Catalyses the transfer of the acetyl group from 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) to the sn-2 position of lyso-glycerophospholipids containing ethanolamine, choline, serine, inositol or phosphate groups at the sn-3 position as well as to sphingosine and long-chain fatty alcohols. The organyl group can be alkyl, acyl or alk-1-enyl (sometimes also collectively referred to as 'radyl').
Catalyses the transfer of the acetyl group from 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) to the sn-2 position of lyso-glycerophospholipids containing ethanolamine, choline, serine, inositol or phosphate groups at the sn-3 position as well as to sphingosine and long-chain fatty alcohols. The organyl group can be alkyl, acyl or alk-1-enyl (sometimes also collectively referred to as 'radyl').
the enzyme may participate in the biosynthesis of ethanolamine plasmalogen and acyl analogs of platelet-activating factor, in vivo, finetuning of platelet-activating factor biological responses and cross-talk between de novo and remodeling pathways of platelet biosynthesis
the enzyme transfers short-chain fatty acids from platelet-activating factor PAF and its close ether- and ester-linked analogues to ether/ester-linked lysophospholipids, enzyme activity distribution within different LDL-subfactions, overview
the enzyme may participate in the biosynthesis of ethanolamine plasmalogen and acyl analogs of platelet-activating factor, in vivo, finetuning of platelet-activating factor biological responses and cross-talk between de novo and remodeling pathways of platelet biosynthesis
the enzyme transfers short-chain fatty acids from platelet-activating factor PAF and its close ether- and ester-linked analogues to ether/ester-linked lysophospholipids, enzyme activity distribution within different LDL-subfactions, overview
lyso- platelet-activating factor accumulation and an increase in platelet-activating factor bioactivity is observed in the aorta of some patients. In atherogenic aortas, an imbalance between PAF-AH and transacetylase activity, as well as lyso-platelet-activating factor accumulation, may lead to unregulated platelet-activating factor formation and to progression of atherosclerosis
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
enzyme activity is increased in the supplement group (receive Aloe gel, grape juice, Polygonum cuspidatum extract as well as vitamins) at 4 and 8 weeks compared with baseline levels
A novel CoA-independent transacetylase produces the ethanolamine plasmalogen and acetyl analogs of platelet-activating factor (PAF) with PAF as the actetate donor in HL-60 cells
The role of platelet-activating factor-dependent transacetylase in the biosynthesis of 1-acyl-2-acetyl-sn-glycero-3-phosphocholine by stimulated endothelial cells
2.3.1.149 Platelet-activating factor acetyltransferase
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