
Homo sapiens
Manually annotated by BRENDA team
Gurvitz, A.
A novel circuit overrides Adr1p control during expression of Saccharomyces cerevisiae 2-trans-enoyl-ACP reductase Etr1p of mitochondrial type 2 fatty acid synthase
FEMS Microbiol. Lett.
297
255-260
2009
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Lu, S.; Archer, M.C.
Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells
Int. J. Cancer
126
416-425
2010
Homo sapiens
Manually annotated by BRENDA team
Duckett, S.K.; Pratt, S.L.; Pavan, E.
Corn oil or corn grain supplementation to steers grazing endophyte-free tall fescue. II. Effects on subcutaneous fatty acid content and lipogenic gene expression
J. Anim. Sci.
87
1120-1128
2009
Bos taurus
Manually annotated by BRENDA team
Gurvitz, A.
Caenorhabditis elegans F09E10.3 encodes a putative 3-oxoacyl-thioester reductase of mitochondrial type 2 fatty acid synthase FASII that is functional in yeast
J. Biomed. Biotechnol.
2009
235868
2009
Caenorhabditis elegans
Manually annotated by BRENDA team
Crescenzo, R.; Bianco, F.; Falcone, I.; Prisco, M.; Dulloo, A.G.; Liverini, G.; Iossa, S.
Hepatic mitochondrial energetics during catch-up fat after caloric restriction
Metabolism
59
1221-1230
2010
Rattus norvegicus
Manually annotated by BRENDA team
Gurvitz, A.
The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2
Mol. Genet. Genomics
282
407-416
2009
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Choi, J.S.; Kim, H.; Jung, M.H.; Hong, S.; Song, J.
Consumption of barley beta-glucan ameliorates fatty liver and insulin resistance in mice fed a high-fat diet
Mol. Nutr. Food Res.
54
1004-1013
2010
Mus musculus
Manually annotated by BRENDA team
Lau, D.S.; Archer, M.C.
The 10t,12c isomer of conjugated linoleic acid inhibits fatty acid synthase expression and enzyme activity in human breast, colon, and prostate cancer cells
Nutr. Cancer
62
116-121
2010
Homo sapiens
Manually annotated by BRENDA team
Chen, Q.; Reimer, R.A.
Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro
Nutrition
25
340-349
2009
Homo sapiens
Manually annotated by BRENDA team
Fujimoto, T.; Miyasaka, K.; Koyanagi, M.; Tsunoda, T.; Baba, I.; Doi, K.; Ohta, M.; Kato, N.; Sasazuki, T.; Shirasawa, S.
Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice
PLoS One
4
e4240
2009
Mus musculus
Manually annotated by BRENDA team
Gurvitz, A.
A C. elegans model for mitochondrial fatty acid synthase II: the longevity-associated gene W09H1.5/mecr-1 encodes a 2-trans-enoyl-thioester reductase
PLoS ONE
4
e7791
2009
Caenorhabditis elegans
Manually annotated by BRENDA team
Nguyen, L.N.; Trofa, D.; Nosanchuk, J.D.
Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infection
PLoS ONE
4
e8421
2009
Candida parapsilosis
Manually annotated by BRENDA team
Antelo, L.; Schlipp, A.; Hof, C.; Eisfeld, K.; Berg, H.; Hornbogen, T.; Zocher, R.; Anke, H.
The fatty acid synthase of the basidiomycete Omphalotus olearius is a single polypeptide
Z. Naturforsch. C
64
244-250
2009
Omphalotus olearius
Manually annotated by BRENDA team
Zeng, X.F.; Li, W.W.; Fan, H.J.; Wang, X.Y.; Ji, P.; Wang, Z.R.; Ma, S.; Li, L.L.; Ma, X.F.; Yang, S.Y.
Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain
Bioorg. Med. Chem. Lett.
21
4742-4744
2011
Homo sapiens (P49327)
Manually annotated by BRENDA team
Razani, B.; Zhang, H.; Schulze, P.C.; Schilling, J.D.; Verbsky, J.; Lodhi, I.J.; Topkara, V.K.; Feng, C.; Coleman, T.; Kovacs, A.; Kelly, D.P.; Saffitz, J.E.; Dorn, G.W.; Nichols, C.G.; Semenkovich, C.F.
Fatty acid synthase modulates homeostatic responses to myocardial stress
J. Biol. Chem.
286
30949-30961
2011
Mus musculus
Manually annotated by BRENDA team
Oh, J.; Hwang, I.H.; Hong, C.E.; Lyu, S.Y.; Na, M.
Inhibition of fatty acid synthase by ginkgolic acids from the leaves of Ginkgo biloba and their cytotoxic activity
J. Enzyme Inhib. Med. Chem.
28
565-568
2013
Gallus gallus, Homo sapiens
Manually annotated by BRENDA team
Pappenberger, G.; Benz, J.; Gsell, B.; Hennig, M.; Ruf, A.; Stihle, M.; Thoma, R.; Rudolph, M.G.
Structure of the human fatty acid synthase KS-MAT didomain as a framework for inhibitor design
J. Mol. Biol.
397
508-519
2010
Homo sapiens (P49327)
Manually annotated by BRENDA team
Gipson, P.; Mills, D.J.; Wouts, R.; Grininger, M.; Vonck, J.; Kuehlbrandt, W.
Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy
Proc. Natl. Acad. Sci. USA
107
9164-9169
2010
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Yu, X.; Liu, T.; Zhu, F.; Khosla, C.
In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli
Proc. Natl. Acad. Sci. USA
108
18643-18648
2011
Escherichia coli
Manually annotated by BRENDA team
Zhao, W.; Wang, Y.; Hao, W.; Zhao, M.; Peng, S.
In vitro inhibition of fatty acid synthase by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose plays a vital role in anti-tumour activity
Biochem. Biophys. Res. Commun.
445
346-351
2014
Homo sapiens
Manually annotated by BRENDA team
Cui, W.; Liang, Y.; Tian, W.; Ji, M.; Ma, X.
Regulating effect of beta-ketoacyl synthase domain of fatty acid synthase on fatty acyl chain length in de novo fatty acid synthesis
Biochim. Biophys. Acta
1861
149-155
2016
Homo sapiens
Manually annotated by BRENDA team
Liang, Y.; Tian, W.; Ma, X.
Inhibitory effects of grape skin extract and resveratrol on fatty acid synthase
BMC Complement. Altern. Med.
13
361
2013
Gallus gallus
Manually annotated by BRENDA team
Hopperton, K.E.; Duncan, R.E.; Bazinet, R.P.; Archer, M.C.
Fatty acid synthase plays a role in cancer metabolism beyond providing fatty acids for phospholipid synthesis or sustaining elevations in glycolytic activity
Exp. Cell Res.
320
302-310
2014
Homo sapiens
Manually annotated by BRENDA team
Hopcroft, P.; Fisher, D.
Development of a medium-throughput targeted LCMS assay to detect endogenous cellular levels of malonyl-CoA to screen fatty acid synthase inhibitors
J. Biomol. Screen.
21
111-116
2016
Homo sapiens
Manually annotated by BRENDA team
Liu, H.; Wu, X.; Dong, Z.; Luo, Z.; Zhao, Z.; Xu, Y.; Zhang, J.T.
Fatty acid synthase causes drug resistance by inhibiting TNF-alpha and ceramide production
J. Lipid Res.
54
776-785
2013
Homo sapiens
Manually annotated by BRENDA team
Bollu, L.R.; Katreddy, R.R.; Blessing, A.M.; Pham, N.; Zheng, B.; Wu, X.; Weihua, Z.
Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation
Oncotarget
6
34992-35003
2015
Homo sapiens
Manually annotated by BRENDA team
Wang, Y.; Nie, F.; Ouyang, J.; Wang, X.; Ma, X.
Inhibitory effects of sea buckthorn procyanidins on fatty acid synthase and MDA-MB-231 cells
Tumour Biol.
35
9563-9569
2014
Homo sapiens
Manually annotated by BRENDA team
Rittner, A.; Paithankar, K.S.; Huu, K.V.; Grininger, M.
Characterization of the polyspecific transferase of murine type I fatty acid synthase (FAS) and implications for polyketide synthase (PKS) engineering
ACS Chem. Biol.
13
723-732
2018
Mus musculus (P19096)
Manually annotated by BRENDA team
Topolska, M.; Martinez-Montanes, F.; Ejsing, C.S.
Topolska, M.; Martixadnez-Montanes, F.; Ejsing, C. A simple and direct assay for monitoring fatty acid synthase activity and product-specificity by high-resolution mass spectrometry
Biomolecules
10
118
2020
Bos taurus (Q71SP7)
Manually annotated by BRENDA team
Rossini, E.; Gajewski, J.; Klaus, M.; Hummer, G.; Grininger, M.
Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs)
Chem. Commun. (Camb.)
54
11606-11609
2018
Corynebacterium ammoniagenes
Manually annotated by BRENDA team
Crous-Maso, J.; Palomeras, S.; Relat, J.; Camo, C.; Martinez-Garza, U.; Planas, M.; Feliu, L.; Puig, T.
(-)-Epigallocatechin 3-gallate synthetic analogues inhibit fatty acid synthase and show anticancer activity in triple negative breast cancer
Molecules
23
1160
2018
Homo sapiens (P49327)
Manually annotated by BRENDA team
Rittner, A.; Paithankar, K.S.; Drexler, D.J.; Himmler, A.; Grininger, M.
Probing the modularity of megasynthases by rational engineering of a fatty acid synthase Type I
Protein Sci.
28
414-428
2019
Mus musculus (P19096)
Manually annotated by BRENDA team