Information on EC 2.3.1.102 - N6-hydroxylysine N-acetyltransferase

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The expected taxonomic range for this enzyme is: Escherichia coli

EC NUMBER
COMMENTARY hide
2.3.1.102
-
RECOMMENDED NAME
GeneOntology No.
N6-hydroxylysine N-acetyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + N6-hydroxy-L-lysine = CoA + N6-acetyl-N6-hydroxy-L-lysine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
aerobactin biosynthesis
Lysine degradation
-
-
Microbial metabolism in diverse environments
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-
SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:N6-hydroxy-L-lysine 6-acetyltransferase
Involved in the synthesis of aerobactin from lysine in a strain of Escherichia coli.
CAS REGISTRY NUMBER
COMMENTARY hide
101077-53-6
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + (5-hydroxyamine)pentan-1-amine
CoA + N-(5-aminopentyl)-N-hydroxyacetamide
show the reaction diagram
-
-
-
-
?
acetyl-CoA + DL-N6-hydroxylysine
CoA + N6-acetyl-N6-hydroxylysine
show the reaction diagram
-
-
-
-
?
acetyl-CoA + hydroxylamine
CoA + N-acetylhydroxylamine
show the reaction diagram
-
-
-
-
?
acetyl-CoA + L-N5-hydroxyornithine
CoA + N5-acetyl-N5-hydroxyornithine
show the reaction diagram
-
-
-
-
?
acetyl-CoA + L-N6-hydroxylysine
CoA + N6-acetyl-N6-hydroxylysine
show the reaction diagram
acetyl-CoA + N-methylhydroxylamine
CoA + N-acetyl-N-methylhydroxylamine
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + L-N6-hydroxylysine
CoA + N6-acetyl-N6-hydroxylysine
show the reaction diagram
-
-
-
?
additional information
?
-
-
enzyme is involved in the biosynthesis of aerobactin in E. coli
-
-
-
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Coomassie brilliant blue
-
mixed inhibitor
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.33
1-amino-5-(hydroxyamino)pentane
-
-
0.043 - 1.81
acetyl-CoA
329.4
hydroxylamine
-
-
0.317
L-N5-hydroxyornithine
-
-
0.055
L-N6-hydroxylysine
-
-
0.396
N-Methylhydroxylamine
-
-
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0000797
1-amino-5(hydroxyamino)pentane
Escherichia coli
-
-
0.00177
hydroxylamine
Escherichia coli
-
-
0.0000385
N-Methylhydroxylamine
Escherichia coli
-
-
0.0000477
N6-hydroxylysine
Escherichia coli
-
-
0.000112
N6-Hydroxyornithine
Escherichia coli
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-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00071
Coomassie brilliant blue
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-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
26
-
N6-hydroxylysine
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
-
assay at
40
-
sharp decline above
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
33000
-
SDS-PAGE, calculated from DNA sequence
150000 - 200000
-
gel filtration, native enzyme
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 33000, SDS-PAGE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
20°C, stable for several days
-
4°C, stable for several months
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
with plasmid pABN11
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Show AA Sequence (186 entries)
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