Information on EC 2.3.1.53 - phenylalanine N-acetyltransferase

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The expected taxonomic range for this enzyme is: Escherichia coli

EC NUMBER
COMMENTARY hide
2.3.1.53
-
RECOMMENDED NAME
GeneOntology No.
phenylalanine N-acetyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + L-phenylalanine = CoA + N-acetyl-L-phenylalanine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Phenylalanine metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:L-phenylalanine N-acetyltransferase
Also acts, more slowly, on L-histidine and L-alanine.
CAS REGISTRY NUMBER
COMMENTARY hide
9075-16-5
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
K12
-
-
Manually annotated by BRENDA team
K12
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + L-alanine
CoA + N-acetyl-L-alanine
show the reaction diagram
acetyl-CoA + L-histidine
CoA + N-acetyl-L-histidine
show the reaction diagram
acetyl-CoA + L-phenylalanine
CoA + N-acetyl-L-phenylalanine
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + L-phenylalanine
CoA + N-acetyl-L-phenylalanine
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
iodoacetamide
-
0.5 mM, total inhibition
N-ethylmaleimide
-
0.1 mM, total inhibition
p-hydroxymercuribenzoate
-
0.1 mM, total inhibition
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.13
acetyl-CoA
-
-
3.3
L-phenylalanine
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
75
-
L-phenylalanine
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
18000
-
low speed sedimentation without reaching equilibrium
24000
-
gel filtration
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE