Information on EC 2.1.4.2 - scyllo-inosamine-4-phosphate amidinotransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results (more...)
Include results (AMENDA + additional results, but less precise; more...)


The expected taxonomic range for this enzyme is: Streptomyces

EC NUMBER
COMMENTARY hide
2.1.4.2
-
RECOMMENDED NAME
GeneOntology No.
scyllo-inosamine-4-phosphate amidinotransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate = L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
show the reaction diagram
1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate, streptamine phosphate and 2-deoxystreptamine phosphate can also act as acceptors; canavanine can act as donor
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amidine group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Biosynthesis of antibiotics
-
-
streptomycin biosynthesis
-
-
Streptomycin biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase
1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate, streptamine phosphate and 2-deoxystreptamine phosphate can also act as acceptors; canavanine can act as donor.
CAS REGISTRY NUMBER
COMMENTARY hide
52227-63-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
no activity in Streptomyces griseus
-
-
-
Manually annotated by BRENDA team
no activity in Streptomyces griseus ATCC 10971
-
-
-
Manually annotated by BRENDA team
Streptomyces consensus
-
-
-
Manually annotated by BRENDA team
strB1, genebank acc. No.
SwissProt
Manually annotated by BRENDA team
strB2, genebank acc. No.
SwissProt
Manually annotated by BRENDA team
ATCC10137
-
-
Manually annotated by BRENDA team
strain SPH
-
-
Manually annotated by BRENDA team
EMBL accession number
SwissProt
Manually annotated by BRENDA team
strain W4
-
-
Manually annotated by BRENDA team
ATCC 12760
-
-
Manually annotated by BRENDA team
forma glebosus, ATCC 14607
-
-
Manually annotated by BRENDA team
ATCC 12853
-
-
Manually annotated by BRENDA team
ATCC 23265
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-deoxystreptidine 6-phosphate + scyllo-inosaminephosphate
?
show the reaction diagram
-
-
-
?
arginine + 1,4-diaminobutylphosphonic acid
ornithine + ?
show the reaction diagram
-
-
-
-
?
arginine + 1-D-1,3-diamino-1,2,3-trideoxy-scyllo-inositol 6-phosphate
ornithine + ?
show the reaction diagram
-
-
-
-
?
arginine + 1-D-1,3-diamino-1,3-dideoxy-scyllo-inositol 6-phosphate
ornithine + ?
show the reaction diagram
-
-
-
-
?
arginine + 1-D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate
ornithine + ?
show the reaction diagram
-
-
-
-
?
arginine + 1-D-1-O-carbamoyl-3-amino-3-deoxy-scyllo-inositol 6-phosphate
ornithine + ?
show the reaction diagram
-
-
-
-
?
arginine + 2-amino-2-deoxy-neo-inositol 5-phosphate
?
show the reaction diagram
-
-
-
?
arginine + 2-amino-2-deoxy-neoinositol 5-phosphate
ornithine + ?
show the reaction diagram
arginine + 2-deoxystreptamine 6-phosphate
N-amidino-2-deoxystreptamine 6-phosphate + ornithine
show the reaction diagram
arginine + 2-deoxystreptidine
ornithine + ?
show the reaction diagram
arginine + 3-amino-3-deoxy-scyllo-inosamine 4-phosphate
?
show the reaction diagram
-
-
-
?
arginine + canaline
?
show the reaction diagram
-
-
-
?
arginine + hydroxylamine
ornithine + hydroxyguanidine
show the reaction diagram
arginine + inosamine phosphate
ornithine + ?
show the reaction diagram
-
-
-
-
?
arginine + N-amidinostreptamine 6-phosphate
?
show the reaction diagram
-
-
-
?
arginine + NH2OH
ornithine + ?
show the reaction diagram
-
-
-
-
?
arginine + ornithine
?
show the reaction diagram
-
-
-
?
arginine + scyllo-inosamine 4-phosphate
?
show the reaction diagram
-
-
-
?
arginine + scyllo-inosamine 4-phosphate
ornithine + N-amidino-scyllo-inosamine-4-phosphate
show the reaction diagram
arginine + streptamine 6-phosphate
ornithine + N-amidinostreptamine 6-phosphate
show the reaction diagram
-
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
show the reaction diagram
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
show the reaction diagram
L-canavanine + L-ornithine
L-canaline + L-arginine
show the reaction diagram
N-amidino-scyllo-inosamine 4-phosphate + scyllo-inosaminephosphate
?
show the reaction diagram
weak amidino donor
-
-
?
streptidine 6-phosphate + scyllo-inosaminephosphate
?
show the reaction diagram
-
-
-
?
streptidine phosphate + glycylglycine
?
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cystamine
cystine
formamidine disulfidedihydrochloride
ornithine
p-chloromercuribenzoate
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
42000
-
SDS-PAGE
68900
-
sedimentation analysis
80300
-
calculated molecular mass
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
tetragonal-bipyramidal shaped crystals, belonging to the tetragonal space group P4(3), a = b = 121.3 A, c = 63.74 A
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
strain strB1, cloned as N-terminal hexa-histidine fusion protein