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Disease on EC 2.3.1.6 - choline O-acetyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
acetylcholinesterase deficiency
Congenital myasthenic syndromes.
[Molecular bases and therapeutic strategies of defective neuromuscular transmissions: lessons learned from a prototypical synapse]
Acquired Immunodeficiency Syndrome
Brain choline acetyltransferase reduction in SIV infection. An index of early dementia?
Adenocarcinoma
Synthesis of acetylcholine by lung cancer.
Alzheimer Disease
82-kDa choline acetyltransferase is in nuclei of cholinergic neurons in human CNS and altered in aging and Alzheimer disease.
A cholinergic connection between normal aging and senile dementia in the human hippocampus.
A comparison of brain choline acetyltransferase activity in Alzheimer's disease, multi-infarct dementia, and combined dementia.
A correlative study of calcium channel antagonist binding and local neuropathological features in the hippocampus in Alzheimer's disease.
A pathological study of the association between Lewy body disease and Alzheimer's disease.
A post-mortem study of the cholinergic and GABA systems in senile dementia.
A quantitative study of the neurofibrillary tangles and the choline acetyltransferase activity in the cerebral cortex and the amygdala in Alzheimer's disease.
A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele.
A silk peptide fraction restores cognitive function in AF64A-induced Alzheimer disease model rats by increasing expression of choline acetyltransferase gene.
Absence of cholinergic deficits in "pure" vascular dementia.
Adult dementia: history, biopsy, pathology.
Advances in Alzheimer's disease. A review for the family physician.
Age-impaired impulse flow from nucleus basalis to cortex.
Alterations of muscarinic acetylcholine receptor subtypes in diffuse lewy body disease: relation to Alzheimer's disease.
Alternative therapy of Alzheimer's disease via supplementation with choline acetyltransferase.
Alzheimer's disease. Aminergic-cholinergic alterations in hypothalamus.
Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities.
Alzheimer's disease: choline acetyltransferase activity in brain tissue from clinical and pathological subgroups.
Alzheimer's disease: is the decrease of the cholinergic innervation of the hippocampus related to intrinsic hippocampal pathology?
ApoE-epsilon 4-dependent association of the choline acetyltransferase gene polymorphisms (2384G>A and 1882G>A) with Alzheimer's disease.
Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease.
Are the neurochemical and behavioral changes induced by lesions of the nucleus basalis in the rat a model of Alzheimer's disease?
Arginine vasopressin and choline acetyltransferase in brains of patients with Alzheimer type senile dementia.
Association of Choline Acetyltransferase Gene Polymorphisms (SNPs rs868750G/A, rs1880676G/A, rs2177369G/A and rs3810950G/A) with Alzheimer's Disease Risk: A Meta-Analysis.
Association of the Choline Acetyltransferase Gene with Responsiveness to Acetylcholinesterase Inhibitors in Alzheimer's Disease.
Autoradiographic comparison of [3H](-)nicotine, [3H]cytisine and [3H]epibatidine binding in relation to vesicular acetylcholine transport sites in the temporal cortex in Alzheimer's disease.
BDNF-, IGF-1- and GDNF-secreting human neural progenitor cells rescue amyloid ?-induced toxicity in cultured rat septal neurons.
Bilateral symmetry of cholinergic deficits in Alzheimer's disease.
Biochemical measurements in Alzheimer's disease reveal a necessity for improved neuroimaging techniques to study metabolism.
Brain choline acetyltransferase activity and neuropeptide Y concentrations in Alzheimer's disease.
Brain choline acetyltransferase and mental function in Alzheimer disease.
Brain choline acetyltransferase reduction in dominantly inherited olivopontocerebellar atrophy.
Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study.
Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome.
Cereboost™, an American ginseng extract, improves cognitive function via up-regulation of choline acetyltransferase expression and neuroprotection.
Chemotherapy of cognitive disorders in geriatric subjects.
Choline Acetyltransferase 2384G>A Polymorphism and the Risk of Alzheimer Disease.
Choline acetyltransferase activity and vesamicol binding in Rett syndrome and in rats with nucleus basalis lesions.
Choline acetyltransferase activity and [3H]vesamicol binding in the temporal cortex of patients with Alzheimer's disease, Parkinson's disease, and rats with basal forebrain lesions.
Choline acetyltransferase and acetylcholinesterase abnormalities in senile dementia: importance of biochemical measurements in human post-mortem brain specimens.
Choline acetyltransferase G +4 A polymorphism confers a risk for Alzheimer's disease in concert with Apolipoprotein E epsilon4.
Choline acetyltransferase immunohistochemistry in brains of Alzheimer's disease patients and controls.
Choline acetyltransferase mRNA expression in the striatal neurons of patients with Alzheimer's disease.
Cholinergic and glutamatergic alterations beginning at the early stages of Alzheimer disease: participation of the phospholipase A2 enzyme.
Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease.
Cholinergic enzymes in neocortex, hippocampus and basal forebrain of non-neurological and senile dementia of Alzheimer-type patients.
Cholinergic enzymes in the spinal cord in Alzheimer-type dementia.
Cholinergic innervation of the amygdaloid complex in the human brain and its alterations in old age and Alzheimer's disease.
Cholinergic system during the progression of Alzheimer's disease: therapeutic implications.
Cholinergic topography in Alzheimer brains: a comparison with changes in the monoaminergic profile.
Chromatographic separation of reaction products from the choline acetyltransferase and carnitine acetyltransferase assay: differential ChAT and CrAT activity in brain extracts from Alzheimer's disease versus controls.
Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques.
Comparative analysis of three different protocols for cholinergic neuron differentiation in vitro using mesenchymal stem cells from human dental pulp.
Convergent cholinergic activities in aging and Alzheimer's disease.
Correction: Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice.
Correlation of choline acetyltransferase activity between the nucleus basalis of Meynert and the cerebral cortex.
Correlation of cortical cholinergic and GABA deficits with quantitative neuropathological findings in senile dementia.
Cortical neuropathological and neurochemical substrates of Alzheimer's and Parkinson's diseases.
Cortical somatostatin-like immunoreactivity in cases of Alzheimer's disease and senile dementia of the Alzheimer type.
Daidzein Activates Choline Acetyltransferase from MC-IXC Cells and Improves Drug-Induced Amnesia.
Decreased choline acetyltransferase mRNA expression in the nucleus basalis of Meynert in Alzheimer disease: an in situ hybridization study.
Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain.
Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease.
Degeneration of the cholinergic innervation of the locus ceruleus in Alzheimer's disease.
Dementia and motor neuron disease: morphometric, biochemical, and Golgi studies.
Differential vulnerability of cholinergic projections to the mediodorsal nucleus of the thalamus in senile dementia of Alzheimer type and progressive supranuclear palsy.
Down's syndrome individuals begin life with normal levels of brain cholinergic markers.
EEG findings in dementia with Lewy bodies and Alzheimer's disease.
Effect of cholinergic and anticholinergic drugs on short-term memory in Alzheimer's dementia: a neuropsychological and computerized electroencephalographic study.
Effects of cholesterol and Its 24S-OH and 25-OH oxysterols on choline acetyltransferase-positive neurons in brain slices.
Effects of estrogens on cholinergic neurons in the rat basal nucleus.
Enantioselective Total Synthesis of (+)-Garsubellin?A.
Endogenous inhibitors of human choline acetyltransferase present in Alzheimer's brain: preliminary observation.
Evaluation of choline acetyltransferase gene polymorphism (2384 G/A) in Alzheimer's disease and mild cognitive impairment.
Evidence for an increased rate of choline efflux across erythrocyte membranes in Alzheimer's disease.
Expression of catalytic trkB gene in the striatum and the basal forebrain of patients with Alzheimer's disease: an in situ hybridization study.
Extensive loss of choline acetyltransferase activity is not reflected by neuronal loss in the nucleus of Meynert in Alzheimer's disease.
Galanin hyperinnervation upregulates choline acetyltransferase expression in cholinergic basal forebrain neurons in Alzheimer's disease.
Galanin-like immunoreactivity is unchanged in Alzheimer's disease and Parkinson's disease dementia cerebral cortex.
Genetic Association of CHAT rs3810950 and rs2177369 Polymorphisms with the Risk of Alzheimer's Disease: A Meta-Analysis.
Genetic variants in the choline acetyltransferase (ChAT) gene are modestly associated with normal cognitive function in the elderly.
Genetic variation in the choline acetyltransferase (CHAT) gene may be associated with the risk of Alzheimer's disease.
Genetic variation in the choline O-acetyltransferase gene in depression and Alzheimer's disease: The VITA and Milano studies.
Heterogeneity and selectivity of the degeneration of cholinergic neurons in the basal forebrain of patients with Alzheimer's disease.
Hippocampal nerve growth factor receptor immunoreactivity in patients with Alzheimer's and Parkinson's disease.
Human neural stem cells over-expressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction.
Human Neural Stem Cells Overexpressing Choline Acetyltransferase Restore Unconditioned Fear in Rats with Amygdala Injury.
Human striatal cholinergic neurons in development, aging and Alzheimer's disease.
Identification of a single nucleotide polymorphism in the choline acetyltransferase gene associated with Alzheimer's disease.
Immunocytochemical distribution of peptidergic and cholinergic fibers in the human amygdala: their depletion in Alzheimer's disease and morphologic alteration in non-demented elderly with numerous senile plaques.
Impaired neurotransmitter systems by Abeta amyloidosis in APPsw transgenic mice overexpressing amyloid beta protein precursor.
Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses.
In vitro effect of aluminum chloride on choline acetyltransferase activity of the rat brain during postnatal growth.
Increased affinity of choline acetyltransferase for choline in Alzheimer's disease: a steady-state kinetic study.
Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: selective effects on specific interleukins and interleukin receptors.
Inhibition of cytosolic human forebrain choline acetyltransferase activity by phospho-L-serine: a phosphomonoester that accumulates during early stages of Alzheimer's disease.
Intralaminar distribution of neurotransmitter-related enzymes in cerebral cortex of Alzheimer's disease.
Is the loss of cerebral cortical choline acetyl transferase activity in Alzheimer's disease due to degeneration of ascending cholinergic nerve cells.
Is the neuronal basis of Alzheimer's disease cholinergic or glutamatergic?
Lack of association between a single nucleotide polymorphism within the choline acetyltransferase gene and patients with Alzheimer's disease.
Lateralization of brain morphologic and cholinergic abnormalities in Alzheimer's disease.
Loss of choline acetyltransferase activity in normal aging and in senile dementia.
Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation.
Loss of nicotinic acetylcholine receptor subunits alpha4 and alpha7 in the cerebral cortex of Parkinson patients.
MicroRNA-132 and early growth response-1 in nucleus basalis of Meynert during the course of Alzheimer's disease.
Monoaminergic innervation of the frontal and temporal lobes in Alzheimer's disease.
Muscarinic cholinergic receptor subtypes in hippocampus in human cognitive disorders.
Muscarinic receptor compensation in hippocampus of Alzheimer patients.
Muscarinic receptor subtypes in human neurodegenerative disorders: focus on Alzheimer's disease.
Neocortical morphometry, lesion counts, and choline acetyltransferase levels in the age spectrum of Alzheimer's disease.
Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients.
Neural restrictive silencer factor and choline acetyltransferase expression in cerebral tissue of Alzheimer's Disease patients: A pilot study.
Neurochemical activities in human temporal lobe related to aging and Alzheimer-type changes.
Neurochemical characteristics of aluminum-induced neurofibrillary degeneration in rabbits.
Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease.
Neuropathological and biochemical observations on the noradrenergic system in Alzheimer's disease.
Neurotensin immunoreactivity in post-mortem brain is increased in Down's syndrome but not in Alzheimer-type dementia.
Neurotoxic effect of enteral aluminium.
Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue.
Neurotransmitter-related enzymes in senile dementia of the Alzheimer type.
Neurotransmitters in basal ganglia and cortex of Alzheimer's disease with and without Lewy bodies.
Neurotransmitters, peptides, and neural cell adhesion molecules in the cortices of normal elderly humans and Alzheimer patients: a comparison.
Neurotrophic factor for central cholinergic neurones is present in both normal and Alzheimer brain tissue.
Nicotinic receptor losses in dementia with Lewy bodies: comparisons with Alzheimer's disease.
Nicotinic receptors, muscarinic receptors and choline acetyltransferase activity in the temporal cortex of Alzheimer patients with differing apolipoprotein E genotypes.
Normal cortical concentration of cholecystokinin-like immunoreactivity with reduced choline acetyltransferase activity in senile dementia of Alzheimer type.
Nuclear 82-kDa choline acetyltransferase decreases amyloidogenic APP metabolism in neurons from APP/PS1 transgenic mice.
Nuclear factor kappaB/p49 is a negative regulatory factor in nerve growth factor-induced choline acetyltransferase promoter activity in PC12 cells.
Nucleus basalis neuronal loss, neuritic plaques and choline acetyltransferase activity in advanced Alzheimer's disease.
Overexpression of the high affinity choline transporter in cortical regions affected by Alzheimer's disease. Evidence from rapid autopsy studies.
Pathological changes in the nucleus of Meynert in Alzheimer's and Parkinson's diseases.
Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice.
Peripheral-type benzodiazepine binding in Alzheimer disease.
Persistence of cholinergic neurons in the basal nucleus in a brain with senile dementia of the Alzheimer's type demonstrated by immunohistochemical staining for choline acetyltransferase.
Polymorphisms at the paraoxonase 1 L55M and Q192R loci affect the pathophysiology of Alzheimer's disease: emphasis on the cholinergic system and beta-amyloid levels.
Positron emission tomography and the possible origins of cytopathology in Alzheimer's disease.
Post-mortem neurochemical changes in Alzheimer's disease compared with normal ageing.
Postmortem studies in schizophrenia.
Preliminary neurochemical findings in non-Alzheimer dementia due to lobar atrophy.
Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease.
Presynaptic cholinergic dysfunction in patients with dementia.
Profound disturbances of spontaneous and learned behaviors following lesions of the nucleus basalis magnocellularis in the rat.
Qualitative abnormalities of choline acetyltransferase in Alzheimer type dementia.
Real-time multiplex PCR assay for genotyping of three apolipoprotein E alleles and two choline acetyltransferase alleles with three hybridization probes.
Reduced cortical choline acetyltransferase activity in senile dementia of Alzheimer type is not accompanied by changes in vasoactive intestinal polypeptide.
Reduced phospholipase D activity in brain tissue samples from Alzheimer's disease patients.
Reduction of choline acetyltransferase activity in primary visual cortex in mild to moderate Alzheimer's disease.
Reductions in acetylcholine and nicotine binding in several degenerative diseases.
Regional brain 5-hydroxytryptamine levels are reduced in senile Down's syndrome as in Alzheimer's disease.
Regional difference in the kinetics of choline acetyltransferase in brains of neurologically normal elderly people and those with Alzheimer-type dementia.
Resilience of Precuneus Neurotrophic Signaling Pathways Despite Amyloid Pathology in Prodromal Alzheimer's Disease.
Selective loss of cholinergic neurons in the ventral striatum of patients with Alzheimer disease.
Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease.
Slowing of electroencephalogram and choline acetyltransferase activity in post mortem frontal cortex in definite Alzheimer's disease.
Substance P-like immunoreactivity, choline acetyltransferase activity and cholinergic muscarinic receptors in Alzheimer's disease and multi-infarct dementia.
Superior frontal cortex cholinergic axon density in mild cognitive impairment and early Alzheimer disease.
Synaptic proteins and choline acetyltransferase loss in visual cortex in dementia with Lewy bodies.
Systematic regional variations in the loss of cortical cholinergic fibers in Alzheimer's disease.
The Anticholinesterase Properties of Plants from the Northeast of Brazil Selected by an Ethnopharmacological Study for Disorders Relating to the Nervous System.
The differential involvement of subcortical nuclei in senile dementia of Alzheimer's type.
The Effect of Choline Acetyltransferase Genotype on Donepezil Treatment Response in Patients with Alzheimer's Disease.
The failing brain.
The nucleus basalis in Alzheimer's disease: cell counts and cortical biochemistry.
The nucleus basalis in Huntington's disease.
The temporal lobe in dementia of Alzheimer's type.
Thyrotropin-releasing hormone, luteinizing hormone-releasing hormone and substance P immuno-reactivity in post-mortem brain from cases of Alzheimer-type dementia and Down's syndrome.
Topographical distribution of neurochemical changes in Alzheimer's disease.
Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy.
Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment.
[Dementia and Parkinson's disease: biochemical and anatomo-clinical correlation]
[Effect of "Xiusanzhen" on learning-memory ability and hippocampal ChAT and AChE activity in Alzheimer disease rats]
[Effects of Chinese herb compound Naoyikang on expression of choline acetyltransferase in brain of rats with Alzheimer's disease]
[Pharmaceutical research strategies in Alzheimer's disease]
Amnesia
Daidzein Activates Choline Acetyltransferase from MC-IXC Cells and Improves Drug-Induced Amnesia.
Dicholine salt of succinic acid, a neuronal insulin sensitizer, ameliorates cognitive deficits in rodent models of normal aging, chronic cerebral hypoperfusion, and beta-amyloid peptide-(25-35)-induced amnesia.
Effect of Tremella fuciformis on the neurite outgrowth of PC12h cells and the improvement of memory in rats.
Effects of MCI-225 on memory and glucose utilization in basal forebrain-lesioned rats.
Effects of nefiracetam, DM-9384 on amnesia and decrease in choline acetyltransferase activity induced by cycloheximide.
Effects of nerve growth factor (NGF) in rats with basal forebrain lesions.
Effects of oleamide on choline acetyltransferase and cognitive activities.
Effects of oral administration of a stimulator for nerve growth factor synthesis in basal forebrain-lesioned rats.
Nelumbo nucifera semen extract improves memory in rats with scopolamine-induced amnesia through the induction of choline acetyltransferase expression.
Premarin improves memory, prevents scopolamine-induced amnesia and increases number of basal forebrain choline acetyltransferase positive cells in middle-aged surgically menopausal rats.
Amyloidosis
Correction: Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice.
Impaired neurotransmitter systems by Abeta amyloidosis in APPsw transgenic mice overexpressing amyloid beta protein precursor.
Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice.
Amyotrophic Lateral Sclerosis
Choline acetyltransferase activities in single spinal motor neurons from patients with amyotrophic lateral sclerosis.
Choline acetyltransferase and substance P-like immuno-reactivity in the human spinal cord: changes in amyotrophic lateral sclerosis.
Cholinergic markers in ALS spinal cord.
Immunohistochemical study on choline acetyltransferase in the spinal cord of patients with amyotrophic lateral sclerosis.
Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation.
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Apnea
Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans.
Clinical and Genetic Features of Congenital Myasthenic Syndromes due to CHAT Mutations: Case Report and Literature Review.
Clinical variability of CMS-EA (congenital myasthenic syndrome with episodic apnea) due to identical CHAT mutations in two infants.
Compound Heterozygous CHAT Gene Mutations of a Large Deletion and a Missense Variant in a Chinese Patient With Severe Congenital Myasthenic Syndrome With Episodic Apnea.
Congenital myasthenic syndrome with episodic apnea in patients homozygous for a CHAT missense mutation.
Congenital myasthenic syndrome with episodic apnea.
Congenital myasthenic syndromes.
[Congenital myasthenic syndromes].
Arthritis, Rheumatoid
Unexpected finding of a marked non-neuronal cholinergic system in human knee joint synovial tissue.
Ataxia
Recurrent deletions and reciprocal duplications of 10q11.21q11.23 including CHAT and SLC18A3 are likely mediated by complex low-copy repeats.
Atherosclerosis
[Innervation of human pia mater arteries of different diameters in arteriosclerosis]
Atrial Fibrillation
Increase of Autonomic Nerve Factors in Epicardial Ganglionated Plexi During Rapid Atrial Pacing Induced Acute Atrial Fibrillation.
Autoimmune Diseases
The mechanism of botulism.
Botulism
The mechanism of botulism.
Bradycardia
Choline acetyltransferase activity in the atria of the rat heart during training bradycardia.
Modulation of neuroinflammation and memory dysfunction using percutaneous vagus nerve stimulation in mice.
Brain Diseases
Brain gamma-aminobutyric acid deficiency in dialysis encephalopathy.
Calcium metabolism in aluminum encephalopathy.
Do raised brain aluminium levels in Alzheimer's dementia contribute to cholinergic neuronal deficits?
Brain Injuries
Quantitative assessment of neuroprotection against NMDA-induced brain injury.
The effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate in different regions following hypoxic-ischemic brain injury in adult rats.
Brain Injuries, Traumatic
Chronic administration of a partial muscarinic M1 receptor agonist attenuates decreases in forebrain choline acetyltransferase immunoreactivity following experimental brain trauma.
Disruption of basal forebrain cholinergic neurons after traumatic brain injury does not compromise environmental enrichment-mediated cognitive benefits.
Immunohistochemical analysis for acetylcholinesterase and choline acetyltransferase in mouse cerebral cortex after traumatic brain injury.
Brain Ischemia
3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia.
Age-dependent vulnerability of brain choline acetyltransferase activity to transient cerebral ischemia in rats.
Selective neuronal vulnerability following mild focal brain ischemia in the mouse.
The effects of bilateral common carotid artery occlusion on expression of peripherin and choline acetyltransferase activity in C57BL/6 mice.
Time dependent changes of striatal interneurons after focal cerebral ischemia in rats.
[The effects of ischemia and postischemic reperfusion on the brain cholinergic system of the rat]
Brain Neoplasms
Exenatide reduces TNF-? expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats.
Bronchopneumonia
Choline acetyltransferase and acetylcholinesterase abnormalities in senile dementia: importance of biochemical measurements in human post-mortem brain specimens.
CADASIL
Cholinergic neuronal deficits in CADASIL.
Carcinoma
Activated cholinergic signaling provides a target in squamous cell lung carcinoma.
Cancer-associated differences in acetylcholinesterase activity in bronchial aspirates from patients with lung cancer.
Synthesis of acetylcholine by lung cancer.
Carcinoma, Embryonal
Midkine is a mediator of retinoic acid induced neuronal differentiation of embryonal carcinoma cells.
Carcinoma, Squamous Cell
Cancer-associated differences in acetylcholinesterase activity in bronchial aspirates from patients with lung cancer.
Cardiomegaly
Acetylcholine levels, choline acetyltransferase and acetylcholinesterase molecular forms during thyroxine-induced cardiac hypertrophy.
Cardiomyopathies
Changes in parasympathetic system in medulla oblongata in male pigs in the course of tachycardia-induced cardiomyopathy.
Cataplexy
Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons.
Central Nervous System Diseases
Convergent cholinergic activities in aging and Alzheimer's disease.
Cerebellar Ataxia
Absence of modification in GABA and benzodiazepine binding and in choline acetyltransferase activity in brain areas of the epileptic mutant mouse tottering.
Cerebrovascular Disorders
Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities.
Chagas Disease
Changes in choline acetyltransferase activity of rat tissues during Chagas' disease.
Cholera
Brainstem dopaminergic, cholinergic and serotoninergic afferents to the pallidum in the squirrel monkey.
Excitatory Impact of Dental Occlusion on Dorsal Motor Nucleus of Vagus.
Expression of cell fate determinants and plastic changes after neurotoxic lesion of adult mice spinal cord by cholera toxin-B saporin.
GABAergic and other noncholinergic basal forebrain neurons, together with cholinergic neurons, project to the mesocortex and isocortex in the rat.
Genetic evidence that chloroadenosine increases the specific activity of choline acetyltransferase in PC12 cells via modulation of an adenosine-dependent adenylate cyclase.
Immunohistochemical characterization of cardiac vagal preganglionic neurons in the rat.
Involvement of brain-derived neurotrophic factor and sonic hedgehog in the spinal cord plasticity after neurotoxic partial removal of lumbar motoneurons.
Noggin and Sonic hedgehog are involved in compensatory changes within the motoneuron-depleted mouse spinal cord.
Orexin-immunoreactive inputs to rat sympathetic preganglionic neurons.
Pedunculopontine nucleus in the squirrel monkey: cholinergic and glutamatergic projections to the substantia nigra.
Projections of GABAergic and cholinergic basal forebrain and GABAergic preoptic-anterior hypothalamic neurons to the posterior lateral hypothalamus of the rat.
The organization of cholinergic projections in the visual thalamus of the mouse.
The use of peroxidase substrate Vector VIP in electron microscopic single and double antigen localization.
Variability in the occurrence of nitric oxide synthase immunoreactivity in different populations of rat sympathetic preganglionic neurons.
choline o-acetyltransferase deficiency
Alzheimer's disease or "Alzheimerism"?
Brain neurotransmitter changes in three patients who had a fatal hyperthermia syndrome.
Congenital myasthenic syndrome with episodic apnea.
Congenital myasthenic syndromes in Turkey: Clinical clues and prognosis with long term follow-up.
Congenital Myasthenic Syndromes: a Clinical and Treatment Approach.
Pedunculopontine nucleus cholinergic deficiency in cervical dystonia.
The temporal lobe in dementia of Alzheimer's type.
Chorea
Choreic movements in the macaque monkey induced by kainic acid lesions of the striatum combined with L-dopa. Pharmacological, biochemical and physiological studies on neural mechanisms.
Colitis
Paradoxical regulation of ChAT and nNOS expression in animal models of Crohn's colitis and ulcerative colitis.
[Improvement in colonic inflammatory injury in rats via activating dorsal cholinergic neurons of vagus with electroacupuncture at sensitized acupoints].
Colitis, Ulcerative
Presence of a marked nonneuronal cholinergic system in human colon: Study of normal colon and colon in ulcerative colitis.
Colonic Neoplasms
Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation.
Colorectal Neoplasms
Bedside to Bench: Role of Muscarinic Receptor Activation in Ultrarapid Growth of Colorectal Cancer in a Patient With Pheochromocytoma.
Coma
Cortical glutaminase, beta-glucuronidase and glucose utilization in Alzheimer's disease.
Congenital Abnormalities
New horizons for congenital myasthenic syndromes.
Congenital Hypothyroidism
Vestibular site of action of hypothyroidism in the pigmented rat.
Craniocerebral Trauma
Cortical cholinergic dysfunction after human head injury.
Depletion of choline acetyltransferase activity but preservation of M1 and M2 muscarinic receptor binding sites in temporal cortex following head injury: a preliminary human postmortem study.
Nucleus basalis of Meynert pathology in the human brain after fatal head injury.
Creutzfeldt-Jakob Syndrome
Choline acetyltransferase and acetylcholinesterase abnormalities in senile dementia: importance of biochemical measurements in human post-mortem brain specimens.
Deglutition Disorders
Recurrent deletions and reciprocal duplications of 10q11.21q11.23 including CHAT and SLC18A3 are likely mediated by complex low-copy repeats.
Dementia
A comparative study of choline acetyltransferase from normal and Alzheimer brain.
A comparison of brain choline acetyltransferase activity in Alzheimer's disease, multi-infarct dementia, and combined dementia.
A post-mortem comparison of the cortical cholinergic system in Alzheimer's disease and Pick's disease.
Absence of cholinergic deficits in "pure" vascular dementia.
Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia.
Age-impaired impulse flow from nucleus basalis to cortex.
Alternative therapy of Alzheimer's disease via supplementation with choline acetyltransferase.
Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities.
Alzheimer's disease: a correlative study.
Brain choline acetyltransferase reduction in dominantly inherited olivopontocerebellar atrophy.
Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome.
Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease.
Cholinergic enzymes in the spinal cord in Alzheimer-type dementia.
Cholinergic markers in elderly patients with early signs of Alzheimer disease.
Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life.
Correlation of choline acetyltransferase activity between the nucleus basalis of Meynert and the cerebral cortex.
Cortical cholinergic markers in schizophrenia.
Cortical substance P-like immunoreactivity in cases of Alzheimer's disease and senile dementia of the Alzheimer type.
Dementia with Lewy bodies versus pure Alzheimer disease: differences in cognition, neuropathology, cholinergic dysfunction, and synapse density.
Dementia with Lewy bodies: choline acetyltransferase parallels nucleus basalis pathology.
Dissociation of neuropathology from severity of dementia in late-onset Alzheimer disease.
Do raised brain aluminium levels in Alzheimer's dementia contribute to cholinergic neuronal deficits?
Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease.
Functional Compensation and Mechanism of Choline Acetyltransferase in the Treatment of Cognitive Deficits in Aged Dementia Mice.
Lack of cholinergic deficit in the neocortex in Pick's disease.
Lecithin in Parkinson's disease.
Lewy body disease: Thalamic cholinergic activity related to dementia and parkinsonism.
Loss of pigmented dopamine-beta-hydroxylase positive cells from locus coeruleus in senile dementia of Alzheimer's type.
Monoaminergic innervation of the frontal and temporal lobes in Alzheimer's disease.
Muscarinic binding and choline acetyltransferase activity in Parkinsonian subjects with reference to dementia.
Neurochemical basis of dementia in Parkinson's disease.
Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits.
Neurochemical correlates of major depression in primary dementia.
Neurotensin immunoreactivity in post-mortem brain is increased in Down's syndrome but not in Alzheimer-type dementia.
Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue.
Neurotransmitters in dementia.
Nicotinic receptor losses in dementia with Lewy bodies: comparisons with Alzheimer's disease.
Novel ligands of Choline Acetyltransferase designed by in silico molecular docking, hologram QSAR and lead optimization.
Olfactory tubercle choline acetyltransferase activity in Alzheimer-type dementia, Down's syndrome and Huntington's chorea.
Pharmacologic strategies for augmenting cognitive performance in schizophrenia.
Preliminary neurochemical findings in non-Alzheimer dementia due to lobar atrophy.
Principal Components Methods for Narrow-Sense Heritability in the Analysis of Multidimensional Longitudinal Cognitive Phenotypes.
Progressive supranuclear palsy: relationship between extrapyramidal disturbances, dementia, and brain neurotransmitter markers.
Propentofylline prevents neuronal dysfunction induced by infusion of anti-nerve growth factor antibody into the rat septum.
Qualitative abnormalities of choline acetyltransferase in Alzheimer type dementia.
Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains.
Regional difference in the kinetics of choline acetyltransferase in brains of neurologically normal elderly people and those with Alzheimer-type dementia.
Senile dementia of the Alzheimer type without neocortical neurofibrillary tangles.
Senile dementia of the Alzheimer type.
Some immunohistochemical features of argyrophilic grain dementia with normal cortical choline acetyltransferase levels but extensive subcortical pathology and markedly reduced dopamine.
Substance P-like immunoreactivity, choline acetyltransferase activity and cholinergic muscarinic receptors in Alzheimer's disease and multi-infarct dementia.
Superior frontal cortex cholinergic axon density in mild cognitive impairment and early Alzheimer disease.
Synaptic proteins and choline acetyltransferase loss in visual cortex in dementia with Lewy bodies.
The nucleus basalis in Huntington's disease.
Thyrotropin-releasing hormone, luteinizing hormone-releasing hormone and substance P immuno-reactivity in post-mortem brain from cases of Alzheimer-type dementia and Down's syndrome.
Transducible P11-CNTF rescues the learning and memory impairments induced by amyloid-beta peptide in mice.
Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment.
VIP-sensitive adenylate cyclase, guanylate cyclase, muscarinic receptors, choline acetyltransferase and acetylcholinesterase, in brain tissue afflicted by Alzheimer's disease/senile dementia of the Alzheimer type.
[3H]Kainic acid binding and choline acetyltransferase activity in Alzheimer's dementia.
Dementia, Multi-Infarct
A comparison of brain choline acetyltransferase activity in Alzheimer's disease, multi-infarct dementia, and combined dementia.
Substance P-like immunoreactivity, choline acetyltransferase activity and cholinergic muscarinic receptors in Alzheimer's disease and multi-infarct dementia.
Dementia, Vascular
Absence of cholinergic deficits in "pure" vascular dementia.
Choline Acetyltransferase Activity in Vascular Dementia and Stroke.
Increased neural progenitors in individuals with cerebral small vessel disease.
Demyelinating Diseases
Lead neuropathy. 1) Morphometry, nerve conduction, and choline acetyltransferase transport: new finding of endoneurial edema associated with segmental demyelination.
Diabetes Mellitus, Experimental
Studies of sorbinil on axonal transport in streptozotocin-diabetic rats.
Diphtheria
Striatal cholinergic cell ablation attenuates L-DOPA induced dyskinesia in Parkinsonian mice.
Diverticular Diseases
Smooth muscle cholinergic denervation hypersensitivity in diverticular disease.
Down Syndrome
A commentary on: Overexpression of Dyrk1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome.
Association of phenotypic abnormalities of Down syndrome with an imbalance of genes on chromosome 21.
Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome.
Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases.
Cholinergic enzymes in the spinal cord in Alzheimer-type dementia.
Down's syndrome individuals begin life with normal levels of brain cholinergic markers.
Growth and development of the brain in Down syndrome.
Neurotensin immunoreactivity in post-mortem brain is increased in Down's syndrome but not in Alzheimer-type dementia.
Olfactory tubercle choline acetyltransferase activity in Alzheimer-type dementia, Down's syndrome and Huntington's chorea.
Overexpression of DYRK1A inhibits choline acetyltransferase induction by oleic acid in cellular models of Down syndrome.
Regional brain 5-hydroxytryptamine levels are reduced in senile Down's syndrome as in Alzheimer's disease.
The place of choline acetyltransferase activity measurement in the "cholinergic hypothesis" of neurodegenerative diseases.
Thyrotropin-releasing hormone, luteinizing hormone-releasing hormone and substance P immuno-reactivity in post-mortem brain from cases of Alzheimer-type dementia and Down's syndrome.
[3H]vesamicol binding in human brain cholinergic deficiency disorders.
Drug Resistant Epilepsy
Increased activity of choline acetyltransferase and acetylcholinesterase in actively epileptic human cerebral cortex.
Drug-Related Side Effects and Adverse Reactions
Reduced benzodiazepine receptor binding in cerebral cortical cultures chronically exposed to diazepam.
Dysautonomia, Familial
Trophic functions of the neuron. V. Familial dysautonomia. Choline acetyltransferase in familial dysautonomia.
Dyskinesias
Neuroleptic-induced oral dyskinesias: effects of progabide and lack of correlation with regional changes in glutamic acid decarboxylase and choline acetyltransferase activities.
Dystonia
Pedunculopontine nucleus cholinergic deficiency in cervical dystonia.
Embolism
Changes in cholinergic neurons and failure in learning function after microsphere embolism-induced cerebral ischemia.
Characterization of microsphere embolism-induced impairment of learning and memory function and the cholinergic system.
Failure in learning task and loss of cortical cholingergic fibers in microsphere-embolized rats.
Encephalitis
Disturbance of the cortical cholinergic innervation in Borna disease prior to encephalitis.
Lentiviral infection of rhesus macaques causes long-term injury to cortical and hippocampal projections of prostaglandin-expressing cholinergic basal forebrain neurons.
Encephalomyelitis
Cognitive deficit associated with cholinergic and nerve growth factor down-regulation in experimental allergic encephalomyelitis in rats.
Encephalomyelitis, Venezuelan Equine
Effect of Venezuelan equine encephalomyelitis virus infection on brain choline acetyltransferase and acetylcholinesterase activities.
Epilepsies, Myoclonic
Cerebral choline acetyltransferase and acetylcholinesterase activities in a Sanfilippo syndrome, in a myoclonic epilepsy and in various zones of the human newborn brain.
Epilepsy
Absence of modification in GABA and benzodiazepine binding and in choline acetyltransferase activity in brain areas of the epileptic mutant mouse tottering.
Choline acetyltransferase, glutamic acid decarboxylase and somatostatin in the kainic acid model for chronic temporal lobe epilepsy.
Recurrent deletions and reciprocal duplications of 10q11.21q11.23 including CHAT and SLC18A3 are likely mediated by complex low-copy repeats.
Epilepsy, Temporal Lobe
Choline acetyltransferase, glutamic acid decarboxylase and somatostatin in the kainic acid model for chronic temporal lobe epilepsy.
Essential Hypertension
Cholinergic receptor site binding, choline acetyltransferase, and acetylcholinesterase activity in the forebrain and brainstem of the Dahl rat model of essential hypertension.
Frontotemporal Dementia
Retinoic acid worsens ATG10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through SQSTM1/p62 accumulation.
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.
Gangliosidosis, GM1
Increased acetylcholine synthesis and release in brains of cats with GM1 gangliosidosis.
Gastroparesis
Expression of Dopamine Receptors in the Lateral Hypothalamic Nucleus and Their Potential Regulation of Gastric Motility in Rats With Lesions of Bilateral Substantia Nigra.
Glioblastoma
[Immunohistochemical analysis of tumor cells using choline acetyltransferase (author's transl)]
Glioma
AF64A: an active site directed irreversible inhibitor of choline acetyltransferase.
Discrete acetylcholine release from neuroblastoma or hybrid cells overexpressing choline acetyltransferase into the neuromuscular synaptic cleft.
Enhanced acetylcholine secretion in neuroblastoma x glioma hybrid NG108-15 cells transfected with rat choline acetyltransferase cDNA.
Induction of choline acetyltransferase in the neuroblastoma x glioma cell line NG108-15.
Transcriptional regulation of choline acetyltransferase gene by cyclic AMP.
glutamine-fructose-6-phosphate transaminase (isomerizing) deficiency
Congenital myasthenic syndromes in Turkey: Clinical clues and prognosis with long term follow-up.
Hallucinations
Cholinergic and dopaminergic activities in senile dementia of Lewy body type.
Visual hallucinations are associated with lower alpha bungarotoxin binding in dementia with Lewy bodies.
Heart Arrest
Cardiopulmonary Arrest and Resuscitation Disrupts Cholinergic Anti-Inflammatory Processes: A Role for Cholinergic {alpha}7 Nicotinic Receptors.
Heart Failure
Chemogenetic activation of intracardiac cholinergic neurons improves cardiac function in pressure overload-induced heart failure.
In vitro acetylcholine biosynthesis in normal and failing guinea pig hearts.
Neurochemical indices of autonomic innervation of heart in different experimental models of heart failure.
Hepatic Encephalopathy
Activities of neuronal and astrocytic marker enzymes in autopsied brain tissue from patients with hepatic encephalopathy.
Brain cholinergic impairment in liver failure.
Choline acetyltransferase and acetylcholinesterase activities are unchanged in brain in human and experimental portal-systemic encephalopathy.
Herpes Simplex
Alteration in tyrosine hydroxylase, glutamic acid decarboxylase and choline acetyltransferase in basal ganglia following herpes simplex virus inoculation in rat neostriatum.
Early inhibition of acetylcholinesterase and choline acetyltransferase activity in herpes simplex virus type 1 infection of PC12 cells.
Herpes Zoster
Does the substantia nigra have a cholinergic innervation?
Evidence for a cholinergic fiber tract connecting the thalamus with the head of the striatum of the rat.
Nicotinic cholinoceptor-mediated excitatory postsynaptic potentials in rat nucleus ambiguus.
Projections of brainstem core cholinergic and non-cholinergic neurons of cat to intralaminar and reticular thalamic nuclei.
HIV Infections
Brain choline acetyltransferase reduction in SIV infection. An index of early dementia?
Huntington Disease
Abnormalities of neurotransmitter enzymes in Huntington's chorea.
Alterations in brain muscarinic cholinergic receptor binding and choline acetyltransferase activity in Huntington's disease.
Brain muscarinic cholinergic receptors in Huntington's disease.
Choline acetylase and glutamic acid decarboxylase in Huntington's chorea. A preliminary study.
Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain.
Dementia in Huntington's disease is associated with neurochemical deficits in the caudate nucleus, not the cerebral cortex.
gamma-Glutamyltransferase activity is unchanged in acutely quinolinate-lesioned rat neostriatum but is elevated in Huntington's disease caudate.
Glutamic-acid decarboxylase and choline acetylase in Huntington's chorea and Parkinson's disease.
Huntington's chorea. Post-mortem measurement of glutamic acid decarboxylase, choline acetyltransferase and dopamine in basal ganglia.
Immunohistochemical localization of choline acetyltransferase in the human cerebellum.
Neurochemical alterations in Huntington's chorea: a study of post-mortem brain tissue.
Olfactory tubercle choline acetyltransferase activity in Alzheimer-type dementia, Down's syndrome and Huntington's chorea.
Phosphate-activated glutaminase in relation to Huntington's disease and agonal state.
Regional distribution of choline acetyltransferase in the human brain: changes in Huntington's chorea.
Hypersensitivity
A Tropomyosine Receptor Kinase Inhibitor Blocks Spinal Neuroplasticity Essential for the Anti-Hypersensitivity Effects of Gabapentin and Clonidine in Rats With Peripheral Nerve Injury.
Enhanced parasympathetic nerve activities in experimentally-induced nasal hypersensitivity.
Hypertension
Muscarinic cholinoceptors and choline acetyltransferase activity in the hypothalamus of spontaneously hypertensive rats.
Hyperthyroidism
Temporal, regional and cellular selectivity of neonatal alteration of the thyroid state on neurochemical maturation in the rat.
Thyroid hormone causes sexually distinct neurochemical and morphological alterations in rat septal-diagonal band neurons.
[Choline acetyltransferase activity of the myocardium in hyperthyroid and hypothyroid rats]
Hypertrophy, Right Ventricular
Effects of chronic progressive myocardial hypertrophy on indexes of cardiac autonomic innervation.
Hypoglossal Nerve Injuries
Immunochemical demonstration of reversible reduction in choline acetyltransferase concentration in rat hypoglossal nucleus after hypoglossal nerve transection.
Hypoglycemia
Cholinergic and GABAergic receptor functional deficit in the hippocampus of insulin-induced hypoglycemic and streptozotocin-induced diabetic rats.
Hypothyroidism
Development of cholinergic neurons in rat brain regions: dose-dependent effects of propylthiouracil-induced hypothyroidism.
Thyroid hormone regulates NGF content and p75LNGFR expression in the basal forebrain of adult rats.
Infarction, Middle Cerebral Artery
Neuroprotective effects of human neural stem cells over-expressing choline acetyltransferase in a middle cerebral artery occlusion model.
Infections
Alterations in neurotransmitter-related enzyme activity in scrapie-infected PC12 cells.
Brain choline acetyltransferase reduction in SIV infection. An index of early dementia?
Choline acetyltransferase-expressing T cells are required to control chronic viral infection.
Compound Heterozygous CHAT Gene Mutations of a Large Deletion and a Missense Variant in a Chinese Patient With Severe Congenital Myasthenic Syndrome With Episodic Apnea.
Development of epithelial cholinergic chemosensory cells of the urethra and trachea of mice.
Early inhibition of acetylcholinesterase and choline acetyltransferase activity in herpes simplex virus type 1 infection of PC12 cells.
Effect of Venezuelan equine encephalomyelitis virus infection on brain choline acetyltransferase and acetylcholinesterase activities.
Effects of pseudorabies virus on the neuronal properties of PC12 cells.
Selegiline completely restores choline acetyltransferase activity deficits in simian immunodeficiency infection.
The ChAT-acetylcholine pathway promotes group 2 innate lymphoid cell responses and anti-helminth immunity.
The Cholinergic System Contributes to the Immunopathological Progression of Experimental Pulmonary Tuberculosis.
Transfer of the nerve growth factor gene into cell lines and cultured neurons using a defective herpes simplex virus vector. Transfer of the NGF gene into cells by a HSV-1 vector.
Inflammatory Bowel Diseases
Treatment of inflammatory bowel disease with neural stem cells expressing choline acetyltransferase.
Influenza, Human
Production and functional expression of an epitope-tagged human choline acetyltransferase.
Ischemic Attack, Transient
Age-dependent vulnerability of brain choline acetyltransferase activity to transient cerebral ischemia in rats.
Temporal profile of neurochemical recovery following injury by transient cerebral ischemia.
Kernicterus
Kernicterus: effect on choline acetyltransferase, glutamic acid decarboxylase and tyrosine hydroxylase activities in the brain of the Gunn rat.
Kernicterus: enzymatic evidence for difference between the development of cholinergic and GABAergic innervations in the brain of the Gunn rat.
Lambert-Eaton Myasthenic Syndrome
Eaton-Lambert syndrome: acetylcholine and choline acetyltransferase in skeletal muscle.
Leukemia
Activins as candidate cholinergic differentiation factors in vivo.
Cholinergic differentiation of rat sympathetic neurons in culture: effects of factors applied to distal neurites.
Coordinate regulation of choline acetyltransferase, tyrosine hydroxylase, and neuropeptide mRNAs by ciliary neurotrophic factor and leukemia inhibitory factor in cultured sympathetic neurons.
Coordinated up-regulation of choline acetyltransferase and vesicular acetylcholine transporter gene expression by the retinoic acid receptor alpha, cAMP, and leukemia inhibitory factor/ciliary neurotrophic factor signaling pathways in a murine septal cell line.
Differential expression and regulation of the high-affinity choline transporter CHT1 and choline acetyltransferase in neurons of superior cervical ganglia.
Differential requirements for p21ras and protein kinase C in the regulation of neuronal gene expression by nerve growth factor and neurokines.
Differentiation effects of ciliary neurotrophic factor on human neuroblastoma cells.
Leukemia inhibitory factor (LIF) mediated increase of choline acetyltransferase activity in mouse spinal cord neurons in culture.
Leukemia inhibitory factor maintains choline acetyltransferase expression in vivo.
Quantification of transcriptional activities of reporter gene constructs in primary cultures of sympathetic neurons.
Lung Neoplasms
Use of 11C-Choline positron emission tomography/computed tomography to investigate the mechanism of choline metabolism in lung cancer.
Lymphocytic Choriomeningitis
Choline acetyltransferase-expressing T cells are required to control chronic viral infection.
Effects of persistent lymphocytic choriomeningitis virus infection on cholinergic neurons in the mouse.
Regional tyrosine hydroxylase and choline acetyltransferase concentrations in the brains of lymphocytic choriomeningitis-infected mice.
Lymphoma, B-Cell
Anwulignan Ameliorates the Intestinal Ischemia/Reperfusion.
Malnutrition
Alterations in cognitive function in prepubertal mice with protein malnutrition: relationship to changes in choline acetyltransferase.
Effect of ethanol on axonal transport of cholinergic enzymes in rat sciatic nerve.
Effect of undernutrition on the regional development of transmitter enzymes: glutamate decarboxylase and choline acetyltransferase.
Effects of protein deprivation and re-feeding on P2X2 receptors in enteric neurons.
Regional changes in rat brain choline acetyltransferase and acetylcholinesterase activity resulting from undernutrition imposed during different periods of development.
Melanoma
Induction of cellular contractions in the human melanoma cell line SK-mel 28 after muscarinic cholinergic stimulation.
Memory Disorders
Complementary remedy of aged-related learning and memory deficits via exogenous choline acetyltransferase.
Effect of cholinergic and anticholinergic drugs on short-term memory in Alzheimer's dementia: a neuropsychological and computerized electroencephalographic study.
Human neural stem cells over-expressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction.
Human neural stem cells overexpressing choline acetyltransferase restore cognitive function of kainic Acid-induced learning and memory deficit animals.
Nerve growth factor attenuates cholinergic deficits following traumatic brain injury in rats.
Prevention of age-related memory deficit in transgenic mice by human choline acetyltransferase.
The effects of melatonin and Ginkgo biloba extract on memory loss and choline acetyltransferase activities in the brain of rats infused intracerebroventricularly with beta-amyloid 1-40.
The role of nitric oxide in the PKA inhibitor induced spatial memory deficits in rat: Involvement of choline acetyltransferase.
Mesothelioma
Alpha7-nicotinic acetylcholine receptors affect growth regulation of human mesothelioma cells: role of mitogen-activated protein kinase pathway.
Motor Neuron Disease
Characterisation of the distribution of choline acetyltransferase messenger RNA in human spinal cord and its depletion in motor neurone disease.
T-588 protects motor neuron death following axotomy.
Mucopolysaccharidosis III
Cerebral choline acetyltransferase and acetylcholinesterase activities in a Sanfilippo syndrome, in a myoclonic epilepsy and in various zones of the human newborn brain.
Multiple System Atrophy
Cell type-specific neuronal loss in the putamen of patients with multiple system atrophy.
Studies on neurotransmitter markers and neuronal cell density in the cerebellar system in olivopontocerebellar atrophy and cortical cerebellar atrophy.
Muscle Hypotonia
Recurrent deletions and reciprocal duplications of 10q11.21q11.23 including CHAT and SLC18A3 are likely mediated by complex low-copy repeats.
Muscular Atrophy
Immunization of guinea pigs with human choline acetyltransferase induces selective lower motoneuron destruction.
Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease.
Progesterone modulates brain-derived neurotrophic factor and choline acetyltransferase in degenerating Wobbler motoneurons.
T-588, a novel neuroprotective agent, delays progression of neuromuscular dysfunction in wobbler mouse motoneuron disease.
Muscular Atrophy, Spinal
Choline acetyltransferase expression does not identify early pathogenic events in fetal SMA spinal cord.
Muscular Diseases
Choline acetyltransferase activity in human muscular diseases.
Neurochemical indices of autonomic innervation of heart in different experimental models of heart failure.
Myasthenia Gravis
Choline acetyltransferase and acetylcholinesterase. Their role in the causes of myasthenia gravis.
Choline acetyltransferase in skeletal muscle from patients with myasthenia gravis.
Myasthenic Syndromes, Congenital
A multidimensional computational exploration of congenital myasthenic syndrome causing mutations in human choline acetyltransferase.
Chaperone-Mediated Regulation of Choline Acetyltransferase Protein Stability and Activity by HSC/HSP70, HSP90, and p97/VCP.
Choline Acetyltransferase Mutations Causing Congenital Myasthenic Syndrome: Molecular Findings and Genotype-Phenotype Correlations.
Compound Heterozygous CHAT Gene Mutations of a Large Deletion and a Missense Variant in a Chinese Patient With Severe Congenital Myasthenic Syndrome With Episodic Apnea.
Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyltransferase.
Congenital Myasthenic Syndrome Due to Choline Acetyltransferase Mutations in Infants: Clinical Suspicion and Comprehensive Electrophysiological Assessment Are Important for Early Diagnosis.
Congenital myasthenic syndrome due to novel CHAT mutations in an ethnic kadazandusun family.
Congenital myasthenic syndrome with episodic apnea in patients homozygous for a CHAT missense mutation.
Congenital myasthenic syndrome with episodic apnea.
Congenital myasthenic syndromes.
Congenital Myasthenic Syndromes: a Clinical and Treatment Approach.
Severe Congenital Myasthenia Gravis of the Presynaptic Type with Choline Acetyltransferase Mutation in a Chinese Infant with Respiratory Failure.
Temporary Diazepam Responsive Apneic Attacks and Congenital Myasthenic Syndrome.
Myoclonus
Alzheimer's disease: choline acetyltransferase activity in brain tissue from clinical and pathological subgroups.
Myopathies, Structural, Congenital
New horizons for congenital myasthenic syndromes.
Myositis
Choline acetyltransferase and the nicotinic acetylcholine receptor AChR?7 in experimental myositis.
Narcolepsy
Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons.
Neoplasms
Acetylcholine Receptor Activation as a Modulator of Glioblastoma Invasion.
Acetylcholine synthesis in sympathetic human neuroblastoma.
Analogous ?-Carboline Alkaloids Harmaline and Harmine Ameliorate Scopolamine-Induced Cognition Dysfunction by Attenuating Acetylcholinesterase Activity, Oxidative Stress, and Inflammation in Mice.
Anti-inflammatory activity of Eugenia punicifolia extract on muscular lesion of mdx dystrophic mice.
Anwulignan Ameliorates the Intestinal Ischemia/Reperfusion.
Basic and clinical aspects of non-neuronal acetylcholine: overview of non-neuronal cholinergic systems and their biological significance.
Cerebrospinal fluid cholinergic biomarkers are associated with postoperative delirium in elderly patients undergoing Total hip/knee replacement: a prospective cohort study.
Cholinergic neurons of fetal rat telencephalon in aggregating cell culture respond to NGF as well as to protein kinase C-activating tumor promoters.
Cholinergic system and cell proliferation.
Immunohistochemical identification of cholinergic cells in non-cloned tumor cells.
Indistinguishable patterns of protooncogene expression in two distinct but closely related tumors: Ewing's sarcoma and neuroepithelioma.
Neuroprotective effects of dexpanthenol on streptozotocin-induced neuronal damage in rats.
Overexpression of tumour necrosis factor alpha in the brain of transgenic mice differentially alters nerve growth factor levels and choline acetyltransferase activity.
Resveratrol oligomers from Paeonia suffruticosa protect mice against cognitive dysfunction by regulating cholinergic, antioxidant and anti-inflammatory pathways.
Serotonergic/cholinergic muscle receptor cells in the crab stomatogastric nervous system. II. Rapid nicotinic and prolonged modulatory effects on neurons in the stomatogastric ganglion.
The presence of the APP(swe) mutation in mice does not increase the vulnerability of cholinergic basal forebrain neurons to neuroinflammation.
The toxicity of tumor necrosis factor-alpha upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for Alzheimer's disease.
[Immunohistochemical analysis of tumor cells using choline acetyltransferase (author's transl)]
Nervous System Diseases
A reevaluation of choline acetyltransferase activity in human cerebrospinal fluid and serum.
Age-related changes of neuronal counts in the human pedunculopontine nucleus.
Choline acetyltransferase immunohistochemistry in brains of Alzheimer's disease patients and controls.
Comparative analysis of three different protocols for cholinergic neuron differentiation in vitro using mesenchymal stem cells from human dental pulp.
Neurobehavioral Manifestations
Pharmacologic strategies for augmenting cognitive performance in schizophrenia.
Neuroblastoma
5-Hydroxytryptamine 1A and 2B serotonin receptors in neurite outgrowth: involvement of early growth response protein 1.
A silk peptide fraction restores cognitive function in AF64A-induced Alzheimer disease model rats by increasing expression of choline acetyltransferase gene.
Acetylcholine induces neurite outgrowth and modulates matrix metalloproteinase 2 and 9.
Acetylcholine synthesis and neuron differentiation.
Acetylcholine synthesis in sympathetic human neuroblastoma.
AF64A-induced cytotoxicity and changes in choline acetyltransferase activity in the LA-N-2 neuroblastoma cell line are modulated by choline and hemicholinium-3.
AF64A: an active site directed irreversible inhibitor of choline acetyltransferase.
Choline acetyltransferase level in cyclic AMP and x-ray induced morphologically differentiated neuroblastoma cells in culture.
Cytolysis of neuroblastoma cells in vitro and treatment of neuronal tumors in vivo with bromoacetylcholine.
Differential assay of choline acetyltransferase activity in human neuroblastomas and cloned adrenergic neuroblastoma of mouse.
Differential regulation of phenotypic expression in a pluripotential neuroblastoma cell line.
Discrete acetylcholine release from neuroblastoma or hybrid cells overexpressing choline acetyltransferase into the neuromuscular synaptic cleft.
Effects of cell division, cell density, and cyclic nucleotides on choline acetyltransferase activity in a cholinergic neuroblastoma cell line (S-20Y).
Effects of choline acetyltransferase inhibitors on the growth and differentiation of mouse neuroblastoma cells in culture.
Enhanced acetylcholine secretion in neuroblastoma x glioma hybrid NG108-15 cells transfected with rat choline acetyltransferase cDNA.
High activity of choline acetyltransferase induced in neuroblastoma x glia hybrid cells.
Identification of prosaposin as a neurotrophic factor.
Identification of the neurotrophic factor sequence of prosaposin.
Induction of choline acetyltransferase in the neuroblastoma x glioma cell line NG108-15.
Induction of cholinergic and adrenergic differentiation in N-18 cells by differentiation agents and DNA demethylating agents.
Mechanism of activation of choline acetyltransferase in a human neuroblastoma cell line.
Mechanisms of uptake of gallium by human neuroblastoma cells and effects of gallium and aluminum on cell growth, lysosomal protease, and choline acetyl transferase activity.
Modulation of acetylcholinesterase and voltage-gated Na(+) channels in choline acetyltransferase- transfected neuroblastoma clones.
Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma.
Morphine tolerance in a human neuroblastoma line: changes in choline acetylase and cholinesterase activities.
Overexpression of choline acetyltransferase reconstitutes discrete acetylcholine release in some but not all synapse formation-defective neuroblastoma cells.
Phenotype-dependent susceptibility of cholinergic neuroblastoma cells to neurotoxic inputs.
Phosphorylation of 69-kDa choline acetyltransferase at threonine 456 in response to amyloid-beta peptide 1-42.
Prosaposin and its receptors GRP37 and GPR37L1 show increased immunoreactivity in the facial nucleus following facial nerve transection.
Regulation of choline acetyltransferase activity by cell density in a cultured human neuroblastoma cell line.
Regulation of expression of cholinergic neuronal phenotypic markers in neuroblastoma LA-N-2.
RS-alpha-lipoic acid protects cholinergic cells against sodium nitroprusside and amyloid-beta neurotoxicity through restoration of acetyl-CoA level.
Skeletal muscle proteins stimulate cholinergic differentiation of human neuroblastoma cells.
Stimulation of choline acetyltransferase activity by retinoic acid and sodium butyrate in a cultured human neuroblastoma.
The enzymes of acetyl-CoA metabolism in differentiating cholinergic (s-20) and noncholinergic (NIE-115) neuroblastoma cells.
Transcriptional regulation of choline acetyltransferase gene by cyclic AMP.
Tyrosine hydroxylase and choline acetyltransferase activity in human neuroblastoma. Correlations with clinical features.
Neurodegenerative Diseases
Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases.
Identification and analysis of the human choline acetyltransferase gene promoter.
Loss of nicotinic acetylcholine receptor subunits alpha4 and alpha7 in the cerebral cortex of Parkinson patients.
Oestrogens and the structural and functional plasticity of neurons: implications for memory, ageing and neurodegenerative processes.
The place of choline acetyltransferase activity measurement in the "cholinergic hypothesis" of neurodegenerative diseases.
Neuroinflammatory Diseases
A novel crosslinking protocol stabilizes amyloid ? oligomers capable of inducing Alzheimer's-associated pathologies.
Acetate supplementation attenuates lipopolysaccharide-induced neuroinflammation.
Therapeutic Advantages of Dual Targeting of PPAR-? and PPAR-? in an Experimental Model of Sporadic Alzheimer's Disease.
Neuroma
Evaluation of the long-term regenerative potential in an experimental nerve amputee model.
Neuroma, Acoustic
Accumulation of nerve growth factor in cerebrospinal fluid and biological activity following neurosurgery.
Neuromuscular Diseases
Autoimmune neuromuscular disease induced by a preparation of choline acetyltransferase.
Neuronal Ceroid-Lipofuscinoses
Evidence for Cholinergic Dysfunction in Autosomal Dominant Kufs Disease.
Obesity
Properties of myenteric neurons and mucosal functions in the distal colon of diet-induced obese mice.
Olivopontocerebellar Atrophies
Brain choline acetyltransferase reduction in dominantly inherited olivopontocerebellar atrophy.
Reduced cerebral cortical but elevated striatal concentration of somatostatin-like immunoreactivity in dominantly inherited olivopontocerebellar atrophy.
Studies on neurotransmitter markers and neuronal cell density in the cerebellar system in olivopontocerebellar atrophy and cortical cerebellar atrophy.
Ornithine Carbamoyltransferase Deficiency Disease
Central muscarinic cholinergic M1 and M2 receptor changes in congenital ornithine transcarbamylase deficiency.
Evidence for a central cholinergic deficit in congenital ornithine transcarbamylase deficiency.
Evidence for cholinergic neuronal loss in brain in congenital ornithine transcarbamylase deficiency.
Osteoarthritis
Unexpected finding of a marked non-neuronal cholinergic system in human knee joint synovial tissue.
Paralysis
Brain somatostatin concentrations do not decrease in progressive supranuclear palsy.
D1 and D2-type dopamine receptors in patients with Parkinson's disease and progressive supranuclear palsy.
Differential vulnerability of cholinergic projections to the mediodorsal nucleus of the thalamus in senile dementia of Alzheimer type and progressive supranuclear palsy.
Dopaminergic and cholinergic lesions in progressive supranuclear palsy.
Formation of primary and secondary myotubes in rat lumbrical muscles.
Mesencephalic cholinergic nuclei in progressive supranuclear palsy.
Progressive supranuclear palsy: loss of choline-acetyltransferase-like immunoreactive neurons in the pontine reticular formation.
Reductions in acetylcholine and nicotine binding in several degenerative diseases.
Parkinson Disease
Altered muscarinic and nicotinic receptor densities in cortical and subcortical brain regions in Parkinson's disease.
Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum.
Choline acetyltransferase activity and [3H]vesamicol binding in the temporal cortex of patients with Alzheimer's disease, Parkinson's disease, and rats with basal forebrain lesions.
Choline acetytransferase activity and striatal dopamine receptors in Parkinson's disease in relation to cognitive impairment.
Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease.
Cholinergic receptors in cognitive disorders.
D1 and D2-type dopamine receptors in patients with Parkinson's disease and progressive supranuclear palsy.
GABAA receptor but not muscarinic receptor density was decreased in the brain of patients with Parkinson's disease.
Glutamic-acid decarboxylase and choline acetylase in Huntington's chorea and Parkinson's disease.
Hereditary form of parkinsonism--dementia.
Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson's disease.
Hippocampal nerve growth factor receptor immunoreactivity in patients with Alzheimer's and Parkinson's disease.
Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: selective effects on specific interleukins and interleukin receptors.
Lecithin in Parkinson's disease.
Loss of nicotinic acetylcholine receptor subunits alpha4 and alpha7 in the cerebral cortex of Parkinson patients.
Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease.
Pathological changes in the nucleus of Meynert in Alzheimer's and Parkinson's diseases.
Reduced expression of choline acetyltransferase in vagal motoneurons and gastric motor dysfunction in a 6-OHDA rat model of Parkinson's disease.
Reductions in acetylcholine and nicotine binding in several degenerative diseases.
Parkinsonian Disorders
Cell type-specific neuronal loss in the putamen of patients with multiple system atrophy.
Changes in the neuronal activity in the pedunculopontine nucleus in chronic MPTP-treated primates: an in situ hybridization study of cytochrome oxidase subunit I, choline acetyl transferase and substance P mRNA expression.
Lewy body disease: Thalamic cholinergic activity related to dementia and parkinsonism.
Persistent Infection
Effects of persistent lymphocytic choriomeningitis virus infection on cholinergic neurons in the mouse.
Pheochromocytoma
Bedside to Bench: Role of Muscarinic Receptor Activation in Ultrarapid Growth of Colorectal Cancer in a Patient With Pheochromocytoma.
Cholinergic differentiation of clonal rat pheochromocytoma cells (PC12) induced by retinoic acid: increase of choline acetyltransferase activity and decrease of tyrosine hydroxylase activity.
Expression of the choline acetyltransferase gene depends on protein kinase A activity.
Induction of fibre outgrowth and choline acetyltransferase in PC12 pheochromocytoma cells by conditioned media from glial cells and organ extracts.
Modulation of cholinergic locus expression by glucocorticoids and retinoic acid is cell-type specific.
Nerve growth factor-mediated stimulation of tyrosine hydroxylase activity in a clonal rat pheochromocytoma cell line.
Possible involvements of intracellular Ca2+ and Ca2+ -dependent protein phosphorylation in cholinergic differentiation of clonal rat pheochromocytoma cells (PC12) induced by glioma-conditioned medium and retinoic acid.
Regulation of cholinergic gene expression by nerve growth factor depends on the phosphatidylinositol-3'-kinase pathway.
Regulation of tyrosine hydroxylase and choline acetyltransferase activities by cell density in the PC12 rat pheochromocytoma clonal cell line.
Two distinct monoclonal antibodies raised against mouse beta nerve growth factor. Generation of bi-specific anti-nerve growth factor anti-horseradish peroxidase antibodies for use in a homogeneous enzyme immunoassay.
Pick Disease of the Brain
Altered serotonergic and cholinergic synaptic markers in Pick's disease.
Functional imaging, the frontal lobes, and dementia.
Lack of cholinergic deficit in the neocortex in Pick's disease.
Preliminary neurochemical findings in non-Alzheimer dementia due to lobar atrophy.
Studies on neurotransmitter markers of the basal ganglia in Pick's disease, with special reference to dopamine reduction.
Pituitary Neoplasms
[The effect of acetylcholine on the proliferation and apoptosis of three kinds of cultured human pituitary adenoma cells]
Plasmacytoma
Immunohistochemical localization of choline acetyltransferase using a monoclonal antibody: a radioautographic method.
Primary Dysautonomias
Trophic functions of the neuron. V. Familial dysautonomia. Choline acetyltransferase in familial dysautonomia.
Prolactinoma
[The effect of acetylcholine on the proliferation and apoptosis of three kinds of cultured human pituitary adenoma cells]
Prostatic Hyperplasia
Activation of P2Y6 Receptors Facilitates Nonneuronal Adenosine Triphosphate and Acetylcholine Release from Urothelium with the Lamina Propria of Men with Bladder Outlet Obstruction.
Pseudorabies
CNS cholinergic innervation to the hippocampus in the rat using pseudorabies virus as a neurotracer.
Galanin and neurokinin-1 receptor immunoreactivity spinal neurons controlling the prostate and the bulbospongiosus muscle identified by transsynaptic labeling in the rat.
Pulmonary Disease, Chronic Obstructive
Expression of muscarinic receptors by human macrophages.
In vitro anticholinergic drugs affect CD8+ peripheral blood T-cells apoptosis in COPD.
Non-neuronal cholinergic system contributes to corticosteroid resistance in chronic obstructive pulmonary disease patients.
Smoke, choline acetyltransferase, muscarinic receptors, and fibroblast proliferation in chronic obstructive pulmonary disease.
Rabies
Cholinergic system in experimental rabies in mice.
Neuronal premotor networks involved in eyelid responses: retrograde transneuronal tracing with rabies virus from the orbicularis oculi muscle in the rat.
Spinal and brain circuits to motoneurons of the bulbospongiosus muscle: retrograde transneuronal tracing with rabies virus.
Rectal Neoplasms
Smooth muscle cholinergic denervation hypersensitivity in diverticular disease.
Reperfusion Injury
Nuclear factor erythroid 2-related factor 2 and choline acetyltransferase co-expression in rat spinal cord neurons after ischemia-reperfusion injury.
Respiratory Insufficiency
Compound Heterozygous CHAT Gene Mutations of a Large Deletion and a Missense Variant in a Chinese Patient With Severe Congenital Myasthenic Syndrome With Episodic Apnea.
Severe Congenital Myasthenia Gravis of the Presynaptic Type with Choline Acetyltransferase Mutation in a Chinese Infant with Respiratory Failure.
Rett Syndrome
Choline acetyltransferase activity and vesamicol binding in Rett syndrome and in rats with nucleus basalis lesions.
Neurobiology of Rett syndrome.
Rhinitis, Allergic
Denervation of nasal mucosa induced by posterior nasal neurectomy suppresses nasal secretion, not hypersensitivity, in an allergic rhinitis rat model.
Sarcoma
Altered cellular functions in a PC-12 cell clone chronically infected with retrovirus.
[Immunohistochemical analysis of tumor cells using choline acetyltransferase (author's transl)]
Sciatic Neuropathy
Choline acetyltransferase and acetylcholinesterase in canine spinal ganglia: increase of choline acetyltransferase activity following sciatic nerve lesion.
Scrapie
Alterations in neurotransmitter-related enzyme activity in scrapie-infected PC12 cells.
Changes in tyrosine hydroxylase, glutamic acid decarboxylase and choline acetyltransferase after local microinoculation of scrapie agent into the nigrostriatal system of the golden hamster.
Monoamine abnormalities in the brain of scrapie-infected rats.
Reduced choline-acetyltransferase activity in scrapie mouse brain.
Seizures
Behavioral evidence for increased acetylcholine receptor sensitivity after nucleus basalis magnocellularis lesions in the rat.
Choline acetyltransferase and acetylcholinesterase activities are reduced in rat striatum and frontal cortex after pilocarpine-induced seizures.
Effect of mannitol treatment on brain neurotransmitter markers in kainic acid-induced epilepsy.
Enhanced choline acetyltransferase activity does not explain the action of inhaled convulsants.
Experimental febrile convulsions in the developing rat: effects on the cholinergic system.
Lipoic Acid Increases Hippocampal Choline Acetyltransferase and Acetylcholinesterase Activities and Improvement Memory in Epileptic Rats.
Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via ?7 receptor in hippocampus.
Mechanisms of decreased cholinergic arousal in focal seizures: In vivo whole-cell recordings from the pedunculopontine tegmental nucleus.
Pilocarpine-Induced Seizures Produce Alterations on Choline Acetyltransferase and Acetylcholinesterase Activities and Deficit Memory in Rats.
Protective effects of prenatal choline supplementation on seizure-induced memory impairment.
Trimethyltin syndrome as a hippocampal degeneration model: temporal changes and neurochemical features of seizure susceptibility and learning impairment.
Sepsis
Cholinergic leukocytes in sepsis and at the neuroimmune junction in the spleen.
Huperzine A protects sepsis associated encephalopathy by promoting the deficient cholinergic nervous function.
[Cholinergic anti-inflammatory pathway involves in the neuroprotective effect of huperzine A on sepsis-associated encephalopathy].
Sepsis-Associated Encephalopathy
[Cholinergic anti-inflammatory pathway involves in the neuroprotective effect of huperzine A on sepsis-associated encephalopathy].
Sleep Apnea Syndromes
Recurrent deletions and reciprocal duplications of 10q11.21q11.23 including CHAT and SLC18A3 are likely mediated by complex low-copy repeats.
Sleep Deprivation
Dynamic changes in GABAA receptors on basal forebrain cholinergic neurons following sleep deprivation and recovery.
Small Cell Lung Carcinoma
Synthesis of acetylcholine by lung cancer.
Spinal Cord Injuries
Changes in choline acetyltransferase activity and distribution following incomplete cervical spinal cord injury in the rat.
Changes in choline acetyltransferase distribution in the cervical spinal cord after reversible cervical spinal cord injury.
Changes in synaptic inputs to sympathetic preganglionic neurons after spinal cord injury.
Cholinergic receptor alterations in the brain stem of spinal cord injured rats.
Effect of intravenous transplantation of bone marrow mesenchymal stem cells on neurotransmitters and synapsins in rats with spinal cord injury.
Increase in nerve growth factor-like immunoreactivity and decrease in choline acetyltransferase following contusive spinal cord injury.
Progesterone neuroprotection in traumatic CNS injury and motoneuron degeneration.
Starvation
Effects of choline and quiescence on Drosophila choline acetyltransferase expression and acetylcholine production by transduced rat fibroblasts.
Enzyme markers of maternal malnutrition in fetal rat brain.
Stroke
Choline Acetyltransferase Activity in Vascular Dementia and Stroke.
Neurovascular Specifications in the Alzheimer-Like Brain of Mice Affected by Focal Cerebral Ischemia: Implications for Future Therapies.
Supranuclear Palsy, Progressive
Brain somatostatin concentrations do not decrease in progressive supranuclear palsy.
D1 and D2-type dopamine receptors in patients with Parkinson's disease and progressive supranuclear palsy.
Differential vulnerability of cholinergic projections to the mediodorsal nucleus of the thalamus in senile dementia of Alzheimer type and progressive supranuclear palsy.
Dopaminergic and cholinergic lesions in progressive supranuclear palsy.
Mesencephalic cholinergic nuclei in progressive supranuclear palsy.
Progressive supranuclear palsy: loss of choline-acetyltransferase-like immunoreactive neurons in the pontine reticular formation.
Reductions in acetylcholine and nicotine binding in several degenerative diseases.
Tauopathies
Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum.
MRNA Levels of ACh-Related Enzymes in the Hippocampus of THY-Tau22 Mouse: A Model of Human Tauopathy with No Signs of Motor Disturbance.
Tendinopathy
Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance regarding Achilles tendon tendinosis (tendinopathy).
Tetanus
Altered electrical properties in Drosophila neurons developing without synaptic transmission.
Characterization of the cholinergic neuronal differentiation of the human neuroblastoma cell line LA-N-5 after treatment with retinoic acid.
Differential neurochemical effects of chronic exposure of cerebral cortical cell culture to valproic acid, diazepam, or ethosuximide.
Differential toxicity of chronic exposure to phenytoin, phenobarbital, or carbamazepine in cerebral cortical cell cultures.
Effects of botulinum and tetanus toxins on choline acetyltransferase activity in skeletal muscle in the mouse.
Expression of neuronal markers in chick and quail embryo neuroretina cultures infected with Rous sarcoma virus.
In search of the central respiratory neurons: I. Dissociated cell cultures of respiratory areas from the upper medulla.
Neuronal survival during electrical blockade is increased by 8-bromo cyclic adenosine 3',5' monophosphate.
Reduced benzodiazepine receptor binding in cerebral cortical cultures chronically exposed to diazepam.
Tetanus toxin effect on the metabolism and release of acetylcholine in rat central nervous system.
Thiamine Deficiency
Immunohistochemical estimation of brain choline acetyltransferase and somatostatin related to the impairment of avoidance learning induced by thiamine deficiency.
Tourette Syndrome
Choline Acetyltransferase may contribute to the risk of Tourette syndrome: Combination of Family-based analysis and Case-control study.
Uterine Cervical Neoplasms
Muscarinic cholinergic signaling in cervical cancer cells affects cell motility via ERK1/2 signaling.
Virus Diseases
Altered cellular functions in a PC-12 cell clone chronically infected with retrovirus.
Effect of neurotropic virus infection on neuronal and inducible nitric oxide synthase activity in rat brain.
Effect of Venezuelan equine encephalomyelitis virus infection on brain choline acetyltransferase and acetylcholinesterase activities.