Information on EC 2.1.1.B83 - 7'-O-demethylcephaeline 6',7'-dimethyltransferase

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The expected taxonomic range for this enzyme is: Carapichea ipecacuanha

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EC NUMBER
COMMENTARY hide
2.1.1.B83
preliminary BRENDA-supplied EC number
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RECOMMENDED NAME
GeneOntology No.
7'-O-demethylcephaeline 6',7'-dimethyltransferase
-
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 S-adenosyl-L-methionine + 7'-O-demethylcephaeline = 2 S-adenosyl-L-homocysteine + emetine
show the reaction diagram
S-adenosyl-L-methionine + 7'-O-demethylcephaeline = S-adenosyl-L-homocysteine + cephaeline
show the reaction diagram
S-adenosyl-L-methionine + cephaeline = S-adenosyl-L-homocysteine + emetine
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:7'-O-demethylcephaeline 6',7'-O-dimethyltransferase
-
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top print hide
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
top print hide
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + 7'-O-demethylcephaeline
2 S-adenosyl-L-homocysteine + emetine
show the reaction diagram
S-adenosyl-L-methionine + 7'-O-demethylcephaeline
S-adenosyl-L-homocysteine + cephaeline
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + cephaeline
2 S-adenosyl-L-homocysteine + emetine
show the reaction diagram
-
-
-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2 S-adenosyl-L-methionine + 7'-O-demethylcephaeline
2 S-adenosyl-L-homocysteine + emetine
show the reaction diagram
E7FL15
the enzyme is involved in biosynthesis of emetine
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Co2+
5 mM, 53% inhibition
Mn2+
5 mM, 31% inhibition
Ni2+
5 mM, 83% inhibition
Zn2+
5 mM, 90% inhibition
additional information
-
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.068
cephaeline
pH 6.8, 30°C
0.097
S-adenosyl-L-methionine
pH 6.8, 30°C
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8
cephaline as substrate
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
top print hide
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
40000
x * 40000, SDS-PAGE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 40000, SDS-PAGE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
top print hide
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
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LINKS TO OTHER DATABASES (specific for EC-Number 2.1.1.B83)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)