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(6R,S)-tetrahydrofolate + N-formimidoyl-L-glutamate
5-formimidoyltetrahydrofolate + L-glutamate
-
-
-
-
r
(6S)-tetrahydropteroylpentaglutamate + N-formimidoyl-L-glutamate
5-formiminotetrahydropteroylpentaglutamate + L-glutamate
-
-
-
-
r
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
5-formyltetrahydrofolate + L-glutamate
N-formyl-L-glutamate + tetrahydrofolate
N-formimidoyl-L-Glu-L-Glu-L-Glu + tetrahydrofolate
N-formimidoyl-L-Glu-L-Glu + 5-formimidoyltetrahydrofolate
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
tetrahydropteroic acid + N-formimino-L-glutamate
5-formiminotetrahydropteroic acid + L-glutamate
-
tetrahydropteroic acid is a good alternate substrate
-
?
tetrahydropteroylpentaglutamate + N-formimino-L-glutamate
5-formiminotetrahydropteroylpentaglutamate + L-glutamate
additional information
?
-
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formyltetrahydrofolate + L-glutamate
N-formyl-L-glutamate + tetrahydrofolate
-
formation of N5-formyltetrahydrofolate + L-glutamate
-
?
5-formyltetrahydrofolate + L-glutamate
N-formyl-L-glutamate + tetrahydrofolate
-
N5-formyl group of Citrovorum factor, specific with respect to substrates, formation of N5-formiminotetrahydrofolate and anhydro-Citrovorum factor precedes the formation of the N10-formyl folate derivatives
-
r
5-formyltetrahydrofolate + L-glutamate
N-formyl-L-glutamate + tetrahydrofolate
-
folinic acid binding site, preference for (6R)-enantiomer of folinic acid
-
-
?
N-formimidoyl-L-Glu-L-Glu-L-Glu + tetrahydrofolate
N-formimidoyl-L-Glu-L-Glu + 5-formimidoyltetrahydrofolate
-
-
-
-
?
N-formimidoyl-L-Glu-L-Glu-L-Glu + tetrahydrofolate
N-formimidoyl-L-Glu-L-Glu + 5-formimidoyltetrahydrofolate
-
-
-
-
?
N-formimidoyl-L-Glu-L-Glu-L-Glu + tetrahydrofolate
N-formimidoyl-L-Glu-L-Glu + 5-formimidoyltetrahydrofolate
-
-
-
-
?
N-formimidoyl-L-Glu-L-Glu-L-Glu + tetrahydrofolate
N-formimidoyl-L-Glu-L-Glu + 5-formimidoyltetrahydrofolate
-
-
-
-
?
N-formimidoyl-L-Glu-L-Glu-L-Glu + tetrahydrofolate
N-formimidoyl-L-Glu-L-Glu + 5-formimidoyltetrahydrofolate
-
-
-
-
?
N-formimidoyl-L-Glu-L-Glu-L-Glu + tetrahydrofolate
N-formimidoyl-L-Glu-L-Glu + 5-formimidoyltetrahydrofolate
-
-
-
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
in addition to its enzymatic activity enzyme may have a second physiological function in mediating interaction of Golgi-derived membranes with microtubules
-
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
histidine degradation
-
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
bifunctional formiminotransferase cyclodeaminase, 58K, is associated with the cytoplasmatic surface of the Golgi apparatus in vivo
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
bifunctional formiminotransferase cyclodeaminase, 58K, is associated with the cytoplasmatic surface of the Golgi apparatus in vivo
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
metabolic enzyme involved in the conversion of histidine to glutamic acid
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine metabolism pathway, reaction occurs in vivo within the soluble phase of cytoplasm
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
physiological substrate is (6S)-tetrahydrofolate
natural biosynthetic product is N5-formiminotetrahydrofolate
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
enzyme serves as additional entry point for the folate pool in liver
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
natural biosynthetic product is N5-formiminotetrahydrofolate
?
tetrahydrofolate + N-formimidoyl-L-glutamate
5-formimidoyltetrahydrofolate + L-glutamate
-
-
-
?
tetrahydrofolate + N-formimidoyl-L-glutamate
5-formimidoyltetrahydrofolate + L-glutamate
FTCD in the centrosome may be associated with polyglutamylated residues of centriole microtubules and may play a role in providing centrioles with glutamate produced by cyclodeaminase domains of FTCD
-
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
alpha-L-formamidinoglutaric acid, absolute specificity with regard to the isomers of tetrahydrofolate at position 6, reduced pteroylaspartic acid and reduced pteroyltriglutamic acid can replace tetrahydrofolate
-
r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
specificity, equilibrium lies far on formation of formiminotetrahydrofolate and glutamate
-
r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
transfer of a single carbon from formiminoglutamate to tetrahydrofolate, product is 5-formiminotetrahydrofolate
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
relatively specific for formiminoglutamic acid
-
r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
mode of substrate binding and channeling, 3 glutamate-binding sites, mechanism for product release, His-82 may act as catalytic base required for the formiminotransferase mechanism, an electrostatic tunnel through the width of the domain facilitates recognition of the substrates
labile 5-formiminotetrahydrofolate product
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
tetrahydropteroic acid can replace tetrahydrofolate
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
transfer of a single carbon from formiminoglutamate to tetrahydrofolate, product is 5-formiminotetrahydrofolate
-
?
tetrahydropteroylpentaglutamate + N-formimino-L-glutamate
5-formiminotetrahydropteroylpentaglutamate + L-glutamate
-
bifunctional formiminotetrahydrofolate cyclodeaminase: preference for polyglutamylated substrates, polyglutamylation improves binding of both the folate substrates and formiminoglutamate
-
?
tetrahydropteroylpentaglutamate + N-formimino-L-glutamate
5-formiminotetrahydropteroylpentaglutamate + L-glutamate
-
optimum number of glutamates for channeling of the product to the cyclodeaminase domain is five
-
?
additional information
?
-
-
primary reaction of the over-all reaction formimino-L-glutamate + tetrahydrofolate = N10-formyltetrahydrofolate + glutamate + NH3
-
-
?
additional information
?
-
-
primary reaction of the over-all reaction formimino-L-glutamate + tetrahydrofolate = N10-formyltetrahydrofolate + glutamate + NH3
-
-
?
additional information
?
-
-
not: formamidinoacetic acid, formylisoglutamine, formylglutamine, acetylglutamic acid
-
-
?
additional information
?
-
-
formation of glutamic acid is reversible while formation of ammonia is not
-
-
?
additional information
?
-
p60: bifunctional formiminotransferase cyclodeaminase, can mediate interaction between trans-Golgi network derived vesicles and microtubule in vitro, p60 may bind to the polyglutamate on microtubules, globular hydrophilic protein
-
-
?
additional information
?
-
-
p60: bifunctional formiminotransferase cyclodeaminase, can mediate interaction between trans-Golgi network derived vesicles and microtubule in vitro, p60 may bind to the polyglutamate on microtubules, globular hydrophilic protein
-
-
?
additional information
?
-
-
-
-
-
?
additional information
?
-
-
58K: formiminotransferase cyclodeaminase, bifunctional enzyme catalyzing two consecutive steps in the modification of tetrahydrofolate to 5,10-methenyl tetrahydrofolate
-
-
?
additional information
?
-
-
58K: formiminotransferase cyclodeaminase, bifunctional enzyme catalyzing two consecutive steps in the modification of tetrahydrofolate to 5,10-methenyl tetrahydrofolate
-
-
?
additional information
?
-
FTCD: bifunctional enzyme with 5-formiminotetrahydrofolate:L-glutamate N-formiminotransferase activity, EC 2.1.2.5, and formiminotetrahydrofolate cyclodeaminase activity, EC 4.3.1.4
-
-
?
additional information
?
-
-
primary reaction of the over-all reaction formimino-L-glutamate + tetrahydrofolate = N10-formyltetrahydrofolate + glutamate + NH3
-
-
?
additional information
?
-
-
not: formiminoglycine, very poor substrates: formimino-L-aspartic acid, formyl-L-glutamic acid
-
-
?
additional information
?
-
-
twin enzyme EC 2.1.2.5 and formiminotetrahydrofolate cyclodeaminase EC 4.3.1.4: enzyme system forming N5,10-methenyltetrahydrofolate from formiminoglutamate and tetrahydrofolate
-
-
?
additional information
?
-
-
FTCD: bifunctional enzyme formiminotransferase cyclodeaminase efficiently channels polyglutamated folate between catalytic sites, only the octamer is able to directly transfer pentaglutamated intermediate between active sites, subunit structure
-
-
?
additional information
?
-
-
FTCD: bifunctional enzyme formiminotransferase cyclodeaminase, EC 2.1.2.5 and EC 4.3.1.4, formiminotransferase domain: N-terminal 326 residues, detailed structure
-
-
?
additional information
?
-
-
molecular enzyme complex with formiminotransferase and cyclodeaminase activity, EC 2.1.2.5 and EC 4.3.1.4, both activities are contained in a single polypeptide chain, no substrate: formiminoaspartate
-
-
?
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5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
5-formimidoyltetrahydrofolate + L-glutamate
FTCD in the centrosome may be associated with polyglutamylated residues of centriole microtubules and may play a role in providing centrioles with glutamate produced by cyclodeaminase domains of FTCD
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
in addition to its enzymatic activity enzyme may have a second physiological function in mediating interaction of Golgi-derived membranes with microtubules
-
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
histidine degradation
-
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
bifunctional formiminotransferase cyclodeaminase, 58K, is associated with the cytoplasmatic surface of the Golgi apparatus in vivo
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
bifunctional formiminotransferase cyclodeaminase, 58K, is associated with the cytoplasmatic surface of the Golgi apparatus in vivo
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
metabolic enzyme involved in the conversion of histidine to glutamic acid
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine metabolism pathway, reaction occurs in vivo within the soluble phase of cytoplasm
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
physiological substrate is (6S)-tetrahydrofolate
natural biosynthetic product is N5-formiminotetrahydrofolate
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
enzyme serves as additional entry point for the folate pool in liver
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
natural biosynthetic product is N5-formiminotetrahydrofolate
?
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Slavik, K.; Zizkovsky, V.; Slavikova, V.; Fort, P.
The purification of formiminotransferase and cyclodeaminase by combination of affinity chromatography and isoelectric focusing
Biochem. Biophys. Res. Commun.
59
1173-1184
1974
Sus scrofa
brenda
Hennig, D.; Scales, S.J.; Moreau, A.; Murley, L.L.; De Mey, J.; Kreis, T.E.
A formiminotransferase cyclodeaminase isoform is localized to the Golgi complex and can mediate interaction of trans-Golgi network-derived vesicles with microtubules
J. Biol. Chem.
273
19602-19611
1998
Meleagris gallopavo, Gallus gallus (Q9YH58)
brenda
Gao, Y.S.; Alvarez, C.; Nelson, D.S.; Sztul, E.
Molecular cloning, characterization, and dynamics of rat formiminotransferase cyclodeaminase, a Golgi-associated 58-kDa protein
J. Biol. Chem.
273
33825-33834
1998
Rattus norvegicus
brenda
Tabor, H.; Wyngarden, L.
The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid
J. Biol. Chem.
234
1830-1846
1959
Bos taurus, Cavia porcellus, Oryctolagus cuniculus, Felis catus, Homo sapiens, Mus musculus, Sus scrofa
brenda
Miller, A.; Waelsch, H.
Formimino transfer from formamidinoglutaric acid to tetrahydrofolic acid
J. Biol. Chem.
228
397-417
1957
Bos taurus, Rattus norvegicus
brenda
Silverman, M.; Keresztesy, J.C.; Koval, G.J.; Gardiner, R.C.
Citrovorum factor and the synthesis of formylglutamic acid
J. Biol. Chem.
226
83-94
1957
Sus scrofa
brenda
Beaudet, R.; Mackenzie, R.
Kinetic mechanism of formininotransferase from porcine liver
Biochim. Biophys. Acta
410
252-261
1975
Sus scrofa
brenda
Murley, L.L.; Mejia, N.R.; MacKenzie, R.E.
The nucleotide sequence of porcine formiminotransferase cyclodeaminase. Expression and purification from Escherichia coli
J. Biol. Chem.
268
22820-22824
1993
Sus scrofa (P53603)
brenda
Bashour, A.M.; Bloom, G.S.
58K, a microtubule-binding Golgi protein, is a formiminotransferase cyclodeaminase
J. Biol. Chem.
273
19612-19617
1998
Rattus norvegicus
brenda
Murley, L.L.; MacKenzie, R.E.
The two monofunctional domains of octameric formiminotransferase-cyclodeaminase exist as dimers
Biochemistry
34
10358-10364
1995
Sus scrofa
brenda
Kohls, D.; Sulea, T.; Purisima, E.O.; MacKenzie, R.E.; Vrielink, A.
The crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase: Implications for substrate channeling in a bifunctional enzyme
Structure
8
35-46
2000
Sus scrofa
brenda
Murley, L.L.; MacKenzie, R.E.
Monofunctional domains of formiminotransferase-cyclodeaminase retain similar conformational stabilities outside the bifunctional octamer
Biochim. Biophys. Acta
1338
223-232
1997
Sus scrofa
brenda
Renous, R.; Lapierre, P.; Djilali-Saiah, I.; Vitozzi, S.; Alvarez, F.
Characterization of the antigenicity of the formiminotransferase-cyclodeaminase in type 2 autoimmune hepatitis
Exp. Cell Res.
292
332-341
2004
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