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Information on EC 2.3.1.60 - gentamicin 3-N-acetyltransferase Word Map on EC 2.3.1.60
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The enzyme appears in viruses and cellular organisms
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gentamicin 3-N-acetyltransferase
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acetyl-CoA + gentamicin C = CoA + N3-acetylgentamicin C
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Acyl group transfer
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acetyl-CoA:gentamicin-C N3-acetyltransferase
Also acetylates sisomicin.
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3-N-aminoglycoside acetyltransferase
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acetyltransferase, gentamicin 3-
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aminoglycoside acetyltransferase
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aminoglycoside acetyltransferase AAC(3)-1
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gentamicin acetyltransferase I
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additional information
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cf. EC 2.3.1.59
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gene aacC1; diverse clinical isolates, gene aacC1
UniProt
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strain C600 containing R-factor JR88
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isolated from diarrheic neonatal calves in Egypt, gene aac(3)-Id
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strain C600 containing R-factor JR88
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strains JR88 and 72091801
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physiological function
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aminoglycoside acetyltransferase gene aac(3)-Id confers resistance to gentamicin and sisomicin
additional information
presence of genes encoding the following aminoglycoside-modifying enzymes: aph (3')-V1, aph (3')-Ia, aac (3)-Ia, aac (3) IIa, aac (6')-Ih, aac (6')-Ib and ant (2')-Ia responsible for resistance in 4 different groups of clinical isolates, overview
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acetoacetyl-CoA + gentamicin
CoA + N3'-acetoacetyl-gentamicin
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acetyl-CoA + fortimicin A
CoA + N2'-acetylfortimicin A
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acetyl-CoA + gentamicin
CoA + N3'-acetyl-gentamicin
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acetyl-CoA + gentamicin A
CoA + N3'-acetylgentamicin A
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acetyl-CoA + gentamicin B
CoA + N3'-acetylgentamicin B
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acetyl-CoA + gentamicin B1
CoA + N3'-acetylgentamicin B1
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acetyl-CoA + gentamicin C1
CoA + N3'-acetylgentamicin C1
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acetyl-CoA + gentamicin C1a
CoA + N3'-acetylgentamicin C1a
acetyl-CoA + gentamicin C2
CoA + N3'-acetylgentamicin C2
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acetyl-CoA + gentamicin XK62-2
CoA + N3'-acetylgentamicin XK62-2
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acetyl-CoA + kanamycin B
CoA + N3'-acetylkanamycin B
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acetyl-CoA + N-ethylsisomicin
CoA + N3'-acetylethylsisomicin
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acetyl-CoA + neamine
CoA + N3'-acetylneamine
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acetyl-CoA + nebramine
CoA + N2'-acetylnebramine
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acetyl-CoA + sisomicin
CoA + N3'-acetyl-sisomicin
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acetyl-CoA + sisomicin
CoA + N3'-acetylsisomicin
acetyl-CoA + tobramycin
CoA + N3'-acetyltobramycin
additional information
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acetyl-CoA + gentamicin C1a
CoA + N3'-acetylgentamicin C1a
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acetyl-CoA + gentamicin C1a
CoA + N3'-acetylgentamicin C1a
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best substrate
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acetyl-CoA + gentamicin C1a
CoA + N3'-acetylgentamicin C1a
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enzyme modifies the 3-N-position of the deoxystreptamine ring
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?
acetyl-CoA + gentamicin C1a
CoA + N3'-acetylgentamicin C1a
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acetyl-CoA + gentamicin C1a
CoA + N3'-acetylgentamicin C1a
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best substrate
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acetyl-CoA + gentamicin C1a
CoA + N3'-acetylgentamicin C1a
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enzyme modifies the 3-N-position of the deoxystreptamine ring
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?
acetyl-CoA + sisomicin
CoA + N3'-acetylsisomicin
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best substrate
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acetyl-CoA + sisomicin
CoA + N3'-acetylsisomicin
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best substrate
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acetyl-CoA + tobramycin
CoA + N3'-acetyltobramycin
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acetyl-CoA + tobramycin
CoA + N3'-acetyltobramycin
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additional information
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determination of imipenem, meropenem, and gentamicin resistant clinical isolates
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additional information
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substrate structure/activity relationship
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additional information
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substrate structure/activity relationship
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additional information
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O05286
determination of imipenem, meropenem, and gentamicin resistant clinical isolates
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2-deoxystreptamine
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weak
gentamicin C1a
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substrate inhibition
neomycin
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best inhibitor
additional information
determination of imipenem, meropenem, and gentamicin resistant clinical isolates
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additional information
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inhibition kinetics
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additional information
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N-methylmaleimide and DTT have no effect on activity
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0.0039 - 0.0048
acetyl-CoA
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0.0003 - 0.0005
gentamicin C1a
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additional information
additional information
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kinetic pattern
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3.57
N3'-acetylgentamicin C1a
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additional information
analysis of enzyme expression in several clinical isolates, overview
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17000
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4 * 17000, SDS-PAGE
63000
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equilibrium sedimentation centrifugation
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tetramer
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4 * 17000, SDS-PAGE
tetramer
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4 * 17000, SDS-PAGE
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4
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irreversible inactivation
637298
4.5
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no activity, restorable by neutralization
637298
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lyophilization, stable to
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20°C, lyophilized, up to 1 month
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frozen, redissolved ammonium sulfate precipitate, at least 1 month
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refrigerated, lyophilized, up to 1 month
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gene aac(3)-Id, DNA and amino acid sequence determination and analysis, detection and identification of class 1 and class 2 integrons and their antimicrobial resistance gene cassettes, overview
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AACC1_PSEAI
177
19442
Swiss-Prot
E3SCF8_KLEPN
246
26259
TrEMBL
A0A1P8F861_9CHLR
176
19916
TrEMBL
D3SAH2_THISK
Thioalkalivibrio sp. (strain K90mix)
199
21738
TrEMBL
B8GSK1_THISH
Thioalkalivibrio sulfidiphilus (strain HL-EbGR7)
157
17318
TrEMBL
B0VD88_ACIBY
Acinetobacter baumannii (strain AYE)
177
19388
TrEMBL
A0A1V2MP07_9ACTN
221
23648
TrEMBL
A0A173KXQ4_9SPHN
158
17012
TrEMBL
C7CIB8_METED
Methylobacterium extorquens (strain DSM 6343 / CIP 106787 / DM4)
182
19191
TrEMBL
A0A1V2MUR6_9ACTN
422
44814
TrEMBL
A0A1V2MYF0_9ACTN
286
31142
TrEMBL
A0A1V2MW82_9ACTN
188
21404
TrEMBL
C5D0X2_VARPS
Variovorax paradoxus (strain S110)
163
17778
TrEMBL
K9Q344_9CYAN
154
17397
TrEMBL
Q21JM9_SACD2
Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
158
17629
TrEMBL
H1KDI8_METEX
182
19403
TrEMBL
C5B2T1_METEA
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)
182
19403
TrEMBL
A1B7D4_PARDP
Paracoccus denitrificans (strain Pd 1222)
152
16447
TrEMBL
A0A1V2N0P9_9ACTN
252
26856
TrEMBL
A0A1V2MWY4_9ACTN
165
18044
TrEMBL
A0A031J9I9_SPHPI
158
16840
TrEMBL
A0A086PCH3_SPHHM
Sphingobium herbicidovorans (strain ATCC 700291 / DSM 11019 / NBRC 16415 / MH)
158
16993
TrEMBL
A0A095D791_9SPHN
151
16590
TrEMBL
B7L2P3_METC4
Methylobacterium extorquens (strain CM4 / NCIMB 13688)
182
19436
TrEMBL
A0A1V2MVT6_9ACTN
205
22969
TrEMBL
A0A1V2MMI1_9ACTN
183
19472
TrEMBL
M5R4L1_9BACI
268
30509
TrEMBL
A0A0D6JK74_9RHIZ
164
17987
TrEMBL
A4XWX5_PSEMY
Pseudomonas mendocina (strain ymp)
175
19155
TrEMBL
A1B6U6_PARDP
Paracoccus denitrificans (strain Pd 1222)
152
16475
TrEMBL
A0A0L0LFC6_9BACT
143
15929
TrEMBL
A0A1V2N1K0_9ACTN
333
35286
TrEMBL
A9W8G5_METEP
Methylobacterium extorquens (strain PA1)
179
19085
TrEMBL
A1ZN12_9BACT
148
16827
TrEMBL
Q1GVH5_SPHAL
Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256)
152
16319
TrEMBL
O05286_ACIBA
154
16971
TrEMBL
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Williams, J.W.; Northrop, D.B.
Purification and properties of gentamicin acetyltransferase I
Biochemistry
15
125-131
1976
Escherichia coli, Escherichia coli C600
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Williams, J.W.; Northrop, D.B.
Substrate specificity and structure-activity relationships of gentamicin acetyltransferase I. The dependence of antibiotic resistance upon substrate Vmax/Km values
J. Biol. Chem.
253
5908-5914
1978
Escherichia coli, Escherichia coli C600
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Vliegenthart, John S.; Ketelaar-Van Gaalen, Petra A.G.; Van de Klundert, Jos A.M.
Identification of three genes coding for aminoglycoside-modifying enzymes by means of the polymerase chain reaction
J. Antimicrob. Chemother.
25
759-765
1990
Escherichia coli
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Ahmed, A.M.; Younis, E.E.; Osman, S.A.; Ishida, Y.; El-Khodery, S.A.; Shimamoto, T.
Genetic analysis of antimicrobial resistance in Escherichia coli isolated from diarrheic neonatal calves
Vet. Microbiol.
136
397-402
2009
Escherichia coli
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Atasoy, A.R.; Ciftci, I.H.; Petek, M.
Modifying enzymes related aminoglycoside: analyses of resistant Acinetobacter isolates
Int. J. Clin. Exp. Med.
8
2874-2880
2015
Acinetobacter baumannii (O05286)
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