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Enzyme Nomenclature
Information on EC 2.2.1.8 - fluorothreonine transaldolase
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The expected taxonomic range for this enzyme is: Streptomyces cattleya
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EC NUMBER 
COMMENTARY 
2.2.1.8
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RECOMMENDED NAME
GeneOntology No.
fluorothreonine transaldolase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
aldehyde group transfer
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
fluoroacetaldehyde:L-threonine aldehydetransferase
A pyridoxal phosphate protein. Can also convert chloroacetaldehyde into4-chloro-L-threonine. Unlike EC 2.1.2.1, glycine hydroxymethyltransferase, does not use glycine as a substrate.
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CAS REGISTRY NUMBER
COMMENTARY
403503-13-9
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
physiological function
final step of 4-fluorothreonine biosynthesis
physiological function
gene disruption of the transaldolase results in a mutant which can produce fluoroacetate but is blocked in its ability to biosynthesise 4-fluorothreonine, revealing a branchpoint role for the PLP-transaldolase
physiological function
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gene disruption of the transaldolase results in a mutant which can produce fluoroacetate but is blocked in its ability to biosynthesise 4-fluorothreonine, revealing a branchpoint role for the PLP-transaldolase
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-threonine + fluoroacetaldehyde
4-fluoro-L-threonine + acetaldehyde
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-
-
?
fluoroacetaldehyde + L-threonine
acetaldehyde + 4-fluoro-L-threonine
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-
-
?
fluoroacetaldehyde + L-threonine
acetaldehyde + 4-fluoro-L-threonine
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-
-
?
L-threonine + chloroacetaldehyde
acetaldehyde + 4-chloro-L-threonine
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-
-
?
L-threonine + chloroacetaldehyde
acetaldehyde + 4-chloro-L-threonine
-
-
-
?
L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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C3 and C4 of threonine are replaced with the aldehyde carbons, generating a new molecule of threonine
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?
L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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the enzyme-PLP complex accepts acetaldehyde as a substrate and generates a new molecule of threonine in a neutral crossover reaction
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?
L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
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L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
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?
L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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C3 and C4 of threonine are replaced with the aldehyde carbons, generating a new molecule of threonine
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?
L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
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?
L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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the enzyme-PLP complex accepts acetaldehyde as a substrate and generates a new molecule of threonine in a neutral crossover reaction
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?
L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-threonine + fluoroacetaldehyde
4-fluoro-L-threonine + acetaldehyde
B6VP39
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-
-
?
L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
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-
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L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
-
?
L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
-
?
L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
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enzyme is important in biosynthesis of 4-fluorothreonine
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-
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
dimer
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli BL21, transfection to Streptococcus lividans TK24
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LINKS TO OTHER DATABASES (specific for EC-Number 2.2.1.8)
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