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Information on EC 2.2.1.8 - fluorothreonine transaldolase Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
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The expected taxonomic range for this enzyme is: Streptomyces cattleya
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fluorothreonine transaldolase
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L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine
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aldehyde group transfer
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fluoroacetate and fluorothreonine biosynthesis
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fluoroacetaldehyde:L-threonine aldehydetransferase
A pyridoxal phosphate protein. Can also convert chloroacetaldehyde into4-chloro-L-threonine. Unlike EC 2.1.2.1, glycine hydroxymethyltransferase, does not use glycine as a substrate.
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4-fluorothreoinine transaldolase
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gene is located on the megaplasmid
UniProt
brenda
NRRL 8057
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brenda
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UniProt
brenda
gene is located on the megaplasmid
UniProt
brenda
NRRL 8057
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brenda
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physiological function
final step of 4-fluorothreonine biosynthesis
physiological function
gene disruption of the transaldolase results in a mutant which can produce fluoroacetate but is blocked in its ability to biosynthesise 4-fluorothreonine, revealing a branchpoint role for the PLP-transaldolase
physiological function
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gene disruption of the transaldolase results in a mutant which can produce fluoroacetate but is blocked in its ability to biosynthesise 4-fluorothreonine, revealing a branchpoint role for the PLP-transaldolase
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fluoroacetaldehyde + L-threonine
acetaldehyde + 4-fluoro-L-threonine
L-threonine + chloroacetaldehyde
acetaldehyde + 4-chloro-L-threonine
L-threonine + fluoroacetaldehyde
4-fluoro-L-threonine + acetaldehyde
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L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
fluoroacetaldehyde + L-threonine
acetaldehyde + 4-fluoro-L-threonine
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fluoroacetaldehyde + L-threonine
acetaldehyde + 4-fluoro-L-threonine
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L-threonine + chloroacetaldehyde
acetaldehyde + 4-chloro-L-threonine
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L-threonine + chloroacetaldehyde
acetaldehyde + 4-chloro-L-threonine
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L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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C3 and C4 of threonine are replaced with the aldehyde carbons, generating a new molecule of threonine
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L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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the enzyme-PLP complex accepts acetaldehyde as a substrate and generates a new molecule of threonine in a neutral crossover reaction
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L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
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L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
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L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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C3 and C4 of threonine are replaced with the aldehyde carbons, generating a new molecule of threonine
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L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
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L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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the enzyme-PLP complex accepts acetaldehyde as a substrate and generates a new molecule of threonine in a neutral crossover reaction
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L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
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L-threonine + fluoroacetaldehyde
4-fluoro-L-threonine + acetaldehyde
B6VP39
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L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
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L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
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L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
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L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
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pyridoxal 5'-phosphate
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pyridoxal 5'-phosphate protein
pyridoxal 5'-phosphate
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60000
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2 * 60000, SDS-PAGE
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dimer
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2 * 60000, SDS-PAGE
dimer
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2 * 60000, SDS-PAGE
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partially by Ni-affinity column, size exclusion chromatography
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expression in Escherichia coli BL21, transfection to Streptococcus lividans TK24
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4FTAS_STRCT
634
69529
Swiss-Prot
A0A1X7BQI7_9RHOB
435
45863
TrEMBL
A0A0P1EFM6_9RHOB
435
46599
TrEMBL
A0A0P1IFE6_9RHOB
436
46078
TrEMBL
A0A0P1E9P2_9RHOB
435
46477
TrEMBL
A0A0M6Y6Q4_9RHOB
440
46067
TrEMBL
A0A0N7LXJ0_9RHOB
141
14632
TrEMBL
A0A165MZ72_9RHOB
445
47482
TrEMBL
A0A1V6K2W8_9BACT
477
53667
TrEMBL
A0A1V6B0D7_9BACT
479
52974
TrEMBL
A0A1M7YQP8_9VIBR
419
47095
TrEMBL
A0A1C3IZX4_9VIBR
373
40325
TrEMBL
A0A0K0YA73_9RHOB
436
46289
TrEMBL
A0A165PF11_9RHOB
445
47234
TrEMBL
A0A1A8T179_9GAMM
391
42700
TrEMBL
A0A166C4I3_9RHOB
445
47277
TrEMBL
A0A1S8SGR0_CLOBE
448
51059
TrEMBL
F8JMF0_STREN
Streptomyces cattleya (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057)
634
69529
TrEMBL
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Murphy, C.D.; Schaffrath, C.; O'Hagan, D.
Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya
Chemosphere
52
455-461
2003
Streptomyces cattleya, Streptomyces cattleya NRRL 8057
brenda
Murphy, C.D.; O'Hagan, D.; Schaffrath, C.
Identification of a PLP-dependent threonine transaldolase: a novel enzyme involved in 4-fluorothreonine biosynthesis in Streptomyces cattleya
Angew. Chem.
40
4479-4481
2001
Streptomyces cattleya, Streptomyces cattleya NRRL 8057
brenda
Deng, H.; Cross, S.M.; McGlinchey, R.P.; Hamilton, J.T.; OHagan, D.
In vitro reconstituted biotransformation of 4-fluorothreonine from fluoride ion: application of the fluorinase
Chem. Biol.
15
1268-1276
2008
Streptomyces cattleya (B6VP39)
brenda
Zhao, C.; Li, P.; Deng, Z.; Ou, H.Y.; McGlinchey, R.P.; OHagan, D.
Insights into fluorometabolite biosynthesis in Streptomyces cattleya DSM46488 through genome sequence and knockout mutants
Bioorg. Chem.
44
1-7
2012
Streptomyces cattleya (F8JMF0), Streptomyces cattleya DSM 46488 (F8JMF0)
brenda
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