Information on EC 2.1.1.89 - tetrahydrocolumbamine 2-O-methyltransferase

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The expected taxonomic range for this enzyme is: Coptis japonica

EC NUMBER
COMMENTARY hide
2.1.1.89
-
RECOMMENDED NAME
GeneOntology No.
tetrahydrocolumbamine 2-O-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine = S-adenosyl-L-homocysteine + tetrahydropalmatine
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
palmatine biosynthesis
-
-
Isoquinoline alkaloid biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase
Involved in the biosynthesis of the berberine alkaloids.
CAS REGISTRY NUMBER
COMMENTARY hide
93792-09-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Berberis aggregata
-
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
no activity in Glaucium flavum
-
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + (R,S)-5,8,13,13a-tetrahydrocolumbamine
S-adenosyl-L-homocysteine + (R,S)-tetrahydropalmatine
show the reaction diagram
-
-
-
ir
S-adenosyl-L-methionine + tetrahydrocolumbamine
S-adenosyl-L-homocysteine + tetrahydropalmatine
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + (R,S)-5,8,13,13a-tetrahydrocolumbamine
S-adenosyl-L-homocysteine + (R,S)-tetrahydropalmatine
show the reaction diagram
Q8H9A8
-
-
-
ir
S-adenosyl-L-methionine + tetrahydrocolumbamine
S-adenosyl-L-homocysteine + tetrahydropalmatine
show the reaction diagram
Berberis aggregata
-
enzyme is involved in the biosynthesis of berberine alkaloids
-
?
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
Berberis aggregata
-
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
Berberis aggregata
-
-
Manually annotated by BRENDA team