Information on EC 2.3.1.148 - glycerophospholipid acyltransferase (CoA-dependent)

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.3.1.148
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RECOMMENDED NAME
GeneOntology No.
glycerophospholipid acyltransferase (CoA-dependent)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1-organyl-2-acyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine = 1-organyl-2-acyl-sn-glycero-3-phosphoethanolamine + 1-organyl-2-lyso-sn-glycero-3-phosphocholine
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
1-organyl-2-acyl-sn-glycero-3-phosphocholine:1-organyl-2-lyso-sn-glycero-3-phosphoethanolamine acyltransferase (CoA-dependent)
Catalyses the transfer of fatty acids from intact choline- or ethanolamine-containing glycerophospholipids to the sn-2 position of a lyso-glycerophospholipid. The organyl group on sn-1 of the donor or acceptor molecule can be alkyl, acyl or alk-1-enyl. The term 'radyl' has sometimes been used to refer to such substituting groups. Differs from EC 2.3.1.147 glycerophospholipid arachidonoyl-transferase (CoA-independent) in requiring CoA and not favouring the transfer of polyunsaturated acyl groups.
CAS REGISTRY NUMBER
COMMENTARY hide
9054-54-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
1-Acyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine
1-Acyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine
show the reaction diagram
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transfer of arachidonate occurs through a bidirectional movement
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1-Acyl-2-arachidonoyl-sn-glycero-3-phosphoinositol + lyso-phosphatidylcholine
1-Acyl-2-lyso-sn-glycero-3-phosphoinositol + ?
show the reaction diagram
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1-Acyl-2-arachidonoyl-sn-glycero-3-phosphophoinositol + lyso-phosphatidylethanolamine
1-Acyl-2-lyso-sn-glycero-3-phosphoinositol + arachidonoylphosphatidylethanolamine
show the reaction diagram
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unidirectional transfer process of arachidonate
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1-Alkyl-2-lyso-sn-glycero-3-phosphocholine + phospholipid
?
show the reaction diagram
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1-Hexadecyl-2-lyso-glycerophosphocholine + phospholipid
?
show the reaction diagram
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lyso-Pasmenylethanolamine + phospholipid
?
show the reaction diagram
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lyso-Phosphatidylethanolamine + phospholipid
Phosphatidylethanolamine + lyso-phospholipid
show the reaction diagram
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lyso-Phosphatidylinositol + phospholipid
Phosphatidylinositol + lyso-phospholipid
show the reaction diagram
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lyso-Phosphatidylserine + phospholipid
Phosphatidylserine + lyso-phospholipid
show the reaction diagram
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Phosphatidylcholine + lyso-phosphatidylethanolamine
lyso-Phosphatidylcholine + phosphatidylethanolamine
show the reaction diagram
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Phosphatidylcholine + lyso-phosphatidylinositol
lyso-Phosphatidylcholine + phosphatidylinositol
show the reaction diagram
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the linoleoyl transfer takes place at about 25% of the rate of arachidonoyl transfer
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Phosphatidylinositol + lyso-phosphatidylcholine
lyso-Phosphatidylcholine + phosphatidylinositol
show the reaction diagram
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the linoleoyl transfer takes place at about 25% of the rate of arachidonoyl transfer
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additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Zn2+
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strong
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0038
1-acyl-2-lyso-glycerophosphocholine
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0.0015
1-hexadecyl-2-lyso-glycerophosphocholine
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0.076
lyso-phosphatidylserine
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0.017
palmitoyl-lyso-glycerophosphocholine
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4.5
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bimodal pH-optimum, at pH 4.5 and at pH 7.5. The activity is 4-5times higher at pH 4.5 than at pH 7.5
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE