Information on EC 2.2.1.8 - fluorothreonine transaldolase

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The expected taxonomic range for this enzyme is: Streptomyces cattleya

EC NUMBER
COMMENTARY hide
2.2.1.8
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RECOMMENDED NAME
GeneOntology No.
fluorothreonine transaldolase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-threonine + fluoroacetaldehyde = acetaldehyde + 4-fluoro-L-threonine
show the reaction diagram
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-
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aldehyde group transfer
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
fluoroacetate and fluorothreonine biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
fluoroacetaldehyde:L-threonine aldehydetransferase
A pyridoxal phosphate protein. Can also convert chloroacetaldehyde into4-chloro-L-threonine. Unlike EC 2.1.2.1, glycine hydroxymethyltransferase, does not use glycine as a substrate.
CAS REGISTRY NUMBER
COMMENTARY hide
403503-13-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene is located on the megaplasmid
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
fluoroacetaldehyde + L-threonine
acetaldehyde + 4-fluoro-L-threonine
show the reaction diagram
L-threonine + chloroacetaldehyde
acetaldehyde + 4-chloro-L-threonine
show the reaction diagram
L-threonine + fluoroacetaldehyde
4-fluoro-L-threonine + acetaldehyde
show the reaction diagram
-
-
-
?
L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-threonine + fluoroacetaldehyde
4-fluoro-L-threonine + acetaldehyde
show the reaction diagram
B6VP39
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-
-
?
L-threonine + fluoroacetaldehyde
acetaldehyde + 4-fluoro-L-threonine
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
60000
-
2 * 60000, SDS-PAGE
120000
-
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partially by Ni-affinity column, size exclusion chromatography
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli BL21, transfection to Streptococcus lividans TK24