Information on EC 2.3.1.126 - isocitrate O-dihydroxycinnamoyltransferase

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The expected taxonomic range for this enzyme is: Amaranthus

EC NUMBER
COMMENTARY hide
2.3.1.126
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RECOMMENDED NAME
GeneOntology No.
isocitrate O-dihydroxycinnamoyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
caffeoyl-CoA + isocitrate = CoA + 2-O-caffeoylisocitrate
show the reaction diagram
Feruoyl-CoA and 4-coumaroyl-CoA can also act as donors
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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-
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SYSTEMATIC NAME
IUBMB Comments
caffeoyl-CoA:isocitrate 3-O-(3,4-dihydroxycinnamoyl)transferase
Feruloyl-CoA and 4-coumaroyl-CoA can also act as donors.
CAS REGISTRY NUMBER
COMMENTARY hide
112352-88-2
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
ssp. paniculatus (L.) Hejny
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Manually annotated by BRENDA team
L. cv. Oeschberg; Willd.
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
caffeoyl-CoA + isocitrate
CoA + 2-caffeoylisocitrate
show the reaction diagram
caffeoyl-CoA + isocitric acid
CoA + (E)-caffeoylisocitric acid
show the reaction diagram
-
-
-
r
feruloyl-CoA + isocitric acid
CoA + feruloylisocitric acid
show the reaction diagram
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-
-
r
sinapoyl-CoA + isocitric acid
CoA + sinapoylisocitric acid
show the reaction diagram
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minor activity compared to caffeoyl-CoA
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r
additional information
?
-
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citric, malic tartaric and quinic acids are not accepted as substrates
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-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
caffeoyl-CoA + isocitrate
CoA + 2-caffeoylisocitrate
show the reaction diagram
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.208 - 0.412
isocitric acid
0.055
p-Coumaroyl-CoA
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-
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, protein preparation shows no loss of enzymatic activity when stored for several weeks
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE