Reference on EC 2.3.1.180 - beta-ketoacyl-[acyl-carrier-protein] synthase III
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Clough, R.; Matthis, A.L.; Barnum, S.R.; Jaworski, J.G.
Purification and characterization of 3-ketoacyl-acyl carrier protein synthase III from spinach. A condensing enzyme utilizing acetyl-coenzyme A to initiate fatty acid synthesis
J. Biol. Chem.
267
20992-20998
1992
Spinacia oleracea
Verwoert, I.I.G.S.; van der Linden, K.H.; Walsh, M.C.; Nijkamp, H.J.J.; Stuitje, A.R.
Modification of Brassica napus seed oil by expression of the Escherichia coli fabH gene, encoding 3-ketoacyl-acyl carrier protein synthase III
Plant Mol. Biol.
27
875-886
1995
Escherichia coli
Han, L.; Lobo, S.; Reynolds, K.A.
Characterization of beta-ketoacyl-acyl carrier protein synthase III from Streptomyces glaucescens and its role in initiation of fatty acid biosynthesis
J. Bacteriol.
180
4481-4486
1998
Streptomyces glaucescens
Bao, W.; Sheldon, P.J.; Hutchinson, C.R.
Purification and properties of the Streptomyces peucetius DpsC beta-ketoacyl:acyl carrier protein synthase III that specifies the propionate-starter unit for type II polyketide biosynthesis
Biochemistry
38
9752-9757
1999
Streptomyces peucetius
Choi, K.H.; Heath, R.J.; Rock, C.O.
beta-ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis
J. Bacteriol.
182
365-370
2000
Bacillus subtilis
Smirnova, N.; Reynolds, K.A.
Engineered fatty acid biosynthesis in Streptomyces by altered catalytic function of beta-ketoacyl-acyl carrier protein synthase III
J. Bacteriol.
183
2335-2342
2001
Streptomyces glaucescens
Khandekar, S.S.; Gentry, D.R.; Van Aller, G.S.; Warren, P.; Xiang, H.; Silverman, C.; Doyle, M.L.; Chambers, P.A.; Konstantinidis, A.K.; Brandt, M.; Daines, R.A.; Lonsdale, J.T.
Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH)
J. Biol. Chem.
276
30024-30030
2001
Streptococcus pneumoniae (P0A3C5), Streptococcus pneumoniae
He, X.; Reynolds, K.A.
Purification, characterization, and identification of novel inhibitors of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus
Antimicrob. Agents Chemother.
46
1310-1318
2002
Staphylococcus aureus
Lai, C.Y.; Cronan, J.E.
beta-Ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis
J. Biol. Chem.
278
51494-51503
2003
Escherichia coli, Lactococcus lactis ssp. lactis, Lactococcus lactis ssp. lactis IL1403
Brown, A.K.; Sridharan, S.; Kremer, L.; Lindenberg, S.; Dover, L.G.; Sacchettini, J.C.; Besra, G.S.
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-ACP synthase III mtFabH: Factors influencing catalysis and substrate specificity
J. Biol. Chem.
280
32539-32547
2005
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNG3)
Musayev, F.; Sachdeva, S.; Scarsdale, J.N.; Reynolds, K.A.; Wright, H.T.
Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A
J. Mol. Biol.
346
1313-1321
2005
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNG3)
Qiu, X.; Choudhry, A.E.; Janson, C.A.; Grooms, M.; Daines, R.A.; Lonsdale, J.T.; Khandekar, S.S.
Crystal structure and substrate specificity of the beta-ketoacyl-acyl carrier protein synthase III (FabH) from Staphylococcus aureus
Protein Sci.
14
2087-2094
2005
Staphylococcus aureus
Janson, C.A.; Konstantinidis, A.K.; Lonsdale, J.T.; Qiu, X.
Crystallization of Escherichia coli beta-ketoacyl-ACP synthase III and the use of a dry flash-cooling technique for data collection
Acta Crystallogr. Sect. D
56
747-748
2000
Escherichia coli
He, X.; Reeve, A.M.; Desai, U.R.; Kellogg, G.E.; Reynolds, K.A.
1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)
Antimicrob. Agents Chemother.
48
3093-3102
2004
Staphylococcus aureus, Escherichia coli (P0A6R0), Escherichia coli
Kiatpapan, P.; Kobayashi, H.; Sakaguchi, M.; Ono, H.; Yamashita, M.; Kaneko, Y.; Murooka, Y.
Molecular characterization of Lactobacillus plantarum genes for beta-ketoacyl-acyl carrier protein synthase III (fabH) and acetyl coenzyme A carboxylase (accBCDA), which are essential for fatty acid biosynthesis
Appl. Environ. Microbiol.
67
426-433
2001
Lactiplantibacillus plantarum (Q88YZ4), Lactiplantibacillus plantarum, Lactiplantibacillus plantarum ATCC BAA-793 (Q88YZ4)
Nomura, C.T.; Taguchi, K.; Taguchi, S.; Doi, Y.
Coexpression of genetically engineered 3-ketoacyl-ACP synthase III (fabH) and polyhydroxyalkanoate synthase (phaC) genes leads to short-chain-length-medium-chain-length polyhydroxyalkanoate copolymer production from glucose in Escherichia coli JM109
Appl. Environ. Microbiol.
70
999-1007
2004
Escherichia coli
Khandekar, S.S.; Konstantinidis, A.K.; Silverman, C.; Janson, C.A.; McNulty, D.E.; Nwagwu, S.; Van Aller, G.S.; Doyle, M.L.; Kane, J.F.; Qiu, X.; Lonsdale, J.
Expression, purification, and crystallization of the Escherichia coli selenomethionyl beta-ketoacyl-acyl carrier protein synthase III
Biochem. Biophys. Res. Commun.
270
100-107
2000
Escherichia coli
Abbadi, A.; Brummel, M.; Schutt, B.S.; Slabaugh, M.B.; Schuch, R.; Spener, F.
Reaction mechanism of recombinant 3-oxoacyl-(acyl-carrier-protein) synthase III from Cuphea wrightii embryo, a fatty acid synthase type II condensing enzyme
Biochem. J.
345
153-160
2000
Cuphea wrightii
Florova, G.; Kazanina, G.; Reynolds, K.A.
Enzymes involved in fatty acid and polyketide biosynthesis in Streptomyces glaucescens: role of FabH and FabD and their acyl carrier protein specificity
Biochemistry
41
10462-10471
2002
Streptomyces glaucescens
Revill, W.P.; Bibb, M.J.; Scheu, A.K.; Kieser, H.J.; Hopwood, D.A.
beta-Ketoacyl acyl carrier protein synthase III (FabH) is essential for fatty acid biosynthesis in Streptomyces coelicolor A3(2)
J. Bacteriol.
183
3526-3530
2001
Streptomyces coelicolor (P72392), Streptomyces coelicolor, Streptomyces coelicolor A3(2) (P72392), Streptomyces coelicolor A3(2)
Li, Y.; Florova, G.; Reynolds, K.A.
Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH)
J. Bacteriol.
187
3795-3799
2005
Streptomyces coelicolor
Tsay, J.T.; Oh, W.; Larson, T.J.; Jackowski, S.; Rock, C.O.
Isolation and characterization of the beta-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12
J. Biol. Chem.
267
6807-6814
1992
Escherichia coli K-12 (P0A6R0), Escherichia coli K-12
Heath, R.J.; Rock, C.O.
Inhibition of beta-ketoacyl-acyl carrier protein synthase III (FabH) by acyl-acyl carrier protein in Escherichia coli
J. Biol. Chem.
271
10996-11000
1996
Escherichia coli
Qiu, X.; Janson, C.A.; Konstantinidis, A.K.; Nwagwu, S.; Silverman, C.; Smith, W.W.; Khandekar, S.; Lonsdale, J.; Abdel-Meguid, S.S.
Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis
J. Biol. Chem.
274
36465-36471
1999
Escherichia coli
Choi, K.H.; Kremer, L.; Besra, G.S.; Rock, C.O.
Identification and substrate specificity of beta-ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis
J. Biol. Chem.
275
28201-28207
2000
Mycobacterium tuberculosis
Scarsdale, J.N.; Kazanina, G.; He, X.; Reynolds, K.A.; Wright, H.T.
Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III
J. Biol. Chem.
276
20516-20522
2001
Mycobacterium tuberculosis
Nie, Z.; Perretta, C.; Lu, J.; Su, Y.; Margosiak, S.; Gajiwala, K.S.; Cortez, J.; Nikulin, V.; Yager, K.M.; Appelt, K.; Chu, S.
Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents
J. Med. Chem.
48
1596-1609
2005
Enterococcus faecalis
Qiu, X.; Janson, C.A.; Smith, W.W.; Head, M.; Lonsdale, J.; Konstantinidis, A.K.
Refined structures of beta-ketoacyl-acyl carrier protein synthase III
J. Mol. Biol.
307
341-356
2001
Escherichia coli (P0A6R0), Escherichia coli
Hwang, S.K.; Hwang, Y.S.
Molecular cloning and functional expression of Perilla frutescens 3-ketoacyl-(acyl carrier protein) synthase III
Mol. Cells
10
375-381
2000
Perilla frutescens (O48944), Perilla frutescens (O48945), Perilla frutescens
Abbadi, A.; Brummel, M.; Spener, F.
Knockout of the regulatory site of 3-ketoacyl-ACP synthase III enhances short- and medium-chain acyl-ACP synthesis
Plant J.
24
1-9
2000
Cuphea wrightii (P49244), Cuphea wrightii (P49245), Cuphea wrightii
Dehesh, K.; Tai, H.; Edwards, P.; Byrne, J.; Jaworski, J.G.
Overexpression of 3-ketoacyl-acyl-carrier protein synthase IIIs in plants reduces the rate of lipid synthesis
Plant Physiol.
125
1103-1114
2001
Brassica napus, Cuphea hookeriana, Nicotiana tabacum, Spinacia oleracea (Q07510), Spinacia oleracea
Brueck, F.M.; Brummel, M.; Schuch, R.; Spener, F.
In-vitro evidence for feed-back regulation of beta-ketoacyl-acyl carrier protein synthase III in medium-chain fatty acid biosynthesis
Planta
198
271-278
1996
Cuphea lanceolata
-
Jones, A.L.; Gane, A.M.; Herbert, D.; Willey, D.L.; Rutter, A.J.; Kille, P.; Dancer, J.E.; Harwood, J.L.
beta-Ketoacyl-acyl carrier protein synthase III from pea (Pisum sativum L.): properties, inhibition by a novel thiolactomycin analogue and isolation of a cDNA clone encoding the enzyme
Planta
216
752-761
2003
Pisum sativum (Q9FSD6), Pisum sativum
Davies, C.; Heath, R.J.; White, S.W.; Rock, C.O.
The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from Escherichia coli
Structure
8
185-195
2000
Escherichia coli
Alhamadsheh, M.M.; Waters, N.C.; Huddler, D.P.; Kreishman-Deitrick, M.; Florova, G.; Reynolds, K.A.
Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH)
Bioorg. Med. Chem. Lett.
17
879-883
2007
Plasmodium falciparum, Escherichia coli (P0A6R0), Escherichia coli, Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis, Plasmodium falciparum D6, Mycobacterium tuberculosis H37Rv (P9WNG3)
Wang, J.; Kodali, S.; Lee, S.H.; Galgoci, A.; Painter, R.; Dorso, K.; Racine, F.; Motyl, M.; Hernandez, L.; Tinney, E.; Colletti, S.L.; Herath, K.; Cummings, R.; Salazar, O.; Gonzalez, I.; Basilio, A.; Vicente, F.; Genilloud, O.; Pelaez, F.; Jayasuriya, H.; Young, K.; Cully, D.F.; Singh, S.B.
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties
Proc. Natl. Acad. Sci. USA
104
7612-7616
2007
Staphylococcus aureus
Sachdeva, S.; Musayev, F.; Alhamadsheh, M.M.; Neel Scarsdale, J.; Tonie Wright, H.; Reynolds, K.A.
Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates
Bioorg. Chem.
36
85-90
2008
Mycobacterium tuberculosis
Jeong, K.; Lee, J.; Kim, Y.
Homology modeling and docking study of beta-ketoacyl acyl carrier protein synthase III from Enterococcus faecalis
Bull. Korean Chem. Soc.
28
1335-1340
2007
Enterococcus faecalis
-
Alhamadsheh, M.M.; Musayev, F.; Komissarov, A.A.; Sachdeva, S.; Wright, H.T.; Scarsdale, N.; Florova, G.; Reynolds, K.A.
Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes
Chem. Biol.
14
513-524
2007
Escherichia coli, Mycobacterium tuberculosis
Sachdeva, S.; Musayev, F.N.; Alhamadsheh, M.M.; Scarsdale, J.N.; Wright, H.T.; Reynolds, K.A.
Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH
Chem. Biol.
15
402-412
2008
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNG3)
Ashek, A.; San Juan, A.A.; Cho, S.J.
HQSAR study of beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
J. Enzyme Inhib. Med. Chem.
22
7-14
2007
Enterococcus faecalis
Sachdeva, S.; Reynolds, K.A.
Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase III (mtFabH) assay: principles and method
Methods Mol. Med.
142
205-213
2008
Mycobacterium tuberculosis
Castillo, Y.P.; Perez, M.A.
Bacterial beta-ketoacyl-acyl carrier protein synthase III (FabH): an attractive target for the design of new broad-spectrum antimicrobial agents
Mini Rev. Med. Chem.
8
36-45
2008
Streptococcus pneumoniae, Escherichia coli, Enterococcus faecium, Haemophilus influenzae, Staphylococcus aureus, Mycobacterium tuberculosis, Neisseria meningitidis, Pseudomonas aeruginosa, Streptococcus pyogenes
Li, J.; Li, M.; Wu, P.; Tian, C.; Jiang, H.; Wu, G.
Molecular cloning and expression analysis of a gene encoding a putative beta-ketoacyl-acyl carrier protein (ACP) synthase III (KAS III) from Jatropha curcas
Tree Physiol.
28
921-927
2008
Jatropha curcas
Huynh, K.H.; Natarajan, S.; Song, N.H.; Ngo, P.T.; Ahn, Y.J.; Kim, J.G.; Lee, B.M.; Eo, Y.D.; Kang, L.W.
Cloning, expression, crystallization and preliminary X-ray crystallographic analysis of beta-ketoacyl-ACP synthase III (FabH) from Xanthomonas oryzae pv. oryzae
Acta Crystallogr. Sect. F
65
460-462
2009
Xanthomonas oryzae pv. oryzae, Xanthomonas oryzae pv. oryzae Xoo KACC10331
Matsumoto, K.; Murata, T.; Nagao, R.; Nomura, C.T.; Arai, S.; Arai, Y.; Takase, K.; Nakashita, H.; Taguchi, S.; Shimada, H.
Production of short-chain-length/medium-chain-length polyhydroxyalkanoate (PHA) copolymer in the plastid of Arabidopsis thaliana using an engineered 3-ketoacyl-acyl carrier protein synthase III
Biomacromolecules
10
686-690
2009
Arabidopsis thaliana, Escherichia coli
Lv, P.C.; Wang, K.R.; Yang, Y.; Mao, W.J.; Chen, J.; Xiong, J.; Zhu, H.L.
Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors
Bioorg. Med. Chem. Lett.
19
6750-6754
2009
Escherichia coli
Lee, J.Y.; Jeong, K.W.; Lee, J.U.; Kang, D.I.; Kim, Y.
Novel E. coli beta-ketoacyl-acyl carrier protein synthase III inhibitors as targeted antibiotics
Bioorg. Med. Chem.
17
1506-1513
2009
Escherichia coli K-12
Lee, J.Y.; Jeong, K.W.; Shin, S.; Lee, J.U.; Kim, Y.
Antimicrobial natural products as beta-ketoacyl-acyl carrier protein synthase III inhibitors
Bioorg. Med. Chem.
17
5408-5413
2009
Escherichia coli K-12
Li, H.Q.; Shi, L.; Li, Q.S.; Liu, P.G.; Luo, Y.; Zhao, J.; Zhu, H.L.
Synthesis of C(7) modified chrysin derivatives designing to inhibit beta-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics
Bioorg. Med. Chem.
17
6264-6269
2009
Escherichia coli (P0A6R0), Escherichia coli
Singh, S.; Soni, L.; Gupta, M.; Prabhakar, Y.; Kaskhedikar, S.
QSAR studies on benzoylaminobenzoic acid derivatives as inhibitors of beta-ketoacyl-acyl carrier protein synthase III
Eur. J. Med. Chem.
43
1071-1080
2008
Streptococcus pneumoniae, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, Neisseria meningitidis, Streptococcus pyogenes
Singh, A.K.; Zhang, Y.M.; Zhu, K.; Subramanian, C.; Li, Z.; Jayaswal, R.K.; Gatto, C.; Rock, C.O.; Wilkinson, B.J.
FabH selectivity for anteiso branched-chain fatty acid precursors in low-temperature adaptation in Listeria monocytogenes
FEMS Microbiol. Lett.
301
188-192
2009
Listeria monocytogenes (C0LNR0), Listeria monocytogenes, Listeria monocytogenes 10403S (C0LNR0)
Veyron-Churlet, R.; Molle, V.; Taylor, R.C.; Brown, A.K.; Besra, G.S.; Zanella-Cleon, I.; Fuetterer, K.; Kremer, L.
The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue
J. Biol. Chem.
284
6414-6424
2009
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNG3)
Lee, P.J.; Bhonsle, J.B.; Gaona, H.W.; Huddler, D.P.; Heady, T.N.; Kreishman-Deitrick, M.; Bhattacharjee, A.; McCalmont, W.F.; Gerena, L.; Lopez-Sanchez, M.; Roncal, N.E.; Hudson, T.H.; Johnson, J.D.; Prigge, S.T.; Waters, N.C.
Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents
J. Med. Chem.
52
952-963
2009
Plasmodium falciparum
Al-Balas, Q.; Anthony, N.G.; Al-Jaidi, B.; Alnimr, A.; Abbott, G.; Brown, A.K.; Taylor, R.C.; Besra, G.S.; McHugh, T.D.; Gillespie, S.H.; Johnston, B.F.; Mackay, S.P.; Coxon, G.D.
Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH
PLoS ONE
4
e5617
2009
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNG3)
Wen, L.; Chmielowski, J.N.; Bohn, K.C.; Huang, J.K.; Timsina, Y.N.; Kodali, P.; Pathak, A.K.
Functional expression of Francisella tularensis FabH and FabI, potential antibacterial targets
Protein Expr. Purif.
65
83-91
2009
Francisella tularensis subsp. holarctica (A0SPA8)
Pereira, J.H.; Goh, E.B.; Keasling, J.D.; Beller, H.R.; Adams, P.D.
Structure of FabH and factors affecting the distribution of branched fatty acids in Micrococcus luteus
Acta Crystallogr. Sect. D
68
1320-1328
2012
Micrococcus luteus (C5CAR9)
Du, Y.; Gisselberg, J.E.; Johnson, J.D.; Lee, P.J.; Prigge, S.T.; Bachmann, B.O.
Lactococcus lactis fabH, encoding beta-ketoacyl-acyl carrier protein synthase, can be functionally replaced by the Plasmodium falciparum congener
Appl. Environ. Microbiol.
76
3959-3966
2010
Plasmodium falciparum (O77078), Plasmodium falciparum, Lactococcus lactis (Q9CHG0), Lactococcus lactis, Lactococcus lactis IL1403 (Q9CHG0)
Lv, P.C.; Sun, J.; Luo, Y.; Yang, Y.; Zhu, H.L.
Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors
Bioorg. Med. Chem. Lett.
20
4657-4660
2010
Escherichia coli
Yang, Y.S.; Zhang, F.; Gao, C.; Zhang, Y.B.; Wang, X.L.; Tang, J.F.; Sun, J.; Gong, H.B.; Zhu, H.L.
Discovery and modification of sulfur-containing heterocyclic pyrazoline derivatives as potential novel class of beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
Bioorg. Med. Chem. Lett.
22
4619-4624
2012
Escherichia coli
Li, Z.L.; Li, Q.S.; Zhang, H.J.; Hu, Y.; Zhu, D.D.; Zhu, H.L.
Design, synthesis and biological evaluation of urea derivatives from o-hydroxybenzylamines and phenylisocyanate as potential FabH inhibitors
Bioorg. Med. Chem.
19
4413-4420
2011
Escherichia coli
Li, H.Q.; Luo, Y.; Zhu, H.L.
Discovery of vinylogous carbamates as a novel class of beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
Bioorg. Med. Chem.
19
4454-4459
2011
Escherichia coli
Zhang, H.J.; Zhu, D.D.; Li, Z.L.; Sun, J.; Zhu, H.L.
Synthesis, molecular modeling and biological evaluation of beta-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents
Bioorg. Med. Chem.
19
4513-4519
2011
Escherichia coli
Li, Y.; Luo, Y.; Hu, Y.; Zhu, D.D.; Zhang, S.; Liu, Z.J.; Gong, H.B.; Zhu, H.L.
Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors
Bioorg. Med. Chem.
20
4316-4322
2012
Escherichia coli
Mueller, A.P.; Nomura, C.T.
Mutations to the active site of 3-ketoacyl-ACP synthase III (FabH) increase polyhydroxyalkanoate biosynthesis in transgenic Escherichia coli
J. Biosci. Bioeng.
113
300-306
2012
Escherichia coli
Gonzalez-Mellado, D.; von Wettstein-Knowles, P.; Garces, R.; Martinez-Force, E.
The role of beta-ketoacyl-acyl carrier protein synthase III in the condensation steps of fatty acid biosynthesis in sunflower
Planta
231
1277-1289
2010
Helianthus annuus (A5A0S1), Helianthus annuus CAS-6 (A5A0S1)
Cheng, K.; Xue, J.Y.; Zhu, H.L.
Design, synthesis and antibacterial activity studies of thiazole derivatives as potent ecKAS III inhibitors
Bioorg. Med. Chem. Lett.
23
4235-4238
2013
Escherichia coli (P0A6R0), Escherichia coli
Song, X.; Yang, Y.; Zhao, J.; Chen, Y.
Synthesis and antibacterial activity of cinnamaldehyde acylhydrazone with a 1,4-benzodioxan fragment as a novel class of potent beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitor
Chem. Pharm. Bull.
62
1110-1118
2014
Staphylococcus aureus, Bacillus subtilis (O07600), Escherichia coli (P0A6R0), Pseudomonas aeruginosa (Q9HYR2), Bacillus subtilis 168 (O07600), Staphylococcus aureus ATCC 6538
Wang, Y.; Ma, S.
Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents
ChemMedChem
8
1589-1608
2013
Pseudomonas aeruginosa (A0A072ZQE7), Bacillus subtilis (O34746), Streptococcus pneumoniae (P0A3C5), Escherichia coli (P0A6R0), Haemophilus influenzae (P43711), Staphylococcus aureus (P99159), Mycobacterium tuberculosis (P9WNG3), Staphylococcus aureus N315 (P99159), Mycobacterium tuberculosis H37Rv (P9WNG3)
Li, J.R.; Li, D.D.; Wang, R.R.; Sun, J.; Dong, J.J.; Du, Q.R.; Fang, F.; Zhang, W.M.; Zhu, H.L.
Design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity
Eur. J. Med. Chem.
75
438-447
2014
Escherichia coli (P0A6R0)
Misra, N.; Patra, M.; Panda, P.; Sukla, L.; Mishra, B.
Homology modeling and docking studies of FabH (beta-ketoacyl-ACP synthase III) enzyme involved in type II fatty acid biosynthesis of Chlorella variabilis: a potential algal feedstock for biofuel production
J. Biomol. Struct. Dyn.
31
241-257
2013
Chlorella variabilis
Ramamoorthy, D.; Turos, E.; Guida, W.C.
Identification of a new binding site in E. coli FabH using molecular dynamics simulations: validation by computational alanine mutagenesis and docking studies
J. Chem. Inf. Model.
53
1138-1156
2013
Escherichia coli (P0A6R0)
Mittal, A.; Johnson, M.E.
Conformational diversity of bacterial FabH: implications for molecular recognition specificity
J. Mol. Graph. Model.
55
115-122
2015
Escherichia coli (P0A6R0), Enterococcus faecalis (Q820T1), Enterococcus faecalis ATCC 700802 (Q820T1)
Shamim, A.; Abbasi, S.W.; Azam, S.S.
Structural and dynamical aspects of Streptococcus gordonii FabH through molecular docking and MD simulations
J. Mol. Graph. Model.
60
180-196
2015
Streptococcus gordonii (A8AYW5), Streptococcus gordonii ATCC 35105 (A8AYW5)
Kuo, J.; Khosla, C.
The initiation ketosynthase (FabH) is the sole rate-limiting enzyme of the fatty acid synthase of Synechococcus sp. PCC 7002
Metab. Eng.
22
53-59
2014
Synechococcus sp. (B1XPH5), Synechococcus sp.
Nanson, J.D.; Himiari, Z.; Swarbrick, C.M.; Forwood, J.K.
Structural characterisation of the beta-ketoacyl-acyl carrier protein synthases, FabF and FabH, of Yersinia pestis
Sci. Rep.
5
14797
2015
Yersinia pestis (Q8ZFT7)
Abugrain, M.E.; Brumsted, C.J.; Osborn, A.R.; Philmus, B.; Mahmud, T.
A highly promiscuous beta-ketoacyl-ACP synthase (KAS) III-like protein is involved in pactamycin biosynthesis
ACS Chem. Biol.
12
362-366
2017
Streptomyces pactum
Meng, Q.; Liang, H.; Gao, H.
Roles of multiple KASIII homologues of Shewanella oneidensis in initiation of fatty acid synthesis and in cerulenin resistance
Biochim. Biophys. Acta
1863
1153-1163
2018
Shewanella oneidensis, Shewanella oneidensis ATCC 700550
Zhou, Y.; Yang, Y.S.; Song, X.D.; Lu, L.; Zhu, H.L.
Study of Schiff-base-derived with dioxygenated rings and nitrogen heterocycle as potential beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors
Chem. Pharm. Bull.
65
178-185
2017
Escherichia coli (P0A6R0)
Patil, K.; Wakkar, L.; Undare, S.; Kolekar, G.; Deshmukh, M.; Choudhari, P.; Anbhule, P.
Selective synthesis of 10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione using copper oxide nanoparticles for potential inhibitors of beta-ketoacyl-[acyl-carrier-protein] synthase III of Mycobacterium tuberculosis
Indian J. Chem.
55B
1151-1159
2016
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
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Zhang, D.; Zhang, F.; Liu, W.
A KAS-III heterodimer in lipstatin biosynthesis nondecarboxylatively condenses C8 and C14 fatty acyl-CoA substrates by a variable mechanism during the establishment of a C22 aliphatic skeleton
J. Am. Chem. Soc.
141
3993-4001
2019
Streptomyces toxytricini
Cao, W.; Ma, W.; Zhang, B.; Wang, X.; Chen, K.; Li, Y.; Ouyang, P.
Improved pinocembrin production in Escherichia coli by engineering fatty acid synthesis
J. Ind. Microbiol. Biotechnol.
43
557-566
2016
Escherichia coli (P0A6R0)
Nofiani, R.; Philmus, B.; Nindita, Y.; Mahmud, T.
3-Ketoacyl-ACP synthase (KAS) III homologues and their roles in natural product biosynthesis
MedChemComm
10
1517-1530
2019
Micromonospora echinospora, Corallococcus coralloides, Pseudomonas putida, Pseudomonas chlororaphis subsp. aurantiaca, Streptomyces albus, Streptomyces antibioticus, Streptomyces coelicolor, Streptomyces griseus, Streptomyces peucetius, Streptomyces tendae, Streptomyces viridochromogenes, Streptomyces toxytricini, Streptomyces galilaeus, Micromonospora carbonacea, Actinomadura kijaniata, Myxococcus fulvus, Streptomyces sp. CL190, Micromonospora maris, Streptomyces sp. MA347, Streptomyces nodosus subsp. asukaensis, Streptomyces sp. KCTC 11604BP, Streptomyces sp. SN-593, Streptomyces sp. 88-682, Streptomyces sp. NRRL 11266, Polymorphospora rubra, Streptomyces sp. SF2575, Streptomyces pactum, Dactylosporangium aurantiacum subsp. hamdenensis, Actinoplanes deccanensis, Streptomyces sp. NRRL 12068, Streptomyces sp. A2991200, Streptomyces sp. CM020, Streptomyces roseofulvus, Streptomyces griseoruber, Escherichia coli (P0A6R0), Pseudomonas aeruginosa (Q9HYR2), Myxococcus fulvus Mxf50, Pseudomonas putida BW11M1, Streptomyces pactum ATCC 27456, Streptomyces albus XM211, Corallococcus coralloides B035, Micromonospora maris AB-18-032, Streptomyces antibioticus DSM 4072, Polymorphospora rubra K07-0510, Streptomyces roseofulvus AM-3867, Streptomyces griseus ATCC 49344, Dactylosporangium aurantiacum subsp. hamdenensis NRRL 18085, Micromonospora echinospora NRRL 15839, Streptomyces tendae HKI 017, Streptomyces coelicolor M511, Streptomyces viridochromogenes Tue57, Streptomyces antibioticus Tue2706, Pseudomonas chlororaphis subsp. aurantiaca BL915, Streptomyces galilaeus 3AR-33, Actinomadura kijaniata SCC1256
Lee, W.C.; Jeong, M.C.; Lee, Y.; Kwak, C.; Lee, J.Y.; Kim, Y.
Structure and substrate specificity of beta-ketoacyl-acyl carrier protein synthase III from Acinetobacter baumannii
Mol. Microbiol.
108
567-577
2018
Acinetobacter baumannii
Yu, Y.; Ma, J.; Miao, X.; Wang, H.
Biological function research of 3-ketoacyl ACP synthase III from different bacteria
Prog. Biochem. Biophys.
43
1004-1012
2016
Staphylococcus aureus, Ralstonia solanacearum, Streptomyces coelicolor, Xanthomonas oryzae pv. oryzae, Bacillus subtilis (O34746 AND O07600), Escherichia coli (P0A6R0), Bacillus subtilis 168 (O34746 AND O07600)
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Alhamadsheh, M.; Waters, N.; Sachdeva, S.; Lee, P.; Reynolds, K.
Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors
Bioorg. Med. Chem. Lett.
18
6402-6405
2008
Plasmodium falciparum, Escherichia coli (P0A6R0), Escherichia coli
Alhamadsheh, M.; Musayev, F.; Komissarov, A.; Sachdeva, S.; Wright, H.; Scarsdale, N.; Florova, G.; Reynolds, K.
Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes
Chem. Biol.
14
513-524
2007
Escherichia coli (P0A6R0), Escherichia coli
Choi, K.; Heath, R.; Rock, C.
beta-Ketoacyl-acyl carrier protein synthase III (FabH) is a determining factor in branched-chain fatty acid biosynthesis
J. Bacteriol.
182
365-370
2000
Bacillus subtilis (O07600), Bacillus subtilis (O34746), Bacillus subtilis, Bacillus subtilis 168 (O07600), Bacillus subtilis 168 (O34746)
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