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Information on EC 2.1.1.94 - tabersonine 16-O-methyltransferase Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
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The expected taxonomic range for this enzyme is: Catharanthus roseus
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tabersonine 16-O-methyltransferase
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S-adenosyl-L-methionine + 16-hydroxytabersonine = S-adenosyl-L-homocysteine + 16-methoxytabersonine
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methyl group transfer
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vindoline and vinblastine biosynthesis
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Indole alkaloid biosynthesis
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S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase
Involved in the biosynthesis of vindoline from tabersonine in the Madagascar periwinkle, Catharanthus roseus.
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11-demethyl-17-deacetylvindoline 11-methyltransferase
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11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase
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11-O-demethyl-17-O-deacetylvindoline O-methyltransferase
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16-hydroxytabersonine 16-O-methyltransferase
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16-hydroxytabersonine-16-O-methyltransferase
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methyltransferase, 11-demethyl-17-deacetylvindoline 11-
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S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase
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UniProt
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S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline
S-adenosyl-L-homocysteine + 17-O-deacetylvindoline
S-adenosyl-L-methionine + 16-hydroxytabersonine
S-adenosyl-L-homocysteine + 16-methoxytabersonine
S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline
S-adenosyl-L-homocysteine + 17-O-deacetylvindoline
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11-O-demethylvindoline is not accepted as substrate
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S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline
S-adenosyl-L-homocysteine + 17-O-deacetylvindoline
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involved in biosynthesis of the alkaloid vindoline
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S-adenosyl-L-methionine + 16-hydroxytabersonine
S-adenosyl-L-homocysteine + 16-methoxytabersonine
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S-adenosyl-L-methionine + 16-hydroxytabersonine
S-adenosyl-L-homocysteine + 16-methoxytabersonine
16OMT is highly specific for its alkaloid substrate 16-hydroxytabersonine
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S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline
S-adenosyl-L-homocysteine + 17-O-deacetylvindoline
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involved in biosynthesis of the alkaloid vindoline
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S-adenosyl-L-homocysteine
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product inhibition
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0.0026
16-hydroxytabersonine
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0.0217
S-adenosyl-L-methionine
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0.006
S-adenosyl-L-homocysteine
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product inhibition
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0.000417
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16-hydroxytabersonine as a substrate
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specifically located in the epidermis of aerial organs
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predominatly expressed in leaf epidermis
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using PD-10 column chromatography, Sephadex G150 column chromatography, adenosine-agarose affinity resin and Mono Q anion exchange column chromatography
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16-hydroxytabersonine-16-O-methyltransferase is isolated and cloned as a His-tagged fusion protein in Escherichia coli
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HTOMT_CATRO
355
39863
Swiss-Prot
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Fahn, W.; Laussermair, E.; Deus-Neumann, B.; Stöckigt, J.
Late enzymes of vindoline biosynthesis. S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase and unspecific acetylesterase
Plant Cell Rep.
4
337-340
1985
Catharanthus roseus
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Levac, D.; Murata, J.; Kim, W.S.; De Luca, V.
Application of carborundum abrasion for investigating the leaf epidermis: molecular cloning of Catharanthus roseus 16-hydroxytabersonine-16-O-methyltransferase
Plant J.
53
225-236
2008
Catharanthus roseus (B0EXJ8), Catharanthus roseus
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Guirimand, G.; Guihur, A.; Poutrain, P.; Hericourt, F.; Mahroug, S.; St-Pierre, B.; Burlat, V.; Courdavault, V.
Spatial organization of the vindoline biosynthetic pathway in Catharanthus roseus
J. Plant Physiol.
168
549-557
2010
Catharanthus roseus (B0EXJ8), Catharanthus roseus
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