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IUBMB CommentsInvolved in the biosynthesis of the berberine alkaloids.
The enzyme appears in viruses and cellular organisms
Synonyms
tetrahydrocolumbamine omt,
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methyltransferase, tetrahydrocolumbamine
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tetrahydrocolumbamine methyltransferase
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tetrahydrocolumbamine O-methyltransferase
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tetrahydrocolumbamine OMT
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S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine = S-adenosyl-L-homocysteine + tetrahydropalmatine
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methyl group transfer
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S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase
Involved in the biosynthesis of the berberine alkaloids.
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S-adenosyl-L-methionine + (R,S)-5,8,13,13a-tetrahydrocolumbamine
S-adenosyl-L-homocysteine + (R,S)-tetrahydropalmatine
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ir
S-adenosyl-L-methionine + tetrahydrocolumbamine
S-adenosyl-L-homocysteine + tetrahydropalmatine
S-adenosyl-L-methionine + tetrahydrocolumbamine
S-adenosyl-L-homocysteine + tetrahydropalmatine
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no activity with tetrahydrojatrorhizine, tetrahydropalmatrubine, columbamine, jatrorrhizine and palmatrubine
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S-adenosyl-L-methionine + tetrahydrocolumbamine
S-adenosyl-L-homocysteine + tetrahydropalmatine
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enzyme is involved in the biosynthesis of berberine alkaloids
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S-adenosyl-L-methionine + (R,S)-5,8,13,13a-tetrahydrocolumbamine
S-adenosyl-L-homocysteine + (R,S)-tetrahydropalmatine
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ir
S-adenosyl-L-methionine + tetrahydrocolumbamine
S-adenosyl-L-homocysteine + tetrahydropalmatine
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enzyme is involved in the biosynthesis of berberine alkaloids
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brenda
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UniProt
brenda
no activity in Glaucium flavum
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brenda
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brenda
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COOMT_COPJA
351
0
39282
Swiss-Prot
other Location (Reliability: 2)
SOMT1_PAPSO
390
0
42699
Swiss-Prot
other Location (Reliability: 2)
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Beecher, C.W.W.; Kelleher, W.J.
enzymatic study of the late stages of protoberberine alkaloid biosynthesis
Tetrahedron Lett.
25
4595-4598
1984
Berberis aggregata
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brenda
Chang, L.; Hagel, J.M.; Facchini, P.J.
Isolation and characterization of O-methyltransferases involved in the biosynthesis of glaucine in Glaucium flavum
Plant Physiol.
169
1127-1140
2015
no activity in Glaucium flavum, Coptis japonica (Q8H9A8), Coptis japonica
brenda
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