Information on EC 2.3.1.205 - fumigaclavine B O-acetyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Aspergillus fumigatus

EC NUMBER
COMMENTARY hide
2.3.1.205
-
RECOMMENDED NAME
GeneOntology No.
fumigaclavine B O-acetyltransferase
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + fumigaclavine B = CoA + fumigaclavine A
show the reaction diagram
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
fumigaclavine biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:fumigaclavine B O-acetyltransferase
The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene AFUA_2G18020
UniProt
Manually annotated by BRENDA team
gene AFUA_2G18020
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + fumigaclavine B
CoA + fumigaclavine A
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + fumigaclavine B
CoA + fumigaclavine A
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
22% activation at 5 mM
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.122
acetyl-CoA
pH not specified in the publication, 37C, recombinant His6-tagged enzyme
0.147
fumigaclavine B
pH not specified in the publication, 37C, recombinant His6-tagged enzyme
additional information
additional information
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.6
acetyl-CoA
Aspergillus fumigatus
Q4WZ64
pH not specified in the publication, 37C, recombinant His6-tagged enzyme
0.6
fumigaclavine B
Aspergillus fumigatus
Q4WZ64
pH not specified in the publication, 37C, recombinant His6-tagged enzyme
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
55000
1 * 55000, about, wild-type enzyme, sequence calculation, 1 * 56700, about, His6-tagged enzyme, sequence calculation, 1 * 57000, recombinant His6-tagged enzyme, SDS-PAGE
56700
1 * 55000, about, wild-type enzyme, sequence calculation, 1 * 56700, about, His6-tagged enzyme, sequence calculation, 1 * 57000, recombinant His6-tagged enzyme, SDS-PAGE
57000
1 * 55000, about, wild-type enzyme, sequence calculation, 1 * 56700, about, His6-tagged enzyme, sequence calculation, 1 * 57000, recombinant His6-tagged enzyme, SDS-PAGE
60800
recombinant His6-tagged enzyme, gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene AFUA_2G18020, DNA and amino acid seqquence determmination and analysis, sequence comparison, expression of His6-tagged FgaAT in Escherichia coli