Information on EC 2.3.1.245 - 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Escherichia coli

EC NUMBER
COMMENTARY hide
2.3.1.245
-
RECOMMENDED NAME
GeneOntology No.
3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
glycerone phosphate + acetyl-CoA = 3-hydroxy-5-phosphonooxypentane-2,4-dione + coenzyme A
show the reaction diagram
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
autoinducer AI-2 degradation
-
-
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:glycerone phosphate C-acetyltransferase
The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
-
the enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-hydroxy-5-phosphonooxypentane-2,4-dione + coenzyme A
glycerone phosphate + acetyl-CoA
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3-hydroxy-5-phosphonooxypentane-2,4-dione + coenzyme A
glycerone phosphate + acetyl-CoA
show the reaction diagram
-
the enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2 i.e. (S)-4,5-dihydroxypentane-2,3-dione
-
-
?
PDB
SCOP
CATH
ORGANISM
UNIPROT
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decamer
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
crystals of the catalytically inactive mutant enzyme K203A
-
hanging drop method with a well solution of 22% PEG 400, 200 mM MgCl2, 100 mM Tris pH 8.0
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli strain BL21
-
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K203A
-
inactive mutant enzyme
Show AA Sequence (462 entries)
Please use the Sequence Search for a specific query.