Reference on EC 2.3.1.43 - phosphatidylcholine-sterol O-acyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bartlett, K.; Keat, M.J.; Mercer, E.I.
Biosynthesis of sterols in Phycomyces blakesleeanus
Phytochemistry
13
1107-1113
1974
Phycomyces blakesleeanus
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Buckley, J.T.; Halasa, L.N.; MacIntyre, S.
Purification and partial characterization of a bacterial phospholipid: cholesterol acyltransferase
J. Biol. Chem.
257
3320-3325
1982
Aeromonas salmonicida
Doi, Y.; Nishida, T.
Lecithin-cholesterol acyltransferase from human plasma
Methods Enzymol.
71
753-767
1981
Homo sapiens
Verdery III, R.B.; Gatt, S.
Assay for lecithin: cholesterol acyltransferase
Methods Enzymol.
72
375-384
1981
Homo sapiens
Ogawa, Y.; Fielding, C.J.
Assay of cholesteryl ester transfer activity and purification of a cholesteryl ester transfer protein
Methods Enzymol.
111
274-285
1985
Homo sapiens
Albers, J.J.; Chen, C.H.; Lacko, A.G.
Isolation, characterization, and assay of lecithin-cholesterol acyltransferase
Methods Enzymol.
129
763-783
1986
Homo sapiens
Fielding, C.J.
Mechanisms of action of lecithin-cholesterol acyltransferase
Methods Enzymol.
129
783-790
1986
Homo sapiens
Parks, J.S.; Thuren, T.Y.; Schmitt, J.D.
Inhibition of lecithin:cholesterol acyltransferase activity by synthetic phosphatidylcholine species containing eicosapentaenoic acid or docosahexaenoic acid in the sn-2 position
J. Lipid Res.
33
879-887
1992
Homo sapiens
Yamamoto, M.; Yamamoto, I.; Tanaka, Y.; Michihiro, S.
Purification of horse (Equus caballus) serum lecithin:cholesterol acyltransferase
Comp. Biochem. Physiol. B
88
363-368
1987
Equus caballus
Chong, K.S.; Mehrnoosh, J.; Hara, S.; Lacko, A.G.
Characterization of lecithin-cholesterol acyltransferase from human plasma. 3. Chemical properties of the enzyme
Can. J. Biochem. Cell Biol.
61
875-881
1983
Homo sapiens
Lacko, A.G.; Varma, K.G.; Rutenberg, H.L.; Soloff, L.A.
Studies on enzymatic and molecular properties of lecithin:cholesterol acyltransferase
Scand. J. Clin. Lab. Invest.
33
29-34
1974
Homo sapiens
-
Jauhiainen, M.; Yuan, W.; Gelb, M.H.; Dolphin, P.J.
Human plasma lecithin-cholesterol acyltransferase. Inhibition of the phospholipase A2-like activity by sn-2-difluoroketone phosphatidylcholine analogues
J. Biol. Chem.
264
1963-1967
1989
Homo sapiens
Collet, X.; Fielding, C.J.
Effects of inhibitors of N-linked oligosaccharide processing on the secretion, stability, and activity of lecithin:cholesterol acyltransferase
Biochemistry
30
3228-3234
1991
Homo sapiens
Knipping, G.
Isolation and properties of porcine lecithin:cholesterol acyltransferase
Eur. J. Biochem.
154
289-294
1986
Sus scrofa
Aron, L.; Jones, S.; Fielding, C.J.
Human plasma lecithin-cholesterol acyltransferase. Characterization of cofactor-dependent phospholipase activity
J. Biol. Chem.
253
7220-7226
1978
Homo sapiens
Park, Y.B.; Lacko, A.G.
Isolation and characterization of lecithin-cholesterol acyltransferase from hog plasma
Biochim. Biophys. Acta
877
179-190
1986
Sus scrofa
Zhou, G.; Jauhiainen, M.; Stevenson, K.; Dolphin, P.J.
Human plasma lecithin:cholesterol acyltransferase. Preparation and use of immobilized p-aminophenylarsenoxide as a catalytic site-directed covalent ligand in enzyme purification
J. Chromatogr.
568
69-83
1991
Homo sapiens
Subbaiah, P.V.
Lysolecithin acyltransferase of human plasma: assay and characterization of enzyme activity
Methods Enzymol.
129
790-797
1986
Homo sapiens
Pownall, H.J.; Pao, Q.; Brockman, H.L.; Massey, J.B.
Inhibition of lecithin-cholesterol acyltransferase by diphytanoyl phosphatidylcholine
J. Biol. Chem.
262
9033-9036
1987
Homo sapiens
Chen, C.H.; Albers, J.J.
A rapid large-scale procedure for purification of lecithin-cholesterol acyltransferase from human and animal plasma
Biochim. Biophys. Acta
834
188-195
1985
Canis lupus familiaris, Capra hircus, Oryctolagus cuniculus, Homo sapiens, Sus scrofa
Mahadevan, V.; Soloff, L.A.
A method for isolating human plasma lecithin:cholesterol acyltransferase without using anti-apolipoprotein D, and its characterization
Biochim. Biophys. Acta
752
89-97
1983
Homo sapiens
Varma, K.G.; Soloff, L.A.
A method for the purification of milligram quantities of stable human phosphatidylcholine-cholesterol acyltransferase
Biochem. J.
155
583-588
1976
Homo sapiens
Kitabatake, K.; Piran, U.; Kamio, Y.; Doi, Y.; Nishida, T.
Purification of human plasma lecithin:cholesterol acyltransferase and its specificity towards the acyl acceptor
Biochim. Biophys. Acta
573
145-154
1979
Homo sapiens
Doi, Y.; Nishida, T.
Microheterogeneity and physical properties of human lecithin-cholesterol acyltransferase
J. Biol. Chem.
258
5840-5846
1983
Homo sapiens
Chaves, M.E.C.; Harry, D.S.; Owen, J.; McIntyre, N.
Purification of lecithin-cholesterol acyltransferase from human plasma
Biochem. Soc. Trans.
13
145-146
1985
Homo sapiens
-
Chong, K.S.; Hara, S.; Thompson, R.E.; Lacko, A.G.
Characterization of lecithin:cholesterol acyltransferase from human plasma: II. Physical properties of the enzyme
Arch. Biochem. Biophys.
222
553-560
1983
Homo sapiens
Chong, K.S.; Davidson, L.; Huttash, R.G.; Lacko, A.G.
Characterization of lecithin: cholesterol acyltransferase from human plasma: purification of the enzyme
Arch. Biochem. Biophys.
211
119-124
1981
Homo sapiens
Suzue, G.; Vezina, C.; Marcel, Y.L.
Purification of human plasma lecithin:cholesterol acyltransferase and its activation by metal ions
Can. J. Biochem.
58
539-541
1980
Homo sapiens
Smith, N.B.; Kuksis, A.
Stereochemical substrate requirements of lecithin:cholesterol acyltransferase and its inhibition by enantiomeric lysolecithins
Can. J. Biochem.
58
1286-1291
1980
Homo sapiens
Furukawa, Y.; Urano, T.; Itoh, H.; Takahashi, C.; Kimura, S.
Isolation and properties of rat plasma lecithin-cholesterol acyltransferase
J. Biochem.
105
962-967
1989
Rattus norvegicus
Furukawa, Y.; Nishida, T.
Stability and properties of lecithin-cholesterol acyltransferase
J. Biol. Chem.
254
7213-7219
1979
Homo sapiens
Chung, J.; Abano, D.A.; Fless, G.M.; Scanu, A.M.
Isolation, properties, and mechanism of in vitro action of lecithin: cholesterol acyltransferase from human plasma
J. Biol. Chem.
254
7456-7464
1979
Homo sapiens
Albers, J.J.; Cabana, V.G.; De Barden Stahl, Y.
Purification and characterization of human plasma lecithin: cholesterol acyltransferase
Biochemistry
15
1084-1087
1976
Homo sapiens
Liu, M.; Subbaiah, P.V.
Hydrolysis and transesterification of platelet-activating factor by lecithin-cholesterol acyltransferase
Proc. Natl. Acad. Sci. USA
91
6035-6039
1994
Homo sapiens
Jonas, A.
Lecithin cholesterol acyltransferase
Biochim. Biophys. Acta
1529
245-256
2000
Homo sapiens
Liu, M.; Subbaiah, P.V.
Activation of plasma lysolecithin acyltransferase reaction by apolipoproteins A-I, C-I and E
Biochim. Biophys. Acta
1168
144-152
1993
Homo sapiens
O, K.; Hill, J.S.; Wang, X.; McLeod, R.; Pritchard, P.H.
Lecithin:cholesterol acyltransferase: Role of N-linked glycosylation in enzyme function
Biochem. J.
294
879-884
1993
Homo sapiens
Lee, Y.P.; Adimoolam, S.; Liu, M.; Subbaiah, P.V.; Glenn, K.; Jonas, A.
Analysis of human lecithin-cholesterol acyltransferase activity by carboxyl-terminal truncation
Biochim. Biophys. Acta
1344
250-261
1997
Homo sapiens
Ayyobi, A.F.; Lacko, A.G.; Murray, K.; Nair, M.; Li, M.; Molhuizen, H.O.F.; Pritchard, P.H.
Biochemical and compositional analyses of recombinant lecithin:cholesterol acyltransferase (LCAT) obtained from a hepatic source
Biochim. Biophys. Acta
1484
1-13
2000
Homo sapiens
Davit-Spraul, A.; Therond, P.; Leroy, A.; Palmade-Rieunier, F.; Rousset, C.; Moatti, N.; Legrand, A.
Inhibition of lecithin cholesterol acyltransferase by phosphatidylcholine hydroperoxides
FEBS Lett.
447
106-110
1999
Homo sapiens
Hida, Y.; Furukawa, Y.; Urano, T.; Kim, H.J.; Kimura, S.
Substrate specificity of rat plasma lecithin-cholesterol acyltransferase towards a molecular species of phosphatidylcholine
Biosci. Biotechnol. Biochem.
57
1111-1114
1993
Homo sapiens, Rattus norvegicus
Calabresi, L.; Franceschini, G.; Burkybile, A.; Jonas, A.
Activation of lecithin cholesterol acyltransferase by a disulfide-linked apolipoprotein A-I dimer
Biochem. Biophys. Res. Commun.
232
345-349
1997
Homo sapiens
Demeester, N.; Castro, G.; Desrumaux, C.; De Geitere, C.; Fruchart, J.C.; Santens, P.; Mulleners, E.; Engelborghs, S.; De Deyn, P.P.; Vandekerckhove, J.; Rosseneu, M.; Labeur, C.
Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease
J. Lipid Res.
41
963-974
2000
Homo sapiens
Qu, S.J.; Fan, H.Z.; Blanco-Vaca, F.; Pownall, H.J.
Effects of site-directed mutagenesis on the N-glycosylation sites of human lecithin:cholesterol acyltransferase
Biochemistry
32
8732-8736
1993
Homo sapiens
Subbaiah, P.V.; Liu, M.; Paltauf, F.
Role of sn-2 acyl group of phosphatidyl choline in determining the positional specificity of lecithin-cholesterol acyltransferase
Biochemistry
33
13259-13266
1994
Homo sapiens
Parks, J.S.; Huggins, K.W.; Gebre, A.K.; Burleson, E.R.
Phosphatidylcholine fluidity and structure affect lecithin:cholesterol acyltransferase activity
J. Lipid Res.
41
546-553
2000
Homo sapiens
Lacko, A.G.; Reason, A.J.; Nuckolls, C.; Kudchodkar, B.J.; Nair, M.P.; Sundarrajan, G.; Pritchard, P.H.; Morris, H.R.; Dell, A.
Characterization of recombinant human plasma lecithin: cholesterol acyltransferase (LCAT): N-linked carbohydrate structures and catalytic properties
J. Lipid Res.
39
807-820
1998
Homo sapiens
Chisholm, J.W.; Gebre, A.K.; Parks, J.S.
Characterization of C-terminal histidine-tagged human recombinant lecithin:cholesterol acyltransferase
J. Lipid Res.
40
1512-1519
1999
Homo sapiens
Jin, L.; Lee, Y.P.; Jonas, A.
Biochemical and biophysical characterization of human recombinant lecithin: cholesterol acyltransferase
J. Lipid Res.
38
1085-1093
1997
Homo sapiens
Nair, M.P.; Kudchodkar, B.J.; Pritchard, P.H.; Lacko, A.G.
Purification of recombinant lecithin: cholesterol acyltransferase
Protein Expr. Purif.
10
38-41
1997
Homo sapiens
Krimbou, L.; Marcil, M.; Davignon, J.; Genest, J.Jr.
Interaction of lecithin:cholesterol acyltransferase (LCAT).a2-macroglobulin complex with low density lipoprotein receptor-related protein (LRP). Evidence for an a2-macroglobulin/LRP receptor-mediated system participating in LCAT clearance
J. Biol. Chem.
276
33241-33248
2001
Homo sapiens
Adimoolam, S.; Jin, L.; Grabbe, E.; Shieh, J.J.; Jonas, A.
Structural and functional properties of two mutants of lecithin-cholesterol acyltransferase (T123I and N228K)
J. Biol. Chem.
273
32561-32567
1998
Homo sapiens
Hengstschlaeger-Ottnad, E.; Kuchler, K.; Schneider, W.J.
Chicken lecithin-cholesterol acyltransferase. Molecular characterization reveals unusual structure and expression pattern
J. Biol. Chem.
270
26139-26145
1995
Gallus gallus (P53760), Gallus gallus
Zhao, Y.; Wang, J.; Gebre, A.K.; Chisholm, J.W.; Parks, J.S.
Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chains
Biochemistry
42
13941-13949
2003
Homo sapiens
Nakamura, Y.; Kotite, L.; Gan, Y.; Spencer, T.A.; Fielding, C.J.; Fielding, P.E.
Molecular mechanism of reverse cholesterol transport: reaction of pre-beta-migrating high-density lipoprotein with plasma lecithin/cholesterol acyltransferase
Biochemistry
43
14811-14820
2004
Homo sapiens
Alexander, E.T.; Bhat, S.; Thomas, M.J.; Weinberg, R.B.; Cook, V.R.; Bharadwaj, M.S.; Sorci-Thomas, M.
Apolipoprotein A-I helix 6 negatively charged residues attenuate lecithin-cholesterol acyltransferase (LCAT) reactivity
Biochemistry
44
5409-5419
2005
Homo sapiens
Hoang, A.; Huang, W.; Sasaki, J.; Sviridov, D.
Natural mutations of apolipoprotein A-I impairing activation of lecithin:cholesterol acyltransferase
Biochim. Biophys. Acta
1631
72-76
2003
Homo sapiens
Vickaryous, N.K.; Teh, E.M.; Stewart, B.; Dolphin, P.J.; Too, C.K.; McLeod, R.S.
Deletion of N-terminal amino acids from human lecithin:cholesterol acyltransferase differentially affects enzyme activity toward alpha- and beta-substrate lipoproteins
Biochim. Biophys. Acta
1646
164-172
2003
Homo sapiens
Lima, V.L.M.; Coelho, L.C.B.B.; Kennedy, J.F.; Owen, J.S.; Dolphin, P.J.
Lecithin-cholesterol acyltransferase (LCAT) as a plasma glycoprotein: an overview
Carbohydr. Polym.
55
179-191
2004
Homo sapiens
-
Temel, R.E.; Gebre, A.K.; Parks, J.S.; Rudel, L.L.
Compared with acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol
J. Biol. Chem.
278
47594-47601
2003
Homo sapiens
Lane, S.B.; Tchedre, K.T.; Nair, M.P.; Thigpen, A.E.; Lacko, A.G.
Characterization of lecithin:cholesterol acyltransferase expressed in a human lung cell line
Protein Expr. Purif.
36
157-164
2004
Homo sapiens (P04180), Homo sapiens
Idzior-Walus, B.; Sieradzki, J.; Kostner, G.; Ma?ecki, M.T.; Klupa, T.; Weso?owska, T.; Rostworowski, W.; Hartwich, J.; Walu?, M.; Kie?, A.D.; Naruszewicz, M.
Familial lecithin-cholesterol acyltransferase deficiency: biochemical characteristics and molecular analysis of a new LCAT mutation in a Polish family
Atherosclerosis
185
413-420
2006
Homo sapiens
Zhao, Y.; Thorngate, F.E.; Weisgraber, K.H.; Williams, D.L.; Parks, J.S.
Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins
Biochemistry
44
1013-1025
2005
Mus musculus, Mus musculus C57BL/6
Subbaiah, P.V.; Horvath, P.; Achar, S.B.
Regulation of the activity and fatty acid specificity of lecithin-cholesterol acyltransferase by sphingomyelin and its metabolites, ceramide and ceramide phosphate
Biochemistry
45
5029-5038
2006
Homo sapiens
Kassai, A.; Illyes, L.; Mirdamadi, H.Z.; Seres, I.; Kalmar, T.; Audikovszky, M.; Paragh, G.
The effect of atorvastatin therapy on lecithin:cholesterol acyltransferase, cholesteryl ester transfer protein and the antioxidant paraoxonase
Clin. Biochem.
40
1-5
2007
Homo sapiens
Bender, B.U.; Quaschning, T.; Neumann, H.P.; Schmidt, D.; Kraemer-Guth, A.
A novel frameshift mutation of the lecithin:cholesterol acyltransferase (LCAT) gene associated with renal failure in familial LCAT deficiency
Clin. Chem. Lab. Med.
45
483-486
2007
Homo sapiens
Nobecourt, E.; Davies, M.J.; Brown, B.E.; Curtiss, L.K.; Bonnet, D.J.; Charlton, F.; Januszewski, A.S.; Jenkins, A.J.; Barter, P.J.; Rye, K.A.
The impact of glycation on apolipoprotein A-I structure and its ability to activate lecithin:cholesterol acyltransferase
Diabetologia
50
643-653
2007
Homo sapiens
Reshetnyak, Y.; Tchedre, K.T.; Nair, M.P.; Pritchard, P.H.; Lacko, A.G.
Structural differences between wild-type and fish eye disease mutant of lecithin:cholesterol acyltransferase
J. Biomol. Struct. Dyn.
24
75-82
2006
Homo sapiens
Lee, R.G.; Shah, R.; Sawyer, J.K.; Hamilton, R.L.; Parks, J.S.; Rudel, L.L.
ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice
J. Lipid Res.
46
1205-1212
2005
Mus musculus
Koukos, G.; Chroni, A.; Duka, A.; Kardassis, D.; Zannis, V.I.
Naturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: the abnormal HDL phenotypes can be corrected by treatment with LCAT
Biochem. J.
406
167-174
2007
Homo sapiens
Salvatore, A.; Cigliano, L.; Bucci, E.M.; Corpillo, D.; Velasco, S.; Carlucci, A.; Pedone, C.; Abrescia, P.
Haptoglobin binding to apolipoprotein A-I prevents damage from hydroxyl radicals on its stimulatory activity of the enzyme lecithin-cholesterol acyl-transferase
Biochemistry
46
11158-11168
2007
Homo sapiens
Borggreve, S.E.; de Vries, R.; Dallinga-Thie, G.M.; Wolffenbuttel, B.H.; Groen, A.K.; van Tol, A.; Dullaart, R.P.
The ability of plasma to stimulate fibroblast cholesterol efflux is associated with the -629C-->A cholesteryl ester transfer protein promoter polymorphism: role of lecithin: cholesterol acyltransferase activity
Biochim. Biophys. Acta
1781
10-15
2008
Homo sapiens
Nakhjavani, M.; Esteghamati, A.; Esfahanian, F.; Ghanei, A.; Rashidi, A.; Hashemi, S.
HbA1c negatively correlates with LCAT activity in type 2 diabetes
Diabetes Res. Clin. Pract.
81
38-41
2008
Homo sapiens
Nobecourt, E.; Zeng, J.; Davies, M.J.; Brown, B.E.; Yadav, S.; Barter, P.J.; Rye, K.A.
Effects of cross-link breakers, glycation inhibitors and insulin sensitisers on HDL function and the non-enzymatic glycation of apolipoprotein A-I
Diabetologia
51
1008-1017
2008
Homo sapiens
Prost, J.; Belleville, J.; Bouchenak, M.
Serum lecithin: cholesterol acyltransferase activity, HDL2 and HDL3 composition in hypertensive mothers and their small for gestational age newborns
Eur. J. Pediatr.
167
525-532
2008
Homo sapiens
Soulimane-Mokhtari, N.A.; Guermouche, B.; Saker, M.; Merzouk, S.; Merzouk, H.; Hichami, A.; Madani, S.; Khan, N.A.; Prost, J.
Serum lipoprotein composition, lecithin cholesterol acyltransferase and tissue lipase activities in pregnant diabetic rats and their offspring receiving enriched n-3 PUFA diet
Gen. Physiol. Biophys.
27
3-11
2008
Rattus norvegicus
Dullaart, R.P.; Perton, F.; Sluiter, W.J.; de Vries, R.; van Tol, A.
Plasma lecithin:cholesterol acyltransferase activity is elevated in metabolic syndrome and is an independent marker of increased carotid artery intima media thickness
J. Clin. Endocrinol. Metab.
93
4860-4866
2008
Homo sapiens
Cigliano, L.; Maresca, B.; Salvatore, A.; Nino, M.; Monfrecola, G.; Ayala, F.; Carlucci, A.; Pugliese, R.C.; Pedone, C.; Abrescia, P.
Haptoglobin from psoriatic patients exhibits decreased activity in binding haemoglobin and inhibiting lecithin-cholesterol acyltransferase activity
J. Eur. Acad. Dermatol. Venereol.
22
417-425
2008
Homo sapiens
Vaysse-Boue, C.; Dabadie, H.; Peuchant, E.; Le Ruyet, P.; Mendy, F.; Gin, H.; Combe, N.
Moderate dietary intake of myristic and alpha-linolenic acids increases lecithin-cholesterol acyltransferase activity in humans
Lipids
42
717-722
2007
Homo sapiens
Dullaart, R.P.; Perton, F.; van der Klauw, M.M.; Hillege, H.L.; Sluiter, W.J.; Sluiter, W.J.
High plasma lecithin:cholesterol acyltransferase activity does not predict low incidence of cardiovascular events: Possible attenuation of cardioprotection associated with high HDL cholesterol
Atherosclerosis
208
537-542
2010
Homo sapiens
Jones, M.K.; Catte, A.; Li, L.; Segrest, J.P.
Dynamics of activation of lecithin:cholesterol acyltransferase by apolipoprotein A-I
Biochemistry
48
11196-11210
2009
Homo sapiens
Dullaart, R.P.; Perton, F.; Kappelle, P.J.; de Vries, R.; Sluiter, W.J.; van Tol, A.
Plasma lecithin: cholesterol acyltransferase activity modifies the inverse relationship of C-reactive protein with HDL cholesterol in nondiabetic men
Biochim. Biophys. Acta
1801
84-88
2010
Homo sapiens
Tanigawa, H.; Billheimer, J.T.; Tohyama, J.; Fuki, I.V.; Ng, D.S.; Rothblat, G.H.; Rader, D.J.
Lecithin: cholesterol acyltransferase expression has minimal effects on macrophage reverse cholesterol transport in vivo
Circulation
120
160-169
2009
Homo sapiens, Mus musculus
Rader, D.
Lecithin: cholesterol acyltransferase and atherosclerosis: another high-density lipoprotein story that doesnt quite follow the script
Circulation
120
549-552
2009
Homo sapiens
Rousset, X.; Vaisman, B.; Amar, M.; Sethi, A.; Remaley, A.
Lecithin: cholesterol acyltransferase - from biochemistry to role in cardiovascular disease
Curr. Opin. Endocrinol. Diabetes Obes.
16
163-171
2009
Oryctolagus cuniculus, Homo sapiens, Mus musculus
Cigliano, L.; Pugliese, C.R.; Spagnuolo, M.S.; Palumbo, R.; Abrescia, P.
Haptoglobin binds the antiatherogenic protein apolipoprotein E - impairment of apolipoprotein E stimulation of both lecithin:cholesterol acyltransferase activity and cholesterol uptake by hepatocytes
FEBS J.
276
6158-6171
2009
Homo sapiens
Pavlovic, N.; Orem, W.; Tatu, C.; Lerch, H.; Bunnell, J.; Feder, G.; Kostic, E.; Ordodi, V.
The role of lecithin cholesterol acyltransferase and organic substances from coal in the etiology of Balkan endemic nephropathy: A new hypothesis
Food Chem. Toxicol.
46
949-954
2008
Homo sapiens
Van Craeyveld, E.; Lievens, J.; Jacobs, F.; Feng, Y.; Snoeys, J.; De Geest, B.
Apolipoprotein A-I and lecithin:cholesterol acyltransferase transfer induce cholesterol unloading in complex atherosclerotic lesions
Gene Ther.
16
757-765
2009
Oryctolagus cuniculus
Holleboom, A.G.; Kuivenhoven, J.A.; Vergeer, M.; Hovingh, G.K.; van Miert, J.N.; Wareham, N.J.; Kastelein, J.J.; Khaw, K.T.; Boekholdt, S.M.
Plasma levels of lecithin:cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women: a prospective case-control analysis nested in the EPIC-Norfolk population study
J. Lipid Res.
51
416-421
2010
Homo sapiens
Sarkar, P.; Bharill, S.; Gryczynski, I.; Gryczynski, Z.; Nair, M.; Lacko, A.
Binding of 8-anilino-1-naphthalenesulfonate to lecithin:cholesterol acyltransferase studied by fluorescence techniques
J. Photochem. Photobiol. B Biol.
92
19-23
2008
Homo sapiens
Angell, R.; Mitsuhashi, Y.; Bigley, K.; Bauer, J.E.
Plasma LCAT activity and lipid subfraction composition in obese beagles undergoing weight loss
Lipids
44
415-424
2009
Canis lupus familiaris
Amar, M.J.; Shamburek, R.D.; Vaisman, B.; Knapper, C.L.; Foger, B.; Hoyt, R.F.; Santamarina-Fojo, S.; Brewer, H.B.; Remaley, A.T.
Adenoviral expression of human lecithin-cholesterol acyltransferase in nonhuman primates leads to an antiatherogenic lipoprotein phenotype by increasing high-density lipoprotein and lowering low-density lipoprotein
Metab. Clin. Exp.
58
568-575
2009
Homo sapiens
Pahl, M.V.; Ni, Z.; Sepassi, L.; Moradi, H.; Vaziri, N.D.
Plasma phospholipid transfer protein, cholesteryl ester transfer protein and lecithin:cholesterol acyltransferase in end-stage renal disease (ESRD)
Nephrol. Dial. Transplant.
24
2541-2546
2009
Homo sapiens
Ghanem, M.M.; El-Deeb, W.M.
Lecithin cholesterol acyltransferase (LCAT) activity as a predictor for ketosis and parturient haemoglobinuria in Egyptian water buffaloes
Res. Vet. Sci.
88
20-25
2010
Bubalus bubalis
Subbaiah, P.V.; Jiang, X.C.; Belikova, N.A.; Aizezi, B.; Huang, Z.H.; Reardon, C.A.
Regulation of plasma cholesterol esterification by sphingomyelin: Effect of physiological variations of plasma sphingomyelin on lecithin-cholesterol acyltransferase activity
Biochim. Biophys. Acta
1821
908-913
2012
Mus musculus
Karavia, E.; Papachristou, D.; Kotsikogianni, I.; Triantafyllidou, I.; Kypreos, K.
Lecithin/cholesterol acyltransferase modulates diet-induced hepatic deposition of triglycerides in mice
J. Nutr. Biochem.
24
567-577
2013
Mus musculus
Chen, Z.; Wang, S.P.; Krsmanovic, M.L.; Castro-Perez, J.; Gagen, K.; Mendoza, V.; Rosa, R.; Shah, V.; He, T.; Stout, S.J.; Geoghagen, N.S.; Lee, S.H.; McLaren, D.G.; Wang, L.; Roddy, T.P.; Plump, A.S.; Hubbard, B.K.; Sinz, C.J.; Johns, D.G.
Small molecule activation of lecithin cholesterol acyltransferase modulates lipoprotein metabolism in mice and hamsters
Metab. Clin. Exp.
61
470-481
2012
Homo sapiens, Macaca mulatta, Mus musculus, Cricetidae
Homan, R.; Esmaeil, N.; Mendelsohn, L.; Kato, G.J.
A fluorescence method to detect and quantitate sterol esterification by lecithin:cholesterol acyltransferase
Anal. Biochem.
441
80-86
2013
Homo sapiens (P04180), Homo sapiens
Aguilar-Espinosa, S.L.; Mendoza-Espinosa, P.; Delgado-Coello, B.; Mas-Oliva, J.
Lecithin cholesterol acyltransferase (LCAT) activity in the presence of Apo-AI-derived peptides exposed to disorder-order conformational transitions
Biochem. Biophys. Res. Commun.
441
469-475
2013
Homo sapiens (P04180), Homo sapiens
Pszenny, V.; Ehrenman, K.; Romano, J.D.; Kennard, A.; Schultz, A.; Roos, D.S.; Grigg, M.E.; Carruthers, V.B.; Coppens, I.
A lipolytic lecithin:cholesterol acyltransferase secreted by Toxoplasma facilitates parasite replication and egress
J. Biol. Chem.
291
3725-3746
2015
Toxoplasma gondii (S8GJB1), Toxoplasma gondii, Toxoplasma gondii ME49 (S8GJB1)
Gu, X.; Wu, Z.; Huang, Y.; Wagner, M.A.; Baleanu-Gogonea, C.; Mehl, R.A.; Buffa, J.A.; DiDonato, A.J.; Hazen, L.B.; Fox, P.L.; Gogonea, V.; Parks, J.S.; DiDonato, J.A.; Hazen, S.L.
A systematic investigation of structure/function requirements for the apolipoprotein A-I - lecithin cholesterol acyltransferase interaction loop of HDL
J. Biol. Chem.
291
6386-6395
2016
Homo sapiens (P04180), Homo sapiens
La Marca, V.; Spagnuolo, M.S.; Cigliano, L.; Marasco, D.; Abrescia, P.
The enzyme lecithin-cholesterol acyltransferase esterifies cerebrosterol and limits the toxic effect of this oxysterol on SH-SY5Y cells
J. Neurochem.
130
97-108
2014
Homo sapiens (P04180)
Glukhova, A.; Hinkovska-Galcheva, V.; Kelly, R.; Abe, A.; Shayman, J.A.; Tesmer, J.J.
Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase
Nat. Commun.
6
6250
2015
Homo sapiens
La Marca, V.; Maresca, B.; Spagnuolo, M.S.; Cigliano, L.; Dal Piaz, F.; Di Iorio, G.; Abrescia, P.
Lecithin-cholesterol acyltransferase in brain: does oxidative stress influence the 24-hydroxycholesterol esterification?
Neurosci. Res.
105
19-27
2016
Homo sapiens (P04180), Homo sapiens
Romanow, W.G.; Piper, D.E.; Fordstrom, P.; Thibault, S.; Zhou, M.; Walker, N.P.
BacMam production of active recombinant lecithin-cholesterol acyltransferase: expression, purification and characterization
Protein Expr. Purif.
105
1-6
2016
Homo sapiens (P04180)
Spahr, C.; Kim, J.J.; Deng, S.; Kodama, P.; Xia, Z.; Tang, J.; Zhang, R.; Siu, S.; Nuanmanee, N.; Estes, B.; Stevens, J.; Zhou, M.; Lu, H.S.
Recombinant human lecithin-cholesterol acyltransferase Fc fusion: analysis of N- and O-linked glycans and identification and elimination of a xylose-based O-linked tetrasaccharide core in the linker region
Protein Sci.
22
1739-1753
2013
Homo sapiens (P04180), Homo sapiens
Fountoulakis, N.; Lioudaki, E.; Lygerou, D.; Dermitzaki, E.K.; Papakitsou, I.; Kounali, V.; Holleboom, A.G.; Stratigis, S.; Belogianni, C.; Syngelaki, P.; Stratakis, S.; Evangeliou, A.; Gakiopoulou, H.; Kuivenhoven, J.A.; Wevers, R.; Dafnis, E.; Stylianou, K.
The P274S mutation of lecithin-cholesterol acyltransferase (LCAT) and its clinical manifestations in a large kindred
Am. J. Kidney Dis.
74
510-522
2019
Homo sapiens (P04180), Homo sapiens
Ossoli, A.; Simonelli, S.; Varrenti, M.; Morici, N.; Oliva, F.; Stucchi, M.; Gomaraschi, M.; Strazzella, A.; Arnaboldi, L.; Thomas, M.J.; Sorci-Thomas, M.G.; Corsini, A.; Veglia, F.; Franceschini, G.; Karathanasis, S.K.; Calabresi, L.
Recombinant LCAT (lecithin cholesterol acyltransferase) rescues defective HDL (high-density lipoprotein)-mediated endothelial protection in acute coronary syndrome
Arterioscler. Thromb. Vasc. Biol.
39
915-924
2019
Homo sapiens (P04180)
Yokoyama, K.; Tani, S.; Matsuo, R.; Matsumoto, N.
Association of lecithin-cholesterol acyltransferase activity and low-density lipoprotein heterogeneity with atherosclerotic cardiovascular disease risk a longitudinal pilot study
BMC Cardiovasc. Disord.
18
224
2018
Homo sapiens (P04180), Homo sapiens
Ama Moor, V.J.; Nya Biapa, P.C.; Nono Njinkio, B.L.; Moukette Moukette, B.; Sando, Z.; Kenfack, C.; Ateba, B.; Ngo Matip, M.E.; Pieme, C.A.; Ngogang, J.
Hypolipidemic effect and activation of lecithin cholesterol acyl transferase (LCAT) by aqueous extract of Spirulina platensis during toxicological investigation
BMC Nutr.
3
25
2017
Rattus norvegicus (P18424), Rattus norvegicus
Manthei, K.A.; Patra, D.; Wilson, C.J.; Fawaz, M.V.; Piersimoni, L.; Shenkar, J.C.; Yuan, W.; Andrews, P.C.; Engen, J.R.; Schwendeman, A.; Ohi, M.D.; Tesmer, J.J.G.
Structural analysis of lecithin cholesterol acyltransferase bound to high density lipoprotein particles
Commun. Biol.
3
28
2020
Homo sapiens (P04180)
Nass, K.J.; van den Berg, E.H.; Gruppen, E.G.; Dullaart, R.P.F.
Plasma lecithin cholesterol acyltransferase and phospholipid transfer protein activity independently associate with nonalcoholic fatty liver disease
Eur. J. Clin. Invest.
48
e12988
2018
Homo sapiens (P04180), Homo sapiens
Soupene, E.; Borja, M.S.; Borda, M.; Larkin, S.K.; Kuypers, F.A.
Featured article alterations of lecithin cholesterol acyltransferase activity and apolipoprotein A-I functionality in human sickle blood
Exp. Biol. Med. (Maywood)
241
1933-1942
2016
Homo sapiens (P04180), Homo sapiens
Abid, D.; Mokhtari-Soulimane, N.; Merzouk, H.; Narce, M.
Linseed oil supplementation improves lecithin cholesterol acyltransferase and tissue lipase activities in pregnant obese rats and their offspring
Int. J. Pharm. Pharm. Sci.
8
194-200
2016
Rattus norvegicus (P18424)
-
Gunawardane, R.; Fordstrom, P.; Piper, D.; Masterman, S.; Siu, S.; Liu, D.; Brown, M.; Lu, M.; Tang, J.; Zhang, R.; Cheng, J.; Gates, A.; Meininger, D.; Chan, J.; Carlson, T.; Walker, N.; Schwarz, M.; Delaney, J.; Zhou, M.
Agonistic human antibodies binding to lecithin-cholesterol acyltransferase modulate high density lipoprotein metabolism
J. Biol. Chem.
291
2799-2811
2016
Macaca fascicularis (A0A2K5WDQ7), Macaca fascicularis, Homo sapiens (P04180), Homo sapiens
Pszenny, V.; Ehrenman, K.; Romano, J.; Kennard, A.; Schultz, A.; Roos, D.; Grigg, M.; Carruthers, V.; Coppens, I.
A lipolytic lecithin cholesterol acyltransferase secreted by Toxoplasma facilitates parasite replication and egress
J. Biol. Chem.
291
3725-3746
2016
Toxoplasma gondii (S8GJB1), Toxoplasma gondii, Toxoplasma gondii ATCC 50611 (S8GJB1)
Casteleijn, M.G.; Parkkila, P.; Viitala, T.; Koivuniemi, A.
Interaction of lecithin cholesterol acyltransferase with lipid surfaces and apolipoprotein A-I-derived peptides
J. Lipid Res.
59
670-683
2018
Homo sapiens (P04180)
Dobiasova, M.
Atherogenic impact of lecithin-cholesterol acyltransferase and its relation to cholesterol esterification rate in HDL (FER(HDL)) and AIP [log(TG/HDL-C)] biomarkers the butterfly effect?
Physiol. Res.
66
193-203
2017
Homo sapiens (P04180)
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