Reference on EC 2.3.1.20 - diacylglycerol O-acyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Kawasaki, T.; Snyder, F.
Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells [published erratum appears in J Biol Chem 1988 Jul 25;263(21):10539]
J. Biol. Chem.
263
2593-2596
1988
Homo sapiens
Bell, R.M.; Coleman, R.A.
Enzymes of triacylglycerol formation in mammals
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
16
87-111
1983
Rattus norvegicus
-
Manganaro, F.; Kuksis, A.
Rapid isolation of a triacylglycerol synthetase complex from rat intestinal mucosa
Can. J. Biochem. Cell Biol.
63
107-114
1985
Rattus norvegicus
Martin, B.A.; Wilson, R.F.
Properties of diacylglycerol acyltransferase from spinach leaves
Lipids
18
1-6
1983
Spinacia oleracea
-
Weiss, S.B.; Kennedy, E.P.; Kiyasu, J.Y.
The enzymatic synthesis of triglycerides
J. Biol. Chem.
235
40-44
1960
Gallus gallus
Coleman, R.A.
Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine
Methods Enzymol.
209
98-104
1992
Rattus norvegicus
Coleman, R.A.; Bell, R.M.
Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols
J. Biol. Chem.
251
4537-4543
1976
Rattus norvegicus
Yamashita, S.; Hosaka, K.; Miki, Y.; Numa, S.
Glycerolipid acyltransferases from rat liver: 1-acylglycerophosphate acyltransferase, 1-acylglycerophosphorylcholine acyltransferase, and diacylglycerol acyltransferase
Methods Enzymol.
71
528-536
1981
Rattus norvegicus
Marshall, M.O.; Knudsen, J.
Specificity of diacylglycerol acyltransferase from bovine mammary gland, liver and adipose tissue towards acyl-CoA esters
Eur. J. Biochem.
94
93-98
1979
Bos taurus, Capra hircus, Oryctolagus cuniculus, Rattus norvegicus
Cao, Y.Z.; Huang, A.H.C.
Diacylglycerol acyltransferase in maturing oil seeds of maize and other species
Plant Physiol.
82
813-820
1986
Brassica napus, Cuphea carthagenensis, Zea mays, Zea mays Mo17
Rodriguez, M.A.; Dias, C.; Lau, T.E.
Reversible ATP-dependent inactivation of adipose diacylglycerol acyltransferase
Lipids
27
577-581
1992
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Parthasarathy, S.; Murari, R.; Crilly, K.S.; Baumann, W.J.
Modulation of diacylglycerol acyltransferase by lysophosphatidylcholine and related monochain phospholipids
Biochim. Biophys. Acta
664
249-254
1981
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Polokoff, M.A.; Bell, R.M.
Solubilization, partial purification and characterization of rat liver microsomal diacylglycerol acyltransferase
Biochim. Biophys. Acta
618
129-142
1980
Rattus norvegicus
Grigor, M.R.; Bell, R.M.
Separate monoacylglycerol and diacylglycerol acyltransferases function in intestinal triacylglycerol synthesis
Biochim. Biophys. Acta
712
464-472
1982
Rattus norvegicus
Marshall, M.O.; Knudsen, J.
Factors influencing the in vitro activity of diacylglycerol acyltransferase from bovine mammary gland and liver towards butyryl-CoA and palmitoyl-CoA
Biochim. Biophys. Acta
617
393-397
1980
Bos taurus
Christiansen, K.
Utilization of endogenous diacylglycerol for the synthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine by lipid particles from bakers yeast (Saccharomyces cerevisiae)
Biochim. Biophys. Acta
574
448-460
1979
Saccharomyces cerevisiae
Bell, R.M.; Miller, Y.
A highly sensitive assay for microsomal diacyglycerol acyltransferase activity from isolated fat cells
Anal. Biochem.
71
436-443
1976
Rattus norvegicus
Kwanyuen, P.; Wilson, R.W.
Subunit and amino acid composition of diacylglycerol acyltransferase from germinating soybean cotyledons
Biochim. Biophys. Acta
1039
67-72
1990
Glycine max
Kwanyuen, P.; Wilson, R.W.
Isolation and purification of diacylglycerol acyltransferase from germinating soybean dotyledons
Biochim. Biophys. Acta
877
238-245
1986
Glycine max
-
Weselake, R.J.; Taylor, D.C.; Pomeroy, D.C.; Lawson, S.L.; Underhill, E.W.
Properties of diacylglycerol acyltransferase from microspore-derived embryos of Brassica napus
Phytochemistry
30
3533-3538
1991
Brassica napus
-
Akao, T.; Kusaka, T.
Solubilization of diglyceride acyltransferase from the membrane of Mycobacterium smegmatis
J. Biochem.
80
723-728
1976
Mycolicibacterium smegmatis
Ichihara, K.; Noda, M.
Some properties of diacylglycerol acyltransferase in a pariculate fraction from maturing safflower seeds
Phytochemistry
21
1895-1901
1982
Carthamus tinctorius
-
Husaka, K.; Schiele, U.; Numa, S.
Diacylglycerol acyltransferase from rat liver microsomes. Separation and acyl-donor specificity
Eur. J. Biochem.
76
113-118
1977
Rattus norvegicus
Andersson, M.; Wettesten, M.; Boren, J.; Magnusson, A.; Sjoberg, A.; Rustaeus, S.; Olofsson, S.O.
Purification of diacylglycerol:acyltransferase from rat liver to near homogeneity
J. Lipid Res.
35
535-545
1994
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Bouvier-Nave, P.; Benveniste, P.; Noiriel, A.; Schaller, H.
Expression in yeast of an acyl-CoA:diacylglycerol acyltransferase cDNA from Caenorhabditis elegans
Biochem. Soc. Trans.
28
692-695
2000
Arabidopsis thaliana, Caenorhabditis elegans, Nicotiana tabacum
Cases, S.; Smith, S.J.; Zheng, Y.W.; Myers, H.M.; Lear, S.R.; Sande, E.; Novak, S.; Collins, C.; Welch, C.B.; Lusis, A.J.; Erickson, S.K.; Farese, R.V., Jr.
Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
Proc. Natl. Acad. Sci. USA
95
13018-13023
1998
Homo sapiens, Mus musculus (Q9Z2A7), Mus musculus
Cases, S.; Stone, S.J.; Zhou, P.; Yen, E.; Tow, B.; Lardizabal, K.D.; Voelker, T.; Farese, R.V., Jr.
Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members
J. Biol. Chem.
276
38870-38876
2001
Homo sapiens (Q96PD7), Homo sapiens, Mus musculus (Q9DCV3), Mus musculus
Cheng, D.; Meegalla, R.L.; He, B.; Cromley, D.A.; Billheimer, J.T.; Young, P.R.
Human acyl-CoA:diacylglycerol acyltransferase is a tetrameric protein
Biochem. J.
359
707-714
2001
Homo sapiens
Furukawa-Stoffer, T.L.; Byers, S.D.; Hodges, D.M.; Laroche, A.; Weselake, R.J.
Identification of N-ethylmaleimide-sensitive and -insensitive phosphatidate phosphatase activity in microspore derived cultures of oilseed rape
Plant Sci.
131
139-147
1998
Brassica napus
-
Hobbs, D.H.; Hills, M.J.
Expression and characterization of diacylglycerol acyltransferase from Arabidopsis thaliana in insect cell cultures
Biochem. Soc. Trans.
28
687-689
2000
Arabidopsis thaliana
Kamisaka, Y.; Mishra, S.; Nakahara, T.
Purification and characterization of diacylglycerol acyltransferase from the lipid body fraction of an oleaginous fungus
J. Biochem.
121
1107-1114
1997
Umbelopsis ramanniana
Lardizabal, K.D.; Mai, J.T.; Wagner, N.W.; Wyrick, A.; Voelker, T.; Hawkins, D.J.
DGAT2 is a new diacylglycerol acyltransferase gene family: purification, cloning, and expression in insect cells of two polypeptides from Mortierella ramanniana with diacylglycerol acyltransferase activity
J. Biol. Chem.
276
38862-38869
2001
Umbelopsis ramanniana
Little, D.; Weselake, R.; Pomeroy, K.; Furukawa-Stoffer, T.; Bagu, J.
Solubilization and characterization of diacylglycerol acyltransferase from microspore-derived cultures of oilseed rape
Biochem. J.
304
951-958
1994
Brassica napus
-
Lozeman, F.J.; Middleton, C.K.; Deng, J.; Kazala, E.C.; Verhaege, C.; Mir, P.S.; Laroche, A.; Bailey, D.R.C.; Weselake, R.J.
Characterization of microsomal diacylglycerol acyltransferase activity from bovine adipose and muscle tissue
Comp. Biochem. Physiol. B
130B
105-115
2001
Bos taurus
-
Meegalla, R.L.; Billheimer, J.T.; Cheng, D.
Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin
Biochem. Biophys. Res. Commun.
298
317-323
2002
Mus musculus
Murray, A.M.B.; Denis, R.; Speake, B.K.
Acyltransferase activities in the yolk sac membrane of the chick embryo
Lipids
34
929-935
1999
Gallus gallus
Nykiforuk, C.L.; Furukawa-Stoffer, T.L.; Huff, P.W.; Sarna, M.; Laroche, A.; Moloney, M.M.; Weselake, R.J.
Characterization of cDNAs encoding diacylglycerol acyltransferase from cultures of Brassica napus and sucrose-mediated induction of enzyme biosynthesis
Biochim. Biophys. Acta
1580
95-109
2002
Brassica napus
Routaboul, J.M.; Benning, C.; Bechtold, N.; Caboche, M.; Lepiniec, L.
The TAG1 locus of Arabidopsis encodes for a diacylglycerol acyltransferase
Plant Physiol. Biochem.
37
831-840
1999
Arabidopsis thaliana
Triki, S.; Ben Hamida, J.; Mazliak, P.
Diacylglycerol acyltransferase in maturing sunflower seeds
Biochem. Soc. Trans.
28
689-692
2000
Helianthus annuus
Valencia-Turcotte, L.; Rodriguez-Sotres, R.
The treatment of purified maize oil bodies with organic solvents and exogenous diacylglycerol allows the detection and solubilization of diacylglycerol acyltransferase
Biochim. Biophys. Acta
1534
14-26
2001
Zea mays
Weselake, R.J.; Nykiforuk, C.L.; Laroche, A.; Patterson, N.A.; Wiehler, W.B.; Szarka, S.J.; Moloney, M.M.; Tari, L.W.; Derekh, U.
Expression and properties of diacylglycerol acyltransferase from cell-suspension cultures of oilseed rape
Biochem. Soc. Trans.
28
684-686
2000
Brassica napus
Weselake, R.J.; Pomeroy, M.K.; Furukawa, T.L.; Golden, J.L.; Little, D.B.; Laroche, A.
Developmental profile of diacylglycerol acyltransferase in maturing seeds of oilseed rape and safflower and microspore-derived cultures of oilseed rape
Plant Physiol.
102
565-571
1993
Brassica napus, Carthamus tinctorius
Yashiro, K.; Kameyama, Y.; Mizuno-Kamiya, M.; Shin, S.O.; Fujita, A.
Microsomal diacylglycerol acyltransferase in rat parotid and submandibular glands: acylation of 1,2-dioleoyl-sn-glycerol dispersed with phospholipids
Int. J. Biochem. Cell Biol.
28
895-903
1996
Rattus norvegicus
Huff, P.W.; Lozeman, F.J.; Kazala, E.C.; Prozniak, C.; Wegner, J.; Deng, J.; Laroche, A.; Mir, P.S.; Aalhus, J.; Weselake, R.J.
Stability of diacylglycerol acyltransferase in dehydrated bovine muscle tissue
Anal. Biochem.
318
254-259
2003
Bos taurus
Uthoff, S.; Stoveken, T.; Weber, N.; Vosmann, K.; Klein, E.; Kalscheuer, R.; Steinbuchel, A.
Thio wax ester biosynthesis utilizing the unspecific bifunctional wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase of Acinetobacter sp. strain ADP1
Appl. Environ. Microbiol.
71
790-796
2005
Acinetobacter sp., Acinetobacter sp. ADP1
Wakimoto, K.; Chiba, H.; Michibata, H.; Seishima, M.; Kawasaki, S.; Okubo, K.; Mitsui, H.; Torii, H.; Imai, Y.
A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice
Biochem. Biophys. Res. Commun.
310
296-302
2003
Homo sapiens, Mus musculus
Daniel, J.; Deb, C.; Dubey, V.S.; Sirakova, T.D.; Abomoelak, B.; Morbidoni, H.R.; Kolattukudy, P.E.
Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in culture
J. Bacteriol.
186
5017-5030
2004
Mycobacterium tuberculosis
Stoveken, T.; Kalscheuer, R.; Malkus, U.; Reichelt, R.; Steinbuchel, A.
The wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase from Acinetobacter sp. strain ADP1: characterization of a novel type of acyltransferase
J. Bacteriol.
187
1369-1376
2005
Acinetobacter baylyi ADP1 (Q8GGG1)
Kalscheuer, R.; Steinbuchel, A.
A novel bifunctional wax ester synthase/acyl-CoA:diacylglycerol acyltransferase mediates wax ester and triacylglycerol biosynthesis in Acinetobacter calcoaceticus ADP1
J. Biol. Chem.
278
8075-8082
2003
Acinetobacter baylyi ADP1 (Q8GGG1), Acinetobacter baylyi ADP1
Yen, C.L.; Brown Iv, C.H.; Monetti, M.; Farese, R.V., Jr.
A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters
J. Lipid Res.
46
2388-2397
2005
Homo sapiens
He, X.; Turner, C.; Chen, G.Q.; Lin, J.T.; McKeon, T.A.
Cloning and characterization of a cDNA encoding diacylglycerol acyltransferase from castor bean
Lipids
39
311-318
2004
Ricinus communis (Q67C39), Ricinus communis
Casaschi, A.; Maiyoh, G.K.; Adeli, K.; Theriault, A.G.
Increased diacylglycerol acyltransferase activity is associated with triglyceride accumulation in tissues of diet-induced insulin-resistant hyperlipidemic hamsters
Metabolism
54
403-409
2005
Mesocricetus auratus
Stahl, U.; Carlsson, A.S.; Lenman, M.; Dahlqvist, A.; Huang, B.; Banas, W.; Banas, A.; Stymne, S.
Cloning and functional characterization of a phospholipid:diacylglycerol acyltransferase from Arabidopsis
Plant Physiol.
135
1324-1335
2004
Arabidopsis thaliana (Q9FNA9)
Chung, M.Y.; Rho, M.C.; Ko, J.S.; Ryu, S.Y.; Jeune, K.H.; Kim, K.; Lee, H.S.; Kim, Y.K.
In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens
Planta Med.
70
258-260
2004
Rattus norvegicus
Dat, N.T.; Cai, X.F.; Rho, M.C.; Lee, H.S.; Bae, K.; Kim, Y.H.
The inhibition of diacylglycerol acyltransferase by terpenoids from Youngia koidzumiana
Arch. Pharm. Res.
28
164-168
2005
Rattus norvegicus
Orland, M.D.; Anwar, K.; Cromley, D.; Chu, C.; Chen, L.; Billheimer, J.T.; Hussain, M.M.; Cheng, D.
Acyl coenzyme A dependent retinol esterification by acyl coenzyme A:diacylglycerol acyltransferase 1
Biochim. Biophys. Acta
1737
76-82
2005
Homo sapiens
Waeltermann, M.; Stoeveken, T.; Steinbuechel, A.
Key enzymes for biosynthesis of neutral lipid storage compounds in prokaryotes: Properties, function and occurrence of wax ester synthases/acyl-CoA:diacylglycerol acyltransferases
Biochimie
89
230-242
2007
Mycolicibacterium smegmatis, Mycobacterium tuberculosis (P9WKC3), Mycobacterium tuberculosis (P9WKC5), Mycobacterium tuberculosis (P9WKC7), Mycobacterium tuberculosis (P9WKC9), Streptomyces avermitilis (Q826D7), Acinetobacter baylyi (Q8GGG1), Streptomyces coelicolor (Q9RIU8), Mycobacterium tuberculosis H37Rv (P9WKC3), Mycobacterium tuberculosis H37Rv (P9WKC5), Mycobacterium tuberculosis H37Rv (P9WKC7), Mycobacterium tuberculosis H37Rv (P9WKC9)
Weselake, R.J.; Madhavji, M.; Szarka, S.J.; Patterson, N.A.; Wiehler, W.B.; Nykiforuk, C.L.; Burton, T.L.; Boora, P.S.; Mosimann, S.C.; Foroud, N.A.; Thibault, B.J.; Moloney, M.M.; Laroche, A.; Furukawa-Stoffer, T.L.
Acyl-CoA-binding and self-associating properties of a recombinant 13.3 kDa N-terminal fragment of diacylglycerol acyltransferase-1 from oilseed rape
BMC Biochem.
7
24
2006
Brassica napus
Oxley, A.; Torstensen, B.E.; Rustan, A.C.; Olsen, R.E.
Enzyme activities of intestinal triacylglycerol and phosphatidylcholine biosynthesis in Atlantic salmon (Salmo salar L.)
Comp. Biochem. Physiol. B
141B
77-87
2005
Salmo salar
-
Ramli, U.S.; Salas, J.J.; Quant, P.A.; Harwood, J.L.
Metabolic control analysis reveals an important role for diacylglycerol acyltransferase in olive but not in oil palm lipid accumulation
FEBS J.
272
5764-5770
2005
Elaeis guineensis, Olea europaea
Lee, S.W.; Rho, M.C.; Park, H.R.; Choi, J.H.; Kang, J.Y.; Lee, J.W.; Kim, K.; Lee, H.S.; Kim, Y.K.
Inhibition of diacylglycerol acyltransferase by alkamides isolated from the fruits of Piper longum and Piper nigrum
J. Agric. Food Chem.
54
9759-9763
2006
Rattus norvegicus
Turkish, A.R.; Henneberry, A.L.; Cromley, D.; Padamsee, M.; Oelkers, P.; Bazzi, H.; Christiano, A.M.; Billheimer, J.T.; Sturley, S.L.
Identification of two novel human acyl-CoA wax alcohol acyltransferases: members of the diacylglycerol acyltransferase 2 (DGAT2) gene superfamily
J. Biol. Chem.
280
14755-14764
2005
Homo sapiens, Homo sapiens (Q6ZPD8), Homo sapiens (Q96PD7)
Stone, S.J.; Levin, M.C.; Farese, R.V.
Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2
J. Biol. Chem.
281
40273-40282
2006
Mus musculus
Yen, C.L.; Monetti, M.; Burri, B.J.; Farese, R.V.
The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters
J. Lipid Res.
46
1502-1511
2005
Mus musculus (Q9DCV3), Mus musculus (Q9Z2A7)
Millar, J.S.; Stone, S.J.; Tietge, U.J.; Tow, B.; Billheimer, J.T.; Wong, J.S.; Hamilton, R.L.; Farese, R.V.; Rader, D.J.
Short-term overexpression of DGAT1 or DGAT2 increases hepatic triglyceride but not VLDL triglyceride or apoB production
J. Lipid Res.
47
2297-2305
2006
Mus musculus (Q9DCV3), Mus musculus (Q9Z2A7), Mus musculus
Soerensen, B.M.; Furukawa-Stoffer, T.L.; Marshall, K.S.; Page, E.K.; Mir, Z.; Forster, R.J.; Weselake, R.J.
Storage lipid accumulation and acyltransferase action in developing flaxseed
Lipids
40
1043-1049
2005
Linum usitatissimum
Lung, S.C.; Weselake, R.J.
Diacylglycerol acyltransferase: a key mediator of plant triacylglycerol synthesis
Lipids
41
1073-1088
2006
Acinetobacter calcoaceticus, Arabidopsis thaliana, Arabidopsis thaliana (Q9SLD2), Arachis hypogaea, Brassica napus, Brassica napus (Q9XGR5), Brassica napus (Q9XGV4), Carthamus tinctorius, Ricinus communis, Ricinus communis (Q67C39), Glycine max, Umbelopsis ramanniana, Mus musculus, Mus musculus (Q9Z2A7), Olea europaea, Rattus norvegicus, Spinacia oleracea, Zea mays, Cuphea sp., Nicotiana tabacum (Q9SEG9)
He, X.; Chen, G.Q.; Lin, J.T.; McKeon, T.A.
Diacylglycerol acyltransferase activity and triacylglycerol synthesis in germinating castor seed cotyledons
Lipids
41
281-285
2006
Ricinus communis
Sirakova, T.D.; Dubey, V.S.; Deb, C.; Daniel, J.; Korotkova, T.A.; Abomoelak, B.; Kolattukudy, P.E.
Identification of a diacylglycerol acyltransferase gene involved in accumulation of triacylglycerol in Mycobacterium tuberculosis under stress
Microbiology
152
2717-2725
2006
Mycobacterium tuberculosis
Kroon, J.T.; Wei, W.; Simon, W.J.; Slabas, A.R.
Identification and functional expression of a type 2 acyl-CoA:diacylglycerol acyltransferase (DGAT2) in developing castor bean seeds which has high homology to the major triglyceride biosynthetic enzyme of fungi and animals
Phytochemistry
67
2541-2549
2006
Ricinus communis
Shockey, J.M.; Gidda, S.K.; Chapital, D.C.; Kuan, J.C.; Dhanoa, P.K.; Bland, J.M.; Rothstein, S.J.; Mullen, R.T.; Dyer, J.M.
Tung tree DGAT1 and DGAT2 have nonredundant functions in triacylglycerol biosynthesis and are localized to different subdomains of the endoplasmic reticulum
Plant Cell
18
2294-2313
2006
Vernicia fordii, Vernicia fordii (Q0QJH9), Vernicia fordii (Q0QJI1)
Saha, S.; Enugutti, B.; Rajakumari, S.; Rajasekharan, R.
Cytosolic triacylglycerol biosynthetic pathway in oilseeds. Molecular cloning and expression of peanut cytosolic diacylglycerol acyltransferase
Plant Physiol.
141
1533-1543
2006
Arachis hypogaea, Arachis hypogaea (Q2KP14), Arachis hypogaea JL 24 (Q2KP14)
Chung, M.Y.; Rho, M.C.; Lee, S.W.; Park, H.R.; Kim, K.; Lee, I.A.; Kim, D.H.; Jeune, K.H.; Lee, H.S.; Kim, Y.K.
Inhibition of diacylglycerol acyltransferase by betulinic acid from Alnus hirsuta
Planta Med.
72
267-269
2006
Homo sapiens, Rattus norvegicus
Wang, H.W.; Zhang, J.S.; Gai, J.Y.; Chen, S.Y.
Cloning and comparative analysis of the gene encoding diacylglycerol acyltransferase from wild type and cultivated soybean
Theor. Appl. Genet.
112
1086-1097
2006
Glycine max (Q5GKZ7), Glycine max
Ilaiyaraja, N.; Rajarani, A.P.; Santha, I.M.
Cloning and characterization of diacylglycerol acyltransferase (DGAT) cDNA sequence from Brassica juncea cv. Pusa Bold
Indian J. Biochem. Biophys.
45
30-36
2008
Brassica juncea (Q4U3T8), Brassica juncea (Q4U3T9)
-
Xu, J.; Francis, T.; Mietkiewska, E.; Giblin, E.M.; Barton, D.L.; Zhang, Y.; Zhang, M.; Taylor, D.C.
Cloning and characterization of an acyl-CoA-dependent diacylglycerol acyltransferase 1 (DGAT1) gene from Tropaeolum majus, and a study of the functional motifs of the DGAT protein using site-directed mutagenesis to modify enzyme activity and oil content
Plant Biotechnol. J.
6
799-818
2008
Tropaeolum majus (Q8RX96), Tropaeolum majus
Li, F.; Wu, X.; Lam, P.; Bird, D.; Zheng, H.; Samuels, L.; Jetter, R.; Kunst, L.
Identification of the wax ester synthase/acyl-coenzyme A: diacylglycerol acyltransferase WSD1 required for stem wax ester biosynthesis in Arabidopsis
Plant Physiol.
148
97-107
2008
Arabidopsis thaliana (Q93ZR6)
Dauk, M.; Lam, P.; Smith, M.
The role of diacylglycerol acyltransferase-1 and phospholipid: diacylglycerol acyltransferase-1 and -2 in the incorporation of hydroxy fatty acids into triacylglycerol in Arabidopsis thaliana expressing a castor bean oleate 12-hydroxylase gene
Botany
87
552-560
2009
Arabidopsis thaliana
-
Mavraganis, I.; Meesapyodsuk, D.; Vrinten, P.; Smith, M.; Qiu, X.
Type II diacylglycerol acyltransferase from Claviceps purpurea with ricinoleic acid, a hydroxyl fatty acid of industrial importance, as preferred substrate
Appl. Environ. Microbiol.
76
1135-1142
2010
Claviceps purpurea
Oh, W.K.; Lee, C.; Seo, J.H.; Chung, M.Y.; Cui, L.; Fomum, Z.T.; Kang, J.S.; Lee, H.S.
Diacylglycerol acyltransferase-inhibitory compounds from Erythrina senegalensis
Arch. Pharm. Res.
32
43-47
2009
Rattus norvegicus
Talhari, D.T.; Moraes, M.L.; Castilho, P.V.; Oliveira, O.N.; Beltramini, L.M.; Araujo, A.P.
Interaction of a C-terminal peptide of Bos taurus diacylglycerol acyltransferase 1 with model membranes
Biochim. Biophys. Acta
1788
2320-2325
2009
Bos taurus (Q8MK44), Bos taurus
Stveken, T.; Kalscheuer, R.; Steinbchel, A.
Both histidine residues of the conserved HHXXXDG motif are essential for wax ester synthase/acyl-CoA:diacylglycerol acyltransferase catalysis
Eur. J. Lipid Sci. Technol.
111
112-119
2009
Acinetobacter baylyi
-
Villanueva, C.J.; Monetti, M.; Shih, M.; Zhou, P.; Watkins, S.M.; Bhanot, S.; Farese, R.V.
Specific role for acyl CoA:diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids
Hepatology
50
434-442
2009
Mus musculus
Park, H.R.; Yoo, M.Y.; Seo, J.H.; Kim, I.S.; Kim, N.Y.; Kang, J.Y.; Cui, L.; Lee, C.S.; Lee, C.H.; Lee, H.S.
Sesquiterpenoids isolated from the flower buds of Tussilago farfara L. inhibit diacylglycerol acyltransferase
J. Agric. Food Chem.
56
10493-10497
2008
Homo sapiens, Rattus norvegicus
Inokoshi, J.; Kawamoto, K.; Takagi, Y.; Matsuhama, M.; Omura, S.; Tomoda, H.
Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes
J. Antibiot.
62
51-54
2009
Homo sapiens (O75907), Homo sapiens (Q96PD7), Homo sapiens
Cheng, D.; Iqbal, J.; Devenny, J.; Chu, C.H.; Chen, L.; Dong, J.; Seethala, R.; Keim, W.J.; Azzara, A.V.; Lawrence, R.M.; Pelleymounter, M.A.; Hussain, M.M.
Acylation of acylglycerols by acyl coenzyme A:diacylglycerol acyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption
J. Biol. Chem.
283
29802-29811
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Conte, G.; Mele, M.; Chessa, S.; Castiglioni, B.; Serra, A.; Pagnacco, G.; Secchiari, P.
Diacylglycerol acyltransferase 1, stearoyl-CoA desaturase 1, and sterol regulatory element binding protein 1 gene polymorphisms and milk fatty acid composition in Italian Brown cattle
J. Dairy Sci.
93
753-763
2010
Bos taurus (Q8MK44), Bos taurus
Lee, S.W.; Rho, M.C.; Choi, J.H.; Kim, K.; Choi, Y.S.; Lee, H.S.; Kim, Y.K.
Inhibition of diacylglycerol acyltransferase by phenylpyropenes produced by Penicillium griseofulvum F1959
J. Microbiol. Biotechnol.
18
1785-1788
2008
Rattus norvegicus
Manas-Fernandez, A.; Vilches-Ferron, M.; Garrido-Cardenas, J.A.; Belarbi, E.H.; Alonso, D.L.; Garcia-Maroto, F.
Cloning and molecular characterization of the acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) gene from Echium
Lipids
44
555-568
2009
Echium pitardii
Hou, X.G.; Moser, S.; Sarr, M.G.; Thompson, G.B.; Que, F.G.; Jensen, M.D.
Visceral and subcutaneous adipose tissue diacylglycerol acyltransferase activity in humans
Obesity (Silver Spring)
17
1129-1134
2009
Homo sapiens
Yu, K.; Li, R.; Hatanaka, T.; Hildebrand, D.
Cloning and functional analysis of two type 1 diacylglycerol acyltransferases from Vernonia galamensis
Phytochemistry
69
1119-1127
2008
Vernonia galamensis (B1NM15), Vernonia galamensis (B1NM16), Vernonia galamensis
Siloto, R.M.; Truksa, M.; Brownfield, D.; Good, A.G.; Weselake, R.J.
Directed evolution of acyl-CoA:diacylglycerol acyltransferase: development and characterization of Brassica napus DGAT1 mutagenized libraries
Plant Physiol. Biochem.
47
456-461
2009
Brassica napus
Kamisaka, Y.; Kimura, K.; Uemura, H.; Shibakami, M.
Activation of diacylglycerol acyltransferase expressed in Saccharomyces cerevisiae: overexpression of Dga1p lacking the N-terminal region in the Deltasnf2 disruptant produces a significant increase in its enzyme activity
Appl. Microbiol. Biotechnol.
88
105-115
2010
Saccharomyces cerevisiae (Q08650), Saccharomyces cerevisiae
Beopoulos, A.; Haddouche, R.; Kabran, P.; Dulermo, T.; Chardot, T.; Nicaud, J.M.
Identification and characterization of DGA2, an acyltransferase of the DGAT1 acyl-CoA:diacylglycerol acyltransferase family in the oleaginous yeast Yarrowia lipolytica. New insights into the storage lipid metabolism of oleaginous yeasts
Appl. Microbiol. Biotechnol.
93
1523-1537
2012
Yarrowia lipolytica (Q6C9V5), Yarrowia lipolytica
Mougenot, P.; Namane, C.; Fett, E.; Camy, F.; Dadji-Faihun, R.; Langot, G.; Monseau, C.; Onofri, B.; Pacquet, F.; Pascal, C.; Crespin, O.; Ben-Hassine, M.; Ragot, J.L.; Van-Pham, T.; Philippo, C.; Chatelain-Egger, F.; Peron, P.; Le Bail, J.C.; Guillot, E.; Chamiot-Clerc, P.; Chabanaud, M.A.; Pruniaux, M.-P.; Schmidt, F.; Venier, O.; Nicolai, E.; Viviani, F.
Thiadiazoles as new inhibitors of diacylglycerol acyltransferase type 1
Bioorg. Med. Chem. Lett.
22
2497-2502
2012
Homo sapiens
Ramli, U.S.; Salas, J.J.; Quant, P.A.; Harwood, J.L.
Metabolic control analysis reveals an important role for diacylglycerol acyltransferase in olive but not in oil palm lipid accumulation
FEBS J.
272
5764-5570
2005
Elaeis guineensis, Olea europaea
Wurie, H.R.; Buckett, L.; Zammit, V.A.
Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides and de novo synthesized fatty acids in HepG2 cells
FEBS J.
279
3033-3047
2012
Homo sapiens (O75907), Homo sapiens (Q96PD7), Homo sapiens
Lee, S.W.; Rho, M.C.; Park, H.R.; Choi, J.H.; Kang, J.Y.; Lee, J.W.; Kim, K.; Lee, H.S.; Kim, Y.K.
Inhibition of diacylglycerol acyltransferase by alkamides isolated from the fruits of Piper longum and Piper nigrum
J. Agric. Food Chem.
54
9759-9763
2006
Rattus norvegicus
Liu, Q.; Siloto, R.M.; Snyder, C.L.; Weselake, R.J.
Functional and topological analysis of yeast acyl-CoA:diacylglycerol acyltransferase 2, an endoplasmic reticulum enzyme essential for triacylglycerol biosynthesis
J. Biol. Chem.
286
13115-13126
2011
Saccharomyces cerevisiae (Q08650), Saccharomyces cerevisiae
McFie, P.J.; Banman, S.L.; Kary, S.; Stone, S.J.
Murine diacylglycerol acyltransferase-2 (DGAT2) can catalyze triacylglycerol synthesis and promote lipid droplet formation independent of its localization to the endoplasmic reticulum
J. Biol. Chem.
286
28235-28246
2011
Mus musculus (Q9DCV3), Mus musculus
Hiramine, Y.; Tanabe, T.
Characterization of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) enzyme of human small intestine
J. Physiol. Biochem.
67
259-264
2011
Homo sapiens
Elamin, A.A.; Stehr, M.; Spallek, R.; Rohde, M.; Singh, M.
The Mycobacterium tuberculosis Ag85A is a novel diacylglycerol acyltransferase involved in lipid body formation
Mol. Microbiol.
81
1577-1592
2011
Mycobacterium tuberculosis (P9WQP3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WQP3)
Zhang, H.; Damude, H.G.; Yadav, N.S.
Three diacylglycerol acyltransferases contribute to oil biosynthesis and normal growth in Yarrowia lipolytica
Yeast
29
25-38
2012
Yarrowia lipolytica (Q6C3R2), Yarrowia lipolytica (Q6C9V5), Yarrowia lipolytica, Yarrowia lipolytica ATCC 20362 (Q6C3R2), Yarrowia lipolytica ATCC 20362 (Q6C9V5)
Chen, Z.; Liu, P.; Liu, Y.; Tang, H.; Chen, Y.; Zhang, L.
Identification and characterization of a type-2 diacylglycerol acyltransferase (DGAT2) from Rhodosporidium diobovatum
Antonie van Leeuwenhoek
106
1127-1137
2014
Rhodotorula diobovata, Rhodotorula diobovata MCCC 2A00023
Villa, J.A.; Cabezas, M.; de la Cruz, F.; Moncalian, G.
Use of limited proteolysis and mutagenesis to identify folding domains and sequence motifs critical for wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase activity
Appl. Environ. Microbiol.
80
1132-1141
2014
Marinobacter nauticus
Kamisaka, Y.; Kimura, K.; Uemura, H.; Yamaoka, M.
Overexpression of the active diacylglycerol acyltransferase variant transforms Saccharomyces cerevisiae into an oleaginous yeast
Appl. Microbiol. Biotechnol.
97
7345-7355
2013
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Greer, M.S.; Truksa, M.; Deng, W.; Lung, S.C.; Chen, G.; Weselake, R.J.
Engineering increased triacylglycerol accumulation in Saccharomyces cerevisiae using a modified type 1 plant diacylglycerol acyltransferase
Appl. Microbiol. Biotechnol.
99
2243-2253
2015
Brassica napus (K9LL63), Brassica napus
Li, C.; Li, L.; Lian, J.; Watts, R.; Nelson, R.; Goodwin, B.; Lehner, R.
Roles of acyl-CoA:diacylglycerol acyltransferases 1 and 2 in triacylglycerol synthesis and secretion in primary hepatocytes
Arterioscler. Thromb. Vasc. Biol.
35
1080-1091
2015
Mus musculus
McFie, P.J.; Jin, Y.; Banman, S.L.; Beauchamp, E.; Berthiaume, L.G.; Stone, S.J.
Characterization of the interaction of diacylglycerol acyltransferase-2 with the endoplasmic reticulum and lipid droplets
Biochim. Biophys. Acta
1841
1318-1328
2014
Mus musculus
Kim, M.O.; Lee, S.; Choi, K.; Lee, S.; Kim, H.; Kang, H.; Choi, M.; Kwon, E.B.; Kang, M.J.; Kim, S.; Lee, H.J.; Lee, H.S.; Kwak, Y.S.; Cho, S.
Discovery of a novel class of diacylglycerol acyltransferase 2 inhibitors with a 1H-pyrrolo[2,3-b]pyridine core
Biol. Pharm. Bull.
37
1655-1660
2014
Homo sapiens
Nakajima, K.; April, M.; Brewer, J.T.; Daniels, T.; Forster, C.J.; Gilmore, T.A.; Jain, M.; Kanter, A.; Kwak, Y.; Li, J.; McQuire, L.; Serrano-Wu, M.H.; Streeper, R.; Szklennik, P.; Thompson, J.; Wang, B.
Discovery of diamide compounds as diacylglycerol acyltransferase 1 (DGAT1) inhibitors
Bioorg. Med. Chem. Lett.
26
1245-1248
2016
Homo sapiens
Mougenot, P.; Namane, C.; Fett, E.; Goumy, F.; Dadji-Faihun, R.; Langot, G.; Monseau, C.; Onofri, B.; Pacquet, F.; Pascal, C.; Crespin, O.; Ben-Hassine, M.; Ragot, J.L.; Van-Pham, T.; Philippo, C.; Chatelain-Egger, F.; Peron, P.; Le Bail, J.C.; Guillot, E.; Chamiot-Clerc, P.; Chabanaud, M.A.; Pruniaux, M.-P.
Synthesis and multiparametric evaluation of thiadiazoles and oxadiazoles as diacylglycerol acyltransferase type 1 inhibitors
Bioorg. Med. Chem. Lett.
26
25-32
2016
Homo sapiens
Hung, C.H.; Ho, M.Y.; Kanehara, K.; Nakamura, Y.
Functional study of diacylglycerol acyltransferase type 2 family in Chlamydomonas reinhardtii
FEBS Lett.
587
2364-2370
2013
Chlamydomonas reinhardtii (R9YW17)
Zhou, X.R.; Shrestha, P.; Yin, F.; Petrie, J.R.; Singh, S.P.
AtDGAT2 is a functional acyl-CoA:diacylglycerol acyltransferase and displays different acyl-CoA substrate preferences than AtDGAT1
FEBS Lett.
587
2371-2376
2013
Arabidopsis thaliana
Caldo, K.M.; Greer, M.S.; Chen, G.; Lemieux, M.J.; Weselake, R.J.
Purification and properties of recombinant Brassica napus diacylglycerol acyltransferase 1
FEBS Lett.
589
773-778
2015
Brassica napus (K9LLA9), Brassica napus
Jin, H.H.; Jiang, J.G.
Phosphatidic acid phosphatase and diacylglycerol acyltransferase: potential targets for metabolic engineering of microorganism oil
J. Agric. Food Chem.
63
3067-3077
2015
Umbelopsis ramanniana
Arroyo-Caro, J.M.; Manas-Fernandez, A.; Alonso, D.L.; Garcia-Maroto, F.
Type I diacylglycerol acyltransferase (MtDGAT1) from Macadamia tetraphylla: cloning, characterization, and impact of its heterologous expression on triacylglycerol composition in yeast
J. Agric. Food Chem.
64
277-285
2016
Macadamia tetraphylla (A0A0U3E0G8), Macadamia tetraphylla
Cui, Y.; Zheng, G.; Li, X.; Lin, H.; Jiang, P.; Qin, S.
Cloning and characterization of a novel diacylglycerol acyltransferase from the diatom Phaeodactylum tricornutum
J. Appl. Phycol.
25
1509-1512
2013
Phaeodactylum tricornutum
-
Chungjatupornchai, W.; Watcharawipas, A.
Diacylglycerol acyltransferase type 2 cDNA from the oleaginous microalga Neochloris oleoabundans: cloning and functional characterization
J. Appl. Phycol.
27
1499-1507
2015
Ettlia oleoabundans (A0A096XN58), Ettlia oleoabundans UTEX 1185 (A0A096XN58)
-
Jin, Y.; McFie, P.J.; Banman, S.L.; Brandt, C.; Stone, S.J.
Diacylglycerol acyltransferase-2 (DGAT2) and monoacylglycerol acyltransferase-2 (MGAT2) interact to promote triacylglycerol synthesis
J. Biol. Chem.
289
28237-28248
2014
Homo sapiens
Pan, X.; Chen, G.; Kazachkov, M.; Greer, M.S.; Caldo, K.M.; Zou, J.; Weselake, R.J.
In vivo and in vitro evidence for biochemical coupling of reactions catalyzed by lysophosphatidylcholine acyltransferase and diacylglycerol acyltransferase
J. Biol. Chem.
290
18068-18078
2015
Linum usitatissimum
Zhang, C.; Iskandarov, U.; Klotz, E.T.; Stevens, R.L.; Cahoon, R.E.; Nazarenus, T.J.; Pereira, S.L.; Cahoon, E.B.
A thraustochytrid diacylglycerol acyltransferase 2 with broad substrate specificity strongly increases oleic acid content in engineered Arabidopsis thaliana seeds
J. Exp. Bot.
64
3189-3200
2013
Thraustochytrium aureum (R9QY77), Thraustochytrium aureum, Thraustochytrium aureum ATCC 34304 (R9QY77)
Li, M.; Zhao, M.; Wu, H.; Wu, W.; Xu, Y.
Cloning, characterization and functional analysis of two type 1 diacylglycerol acyltransferases (DGAT1s) from Tetraena mongolica
J. Integr. Plant Biol.
55
490-503
2013
Tetraena mongolica (M4SZU3), Tetraena mongolica
Ahmad, I.; Sharma, A.K.; Daniell, H.; Kumar, S.
Altered lipid composition and enhanced lipid production in green microalga by introduction of Brassica diacylglycerol acyltransferase 2
Plant Biotechnol. J.
13
540-550
2015
Brassica napus (Q9XGV4), Brassica napus
Seo, J.H.; Kim, M.O.; Han, A.R.; Kwon, E.B.; Kang, M.J.; Cho, S.; Moon, D.O.; Noh, J.R.; Lee, C.H.; Kim, Y.S.; Lee, H.S.
Oleanane-type triterpenoids of Aceriphyllum rossii and their diacylglycerol acyltransferase-inhibitory activity
Planta Med.
81
228-234
2015
Homo sapiens
Kaylor, J.J.; Radu, R.A.; Bischoff, N.; Makshanoff, J.; Hu, J.; Lloyd, M.; Eddington, S.; Bianconi, T.; Bok, D.; Travis, G.H.
Diacylglycerol O-acyltransferase type-1 synthesizes retinyl esters in the retina and retinal pigment epithelium
PLoS ONE
10
e0125921
2015
Mus musculus
Peng, Z.; Li, L.; Yang, L.; Zhang, B.; Chen, G.; Bi, Y.
Overexpression of peanut diacylglycerol acyltransferase 2 in Escherichia coli
PLoS ONE
8
e61363
2013
Arachis hypogaea (G3GD57), Arachis hypogaea (G3GD58), Arachis hypogaea
Ayme, L.; Baud, S.; Dubreucq, B.; Joffre, F.; Chardot, T.
Function and localization of the Arabidopsis thaliana diacylglycerol acyltransferase DGAT2 expressed in yeast
PLoS ONE
9
e92237
2014
Arabidopsis thaliana
Dey, P.; Chakraborty, M.; Kamdar, M.R.; Maiti, M.K.
Functional characterization of two structurally novel diacylglycerol acyltransferase2 isozymes responsible for the enhanced production of stearate-rich storage lipid in Candida tropicalis SY005
PLoS ONE
9
e94472
2014
Candida tropicalis (A0A023PJY4), Candida tropicalis (A0A023PKP7), Candida tropicalis, Candida tropicalis SY005 (A0A023PJY4), Candida tropicalis SY005 (A0A023PKP7), Candida tropicalis SY005
Wang, Z.; Zhang, H.; Zhao, L.; Song, Y.
Identification and characterization of diacylglycerol acyltransferase in oleaginous yeast Rhodosporidium toruloides
Am. J. Biochem. Biotechnol.
12
230-240
2016
Rhodotorula toruloides (A0A2Z6EYT1), Rhodotorula toruloides (A0A511K7D9), Rhodotorula toruloides CGMCC 2.1389 (A0A2Z6EYT1), Rhodotorula toruloides CGMCC 2.1389 (A0A511K7D9)
-
Roettig, A.; Strittmatter, C.S.; Schauer, J.; Hiessl, S.; Poehlein, A.; Daniel, R.; Steinbuechel, A.
Role of wax ester synthase/acyl coenzyme A diacylglycerol acyltransferase in oleaginous Streptomyces sp. strain G25
Appl. Environ. Microbiol.
82
5969-5981
2016
Streptomyces sp. G25
Zhang, N.; Mao, Z.; Luo, L.; Wan, X.; Huang, F.; Gong, Y.
Two bifunctional enzymes from the marine protist Thraustochytrium roseum biochemical characterization of wax ester synthase/acyl-CoA diacylglycerol acyltransferase activity catalyzing wax ester and triacylglycerol synthesis
Biotechnol. Biofuels
10
185
2017
Thraustochytrium roseum (A0A1Z2RWY4), Thraustochytrium roseum (A0A3G1ICG7), Thraustochytrium roseum
Cui, Y.; Zhao, J.; Wang, Y.; Qin, S.; Lu, Y.
Characterization and engineering of a dual-function diacylglycerol acyltransferase in the oleaginous marine diatom Phaeodactylum tricornutum
Biotechnol. Biofuels
11
32
2018
Phaeodactylum tricornutum, Phaeodactylum tricornutum (G4WK06), Phaeodactylum tricornutum (I6QM80)
Luo, X.A.; Zhu, Y.M.; Liu, T.T.; Wang, X.P.; Zhou, P.P.; Bao, Z.D.; Yu, L.J.
Identification and characterization of a novel diacylglycerol acyltransferase gene from Mortierella alpina
Biotechnol. Lett.
39
883-888
2017
Mortierella alpina (A0A1S6XXG5), Mortierella alpina, Mortierella alpina M30 (A0A1S6XXG5)
Zienkiewicz, K.; Benning, U.; Siegler, H.; Feussner, I.
The type 2 acyl-CoA diacylglycerol acyltransferase family of the oleaginous microalga Lobosphaera incisa
BMC Plant Biol.
18
298
2018
Lobosphaera incisa (A0A2H4UKL3), Lobosphaera incisa (A0A386RTI5), Lobosphaera incisa (A0A386RU68), Lobosphaera incisa (A0A3Q8PZB6), Lobosphaera incisa, Lobosphaera incisa SAG 2468 (A0A2H4UKL3), Lobosphaera incisa SAG 2468 (A0A386RTI5), Lobosphaera incisa SAG 2468 (A0A386RU68), Lobosphaera incisa SAG 2468 (A0A3Q8PZB6)
Li, D.; Yin, J.; Li, J.; Nan, F.
Design and synthesis of diacylglycerol acyltransferase 1 inhibitors based on Aphadilactone C
Chinese J. Org. Chem.
36
1359-1367
2016
Homo sapiens (O75907)
-
Tschapalda, K.; Zhang, Y.Q.; Liu, L.; Golovnina, K.; Schlemper, T.; Eichmann, T.O.; Lal-Nag, M.; Sreenivasan, U.; McLenithan, J.; Ziegler, S.; Sztalryd, C.; Lass, A.; Auld, D.; Oliver, B.; Waldmann, H.; Li, Z.; Shen, M.; Boxer, M.B.; Beller, M.
A class of diacylglycerol acyltransferase 1 inhibitors identified by a combination of phenotypic high-throughput screening, genomics, and genetics
EBioMedicine
8
49-59
2016
Homo sapiens
Gajdos, P.; Ledesma-Amaro, R.; Nicaud, J.M.; Certik, M.; Rossignol, T.
Overexpression of diacylglycerol acyltransferase in Yarrowia lipolytica affects lipid body size, number and distribution
FEMS Yeast Res.
16
fow062
2016
Yarrowia lipolytica (A0A1H6PYY9), Yarrowia lipolytica (Q6C9V5), Yarrowia lipolytica, Yarrowia lipolytica CLIB 122 (Q6C9V5), Yarrowia lipolytica E 150 (Q6C9V5)
Zheng, Y.; Jin, Y.; Yuan, Y.; Feng, D.; Chen, L.; Li, D.; Zhou, P.
Identification and function analysis of a type 2 diacylglycerol acyltransferase (DGAT2) from the endosperm of coconut (Cocos nucifera L.)
Gene
702
75-82
2019
Cocos nucifera
Turchetto-Zolet, A.; Christoff, A.; Kulcheski, F.; Loss-Morais, G.; Margis, R.; Margis-Pinheiro, M.
Diversity and evolution of plant diacylglycerol acyltransferase (DGATs) unveiled by phylogenetic, gene structure and expression analyses
Genet. Mol. Biol.
39
524-538
2016
Glycine max (I1L4P1), Glycine max (I1MRZ6), Glycine max (K7LZ65), Arabidopsis thaliana (Q93ZR6), Arabidopsis thaliana (Q9C5W0)
Arroyo-Caro, J.A
; Manas-Fernandez, A.; Alonso, D.L.; Garcia-Maroto, F. Type I diacylglycerol acyltransferase (MtDGAT1) from Macadamia tetraphylla cloning, characterization, and impact of Its heterologous expression on triacylglycerol composition in yeast
J. Agric. Food Chem.
64
277-285
2016
Macadamia tetraphylla (A0A0U3E0G8), Macadamia tetraphylla
Hatanaka, T.; Serson, W.; Li, R.; Armstrong, P.; Yu, K.; Pfeiffer, T.; Li, X.L.; Hildebrand, D.
A Vernonia diacylglycerol acyltransferase can increase renewable oil production
J. Agric. Food Chem.
64
7188-7194
2016
Vernonia galamensis (B1NM15), Vernonia galamensis (B1NM16), Vernonia galamensis, Glycine max (I1MSF2), Glycine max (Q5GKZ7), Glycine max, Arabidopsis thaliana (Q9SLD2), Euphorbia lagascae (T2HV99)
Xu, Y.; Falarz, L.; Chen, G.
Characterization of type-2 diacylglycerol acyltransferases in the green microalga Chromochloris zofingiensis
J. Agric. Food Chem.
67
291-298
2019
Chromochloris zofingiensis, Chromochloris zofingiensis (A0A411PNH6), Chromochloris zofingiensis (A0A411PNL0)
Xu, Y.; Chen, G.; Greer, M.S.; Caldo, K.M.P.; Ramakrishnan, G.; Shah, S.; Wu, L.; Lemieux, M.J.; Ozga, J.; Weselake, R.J.
Multiple mechanisms contribute to increased neutral lipid accumulation in yeast producing recombinant variants of plant diacylglycerol acyltransferase 1
J. Biol. Chem.
292
17819-17831
2017
Camelina sativa (A0A1S6PTV7), Camelina sativa, Brassica napus (Q9M4V2), Brassica napus
Li, D.W.; Cen, S.Y.; Liu, Y.H.; Balamurugan, S.; Zheng, X.Y.; Alimujiang, A.; Yang, W.D.; Liu, J.S.; Li, H.Y.
A type 2 diacylglycerol acyltransferase accelerates the triacylglycerol biosynthesis in heterokont oleaginous microalga Nannochloropsis oceanica
J. Biotechnol.
229
65-71
2016
Nannochloropsis oceanica (A0A191M6B9), Nannochloropsis oceanica, Nannochloropsis oceanica CCAP 849/10 (A0A191M6B9)
Jeennor, S.; Veerana, M.; Anantayanon, J.; Panchanawaporn, S.; Chutrakul, C.; Laoteng, K.
Diacylglycerol acyltransferase 2 of Mortierella alpina with specificity on long-chain polyunsaturated fatty acids a potential tool for reconstituting lipids with nutritional value
J. Biotechnol.
263
45-51
2017
Mortierella alpina (A0A2D2CI94), Mortierella alpina (KY859195), Mortierella alpina, Mortierella alpina ATCC 32222 (A0A2D2CI94)
Hong, D.J.; Jung, S.H.; Kim, J.; Jung, D.; Ahn, Y.G.; Suh, K.H.; Min, K.H.
Synthesis and biological evaluation of novel thienopyrimidine derivatives as diacylglycerol acyltransferase 1 (DGAT-1) inhibitors
J. Enzyme Inhib. Med. Chem.
35
227-234
2020
Canis lupus familiaris (E2RDN4), Canis lupus familiaris, Homo sapiens (O75907), Mus musculus (Q9Z2A7), Mus musculus, Rattus norvegicus (Q9ERM3)
Greer, M.S.; Pan, X.; Weselake, R.J.
Two clades of type-1 Brassica napus diacylglycerol acyltransferase exhibit differences in acyl-CoA preference
Lipids
51
781-786
2016
Brassica napus (K9LMJ4), Brassica napus (Q9M4V2), Brassica napus
Xu, Y.; Caldo, K.M.P.; Pal-Nath, D.; Ozga, J.; Lemieux, M.J.; Weselake, R.J.; Chen, G.
Properties and biotechnological applications of acyl-CoA diacylglycerol acyltransferase and phospholipid diacylglycerol acyltransferase from terrestrial plants and microalgae
Lipids
53
663-688
2018
Arabidopsis thaliana, Arabidopsis thaliana (Q9ASU1), Arabidopsis thaliana (Q9C5W0), Arabidopsis thaliana (Q9SLD2), Arachis hypogaea, Arachis hypogaea (A0A0M3SGK9), Arachis hypogaea (Q2KP14), Chlamydomonas reinhardtii, Linum usitatissimum, Linum usitatissimum (V5LV83), Linum usitatissimum (V5LV86), Nicotiana tabacum, Nicotiana tabacum (Q9SEG9), Phaeodactylum tricornutum, Tropaeolum majus, Tropaeolum majus (Q8RX96), Triadica sebifera, Boechera stricta, Cuphea avigera var. pulcherrima (A0A193DVK9), Cuphea avigera (A0A193DVK9), Ricinus communis (A1A442), Ricinus communis (Q67C39), Zea mays (B0LF77), Echium pitardii (D9U3F8), Glycine max (I1MSF2), Glycine max (Q5GKZ7), Brassica napus (K9LL63), Brassica napus (Q9XGR5), Brassica napus (Q9XGV4), Sesamum indicum (M1E7W9), Vernicia fordii (Q0QJH9), Vernicia fordii (Q0QJI1), Euonymus alatus (Q5UEM2), Olea europaea (Q6ED63), Umbelopsis ramanniana (Q96UY1), Umbelopsis ramanniana (Q96UY2), Caenorhabditis elegans (Q9XUW0), Mus musculus (Q9Z2A7), Thraustochytrium aureum (R9QY77)
Nguyen, T.; Xu, Y.; Abdel-Hameed, M.; Sorensen, J.L.; Singer, S.D.; Chen, G.
Characterization of a type-2 diacylglycerol acyltransferase from Haematococcus pluvialis reveals possible allostery of the recombinant enzyme
Lipids
55
425-433
2020
Haematococcus lacustris (A0A699ZU33), Haematococcus lacustris, Haematococcus lacustris UTEX 2505 (A0A699ZU33)
Klaitong, P.; Fa-Aroonsawat, S.; Chungjatupornchai, W.
Accelerated triacylglycerol production and altered fatty acid composition in oleaginous microalga Neochloris oleoabundans by overexpression of diacylglycerol acyltransferase 2
Microb. Cell Fact.
16
61
2017
Ettlia oleoabundans (A0A096XN58), Ettlia oleoabundans, Ettlia oleoabundans UTEX 1185 (A0A096XN58)
Chhikara, S.; Abdullah, H.M.; Akbari, P.; Schnell, D.; Dhankher, O.P.
Engineering Camelina sativa (L.) Crantz for enhanced oil and seed yields by combining diacylglycerol acyltransferase1 and glycerol-3-phosphate dehydrogenase expression
Plant Biotechnol. J.
16
1034-1045
2018
Arabidopsis thaliana (Q9SLD2), Arabidopsis thaliana
Liu, D.; Ji, H.; Yang, Z.
Functional characterization of three novel genes encoding diacylglycerol acyltransferase (DGAT) from oil-rich tubers of Cyperus esculentus
Plant Cell Physiol.
61
118-129
2020
Cyperus esculentus
Xu, Y.; Caldo, K.M.P.; Falarz, L.; Jayawardhane, K.; Chen, G.
Kinetic improvement of an algal diacylglycerol acyltransferase 1 via fusion with an acyl-CoA binding protein
Plant J.
102
856-871
2020
Chromochloris zofingiensis (A0A411PNL0), Chromochloris zofingiensis
Liu, J.; Han, D.; Yoon, K.; Hu, Q.; Li, Y.
Characterization of type 2 diacylglycerol acyltransferases in Chlamydomonas reinhardtii reveals their distinct substrate specificities and functions in triacylglycerol biosynthesis
Plant J.
86
3-19
2016
Chlamydomonas reinhardtii (A8INZ7), Chlamydomonas reinhardtii (A8J110), Chlamydomonas reinhardtii (H6V962), Chlamydomonas reinhardtii
Caldo, K.M.P.; Shen, W.; Xu, Y.; Hanley-Bowdoin, L.; Chen, G.; Weselake, R.J.; Lemieux, M.J.
Diacylglycerol acyltransferase 1 is activated by phosphatidate and inhibited by SnRK1-catalyzed phosphorylation
Plant J.
96
287-299
2018
Brassica napus (Q9XGR5), Brassica napus
Chellamuthu, M.; Kumaresan, K.; Subramanian, S.; Muthumanickam, H.
Functional analysis of sesame diacylglycerol acyltransferase and phospholipid diacylglycerol acyltransferase genes using in silico and in vitro approaches
Plant Mol. Biol. Rep.
37
146-156
2019
Sesamum indicum (M1E7W9), Sesamum indicum (XP_011098009)
-
Roesler, K.; Shen, B.; Bermudez, E.; Li, C.; Hunt, J.; Damude, H.G.; Ripp, K.G.; Everard, J.D.; Booth, J.R.; Castaneda, L.; Feng, L.; Meyer, K.
An improved variant of soybean type 1 diacylglycerol acyltransferase increases the oil content and decreases the soluble carbohydrate content of soybeans
Plant Physiol.
171
878-893
2016
Corylus americana (A0A161IUT7), Corylus americana, Glycine max (I1MSF2), Glycine max
Iskandarov, U.; Silva, J.E.; Kim, H.J.; Andersson, M.; Cahoon, R.E.; Mockaitis, K.; Cahoon, E.B.
A specialized diacylglycerol acyltransferase contributes to the extreme medium-chain fatty acid content of Cuphea seed oil
Plant Physiol.
174
97-109
2017
Cuphea avigera (A0A193DVK9)
Caldo, K.M.P.; Acedo, J.Z.; Panigrahi, R.; Vederas, J.C.; Weselake, R.J.; Lemieux, M.J.
Diacylglycerol acyltransferase 1 is regulated by Its N-terminal domain in response to allosteric effectors
Plant Physiol.
175
667-680
2017
Brassica napus (K9LL63), Brassica napus
Tan, W.J.; Yang, Y.C.; Zhou, Y.; Huang, L.P.; Xu, L.; Chen, Q.F.; Yu, L.J.; Xiao, S.
Diacylglycerol acyltransferase and diacylglycerol kinase modulate triacylglycerol and phosphatidic acid production in the plant response to freezing stress
Plant Physiol.
177
1303-1318
2018
Arabidopsis thaliana (Q9SLD2), Arabidopsis thaliana Col-0 (Q9SLD2)
Arisz, S.A.; Heo, J.Y.; Koevoets, I.T.; Zhao, T.; van Egmond, P.; Meyer, A.J.; Zeng, W.; Niu, X.; Wang, B.; Mitchell-Olds, T.; Schranz, M.E.; Testerink, C.
Diacylglycerol acyltransferase1 contributes to freezing tolerance
Plant Physiol.
177
1410-1424
2018
Boechera stricta
Haili, N.; Louap, J.; Canonge, M.; Jagic, F.; Louis-Mondesir, C.; Chardot, T.; Briozzo, P.
Expression of soluble forms of yeast diacylglycerol acyltransferase 2 that integrate a broad range of saturated fatty acids in triacylglycerols
PLoS ONE
11
e0165431
2016
Yarrowia lipolytica (Q6C3R2), Yarrowia lipolytica, Yarrowia lipolytica CLIB 122 (Q6C3R2), Yarrowia lipolytica E 150 (Q6C3R2)
Lazaro, B.; Villa, J.A.; Santin, O.; Cabezas, M.; Milagre, C.D.F.; de la Cruz, F.; Moncalian, G.
Heterologous expression of a thermophilic diacylglycerol acyltransferase triggers triglyceride accumulation in Escherichia coli
PLoS ONE
12
e0176520
2017
Thermomonospora curvata (D1AD40), Thermomonospora curvata, Thermomonospora curvata DSM 43183 (D1AD40)
Brandt, C.; McFie, P.J.; Vu, H.; Chumala, P.; Katselis, G.S.; Stone, S.J.
Identification of calnexin as a diacylglycerol acyltransferase-2 interacting protein
PLoS ONE
14
e0210396
2019
Mus musculus (Q9DCV3), Mus musculus
Chen, B.; Wang, J.; Zhang, G.; Liu, J.; Manan, S.; Hu, H.; Zhao, J.
Two types of soybean diacylglycerol acyltransferases are differentially involved in triacylglycerol biosynthesis and response to environmental stresses and hormones
Sci. Rep.
6
28541
2016
Glycine max (K7K424), Glycine max (Q5GKZ7), Glycine max
Panigrahi, R.; Matsui, T.; Song, A.H.; Caldo, K.M.P.; Young, H.S.; Weselake, R.J.; Lemieux, M.J.
Intrinsic disorder in the regulatory N-terminal domain of diacylglycerol acyltransferase 1 from Brassica napus
Sci. Rep.
8
16665
2018
Brassica napus (K9LL63), Brassica napus
Roe, N.D.; Handzlik, M.K.; Li, T.; Tian, R.
The role of diacylglycerol acyltransferase (DGAT) 1 and 2 in cardiac metabolism and function
Sci. Rep.
8
4983
2018
Mus musculus (Q9DCV3), Mus musculus (Q9Z2A7), Mus musculus
Rastogi, S.; Singh, A.K.; Chandra, G.; Kushwaha, P.; Pant, G.; Singh, K.; Mitra, K.; Sashidhara, K.V.; Krishnan, M.Y.
The diacylglycerol acyltransferase Rv3371 of Mycobacterium tuberculosis is required for growth arrest and involved in stress-induced cell wall alterations
Tuberculosis
104
8-19
2017
Mycobacterium tuberculosis (P9WKA9), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKA9), Mycobacterium tuberculosis ATCC 25618 (P9WKA9)
html completed