Disease on EC 2.3.1.57 - diamine N-acetyltransferase
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Acute Kidney Injury
The Role of Spermidine/Spermine-N1-Acetyltransferase in Endotoxin-Induced Acute Kidney Injury.
Adenocarcinoma
Premalignant alterations in rat colonic N1-acetylspermidine levels induced by 1,2-dimethylhydrazine: effects of a high corn oil dietary regimen.
Alopecia
Disturbed keratinocyte differentiation in transgenic mice and organotypic keratinocyte cultures as a result of spermidine/spermine N-acetyltransferase overexpression.
Anhedonia
Major depression model induced by repeated and intermittent lipopolysaccharide administration: Long-lasting behavioral, neuroimmune and neuroprogressive alterations.
Arthritis, Rheumatoid
Inhibition of spermidine/spermine N1-acetyltransferase (SSAT1) activity - a new therapeutical concept in rheumatoid arthritis.
Arthritis, Rheumatoid
Interleukin-1beta induces elevation of spermidine/spermine N1-acetyltransferase activity and an increase in the amount of putrescine in synovial adherent cells from patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Rheumatoid arthritis: SSAT1 inhibition slows synovial fibroblast invasion.
Brain Neoplasms
Spermidine/spermine N1-acetyltransferase 1 is a gene-specific transcriptional regulator that drives brain tumor aggressiveness.
Brain Neoplasms
The polyamine catabolic enzyme SAT1 modulates tumorigenesis and radiation response in GBM.
Breast Neoplasms
A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer.
Breast Neoplasms
Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine.
Breast Neoplasms
Induction of spermidine/spermine N1-acetyltransferase in human breast carcinoma cells. A possible role for calcium.
Breast Neoplasms
Induction of spermidine/spermine N1-acetyltransferase in human cancer cells in response to increased production of reactive oxygen species.
Carcinogenesis
Duplication and diversification of the spermidine/spermine N1-acetyltransferase 1 genes in zebrafish.
Carcinogenesis
Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase.
Carcinogenesis
Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase.
Carcinogenesis
Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis.
Carcinogenesis
Stimulating effect of excess iron feeding on spontaneous lung tumor promotion in mice.
Carcinogenesis
Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis.
Carcinogenesis
Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis.
Carcinoma
Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells.
Carcinoma
Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells.
Carcinoma
Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells.
Carcinoma
Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase.
Carcinoma
High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma.
Carcinoma
Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients.
Carcinoma
Spermidine/spermine N1-acetyltranferase modulation by novel folate cycle inhibitors in cisplatin-sensitive and -resistant human ovarian cancer cell lines.
Carcinoma
Spermidine/spermine N1-acetyltransferase (SSAT) activity in human small-cell lung carcinoma cells following transfection with a genomic SSAT construct.
Carcinoma
Spermidine/spermine N1-acetyltransferase transient overexpression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin.
Carcinoma
Spermidine/spermine N1-acetyltransferase, a new biochemical marker for epithelial proliferation in rat bladder.
Carcinoma
The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine.
Carcinoma, Ehrlich Tumor
Effect of hyperthermia on spermidine/spermine N1-acetyltransferase activity in Ehrlich ascites cells.
Carcinoma, Ehrlich Tumor
Enhancement of spermidine/spermine N1-acetyltransferase activity by treatment with lithium chloride in Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Posttranslational regulation of spermidine/spermine N1-acetyltransferase with stress.
Carcinoma, Hepatocellular
Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells.
Carcinoma, Hepatocellular
Expression of spermidine/spermine N1-acetyltransferase in growing Yoshida AH-130 hepatoma cells.
Carcinoma, Hepatocellular
Increased synthesis of N1-acetylspermidine in hepatic preneoplastic nodules and hepatomas.
Carcinoma, Hepatocellular
[Acetylsalicylic acid strengthens the effects of ANISpm against hepatocellular carcinoma and its molecular mechanism].
Carcinoma, Non-Small-Cell Lung
Tumor necrosis factor alpha induces spermidine/spermine N1-acetyltransferase through nuclear factor kappaB in non-small cell lung cancer cells.
Carcinoma, Transitional Cell
Spermidine/spermine N1-acetyltransferase, a new biochemical marker for epithelial proliferation in rat bladder.
Cataract
Induction of spermidine/spermine N1-acetyltransferase in needle-punctured rat lens as a model of traumatic cataract.
Colitis
DNA microarray technology reveals similar gene expression patterns in rats with vitamin a deficiency and chemically induced colitis.
Colonic Neoplasms
Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells.
Colonic Neoplasms
Nonsteroidal anti-inflammatory drugs stimulate spermidine/spermine acetyltransferase and deplete polyamine content in colon cancer cells.
Colorectal Neoplasms
Adenovirus-mediated expression of spermidine/spermine N1-acetyltransferase gene induces S-phase arrest in human colorectal cancer cells.
Colorectal Neoplasms
Effects of N1, N13-diethylnorspermine (DENSPM) and X-radiation treatment on human colorectal tumor clones with varying X-radiation and drug responses.
Colorectal Neoplasms
Peroxisome proliferator-activated receptor gamma and spermidine/spermine N1-acetyltransferase gene expressions are significantly correlated in human colorectal cancer.
Colorectal Neoplasms
Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/?-catenin signaling pathways in hepatocellular and colorectal carcinoma cells.
Colorectal Neoplasms
The role of spermidine/spermine N1-acetyltransferase in determining response to chemotherapeutic agents in colorectal cancer cells.
Encephalitis, Tick-Borne
Induction of alternatively spliced spermidine/spermine N1-acetyltransferase mRNA in the human kidney cells infected by venezuelan equine encephalitis and tick-borne encephalitis viruses.
Encephalomyelitis, Venezuelan Equine
Induction of alternatively spliced spermidine/spermine N1-acetyltransferase mRNA in the human kidney cells infected by venezuelan equine encephalitis and tick-borne encephalitis viruses.
Glioma
Spermidine acetylation in N1 and N8 position in rat brain and in N-ethyl-N-nitrosourea-induced gliomas.
Infections
Cryptosporidium parvum Induces an Endoplasmic Stress Response in Intestinal Adenocarcinoma HCT-8 Cell Line.
Infections
Polyamine regulation of porcine reproductive and respiratory syndrome virus infection depends on spermidine-spermine acetyltransferase 1.
Insulin Resistance
Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging.
Intestinal Volvulus
Putrescine N-acetyltransferase in Onchocerca volvulus and Ascaris suum, an enzyme which is involved in polyamine degradation and release of N-acetylputrescine.
Leukemia
Ornithine decarboxylase and spermidine/spermine N1-acetyltransferase are induced in K562 cells by S-adenosylmethionine decarboxylase inhibitor methylglyoxal bis(guanylhydrazone) but not by analogous methylglyoxal bis(butylamidinohydrazone).
Lichen Planus, Oral
Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients.
Liver Diseases
Elevation of N1-acetylspermidine and putrescine in hepatic tissues of patients with fulminant hepatitis and liver cirrhosis.
Lung Neoplasms
Differential induction of spermidine/spermine N1-acetyltransferase in human lung cancer cells by the bis(ethyl)polyamine analogues.
Lung Neoplasms
Tumor necrosis factor alpha induces spermidine/spermine N1-acetyltransferase through nuclear factor kappaB in non-small cell lung cancer cells.
Lung Neoplasms
Two active copies of the X-linked gene spermidine/spermine N1-acetyltransferase (SSAT) in a female lung cancer cell line are associated with an increase in sensitivity to an antitumor polyamine analogue.
Lung Neoplasms
Use of amantadine as substrate for SSAT-1 activity as a reliable clinical diagnostic assay for breast and lung cancer.
Melanoma
Antitumor activity of N,N'-bis(ethyl)spermine homologues against human MALME-3 melanoma xenografts.
Melanoma
Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells.
Melanoma
Correlations between polyamine analogue-induced increases in spermidine/spermine N1-acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines.
Melanoma
Differential effects of the spermine analog, N1, N12-bis(ethyl)-spermine, on polyamine metabolism and cell growth in human melanoma cell lines and melanocytes.
Melanoma
Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells.
Melanoma
Knockdown of SSATX, an alternative splicing variant of the SAT1 gene, promotes melanoma progression.
Melanoma
Polyamine and polyamine analog regulation of spermidine/spermine N1-acetyltransferase in MALME-3M human melanoma cells.
Neoplasm Metastasis
Spermidine/spermine N1-acetyltransferase regulates cell growth and metastasis via AKT/?-catenin signaling pathways in hepatocellular and colorectal carcinoma cells.
Neoplasms
1,2-Dimethylhydrazine-induced alterations in N1-acetylspermidine levels and spermidine N1-acetyltransferase activity in rat colonic mucosa.
Neoplasms
1,2-Dimethylhydrazine-induced alterations in N1-acetylspermidine levels in rat distal colonic mucosa: effects of 2-difluoromethylornithine.
Neoplasms
Antitumor efficacy of N1,N11-diethylnorspermine on a human bladder tumor xenograft in nude athymic mice.
Neoplasms
Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells.
Neoplasms
Effect of hyperthermia on spermidine/spermine N1-acetyltransferase activity in Ehrlich ascites cells.
Neoplasms
Elevation in putrescine level and spermidine/spermine N1-acetyltransferase activity coincide with tumor development in 1, 2-dimethylhydrazine-induced rat colon.
Neoplasms
Enhancement of spermidine/spermine N1-acetyltransferase activity by treatment with lithium chloride in Ehrlich ascites tumor cells.
Neoplasms
Expression of spermidine/spermine N1-acetyltransferase in growing Yoshida AH-130 hepatoma cells.
Neoplasms
Growth arrest- and polyamine-dependent expression of spermidine/spermine N1-acetyltransferase in human tumor cells.
Neoplasms
Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues.
Neoplasms
Induction of spermidine/spermine N1-acetyltransferase in human cancer cells in response to increased production of reactive oxygen species.
Neoplasms
Knockdown of SSATX, an alternative splicing variant of the SAT1 gene, promotes melanoma progression.
Neoplasms
Liquid Biopsy in Lung Cancer Screening: The Contribution of Metabolomics. Results of A Pilot Study.
Neoplasms
Overexpression of SSAT by DENSPM treatment induces cell detachment and apoptosis in glioblastoma.
Neoplasms
Posttranslational regulation of spermidine/spermine N1-acetyltransferase with stress.
Neoplasms
Predictive value and clinical significance of increased SSAT-1 activity in healthy adults.
Neoplasms
Prognostic influence on survival of increased ornithine decarboxylase activity in human breast cancer.
Neoplasms
Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells.
Neoplasms
Regulation of spermidine/spermine N1-acetyltransferase expression by cytokines and polyamines in human hepatocarcinoma cells (HepG2).
Neoplasms
Spermidine/spermine N1-acetyltransferase-1 as a diagnostic biomarker in human cancer.
Neoplasms
Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis.
Neoplasms
Stimulating effect of excess iron feeding on spontaneous lung tumor promotion in mice.
Neoplasms
Structure of the human spermidine/spermine N1-acetyltransferase gene (exon/intron gene organization and localization to Xp22.1).
Neoplasms
Tumor necrosis factor alpha induces spermidine/spermine N1-acetyltransferase through nuclear factor kappaB in non-small cell lung cancer cells.
Neoplasms
Tumor progression is accompanied by significant changes in the levels of expression of polyamine metabolism regulatory genes and clusterin (sulfated glycoprotein 2) in human prostate cancer specimens.
Neoplasms
Two active copies of the X-linked gene spermidine/spermine N1-acetyltransferase (SSAT) in a female lung cancer cell line are associated with an increase in sensitivity to an antitumor polyamine analogue.
Neoplasms
Use of amantadine as substrate for SSAT-1 activity as a reliable clinical diagnostic assay for breast and lung cancer.
Neoplasms
Use of amantadine in the evaluation of response to chemotherapy in lung cancer: a pilot study.
Ovarian Neoplasms
Differential induction of spermidine/spermine N1-acetyltransferase activity in cisplatin-sensitive and -resistant ovarian cancer cells in response to N1,N12-bis(ethyl)spermine involves transcriptional and post-transcriptional regulation.
Ovarian Neoplasms
Spermidine/spermine N1-acetyltransferase transient overexpression restores sensitivity of resistant human ovarian cancer cells to N1,N12-bis(ethyl)spermine and to cisplatin.
Pancreatitis
Acute pancreatitis induced by activation of the polyamine catabolism in gene-modified mice and rats overexpressing spermidine/spermine N1-acetyltransferase.
Pancreatitis
Gossypol activates pancreatic polyamine catabolism in normal rats and induces acute pancreatitis in transgenic rats over-expressing spermidine/spermine N1-acetyltransferase.
Papilloma
Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase.
Papilloma
Spermidine/spermine N1-acetyltransferase, a new biochemical marker for epithelial proliferation in rat bladder.
Porcine Reproductive and Respiratory Syndrome
Polyamine regulation of porcine reproductive and respiratory syndrome virus infection depends on spermidine-spermine acetyltransferase 1.
Pterygium
Expression analysis of human pterygium shows a predominance of conjunctival and limbal markers and genes associated with cell migration.
Reperfusion Injury
Spermidine/spermine-N1-acetyltransferase ablation protects against liver and kidney ischemia-reperfusion injury in mice.
Seizures
Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice.
Sepsis
Clonal diversity of methicillin-resistant Staphylococcus aureus (MRSA) from bloodstream infections in northern Japan: Identification of spermidine N-acetyltransferase gene (speG) in staphylococcal cassette chromosomes (SCCs) associated with type II and IV SCCmec.
Squamous Cell Carcinoma of Head and Neck
Levels of potential oral cancer salivary mRNA biomarkers in oral cancer patients in remission and oral lichen planus patients.
Virus Diseases
Polyamine regulation of porcine reproductive and respiratory syndrome virus infection depends on spermidine-spermine acetyltransferase 1.
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