Information on EC 2.3.1.121 - 1-alkenylglycerophosphoethanolamine O-acyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Cavia porcellus

EC NUMBER
COMMENTARY hide
2.3.1.121
-
RECOMMENDED NAME
GeneOntology No.
1-alkenylglycerophosphoethanolamine O-acyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acyl-CoA + 1-alkenylglycerophosphoethanolamine = CoA + 1-alkenyl-2-acylglycerophosphoethanolamine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Ether lipid metabolism
-
-
Metabolic pathways
-
-
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase
Long-chain unsaturated acyl-CoAs are the best substrates.
CAS REGISTRY NUMBER
COMMENTARY hide
112445-17-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
guinea pig
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 1-alkenylglycerophosphoethanolamine
CoA + 1-alkenyl-2-acylglycerophosphoethanolamine
show the reaction diagram
arachidonoyl-CoA + 1-alkenylglycerophosphoethanolamine
CoA + 1-alkenyl-2-arachidonoylglycerophosphoethanolamine
show the reaction diagram
-
-
-
-
?
linoleoyl-CoA + 1-alkenylglycerophosphoethanolamine
CoA + 1-alkenyl-2-linoleoylglycerophosphoethanolamine
show the reaction diagram
-
best substrate
-
-
?
oleoyl-CoA + 1-alkenylglycerophosphoethanolamine
CoA + 1-alkenyl-2-oleoylglycerophosphoethanolamine
show the reaction diagram
-
poor substrate
-
-
?
palmitoyl-CoA + 1-alkenylglycerophosphoethanolamine
CoA + 1-alkenyl-2-palmitoylglycerophosphoethanolamine
show the reaction diagram
-
-
-
-
?
stearoyl-CoA + 1-alkenylglycerophosphoethanolamine
CoA + 1-alkenyl-2-stearoylglycerophosphoethanolamine
show the reaction diagram
-
poor substrate
-
-
?
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acyl-CoA + 1-alkenylglycerophosphoethanolamine
CoA + 1-alkenyl-2-acylglycerophosphoethanolamine
show the reaction diagram
-
involved in glycerophospholipid metabolism
-
-
?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ca2+
-
50% inhibition at 5 mM
iodoacetate
-
inhibition at 0.5 mM
N-ethylmaleimide
-
inhibition at 0.5 mM
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
dithiothreitol
-
activation
glutathione
-
activation
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8 - 9
-
microsomal preparation
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
-
microsomal preparation
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
55
-
56% loss of activity after 1 min