Information on EC 2.2.1.4 - acetoin-ribose-5-phosphate transaldolase

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The expected taxonomic range for this enzyme is: Bacillus pumilus

EC NUMBER
COMMENTARY hide
2.2.1.4
-
RECOMMENDED NAME
GeneOntology No.
acetoin-ribose-5-phosphate transaldolase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3-hydroxybutan-2-one + D-ribose 5-phosphate = acetaldehyde + 1-deoxy-D-altro-heptulose 7-phosphate
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aldehyde group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
3-hydroxybutan-2-one:D-ribose-5-phosphate aldehydetransferase
A thiamine-diphosphate protein.
CAS REGISTRY NUMBER
COMMENTARY hide
87843-76-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
transketolase mutant strain BG2532
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-hydroxybutan-2-one + D-ribose 5-phosphate
acetaldehyde + 1-deoxy-D-altro-heptulose 7-phosphate
show the reaction diagram
-
i.e. acetoin
-
?
methylacetoin + D-ribose 5-phosphate
acetone + 1-deoxy-D-altro-heptulose 7-phosphate
show the reaction diagram
-
-
-
?
additional information
?
-
-
no substrates are acetaldehyde, pyruvate, acetone, hydroxyacetone, acetylacetone i.e. 2,4-pentanedione, propanetriol, diacetyl i.e. 2,3-butanedione, 2,3-butanediol, 1,2,3-butanetriol, 2-butanone
-
-
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
3-hydroxybutan-2-one + D-ribose 5-phosphate
acetaldehyde + 1-deoxy-D-altro-heptulose 7-phosphate
show the reaction diagram
-
i.e. acetoin
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
thiamine diphosphate
-
requirement, thiamine diphosphate protein
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Mg2+
-
requirement
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.5 - 9
-
-
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
120000
-
gel filtration
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 8
-
stable for 1 h at 37°C in the presence of cofactors and 2-mercaptoethanol
486058
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
stable for 1 h at pH 6.0-8.0 in the presence of cofactors and 2-mercaptoethanol
80
-
inactivation after 3 min
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
thiamine diphosphate, or Mg2+, or 2-mercaptoethanol stabilizes
-
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE