Reference on EC 2.3.1.165 - 6-methylsalicylic-acid synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dimroth, P.; Ringelmann, E.; Lynen, F.
6-Methylsalicylic acid synthetase from Penicillium patulum. Some catalytic properties of the enzyme and its relation to fatty acid synthetase
Eur. J. Biochem.
68
591-596
1976
Penicillium griseofulvum, Penicillium griseofulvum NRRL 2159A
Lam, K.S.; Neway, J.O.; Gaucher, G.M.
In vitro stabilization of 6-methylsalicylic acid synthetase from Penicillium urticae
Can. J. Microbiol.
34
30-37
1988
Penicillium griseofulvum, Penicillium griseofulvum NRRL 2159A
Spencer, J.B.; Jordan, P.M.
Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum
Biochem. J.
288
839-846
1992
Penicillium griseofulvum, Penicillium griseofulvum NRRL 2159A
-
Spencer, J.B.; Jordan, P.M.
Investigation of the mechanism and steric course of the reaction catalyzed by 6-methylsalicylic acid synthase from Penicillium patulum using (R)-[1-13C;2-2H] and (S)-[1-13C; 2-2H]malonates
Biochemistry
31
9107-9116
1992
Penicillium griseofulvum
Child, C.J.; Shoolingin-Jordan, P.M.
Inactivation of the polyketide synthase, 6-methylsalicylic acid synthase, by the specific modification of Cys-204 of the beta-ketoacyl synthase by the fungal mycotoxin cerulenin
Biochem. J.
330
933-937
1998
Penicillium griseofulvum
-
Child, C.J.; Spencer, J.B.; Bhogal, P.; Shoolingin-Jordan, P.M.
Structural similarities between 6-methylsalicylic acid synthase from Penicillium patulum and vertebrate type I fatty acid synthase: evidence from thiol modification studies
Biochemistry
35
12267-12274
1996
Penicillium griseofulvum
Campuzano, I.D.G.; Shoolingin-Jordan, P.M.
Incubation of 6-methylsalicylic acid synthase with alternative starter units in the absence of NADPH and the identification of the resulting triaceticacid lactones
Biochem. Soc. Trans.
26
S284
1998
Penicillium griseofulvum
Richardson, M.T.; Pohl, N.L.; Kealey, J.T.; Khosla, C.
Tolerance and specificity of recombinant 6-methylsalicylic acid synthase
Metab. Eng.
1
180-187
1999
Penicillium griseofulvum
Shao, L.; Qu, X.; Jia, X.; Zhao, Q.; Tian, Z.; Wang, M.; Tang, G.; Liu, W.
Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase
Biochem. Biophys. Res. Commun.
345
133-139
2006
Streptomyces antibioticus
Wattanachaisaereekul, S.; Lantz, A.E.; Nielsen, M.L.; Andresson, O.S.; Nielsen, J.
Optimization of heterologous production of the polyketide 6-MSA in Saccharomyces cerevisiae
Biotechnol. Bioeng.
97
893-900
2006
Penicillium griseofulvum, Penicillium griseofulvum (P22367)
Moriguchi, T.; Ebizuka, Y.; Fujii, I.
Analysis of subunit interactions in the iterative type I polyketide synthase ATX from Aspergillus terreus
Chembiochem
7
1869-1874
2006
Aspergillus terreus
Lu, P.; Zhang, A.; Dennis, L.M.; Dahl-Roshak, A.M.; Xia, Y.Q.; Arison, B.; An, Z.; Tkacz, J.S.
A gene (pks2) encoding a putative 6-methylsalicylic acid synthase from Glarea lozoyensis
Mol. Genet. Genomics
273
207-216
2005
Glarea lozoyensis (Q58K76), Glarea lozoyensis
Puel, O.; Tadrist, S.; Delaforge, M.; Oswald, I.P.; Lebrihi, A.
The inability of Byssochlamys fulva to produce patulin is related to absence of 6-methylsalicylic acid synthase and isoepoxydon dehydrogenase genes
Int. J. Food Microbiol.
115
131-139
2007
Paecilomyces niveus (Q96X07), Paecilomyces niveus, Paecilomyces niveus NRRL 2615 (Q96X07)
Panagiotou, G.; Andersen, M.R.; Grotkjaer, T.; Regueira, T.B.; Nielsen, J.; Olsson, L.
Studies on the production of fungal polyketides in Aspergillus nidulans using systems biology tools
Appl. Environ. Microbiol.
75
2212-2220
2009
Penicillium griseofulvum
Moriguchi, T.; Ebizuka, Y.; Fujii, I.
Domain-domain interactions in the iterative type I polyketide synthase ATX from Aspergillus terreus
ChemBioChem
9
1207-1212
2008
Aspergillus terreus, Penicillium griseofulvum
Sanzani, S.; Schena, L.; Nigro, F.; de Girolamo, A.; Ippolito, A.
Effect of quercetin and umbelliferone on the transcript level of Penicillium expansum genes involved in patulin biosynthesis
Eur. J. Plant Pathol.
125
223-233
2009
Penicillium expansum (Q4JIM3)
Bacha, N.; Dao, H.P.; Atoui, A.; Mathieu, F.; OCallaghan, J.; Puel, O.; Liboz, T.; Dobson, A.D.; Lebrihi, A.
Cloning and characterization of novel methylsalicylic acid synthase gene involved in the biosynthesis of isoasperlactone and asperlactone in Aspergillus westerdijkiae
Fungal Genet. Biol.
46
742-749
2009
Aspergillus westerdijkiae
Wattanachaisaereekul, S.; Lantz, A.E.; Nielsen, M.L.; Nielsen, J.
Production of the polyketide 6-MSA in yeast engineered for increased malonyl-CoA supply
Metab. Eng.
10
246-254
2008
Penicillium griseofulvum
Moriguchi, T.; Kezuka, Y.; Nonaka, T.; Ebizuka, Y.; Fujii, I.
Hidden function of catalytic domain in 6-methylsalicylic acid synthase for product release
J. Biol. Chem.
285
15637-15643
2010
Aspergillus terreus
Parascandolo, J.S.; Havemann, J.; Potter, H.K.; Huang, F.; Riva, E.; Connolly, J.; Wilkening, I.; Song, L.; Leadlay, P.F.; Tosin, M.
Insights into 6-methylsalicylic acid bio-assembly by using chemical probes
Angew. Chem. Int. Ed. Engl.
55
3463-3467
2016
Penicillium griseofulvum (P22367)
Holm, D.K.; Petersen, L.M.; Klitgaard, A.; Knudsen, P.B.; Jarczynska, Z.D.; Nielsen, K.F.; Gotfredsen, C.H.; Larsen, T.O.; Mortensen, U.H.
Molecular and chemical characterization of the biosynthesis of the 6-MSA-derived meroterpenoid yanuthone D in Aspergillus niger
Chem. Biol.
21
519-529
2014
Aspergillus niger (G3Y419), Aspergillus niger, Aspergillus niger ATCC 1015 (G3Y419)
Petersen, L.; Holm, D.; Gotfredsen, C.; Mortensen, U.; Larsen, T.
Investigation of a 6-MSA synthase gene cluster in Aspergillus aculeatus reveals 6-MSA-derived aculinic acid, aculins A-B and epi-Aculin A
ChemBioChem
16
2200-2204
2015
Aspergillus aculeatus
Kallscheuer, N.; Kage, H.; Milke, L.; Nett, M.; Marienhagen, J.
Microbial synthesis of the type I polyketide 6-methylsalicylate with Corynebacterium glutamicum
Appl. Microbiol. Biotechnol.
103
9619-9631
2019
Streptomyces antibioticus (Q0R4P8), Streptomyces antibioticus
Hitschler, J.; Boles, E.
De novo production of aromatic m-cresol in Saccharomyces cerevisiae mediated by heterologous polyketide synthases combined with a 6-methylsalicylic acid decarboxylase
Metab. Eng. Commun.
9
e00093
2019
Penicillium griseofulvum (P22367), Penicillium griseofulvum
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