Reference on EC 2.1.2.9 - methionyl-tRNA formyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dickerman, H.W.; Steers, E.; Redfield, B.G.; Weissbach, H.
Methionyl soluble ribonucleic acid transformylase. I. Purification and partial characterization
J. Biol. Chem.
242
1522-1525
1967
Escherichia coli, Escherichia coli B / ATCC 11303
Blanquet, S.; Dessen, P.; Kahn, D.
Properties and specificity of methionyl-tRNAfMet formyltransferase from Escherichia coli
Methods Enzymol.
106
141-152
1984
Escherichia coli, Escherichia coli K12 EM20031(F32)
Giege, R.; Ebel, J.P.; Clarke, B.F.C.
Formylation of mischarged E. coli tRNA Met f
FEBS Lett.
30
291-295
1973
Escherichia coli, Escherichia coli K12 MO
Kahn, D.; Fromant, M.; Fayat, G.; Dessen, P.; Blanquet, S.
Methionyl-transfer-RNA transformylase from Escherichia coli. Purification and characterisation
Eur. J. Biochem.
105
489-497
1980
Escherichia coli, Escherichia coli K12 EM20031(F32)
Guillon, J.M.; Meinnel, T.; Mechulam, Y.; Lazennec, C.; Blanquet, S.; Fayat, G.
Nucleotides of tRNA governing the specificity of Escherichia coli methionyl-tRNA(fMet) formyltransferase
J. Mol. Biol.
224
359-367
1992
Escherichia coli
Lee, C.P.; Seong, B.L.; RajBhandary, U.L.
Structural and sequence elements important for recognition of Escherichia coli formylmethionine tRNA by methionyl-tRNA transformylase are clustered in the acceptor stem
J. Biol. Chem.
266
18012-18017
1991
Escherichia coli
Crosti, P.; Gambini, A.; Lucchini, G.; Bianchetti, R.
Eukaryotic N10-formyl-H4folate:methionyl-tRNAf transformylase. Some properties of the Euglena gracilis enzyme
Biochim. Biophys. Acta
477
356-370
1977
Euglena gracilis, Euglena gracilis Z
Gambini, A.; Crosti, P.; Bianchetti, R.
Inhibitor studies of methionyl-tRNA transformylase of Euglena gracilis
Biochim. Biophys. Acta
613
73-78
1980
Euglena gracilis
Samuel, C.E.; Rabinowitz, J.C.
Initiation of protein synthesis by folate-sufficient and folate-deficient Streptococcus faecalis R: Partial purification and properties of methionyl-transfer ribonucleic acid synthetase and methionyl-transfer ribonucleic acid formyltransferase
J. Bacteriol.
118
21-31
1974
Escherichia coli, Enterococcus faecalis, Enterococcus faecalis R / ATCC 8043, Escherichia coli A19
Halbreich, A.; Rabinowitz, M.
Isolation of Saccharomyces cerevisiae mitochondrial formyltetrahydrofolic acid:methionyl-tRNA transformylase and the hybridization of mitochondrial fMet-tRNA with mitochondrial DNA
Proc. Natl. Acad. Sci. USA
68
294-298
1971
Saccharomyces cerevisiae, Saccharomyces cerevisiae D243-2B-R1
Leis, J.P.; Keller, E.B.
N-formylmethionyl-tRNA of wheat chloroplasts. Its synthesis by a wheat transformylase
Biochemistry
10
889-894
1971
Triticum aestivum
Schmitt, E.; Panvert, M.; Blanquet, S.; Mechulam, Y.
Crystal structure of methionyl-tRNAfMet transformylase complexed with the initiator formyl-methionyl-tRNA
EMBO J.
17
6819-6826
1998
Escherichia coli (P23882)
Schmitt, E.; Blanquet, S.; Mechulam, Y.
Structure of crystalline Escherichia coli methionyl-tRNAMet formyltransferase: Comparison with glycinamide ribonucleotide formyltransferase
EMBO J.
15
4749-4758
1996
Escherichia coli
Takeuchi, N.; Ueda, T.; Watanabe, K.
Expression and characterization of bovine mitochondrial methionyl-tRNA transformylase
J. Biochem.
124
1069-1071
1998
Bos taurus
Takeuchi, N.; Vial, L.; Panvert, M.; Schmitt, E.; Watanabe, K.; Mechulam, Y.; Blanquet, S.
Recognition of tRNAs by methionyl-tRNA transformylase from mammalian mitochondria
J. Biol. Chem.
276
20064-20068
2001
Bos taurus
Ramesh, V.; Gite, S.; Li, Y.; RajBhandary, U.L.
Suppressor mutations in Escherichia coli methionyl-tRNA formyltransferase: Role of a 16-amino acid insertion module in initiator tRNA recognition
Proc. Natl. Acad. Sci. USA
94
13524-13529
1997
Escherichia coli, Escherichia coli CA274, Escherichia coli DH5-alphaF, Escherichia coli JM109
Li, Y.; Ramesh, V.; Mangroo, D.; Taneja, C.; RajBhandary, U.L.
Suppressor mutations in Escherichia coli methionyl-tRNA formyltransferase that compensate for the formylation defect of a mutant tRNA aminoacylated with lysine
Biochemistry
39
8039-8046
2000
Escherichia coli, Escherichia coli CA274, Escherichia coli JM109
Ramesh, V.; Gite, S.; RajBhandary, U.L.
Functional interaction of an arginine conserved in the sixteen amino acid insertion module of Escherichia coli methionyl-tRNA formyltransferase with determinants for formylation in the initiator tRNA
Biochemistry
37
15925-15932
1998
Escherichia coli
Gite, S.; Li, Y.; Ramesh, V.; RajBhandary, U.L.
Escherichia coli methionyl-tRNA formyltransferase: Role of amino acids conserved in the linker region and in the C-terminal domain on the specific recognition of the initiator tRNA
Biochemistry
39
2218-2226
2000
Escherichia coli (P23882), Escherichia coli, Escherichia coli JM109 (P23882), Escherichia coli XL1-Blue (P23882)
Vial, L.; Gomez, P.; Panvert, M.; Schmitt, E.; Blanquet, S.; Mechulam, Y.
Mitochondrial methionyl-tRNAfMet formyltransferase from Saccharomyces cerevisiae: Gene disruption and tRNA substrate specificity
Biochemistry
42
932-939
2003
Saccharomyces cerevisiae
Newton, D.T.; Mangroo, D.
Mapping the active site of the Haemophilus influenzae methionyl-tRNA formyltransferase: Residues important for catalysis and tRNA binding
Biochem. J.
339
63-69
1999
Thermus thermophilus, Haemophilus influenzae, Pseudomonas aeruginosa, Rickettsia prowazekii
-
Mayer, C.; RajBhandary, U.L.
Conformational change of Escherichia coli initiator methionyl-tRNAfMet upon binding to methionyl-tRNA formyl transferase
Nucleic Acids Res.
30
2844-2850
2002
Escherichia coli (P23882), Escherichia coli
Mayer, C.; Kohrer, C.; Kenny, E.; Prusko, C.; RajBhandary, U.L.
Anticodon sequence mutants of Escherichia coli initiator tRNA: effects of overproduction of aminoacyl-tRNA synthetases, methionyl-tRNA formyltransferase, and initiation factor 2 on activity in initiation
Biochemistry
42
4787-4799
2003
Escherichia coli
Charriere, F.; Tan, T.H.; Schneider, A.
Mitochondrial initiation factor 2 of Trypanosoma brucei binds imported formylated elongator-type tRNA(Met)
J. Biol. Chem.
280
15659-15665
2005
Trypanosoma brucei
Newton, D.T.; Niemkiewicz, M.; Lo, R.Y.; Mangroo, D.
Recognition of the initiator tRNA by the Pseudomonas aeruginosa methionyl-tRNA formyltransferase: importance of the base-base mismatch at the end of the acceptor stem
FEMS Microbiol. Lett.
178
289-298
1999
Escherichia coli, Pseudomonas aeruginosa
Williams, E.H.; Butler, C.A.; Bonnefoy, N.; Fox, T.D.
Translation initiation in Saccharomyces cerevisiae mitochondria: functionalinteractions among mitochondrial ribosomal protein Rsm28p, initiation factor 2, methionyl-tRNA-formyltransferase and novel protein Rmd9p
Genetics
175
1117-1126
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P32785)
Nilsson, A.I.; Zorzet, A.; Kanth, A.; Dahlstroem, S.; Berg, O.G.; Andersson, D.I.
Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes
Proc. Natl. Acad. Sci. USA
103
6976-6981
2006
Salmonella enterica
Caughlan, R.E.; Sriram, S.; Daigle, D.M.; Woods, A.L.; Buco, J.; Peterson, R.L.; Dzink-Fox, J.; Walker, S.; Dean, C.R.
Fmt bypass in Pseudomonas aeruginosa causes induction of MexXY efflux pump expression
Antimicrob. Agents Chemother.
53
5015-5021
2009
Pseudomonas aeruginosa
Lee, C.; Tibbetts, A.S.; Kramer, G.; Appling, D.R.
Yeast AEP3p is an accessory factor in initiation of mitochondrial translation
J. Biol. Chem.
284
34116-34125
2009
Saccharomyces cerevisiae
Tucker, E.J.; Hershman, S.G.; Koehrer, C.; Belcher-Timme, C.A.; Patel, J.; Goldberger, O.A.; Christodoulou, J.; Silberstein, J.M.; McKenzie, M.; Ryan, M.T.; Compton, A.G.; Jaffe, J.D.; Carr, S.A.; Calvo, S.E.; RajBhandary, U.L.; Thorburn, D.R.; Mootha, V.K.
Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation
Cell Metab.
14
428-434
2011
Homo sapiens
Pino, P.; Aeby, E.; Foth, B.J.; Sheiner, L.; Soldati, T.; Schneider, A.; Soldati-Favre, D.
Mitochondrial translation in absence of local tRNA aminoacylation and methionyl tRNA Met formylation in Apicomplexa
Mol. Microbiol.
76
706-718
2010
Toxoplasma gondii, Toxoplasma gondii RH
Lewandowski, T.; Huang, J.; Fan, F.; Rogers, S.; Gentry, D.; Holland, R.; Demarsh, P.; Aubart, K.; Zalacain, M.
Staphylococcus aureus formyl-methionyl transferase mutants demonstrate reduced virulence factor production and pathogenicity
Antimicrob. Agents Chemother.
57
2929-2936
2013
Staphylococcus aureus, Staphylococcus aureus WCUH29
Sinha, A.; Koehrer, C.; Weber, M.H.; Masuda, I.; Mootha, V.K.; Hou, Y.M.; RajBhandary, U.L.
Biochemical characterization of pathogenic mutations in human mitochondrial methionyl-tRNA formyltransferase
J. Biol. Chem.
289
32729-32741
2014
Escherichia coli (P23882), Escherichia coli, Homo sapiens (Q96DP5), Homo sapiens
Franco, L.V.R.; Moda, B.S.; Soares, M.A.K.M.; Barros, M.H.
Msc6p is required for mitochondrial translation initiation in the absence of formylated Met-tRNAfMet
FEBS J.
286
1407-1419
2019
Saccharomyces cerevisiae
La Piana, R.; Weraarpachai, W.; Ospina, L.H.; Tetreault, M.; Majewski, J.; Majewski, J.; Bruce Pike, G.; Decarie, J.C.; Tampieri, D.; Brais, B.; Shoubridge, E.A.
Identification and functional characterization of a novel MTFMT mutation associated with selective vulnerability of the visual pathway and a mild neurological phenotype
Neurogenetics
18
97-103
2017
Homo sapiens
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