Information on EC 2.3.1.139 - ecdysone O-acyltransferase

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The expected taxonomic range for this enzyme is: Periplaneta americana

EC NUMBER
COMMENTARY hide
2.3.1.139
-
RECOMMENDED NAME
GeneOntology No.
ecdysone O-acyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
palmitoyl-CoA + ecdysone = CoA + ecdysone palmitate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
palmitoyl-CoA:ecdysone palmitoyltransferase
-
CAS REGISTRY NUMBER
COMMENTARY hide
120038-26-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
palmitoyl-CoA + ecdysone
CoA + ecdysone palmitate
show the reaction diagram
-
-
-
?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
20-hydroxyecdysone
-
at 0.001 mM, 30% inhibition, at 0.01 mM, 90% inhibition
EDTA
-
at 1 mM, 15% inhibition
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0004
ecdysone
-
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 8
-
75% of maximal activity at pH 6.0, 70% of maximal activity at pH 8.0
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
membrane
-
Manually annotated by BRENDA team
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
bovine serum albumin and DTT have no effect
-
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-70°C, 48 h, 60% reduction of activity
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE