Information on EC 2.3.1.228 - isovaleryl-homoserine lactone synthase

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The expected taxonomic range for this enzyme is: Bradyrhizobium

EC NUMBER
COMMENTARY hide
2.3.1.228
-
RECOMMENDED NAME
GeneOntology No.
isovaleryl-homoserine lactone synthase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
isovaleryl-CoA + S-adenosyl-L-methionine = CoA + S-methyl-5'-thioadenosine + N-isovaleryl-L-homoserine lactone
show the reaction diagram
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
isovaleryl-CoA:S-adenosyl-L-methionine isovaleryltranserase (lactone-forming, methylthioadenosine-releasing)
The enzyme, found in the bacterium Bradyrhizobium japonicum, does not accept isovaleryl-[acyl-carrier protein] as acyl donor (cf. EC 2.3.1.184, acyl-homoserine-lactone synthase).
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
isopentyl-CoA + S-adenosyl-L-methionine
CoA + S-methyl-5'-thioadenosine + N-isopentyl-L-homoserine lactone
show the reaction diagram
isovaleryl-ACP + S-adenosyl-L-methionine
ACP + S-methyl-5'-thioadenosine + N-isovaleryl-L-homoserine lactone
show the reaction diagram
isovaleryl-CoA + S-adenosyl-L-methionine
CoA + S-methyl-5'-thioadenosine + N-isovaleryl-L-homoserine lactone
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
isovaleryl-CoA + S-adenosyl-L-methionine
CoA + S-methyl-5'-thioadenosine + N-isovaleryl-L-homoserine lactone
show the reaction diagram
additional information
?
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
isopentyl-CoA
competitive
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0079
isopentyl-CoA
pH 7.3, temperature not specified in the publication
-
0.317
isovaleryl-ACP
pH 7.3, temperature not specified in the publication
-
0.007
isovaleryl-CoA
pH 7.3, temperature not specified in the publication
0.039
S-adenosyl-L-methionine
pH 7.3, temperature not specified in the publication
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.02
isovaleryl-ACP
Bradyrhizobium diazoefficiens
Q89VI2
pH 7.3, temperature not specified in the publication
-
0.021
isovaleryl-CoA
Bradyrhizobium diazoefficiens
Q89VI2
pH 7.3, temperature not specified in the publication
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0063
isovaleryl-ACP
Bradyrhizobium diazoefficiens
Q89VI2
pH 7.3, temperature not specified in the publication
210546
3
isovaleryl-CoA
Bradyrhizobium diazoefficiens
Q89VI2
pH 7.3, temperature not specified in the publication
784
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.021
isopentyl-CoA
Bradyrhizobium diazoefficiens
Q89VI2
pH 7.3, temperature not specified in the publication
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
presence of isovaleryl-homoserrine lactone induces the expression