Information on EC 2.1.1.88 - 8-hydroxyquercetin 8-O-methyltransferase
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The enzyme appears in viruses and cellular organisms
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8-hydroxyquercetin 8-O-methyltransferase
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S-adenosyl-L-methionine + 3,5,7,8,3',4'-hexahydroxyflavone = S-adenosyl-L-homocysteine + 3,5,7,3',4'-pentahydroxy-8-methoxyflavone
S-adenosyl-L-methionine + 3,5,7,8,3',4'-hexahydroxyflavone = S-adenosyl-L-homocysteine + 3,5,7,3',4'-pentahydroxy-8-methoxyflavone

mechanism
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S-adenosyl-L-methionine + 3,5,7,8,3',4'-hexahydroxyflavone = S-adenosyl-L-homocysteine + 3,5,7,3',4'-pentahydroxy-8-methoxyflavone
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methyl group transfer
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gossypetin metabolism
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phenylpropanoids methylation (ice plant)
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S-adenosyl-L-methionine:3,5,7,8,3',4'-hexahydroxyflavone 8-O-methyltransferase
Also acts on 8-hydroxykaempferol, but not on the glycosides of 8-hydroxyflavonols. An enzyme from the flower buds of Lotus corniculatus.
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flavonol 8-O-methyltransferase
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methyltransferase, flavonol 8-
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brenda
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SwissProt
brenda
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S-adenosyl-L-methionine + 3,3',4',5,7,8-hexahydroxyflavone
S-adenosyl-L-homocysteine + 3,3',4',5,7-pentahydroxy-8-methoxyflavone
S-adenosyl-L-methionine + 8-hydroxykaempferol
S-adenosyl-L-homocysteine + 8-methoxykaempferol
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additional information
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not: glycosides of 8-hydroxyflavonols
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S-adenosyl-L-methionine + 3,3',4',5,7,8-hexahydroxyflavone

S-adenosyl-L-homocysteine + 3,3',4',5,7-pentahydroxy-8-methoxyflavone
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S-adenosyl-L-methionine + 3,3',4',5,7,8-hexahydroxyflavone
S-adenosyl-L-homocysteine + 3,3',4',5,7-pentahydroxy-8-methoxyflavone
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i.e. 8-hydroxyquercetin
i.e. 8-methoxyquercetin
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S-adenosyl-L-methionine + 3,3',4',5,7,8-hexahydroxyflavone
S-adenosyl-L-homocysteine + 3,3',4',5,7-pentahydroxy-8-methoxyflavone
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S-adenosyl-L-methionine + 8-hydroxykaempferol
S-adenosyl-L-homocysteine + 8-methoxykaempferol
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8-Methoxykaempferol
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product inhibition, competitive with respect to 8-hydroxykaempferol
EDTA
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in absence of Mg2+
S-adenosyl-L-homocysteine
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product inhibition, non-competitive with respect to S-adenosyl-L-methionine
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0.0013
8-Hydroxykaempferol
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0.053
S-adenosyl-L-methionine
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additional information
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brenda
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expression in Escherichia coli
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Q8OMT_MENPI
366
40849
Swiss-Prot
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Jay, M.; De Luca, V.; Ibrahim, R.K.
Purification, properties and kinetic mechanism of flavonol 8-O-methyltransferase from Lotus corniculatus L
Eur. J. Biochem.
153
321-325
1985
Lotus corniculatus
brenda
Willits, M.G.; Giovanni, M.; Prata, R.T.N.; Kramer, C.M.; De Luca, V.; Steffens, J.C.; Graser, G.
Bio-fermentation of modified flavonoids: an example of in vivo diversification of secondary metabolites
Phytochemistry
65
31-41
2004
Mentha x piperita (Q6VMW0)
brenda
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