Information on EC 2.3.1.112 - D-tryptophan N-malonyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Arachis hypogaea

EC NUMBER
COMMENTARY hide
2.3.1.112
-
RECOMMENDED NAME
GeneOntology No.
D-tryptophan N-malonyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
malonyl-CoA + D-tryptophan = CoA + N2-malonyl-D-tryptophan
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
malonyl-CoA:D-tryptophan N-malonyltransferase
1-Aminocyclopropane-1-carboxylate can act instead of malonyl-CoA.
CAS REGISTRY NUMBER
COMMENTARY hide
94490-01-4
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
peanut, cv. fastigiata (Junagarh-11 or cultivar Shulamit)
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
malonyl-CoA + 1-aminocyclopropan-1-carboxylic acid
CoA + malonyl-1-aminocyclopropan-1-carboxylic acid
show the reaction diagram
-
condensation at 50% the rate of the condensation with D-tryptophan
-
-
?
malonyl-CoA + D-tryptophan
CoA + N2-malonyl-D-tryptophan
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
no substrates are L-tryptophan, anthranilate and 3,4-dichloroaniline
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
malonyl-CoA + D-tryptophan
CoA + N2-malonyl-D-tryptophan
show the reaction diagram
-
-
-
-
?
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
bovine serum albumin
-
2 mg/ml, activation
-
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.025
D-tryptophan
-
-
0.005
malonyl-CoA
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.8
-
broad
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.5 - 9
-
most active
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40000
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
-
1 * 38000, SDS-PAGE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, inactivation after 3 months
-
4°C, considerable loss of activity after several weeks
-
glycerol, 10%, stabilizes during storage
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE