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Information on EC 2.3.1.191 - UDP-3-O-(3-hydroxyacyl)glucosamine N-acyltransferase

for references in articles please use BRENDA:EC2.3.1.191
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EC Tree
IUBMB Comments
The enzyme catalyses a step of lipid A biosynthesis. LpxD from Escherichia coli prefers (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] , but it does not have an absolute specificity for 14-carbon hydroxy fatty acids, as it can transfer other fatty acids, including odd-chain fatty acids, if they are available to the organism .
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
eclpxd, lpxd1, lpxd2, ctlpxd, pa3646, udp-3-o-acyl-glucosamine n-acyltransferase, udp-3-o-(r-3-hydroxyacyl)-glucosamine acyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + a holo-[acyl-carrier protein]
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