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Disease on EC 2.3.1.24 - sphingosine N-acyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
CEBP? facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation.
Ceramide synthases: insights into the expression and prognosis of lung cancer.
Adenocarcinoma of Lung
Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner.
Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1.
Alopecia
Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia.
Ataxia
Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase.
ATM regulates target switching to escalating doses of radiation in the intestines.
Atherosclerosis
[Investigating the role of ceramide metabolism-associated CERS5 (LASS5) gene in atherosclerosis pathogenesis in endothelial cells].
Breast Neoplasms
Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer.
C16?ceramide and sphingosine 1?phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation.
Ceramide synthases CerS4 and CerS5 are upregulated by 17?-estradiol and GPER1 via AP-1 in human breast cancer cells.
Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer.
Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer.
Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.
Long non-coding RNA CERS6-AS1 facilitates the oncogenicity of pancreatic ductal adenocarcinoma by regulating the microRNA-15a-5p/FGFR1 axis.
Long noncoding RNA CERS6-AS1 functions as a malignancy promoter in breast cancer by binding to IGF2BP3 to enhance the stability of CERS6 mRNA.
Carcinogenesis
AKT1/FOXP3 axis-mediated expression of CerS6 promotes p53 mutant pancreatic tumorigenesis.
Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation.
Ceramide synthase 6 predicts the prognosis of human gastric cancer: It functions as an oncoprotein by dysregulating the SOCS2/JAK2/STAT3 pathway.
Carcinoma
Ceramide synthases: insights into the expression and prognosis of lung cancer.
CerS6 regulates cisplatin resistance in oral squamous cell carcinoma by altering mitochondrial fission and autophagy.
Fumonisin B1 Inhibits Endoplasmic Reticulum Stress Associated-apoptosis After FoscanPDT Combined with C6-Pyridinium Ceramide or Fenretinide.
Carcinoma, Hepatocellular
Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels.
Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.
Carcinoma, Squamous Cell
Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells.
Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization.
Ceramide synthases: insights into the expression and prognosis of lung cancer.
Fumonisin B1 Inhibits Endoplasmic Reticulum Stress Associated-apoptosis After FoscanPDT Combined with C6-Pyridinium Ceramide or Fenretinide.
Colitis
Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability.
Adoptive Transfer of Ceramide Synthase 6 Deficient Splenocytes Reduces the Development of Colitis.
Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation.
Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis.
Colitis-Associated Neoplasms
Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation.
Colonic Neoplasms
Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells.
Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1.
Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy.
Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner.
Linking the ceramide synthases (CerSs) 4 and 5 with apoptosis, endometrial and colon cancers.
Colorectal Neoplasms
High CerS5 expression levels associate with reduced patient survival and transition from apoptotic to autophagy signalling pathways in colorectal cancer.
Human IgG antibody profiles differentiate between symptomatic patients with and without colorectal cancer.
Cough
Ceramide: a key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammation.
Cystic Fibrosis
Fenretinide differentially modulates the levels of long- and very long-chain ceramides by downregulating Cers5 enzyme: evidence from bench to bedside.
Cytochrome-c Oxidase Deficiency
Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.
Dementia
Gangliosides' protection against lysosomal pathology of synucleinopathies.
Dermatitis, Atopic
Ceramide synthase 4 is highly expressed in involved skin of patients with atopic dermatitis.
Diabetes Mellitus
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.
Diabetes Mellitus, Type 2
Noncoding Variations in the Gene Encoding Ceramide Synthase 6 are Associated with Type 2 Diabetes in a Large Indigenous Australian Pedigree.
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.
The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach.
Dyspnea
Ceramide: a key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammation.
Encephalomyelitis
Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis.
Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils.
Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent.
Encephalomyelitis, Autoimmune, Experimental
Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis.
Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils.
Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent.
Fatty Liver
Ceramide Synthases Are Attractive Drug Targets for Treating Metabolic Diseases.
Glioblastoma
Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.
PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.
Head and Neck Neoplasms
Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.
Heart Failure
A tissue-specific screen of ceramide expression in aged mice identifies ceramide synthase-1 and ceramide synthase-5 as potential regulators of fiber size and strength in skeletal muscle.
Hematologic Neoplasms
Ceramide synthesis regulates T cell activity and GVHD development.
Hyperglycemia
The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach.
Hypertrophy, Right Ventricular
Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension.
Hypothyroidism
[Analysis of genes related to hypothyroidism during pregnancy].
Ichthyosis
Comprehensive stratum corneum ceramide profiling reveals reduced acylceramides in ichthyosis patient with CERS3 mutations.
Infections
Specific processing of poly(ADP-ribose) polymerase, accompanied by activation of caspase-3 and elevation/reduction of ceramide/hydrogen peroxide levels, during induction of apoptosis in host HL-60 cells infected by the human granulocytic ehrlichiosis (HGE) agent.
Insulin Resistance
Ceramide Synthases Are Attractive Drug Targets for Treating Metabolic Diseases.
CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance.
CerS2 haploinsufficiency inhibits ?-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance.
CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.
Downregulation of lipin-1 induces insulin resistance by increasing intracellular ceramide accumulation in C2C12 myotubes.
Mechanistic interplay between ceramide and insulin resistance.
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.
The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach.
Leishmaniasis
Residue-Specific Message Encoding in CD40-Ligand.
Leukemia
By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, stichoposide D inhibits growth of leukemia xenografts.
Holotoxin A? Induces Apoptosis by Activating Acid Sphingomyelinase and Neutral Sphingomyelinase in K562 and Human Primary Leukemia Cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
A novel mechanism of dasatinib-induced apoptosis in chronic myeloid leukemia; ceramide synthase and ceramide clearance genes.
Liver Diseases
LASS2 regulates hepatocyte steatosis by interacting with NDUFS2/OXPHOS related proteins.
Liver Diseases, Alcoholic
A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis.
Liver Neoplasms
Ceramide synthase-4 orchestrates the cell proliferation and tumor growth of liver cancer in vitro and in vivo through the nuclear factor-?B signaling pathway.
Lung Neoplasms
CEBP? facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation.
CERS6 required for cell migration and metastasis in lung cancer.
Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells.
Lymphatic Metastasis
CERS6 required for cell migration and metastasis in lung cancer.
Magnesium Deficiency
Short-term magnesium deficiency upregulates ceramide synthase in cardiovascular tissues and cells: cross-talk among cytokines, Mg2+, NF-?B, and de novo ceramide.
Melanoma
Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer.
Silencing of CerS6 increases the invasion and glycolysis of melanoma WM35, WM451 and SK28 cell lines via increased GLUT1-induced downregulation of WNT5A.
Metabolic Diseases
CerS2 haploinsufficiency inhibits ?-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance.
Metabolic Syndrome
[Analysis of genes related to hypothyroidism during pregnancy].
Mitochondrial Diseases
Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.
Multiple Sclerosis
Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils.
Neoplasm Metastasis
CEBP? facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation.
Ceramide synthase 6 predicts poor prognosis and activates the AKT/mTOR/4EBP1 pathway in high-grade serous ovarian cancer.
CERS6 required for cell migration and metastasis in lung cancer.
Expression of a tumor-associated gene, LASS2, in the human bladder carcinoma cell lines BIU-87, T24, EJ and EJ-M3.
Targeting ceramide synthase 6-dependent metastasis-prone phenotype in lung cancer cells.
Neoplasms
17-Allylamino-17-Demethoxygeldanamycin and MEK1/2 Inhibitors Kill GI Tumor Cells via Ca2+-Dependent Suppression of GRP78/BiP and Induction of Ceramide and Reactive Oxygen Species.
Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer.
AKT1/FOXP3 axis-mediated expression of CerS6 promotes p53 mutant pancreatic tumorigenesis.
Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network.
Altered mRNA expression levels of the major components of sphingolipid metabolism, ceramide synthases and their clinical implication in colorectal cancer.
Anti-inflammatory and anti-apoptotic effects of fumonisin B1, an inhibitor of ceramide synthase, in a rodent model of splanchnic ischemia and reperfusion injury.
C16?ceramide and sphingosine 1?phosphate/S1PR2 have opposite effects on cell growth through mTOR signaling pathway regulation.
Carcinogenicity and mechanism of action of fumonisin B1: a mycotoxin produced by Fusarium moniliforme (= F. verticillioides).
CEBP? facilitates lamellipodia formation and cancer cell migration through CERS6 upregulation.
Ceramide accumulation is associated with increased apoptotic cell death in cultured fibroblasts of sphingolipid activator protein-deficient mouse but not in fibroblasts of patients with Farber disease.
Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner.
Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells.
Ceramide synthase 6 predicts poor prognosis and activates the AKT/mTOR/4EBP1 pathway in high-grade serous ovarian cancer.
Ceramide synthase 6 predicts the prognosis of human gastric cancer: It functions as an oncoprotein by dysregulating the SOCS2/JAK2/STAT3 pathway.
Ceramide synthase-4 orchestrates the cell proliferation and tumor growth of liver cancer in vitro and in vivo through the nuclear factor-?B signaling pathway.
Ceramide synthases CerS4 and CerS5 are upregulated by 17?-estradiol and GPER1 via AP-1 in human breast cancer cells.
CerS6 regulates cisplatin resistance in oral squamous cell carcinoma by altering mitochondrial fission and autophagy.
Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation.
Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer.
Decreased fumonisin hepatotoxicity in mice with a targeted deletion of tumor necrosis factor receptor 1.
Dihydroceramide desaturase knockdown impacts sphingolipids and apoptosis after photodamage in human head and neck squamous carcinoma cells.
Diverse functions of ceramide in cancer cell death and proliferation.
Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility.
Elevation of sphingoid base 1-phosphate as a potential contributor to hepatotoxicity in fumonisin B1-exposed mice.
Expression of a tumor-associated gene, LASS2, in the human bladder carcinoma cell lines BIU-87, T24, EJ and EJ-M3.
Fumonisin B1 regulates LDL receptor and ABCA1 expression in an LXR dependent mechanism in liver (HepG2) cells.
Fumonisin-induced tumor necrosis factor-alpha expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition.
High CerS5 expression levels associate with reduced patient survival and transition from apoptotic to autophagy signalling pathways in colorectal cancer.
Increased liver tumor formation in neutral sphingomyelinase-2 deficient mice.
Increased susceptibility of renal epithelial cells to TNFalpha-induced apoptosis following treatment with fumonisin B1.
Inhibition of tumor necrosis factor alpha signaling by anti-tumor necrosis factor alpha antibodies and pentoxifylline is unable to prevent fumonisin hepatotoxicity in mice.
LASS2 inhibits proliferation and induces apoptosis in HepG2 cells by affecting mitochondrial dynamics, the cell cycle and the nuclear factor??B pathways.
LASS5 Interacts with SDHB and Synergistically Represses p53 and p21 Activity.
Linking the ceramide synthases (CerSs) 4 and 5 with apoptosis, endometrial and colon cancers.
Long noncoding RNA CERS6-AS1 functions as a malignancy promoter in breast cancer by binding to IGF2BP3 to enhance the stability of CERS6 mRNA.
Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cells.
Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent.
S-adenosylmethionine or 5'-methylthioadenosine are unable to prevent fumonisin B1 hepatotoxicity in mice despite increased oxidation in liver.
Silencing of CerS6 increases the invasion and glycolysis of melanoma WM35, WM451 and SK28 cell lines via increased GLUT1-induced downregulation of WNT5A.
Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases.
Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling.
Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.
Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance.
Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation.
The novel HDAC inhibitor AR-42-induced anti-colon cancer cell activity is associated with ceramide production.
Tolerance to fumonisin toxicity in a mouse strain lacking the P75 tumor necrosis factor receptor.
[Ceramide: a lipid mediator of apoptotic signal transduction]
[pemetrexed + sildenafil], via autophagy-dependent HDAC down-regulation, enhances the immunotherapy response of NSCLC cells.
Neuroblastoma
Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide.
Gangliosides' protection against lysosomal pathology of synucleinopathies.
N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase.
Neurodegenerative Diseases
Assaying Ceramide Synthase Activity In Vitro and in Living Cells Using Liquid Chromatography-Mass Spectrometry.
Defective ceramide synthases in mice cause reduced amplitudes in electroretinograms and altered sphingolipid composition in retina and cornea.
Non-alcoholic Fatty Liver Disease
LASS2 regulates hepatocyte steatosis by interacting with NDUFS2/OXPHOS related proteins.
Obesity
Ceramide Synthase 5 Is Essential to Maintain C16:0-Ceramide Pools and Contributes to the Development of Diet-induced Obesity.
Ceramide Synthases Are Attractive Drug Targets for Treating Metabolic Diseases.
CerS2 haploinsufficiency inhibits ?-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance.
CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.
The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach.
Ovarian Neoplasms
Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells.
Ceramide synthase 6 predicts poor prognosis and activates the AKT/mTOR/4EBP1 pathway in high-grade serous ovarian cancer.
Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer.
Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.
Pancreatic Neoplasms
Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.
Photosensitivity Disorders
Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization.
Plant Diseases
Alteration in sphingolipid metabolism: bioassays for fumonisin- and ISP-I-like activity in tissues, cells and other matrices.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Ceramide synthase-6 confers resistance to chemotherapy by binding to CD95/Fas in T-cell acute lymphoblastic leukemia.
Prostatic Neoplasms
Anti-proliferative and apoptotic effects of anandamide in human prostatic cancer cell lines: implication of epidermal growth factor receptor down-regulation and ceramide production.
Ceramide accumulation is independent of camptothecin-induced apoptosis in prostate cancer LNCaP cells.
Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis.
PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo.
Rectal Neoplasms
Altered mRNA expression levels of the major components of sphingolipid metabolism, ceramide synthases and their clinical implication in colorectal cancer.
Reperfusion Injury
Anti-inflammatory and anti-apoptotic effects of fumonisin B1, an inhibitor of ceramide synthase, in a rodent model of splanchnic ischemia and reperfusion injury.
Retinal Dystrophies
Ceramide synthase TLCD3B is a novel gene associated with human recessive retinal dystrophy.
sphinganine-1-phosphate aldolase deficiency
S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake.
sphingomyelin phosphodiesterase deficiency
Increased liver tumor formation in neutral sphingomyelinase-2 deficient mice.
sphingosine n-acyltransferase deficiency
Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia.
Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation.
Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis.
Defective ceramide synthases in mice cause reduced amplitudes in electroretinograms and altered sphingolipid composition in retina and cornea.
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.
Squamous Cell Carcinoma of Head and Neck
CerS6 regulates cisplatin resistance in oral squamous cell carcinoma by altering mitochondrial fission and autophagy.
Fumonisin B1 Inhibits Endoplasmic Reticulum Stress Associated-apoptosis After FoscanPDT Combined with C6-Pyridinium Ceramide or Fenretinide.
Starvation
Cross-phenotype association tests uncover genes mediating nutrient response in Drosophila.
Stomach Neoplasms
Ceramide synthase 6 predicts the prognosis of human gastric cancer: It functions as an oncoprotein by dysregulating the SOCS2/JAK2/STAT3 pathway.
Comprehensive analysis of LASS6 expression and prognostic value in ovarian cancer.
Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase.
Stomach Ulcer
Attenuation of Acetic Acid-Induced Gastric Ulcer Formation in Rats by Glucosylceramide Synthase Inhibitors.
Thrombosis
Ceramidase critically affects GPVI-dependent platelet activation and thrombus formation.