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Reference on EC 2.3.1.230 - 2-heptyl-4(1H)-quinolone synthase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bera, A.K.; Atanasova, V.; Robinson, H.; Eisenstein, E.; Coleman, J.P.; Pesci, E.C.; Parsons, J.F.
Structure of PqsD, a Pseudomonas quinolone signal biosynthetic enzyme, in complex with anthranilate
Biochemistry
48
8644-8655
2009
Pseudomonas aeruginosa (P20582)
Manually annotated by BRENDA team
Steinbach, A.; Maurer, C.K.; Weidel, E.; Henn, C.; Brengel, C.; Hartmann, R.W.; Negri, M.
Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies
BMC Biophys.
6
10
2013
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Pistorius, D.; Ullrich, A.; Lucas, S.; Hartmann, R.W.; Kazmaier, U.; Müller, R.
Biosynthesis of 2-Alkyl-4(1H)-quinolones in Pseudomonas aeruginosa: potential for therapeutic interference with pathogenicity
Chembiochem
12
850-853
2011
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Storz, M.P.; Maurer, C.K.; Zimmer, C.; Wagner, N.; Brengel, C.; de Jong, J.C.; Lucas, S.; Müsken, M.; Häussler, S.; Steinbach, A.; Hartmann, R.W.
Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitors
J. Am. Chem. Soc.
134
16143-16146
2012
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Zhang, Y.M.; Frank, M.W.; Zhu, K.; Mayasundari, A.; Rock, C.O.
PqsD is responsible for the synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa
J. Biol. Chem.
283
28788-28794
2008
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Weidel, E.; de Jong, J.C.; Brengel, C.; Storz, M.P., Braunshausen, A.; Negri, M.; Plaza, A.; Steinbach, A.; Müller, R.; Hartmann, R.W.
Structure optimization of 2-benzamidobenzoic acids as PqsD inhibitors for Pseudomonas aeruginosa infections and elucidation of binding mode by SPR, STD NMR, and molecular docking
J. Med. Chem.
56
6146-6155
2013
Pseudomonas aeruginosa
Manually annotated by BRENDA team
Storz, M.P.; Brengel, C.; Weidel, E.; Hoffmann, M.; Hollemeyer, K.; Steinbach, A.; Mueller, R.; Empting, M.; Hartmann, R.W.
Biochemical and biophysical analysis of a chiral PqsD inhibitor revealing tight-binding behavior and enantiomers with contrary thermodynamic signatures
ACS Chem. Biol.
8
2794-2801
2013
Pseudomonas aeruginosa (A0A0H2Z7U1)
Manually annotated by BRENDA team
Dulcey, C.E.; Dekimpe, V.; Fauvelle, D.A.; Milot, S.; Groleau, M.C.; Doucet, N.; Rahme, L.G.; Lepine, F.; Deziel, E.
The end of an old hypothesis: the Pseudomonas signaling molecules 4-hydroxy-2-alkylquinolines derive from fatty acids, not 3-ketofatty acids
Chem. Biol.
20
1481-1491
2013
Pseudomonas aeruginosa (A0A0H2Z7U1), Pseudomonas aeruginosa UCBPP-PA14 (A0A0H2Z7U1)
Manually annotated by BRENDA team
Hinsberger, S.; de Jong, J.C.; Groh, M.; Haupenthal, J.; Hartmann, R.W.
Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections
Eur. J. Med. Chem.
76
343-351
2014
Pseudomonas aeruginosa (P20582)
Manually annotated by BRENDA team
Allegretta, G.; Weidel, E.; Empting, M.; Hartmann, R.W.
Catechol-based substrates of chalcone synthase as a scaffold for novel inhibitors of PqsD
Eur. J. Med. Chem.
90
351-359
2015
Pseudomonas aeruginosa (P20582)
Manually annotated by BRENDA team
Hutter, M.C.; Brengel, C.; Negri, M.; Henn, C.; Zimmer, C.; Hartmann, R.W.; Empting, M.; Steinbach, A.
Mechanistic details for anthraniloyl transfer in PqsD: the initial step in HHQ biosynthesis
J. Mol. Model.
20
2255
2014
Pseudomonas aeruginosa (P20582)
Manually annotated by BRENDA team
Storz, M.P.; Allegretta, G.; Kirsch, B.; Empting, M.; Hartmann, R.W.
From in vitro to in cellulo: structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa
Org. Biomol. Chem.
12
6094-6104
2014
Pseudomonas aeruginosa (P20582)
Manually annotated by BRENDA team
Drees, S.; Li, C.; Prasetya, F.; Saleem, M.; Dreveny, I.; Williams, P.; Hennecke, U.; Emsley, J.; Fetzner, S.
PqsBC, a condensing enzyme in the biosynthesis of the pseudomonas aeruginosa quinolone signal Crystal structure, inhibition, and reaction mechanism
J. Biol. Chem.
291
6610-6624
2016
Pseudomonas aeruginosa (Q9I4X2 AND Q9I4X1), Pseudomonas aeruginosa ATCC 15692 (Q9I4X2 AND Q9I4X1)
Manually annotated by BRENDA team