Reference on EC 2.1.1.63 - methylated-DNA-[protein]-cysteine S-methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Olsson, M.; Lindahl, T.
Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue
J. Biol. Chem.
255
10569-10571
1980
Escherichia coli
Foote, R.S.; Mitra, S.; Pal, B.C.
Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli
Biochem. Biophys. Res. Commun.
97
654-659
1980
Escherichia coli
Hashimoto, H.; Inoue, T.; Nishioka, M.; Fujiwara, S.; Takagi, M.; Imanaka, T.; Kai, Y.
Hyperthermostable protein structure maintained by intra and inter-helix ion-pairs in archaeal O6-methylguanine-DNA methyltransferase
J. Mol. Biol.
292
707-716
1999
Thermococcus kodakarensis
Oh, H.K.; Teo, A.K.C.; Ali, R.B.; Lim, A.; Ayi, T.C.; Yarosh, D.B.; Li, B.F.L.
Conformational change in human DNA repair enzyme O6-methylguanine-DNA methyltransferase upon alkylation of its active site by SN1 (indirect-acting) and SN2 (direct-acting) alkylating agents: breaking a "salt-link"?
Biochemistry
35
12259-12266
1996
Homo sapiens
Hazra, T.K.; Roy, R.; Biswas, T.; Grabowski, D.T.; Pegg, A.E.; Mitra, S.
Specific recognition of O6-methylguanine in DNA by active site mutants of human O6-methylguanine-DNA methyltransferase
Biochemistry
36
5769-5776
1997
Homo sapiens
Terashima, I.; Kawate, H.; Sakumi, K.; Sekiguchi, M.; Kohda, K.
Substrate specificity of human O6-methylguanine-DNA methyltransferase for O6-benzylguanine derivatives in oligodeoxynucleotides
Chem. Res. Toxicol.
10
1234-1239
1997
Homo sapiens
Inoue, R.; Abe, M.; Nakabeppu, Y.; Sekiguchi, M.; Mori, T.; Suzuki, T.
Characterization of human polymorphic DNA repair methyltransferase
Pharmacogenetics
10
59-66
2000
Homo sapiens
Inui, H.; Watatani, M.; Yasutomi, M.; Nishisho, I.
Comparison of O6-methylguanine-DNA methyltransferase mRNA levels in Ha-ras mutated and non-mutated rat mammary tumors induced by N-methyl-N-nitrosourea
Carcinogenesis
15
459-463
1994
Rattus norvegicus
Walter, R.B.; Sung, H.M.; Intano, G.W.; Walter, C.A.
Characterization of O6-methylguanine-DNA-methyltransferase (O6-MGMT) activity in Xiphophorus fishes
Mutat. Res.
493
11-22
2001
Xiphophorus couchianus, Xiphophorus hellerii, Xiphophorus maculatus
Leclere, M.M.; Nishioka, M.; Yuasa, T.; Fujiwara, S.; Takagi, M.; Imanaka, T.
The O6-methylguanine-DNA methyltransferase from the hyperthermophilic archaeon Pyrococcus sp. KOD1: a thermostable repair enzyme
Mol. Gen. Genet.
258
69-77
1998
Pyrococcus sp., Pyrococcus sp. KOD1
Liem, L.K.; Lim, A.; Li, B.F.L.
Specificities of human, rat and E.coli O6-methylguanine-DNA methyltransferases towards the repair of O6-methyl and O6-ethylguanine in DNA
Nucleic Acids Res.
22
1613-1619
1994
Escherichia coli, Homo sapiens, Rattus norvegicus
Kleibl, K.
Molecular mechanisms of adaptive response to alkylating agents in Escherichia coli and some remarks on O6-methylguanine DNA-methyltransferase in other organisms
Mutat. Res.
512
67-84
2002
Escherichia coli
Nutt, C.L.; Costello, J.F.; Bambrick, L.L.; Yarosh, D.B.; Swinnen, L.J.; Chambers, A.F.; Cairncross, J.G.
O6-Methylguanine-DNA methyltransferase in tumors and cells of the oligodendrocyte lineage
Can. J. Neurol. Sci.
22
111-115
1995
Homo sapiens, Rattus norvegicus
Chan, C.L.; Wu, Z.; Ciardelli, T.; Eastman, A.; Bresnick, E.
Kinetic and DNA-binding properties of recombinant human O6-methylguanine-DNA methyltransferase
Arch. Biochem. Biophys.
300
193-200
1993
Homo sapiens
Roy, R.; Shiota, S.; Kennel, S.J.; Raha, R.; von Wronski, M.; Brent, T.P.; Mitra, S.
A comparative study of the biochemical properties of human and mouse recombinant O6-methylguanine-DNA methyltransferases
Carcinogenesis
16
405-411
1995
Homo sapiens, Mus musculus
Mattern, J.; Eichhorn, U.; Kaina, B.; Volm, M.
O6-Methylguanine-DNA methyltransferase activity and sensitivity to cyclophosphamide and cisplatin in human lung tumor xenografts
Int. J. Cancer
77
919-922
1998
Homo sapiens
D'Atri, S.; Graziani, G.; Lacal, P.M.; Nistico, V.; Gilberti, S.; Faraoni, I.; Watson, A.J.; Bonmassar, E.; Margison, G.P.
Attenuation of O(6)-methylguanine-DNA methyltransferase activity and mRNA levels by cisplatin and temozolomide in jurkat cells
J. Pharmacol. Exp. Ther.
294
664-671
2000
Homo sapiens
Kreklau, E.L.; Liu, N.; Li, Z.; Cornetta, K.; Erickson, L.C.
Comparison of single- versus double-bolus treatments of O6-benzylguanine for depletion of O6-methylguanine DNA methyltransferase (MGMT) activity in vivo: development of a novel fluorometric oligonucleotide assay for measurement of MGMT activity
J. Pharmacol. Exp. Ther.
297
524-530
2001
Homo sapiens
Bhattacharyya, D.; Hazra, T.K.; Behnke, W.D.; Chong, P.L.; Kurosky, A.; Lee, J.C.; Mitra, S.
Reversible folding of Ada protein (O6-methylguanine-DNA methyltransferase) of Escherichia coli
Biochemistry
37
1722-1730
1998
Escherichia coli
Koike, G.; Maki, H.; Takeya, H.; Hayakawa, H.; Sekiguchi, M.
Purification, structure, and biochemical properties of human O6-methylguanine-DNA methyltransferase
J. Biol. Chem.
265
14754-14762
1990
Homo sapiens
Morgan, S.E.; Kelley, M.R.; Pieper, R.O.
The role of the carboxyl-terminal tail in human O6-methylguanine DNA methyltransferase substrate specificity and temperature sensitivity
J. Biol. Chem.
268
19802-19809
1993
Homo sapiens
Kanugula, S.; Pegg, A.E.
Alkylation damage repair protein O6-alkylguanine-DNA alkyltransferase from the hyperthermophiles Aquifex aeolicus and Archaeoglobus fulgidus
Biochem. J.
375
449-455
2003
Archaeoglobus fulgidus (O27970), Archaeoglobus fulgidus, Aquifex aeolicus (O67467), Aquifex aeolicus
Guengerich, F.P.; Fang, Q.; Liu, L.; Hachey, D.L.; Pegg, A.E.
O6-Alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145
Biochemistry
42
10965-10970
2003
Homo sapiens
Rasimas, J.J.; Kanugula, S.; Dalessio, P.M.; Ropson, I.J.; Fried, M.G.; Pegg, A.E.
Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase
Biochemistry
42
980-990
2003
Homo sapiens
Baumann, R.P.; Shyam, K.; Penketh, P.G.; Remack, J.S.; Brent, T.P.; Sartorelli, A.C.
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity
Cancer Chemother. Pharmacol.
53
288-295
2004
Homo sapiens
Liu, L.; Williams, K.M.; Guengerich, F.P.; Pegg, A.E.
O6-Alkylguanine-DNA alkyltransferase has opposing effects in modulating the genotoxicity of dibromomethane and bromomethyl acetate
Chem. Res. Toxicol.
17
742-752
2004
Homo sapiens
Fang, M.Z.; Jin, Z.; Wang, Y.; Liao, J.; Yang, G.Y.; Wang, L.D.; Yang, C.S.
Promoter hypermethylation and inactivation of O6-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines
Int. J. Oncol.
26
615-622
2005
Homo sapiens
Nishikori, S.; Shiraki, K.; Yokota, K.; Izumikawa, N.; Fujiwara, S.; Hashimoto, H.; Imanaka, T.; Takagi, M.
Mutational effects on O6-methylguanine-DNA methyltransferase from hyperthermophile: Contribution of ion-pair network to protein thermostability
J. Biochem.
135
525-532
2004
Thermococcus kodakarensis
Nishikori, S.; Shiraki, K.; Okanojo, M.; Imanaka, T.; Takagi, M.
Equilibrium and kinetic stability of a hyperthermophilic protein, O6-methylguanine-DNA methyltransferase under various extreme conditions
J. Biochem.
136
503-508
2004
Thermococcus kodakarensis
Rasimas, J.J.; Pegg, A.E.; Fried, M.G.
DNA-binding mechanism of O6-alkylguanine-DNA alkyltransferase
J. Biol. Chem.
278
7973-7980
2003
Homo sapiens
Nelson, M.E.; Loktionova, N.A.; Pegg, A.E.; Moschel, R.C.
2-Amino-O4-benzylpteridine derivatives: potent inactivators of O6-alkylguanine-DNA alkyltransferase
J. Med. Chem.
47
3887-3891
2004
Homo sapiens
Bacolod, M.D.; Johnson, S.P.; Pegg, A.E.; Dolan, M.E.; Moschel, R.C.; Bullock, N.S.; Fang, Q.; Colvin, O.M.; Modrich, P.; Bigner, D.D.; Friedman, H.S.
Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations
Mol. Cancer Ther.
3
1127-1135
2004
Homo sapiens
Esteller, M.; Herman, J.G.
Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer
Oncogene
23
1-8
2004
Homo sapiens
Kanugula, S.; Pauly, G.T.; Moschel, R.C.; Pegg, A.E.
A bifunctional DNA repair protein from Ferroplasma acidarmanus exhibits O6-alkylguanine-DNA alkyltransferase and endonuclease V activities
Proc. Natl. Acad. Sci. USA
102
3617-3622
2005
Ferroplasma acidarmanus
Heinis, C.; Schmitt, S.; Kindermann, M.; Godin, G.; Johnsson, K.
Evolving the substrate specificity of O6-alkylguanine-DNA alkyltransferase through loop insertion for applications in molecular imaging
ACS Chem. Biol.
1
575-584
2006
Homo sapiens
Fang, Q.; Kanugula, S.; Pegg, A.E.
Function of domains of human O6-alkylguanine-DNA alkyltransferase
Biochemistry
44
15396-15405
2005
Homo sapiens
Geoerger, B.; Vassal, G.; Doz, F.; OQuigley, J.; Wartelle, M.; Watson, A.J.; Raquin, M.A.; Frappaz, D.; Chastagner, P.; Gentet, J.C.; Rubie, H.; Couanet, D.; Geoffray, A.; Djafari, L.; Margison, G.P.; Pein, F.
Dose finding and O6-alkylguanine-DNA alkyltransferase study of cisplatin combined with temozolomide in paediatric solid malignancies
Br. J. Cancer
93
529-537
2005
Homo sapiens
Blough, M.D.; Zlatescu, M.C.; Cairncross, J.G.
O6-methylguanine-DNA methyltransferase regulation by p53 in astrocytic cells
Cancer Res.
67
580-584
2007
Homo sapiens, Mus musculus
Hansen, R.J.; Nagasubramanian, R.; Delaney, S.M.; Samson, L.D.; Dolan, M.E.
Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice
Carcinogenesis
28
1111-1116
2007
Mus musculus
Loeber, R.; Rajesh, M.; Fang, Q.; Pegg, A.E.; Tretyakova, N.
Cross-linking of the human DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of 1,2,3,4-diepoxybutane
Chem. Res. Toxicol.
19
645-654
2006
Homo sapiens
Liu, L.; Watanabe, K.; Fang, Q.; Williams, K.M.; Guengerich, F.P.; Pegg, A.E.
Effect of alterations of key active site residues in O6-alkylguanine-DNA Alkyltransferase on its ability to modulate the genotoxicity of 1,2-dibromoethane
Chem. Res. Toxicol.
20
155-163
2007
Homo sapiens
Juillerat, A.; Heinis, C.; Sielaff, I.; Barnikow, J.; Jaccard, H.; Kunz, B.; Terskikh, A.; Johnsson, K.
Engineering substrate specificity of O6-alkylguanine-DNA alkyltransferase for specific protein labeling in living cells
Chembiochem
6
1263-1269
2005
Homo sapiens (P16455), Homo sapiens
Sabharwal, A.; Middleton, M.R.
Exploiting the role of O6-methylguanine-DNA-methyltransferase (MGMT) in cancer therapy
Curr. Opin. Pharmacol.
6
355-363
2006
Escherichia coli, Homo sapiens, Mus musculus, Rattus norvegicus
Povey, A.C.; ODonnell, P.; Barber, P.; Watson, M.; Margison, G.P.; Santibanez Koref, M.F.
Smoking is associated with a decrease of O6-alkylguanine-DNA alkyltransferase activity in bronchial epithelial cells
Int. J. Cancer
119
463-466
2006
Homo sapiens
Schwarzl, S.M.; Smith, J.C.; Kaina, B.; Efferth, T.
Molecular modeling of O6-methylguanine-DNA methyltransferase mutant proteins encoded by single nucleotide polymorphisms
Int. J. Mol. Med.
16
553-557
2005
Homo sapiens (P16455)
Pagani, E.; Falcinelli, S.; Pepponi, R.; Turriziani, M.; Caporaso, P.; Caporali, S.; Bonmassar, E.; DAtri, S.
Combined effect of temozolomide and hyperthermia on human melanoma cell growth and O6-methylguanine-DNA methyltransferase activity
Int. J. Oncol.
30
443-451
2007
Homo sapiens
Zang, H.; Fang, Q.; Pegg, A.E.; Guengerich, F.P.
Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase
J. Biol. Chem.
280
30873-30881
2005
Homo sapiens
Rasimas, J.J.; Kar, S.R.; Pegg, A.E.; Fried, M.G.
Interactions of human O6-alkylguanine-DNA alkyltransferase (AGT) with short single-stranded DNAs
J. Biol. Chem.
282
3357-3366
2007
Homo sapiens (P16455), Homo sapiens
Kuo, C.C.; Liu, J.F.; Chang, J.Y.
DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors
J. Pharmacol. Exp. Ther.
316
946-954
2006
Homo sapiens
Roberts, A.; Pelton, J.G.; Wemmer, D.E.
Structural studies of MJ1529, an O6-methylguanine-DNA methyltransferase
Magn. Reson. Chem.
44
S71-S82
2006
Methanocaldococcus jannaschii
Maxwell, J.A.; Johnson, S.P.; Quinn, J.A.; McLendon, R.E.; Ali-Osman, F.; Friedman, A.H.; Herndon, J.E.; Bierau, K.; Bigley, J.; Bigner, D.D.; Friedman, H.S.
Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma
Mol. Cancer Ther.
5
2531-2539
2006
Homo sapiens
Pearson, S.J.; Ferguson, J.; Santibanez-Koref, M.; Margison, G.P.
Inhibition of O6-methylguanine-DNA methyltransferase by an alkyltransferase-like protein from Escherichia coli
Nucleic Acids Res.
33
3837-3844
2005
Homo sapiens (P16455), Homo sapiens
Shibata, T.; Glynn, N.; McMurry, T.B.; McElhinney, R.S.; Margison, G.P.; Williams, D.M.
Novel synthesis of O6-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT)
Nucleic Acids Res.
34
1884-1891
2006
Homo sapiens
Gronemeyer, T.; Chidley, C.; Juillerat, A.; Heinis, C.; Johnsson, K.
Directed evolution of O6-alkylguanine-DNA alkyltransferase for applications in protein labeling
Protein Eng. Des. Sel.
19
309-316
2006
Homo sapiens
Verbeek, B.; Southgate, T.D.; Gilham, D.E.; Margison, G.P.
O6-Methylguanine-DNA methyltransferase inactivation and chemotherapy
Br. Med. Bull.
85
17-33
2008
Homo sapiens
McMurry, T.B.
MGMT inhibitors--The Trinity College-Paterson Institute experience, a chemists perception
DNA Repair
6
1161-1169
2007
Homo sapiens
Jeuken, J.W.; Cornelissen, S.J.; Vriezen, M.; Dekkers, M.M.; Errami, A.; Sijben, A.; Boots-Sprenger, S.H.; Wesseling, P.
MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas
Lab. Invest.
87
1055-1065
2007
Homo sapiens
Hu, J.; Ma, A.; Dinner, A.R.
A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT
Proc. Natl. Acad. Sci. USA
105
4615-4620
2008
Homo sapiens (P16455)
Reese, J.S.; Roth, J.C.; Gerson, S.L.
Bone marrow-derived cells exhibiting lung epithelial cell characteristics are enriched in vivo using methylguanine DNA methyltransferase-mediated drug resistance
Stem Cells
26
675-681
2008
Mus musculus
Sasai, K.; Nodagashira, M.; Nishihara, H.; Aoyanagi, E.; Wang, L.; Katoh, M.; Murata, J.; Ozaki, Y.; Ito, T.; Fujimoto, S.; Kaneko, S.; Nagashima, K.; Tanaka, S.
Careful exclusion of non-neoplastic brain components is required for an appropriate evaluation of O6-methylguanine-DNA methyltransferase status in glioma: relationship between immunohistochemistry and methylation analysis
Am. J. Surg. Pathol.
32
1220-1227
2008
Homo sapiens
Lee, S.M.; Lee, E.J.; Ko, Y.H.; Lee, S.H.; Maeng, L.; Kim, K.M.
Prognostic significance of O6-methylguanine DNA methyltransferase and p57 methylation in patients with diffuse large B-cell lymphomas
APMIS
117
87-94
2009
Homo sapiens
Hermes, M.; Geisler, H.; Osswald, H.; Riehle, R.; Kloor, D.
Alterations in S-adenosylhomocysteine metabolism decrease O6-methylguanine DNA methyltransferase gene expression without affecting promoter methylation
Biochem. Pharmacol.
75
2100-2111
2008
Homo sapiens
Billson, H.A.; Harrison, K.L.; Lees, N.P.; Hall, C.N.; Margison, G.P.; Povey, A.C.
Dietary variables associated with DNA N7-methylguanine levels and O6-alkylguanine DNA-alkyltransferase activity in human colorectal mucosa
Carcinogenesis
30
615-620
2009
Homo sapiens
Quiros, S.; Roos, W.P.; Kaina, B.
Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles
Cell Cycle
9
168-178
2010
Homo sapiens
Lai, J.C.; Cheng, Y.W.; Goan, Y.G.; Chang, J.T.; Wu, T.C.; Chen, C.Y.; Lee, H.
Promoter methylation of O(6)-methylguanine-DNA-methyltransferase in lung cancer is regulated by p53
DNA Repair
7
1352-1363
2008
Homo sapiens
Nakajima, T.; Yamada, Y.; Shimoda, T.; Matsubara, J.; Kato, K.; Hamaguchi, T.; Shimada, Y.; Okayama, Y.; Oka, T.; Shirao, K.
Combination of O6-methylguanine-DNA methyltransferase and thymidylate synthase for the prediction of fluoropyrimidine efficacy
Eur. J. Cancer
44
400-407
2008
Homo sapiens
Kim, J.I.; Suh, J.T.; Choi, K.U.; Kang, H.J.; Shin, D.H.; Lee, I.S.; Moon, T.Y.; Kim, W.T.
Inactivation of O6-methylguanine-DNA methyltransferase in soft tissue sarcomas: association with K-ras mutations
Hum. Pathol.
40
934-941
2009
Homo sapiens
Nagasaka, T.; Goel, A.; Notohara, K.; Takahata, T.; Sasamoto, H.; Uchida, T.; Nishida, N.; Tanaka, N.; Boland, C.R.; Matsubara, N.
Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis
Int. J. Cancer
122
2429-2436
2008
Homo sapiens
Morita, R.; Nakagawa, N.; Kuramitsu, S.; Masui, R.
An O6-methylguanine-DNA methyltransferase-like protein from Thermus thermophilus interacts with a nucleotide excision repair protein
J. Biochem.
144
267-277
2008
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Fang, Q.; Kanugula, S.; Tubbs, J.L.; Tainer, J.A.; Pegg, A.E.
Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases
J. Biol. Chem.
285
8185-8195
2009
Escherichia coli, Homo sapiens (P16455)
Buccoliero, A.M.; Castiglione, F.; Rossi DeglInnocenti, D.; Paglierani, M.; Maio, V.; Gheri, C.F.; Garbini, F.; Moncini, D.; Taddei, A.; Sardi, I.; Sanzo, M.; Giordano, F.; Mussa, F.; Genitori, L.; Taddei, G.L.
O6-methylguanine-DNA-methyltransferase in recurring anaplastic ependymomas: PCR and immunohistochemistry
J. Chemother.
20
263-268
2008
Homo sapiens
Parkinson, J.; Wheeler, H.; Clarkson, A.; McKenzie, C.; Biggs, M.; Little, N.; Cook, R.; Messina, M.; Robinson, B.; McDonald, K.
Variation of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in serial samples in glioblastoma
J. Neurooncol.
87
71-78
2008
Homo sapiens
Jena, N.R.; Shukla, P.K.; Jena, H.S.; Mishra, P.C.; Suhai, S.
O6-methylguanine repair by O6-alkylguanine-DNA alkyltransferase
J. Phys. Chem. B
113
16285-16290
2009
Homo sapiens (P16455)
Sabharwal, A.; Waters, R.; Danson, S.; Clamp, A.; Lorigan, P.; Thatcher, N.; Margison, G.P.; Middleton, M.R.
Predicting the myelotoxicity of chemotherapy: the use of pretreatment O6-methylguanine-DNA methyltransferase determination in peripheral blood mononuclear cells
Melanoma Res.
21
502-508
2011
Homo sapiens
Zheng, M.; Bocangel, D.; Ramesh, R.; Ekmekcioglu, S.; Poindexter, N.; Grimm, E.A.; Chada, S.
Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells
Mol. Cancer Ther.
7
3842-3851
2008
Homo sapiens
Zhong, Y.; Huang, Y.; Huang, Y.; Zhang, T.; Ma, C.; Zhang, S.; Fan, W.; Chen, H.; Qian, J.; Lu, D.
Effects of O6-methylguanine-DNA methyltransferase (MGMT) polymorphisms on cancer: a meta-analysis
Mutagenesis
25
83-95
2010
Homo sapiens
Remington, M.; Chtchetinin, J.; Ancheta, K.; Nghiemphu, P.L.; Cloughesy, T.; Lai, A.
The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity
Neuro-oncology
11
22-32
2009
Homo sapiens
Hwang, C.S.; Shemorry, A.; Varshavsky, A.
Two proteolytic pathways regulate DNA repair by cotargeting the Mgt1 alkylguanine transferase
Proc. Natl. Acad. Sci. USA
106
2142-2147
2009
Saccharomyces cerevisiae, Saccharomyces cerevisiae JD52
Perugino, G.; Vettone, A.; Illiano, G.; Valenti, A.; Ferrara, M.C.; Rossi, M.; Ciaramella, M.
Activity and regulation of archaeal DNA alkyltransferase: conserved protein involved in repair of DNA alkylation damage
J. Biol. Chem.
287
4222-4231
2012
Saccharolobus solfataricus (Q97VW7), Saccharolobus solfataricus P2 (Q97VW7)
Robinson, C.; Palomo, J.; Vogelbaum, M.A.
Thin layer chromatography-based assay of O6-methylguanine-DNA methyltransferase activity in tissue
Anal. Biochem.
405
263-265
2010
Homo sapiens
Wirtz, S.; Nagel, G.; Eshkind, L.; Neurath, M.F.; Samson, L.D.; Kaina, B.
Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis
Carcinogenesis
31
2111-2117
2010
Mus musculus
Lin, J.W.; Wu, Y.T.; Chang, I.W.
The prognostic impact of O6-methylguanine DNA methyltransferase and epidermal growth factor receptor expressions on primary gliosarcoma: a clinicopathologic and immunohistochemical study of seven cases at a single institution
Indian J. Pathol. Microbiol.
54
683-687
2012
Homo sapiens
Skorvaga, M.; Raven, N.D.; Margison, G.P.
Thermostable archaeal O6-alkylguanine-DNA alkyltransferases
Proc. Natl. Acad. Sci. USA
95
6711-6715
1998
Escherichia coli, Homo sapiens, Pyrobaculum islandicum, Pyrococcus furiosus, Sulfolobus acidocaldarius, Thermococcus litoralis, Escherichia coli BS21
Hongo, A.; Gu, R.; Suzuki, M.; Nemoto, N.; Nishigaki, K.
A radioisotope-nondependent high-sensitivity method for measuring the activity of glioblastoma-related O6-methylguanine DNA methyltransferase
Anal. Biochem.
480
82-84
2015
Homo sapiens
Miggiano, R.; Perugino, G.; Ciaramella, M.; Serpe, M.; Rejman, D.; Pav, O.; Pohl, R.; Garavaglia, S.; Lahiri, S.; Rizzi, M.; Rossi, F.
Crystal structure of Mycobacterium tuberculosis O6-methylguanine-DNA methyltransferase protein clusters assembled onto damaged DNA
Biochem. J.
473
123-133
2016
Mycobacterium tuberculosis (P9WJW5), Mycobacterium tuberculosis
Fahrer, J.; Kaina, B.
O6-methylguanine-DNA methyltransferase in the defense against N-nitroso compounds and colorectal cancer
Carcinogenesis
34
2435-2442
2013
Homo sapiens
Miggiano, R.; Casazza, V.; Garavaglia, S.; Ciaramella, M.; Perugino, G.; Rizzi, M.; Rossi, F.
Biochemical and structural studies of the Mycobacterium tuberculosis O6-methylguanine methyltransferase and mutated variants
J. Bacteriol.
195
2728-2736
2013
Mycobacterium tuberculosis (P9WJW5), Mycobacterium tuberculosis
Chahal, M.; Abdulkarim, B.; Xu, Y.; Guiot, M.C.; Easaw, J.C.; Stifani, N.; Sabri, S.
O6-Methylguanine-DNA methyltransferase is a novel negative effector of invasion in glioblastoma multiforme
Mol. Cancer Ther.
11
2440-2450
2012
Homo sapiens
Nyskohus, L.S.; Watson, A.J.; Margison, G.P.; Le Leu, R.K.; Kim, S.W.; Lockett, T.J.; Head, R.J.; Young, G.P.; Hu, Y.
Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis
Mutat. Res.
758
80-86
2013
Rattus norvegicus
Senthong, P.; Millington, C.L.; Wilkinson, O.J.; Marriott, A.S.; Watson, A.J.; Reamtong, O.; Eyers, C.E.; Williams, D.M.; Margison, G.P.; Povey, A.C.
The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase
Nucleic Acids Res.
41
3047-3055
2013
Homo sapiens
Li, X.; Qian, S.; Zheng, L.; Yang, B.; He, Q.; Hu, Y.
A mechanism-based fluorescent probe for labeling O6-methylguanine-DNA methyltransferase in live cells
Org. Biomol. Chem.
10
3189-3191
2012
Homo sapiens
Kishida, Y.; Natsume, A.; Toda, H.; Toi, Y.; Motomura, K.; Koyama, H.; Matsuda, K.; Nakayama, O.; Sato, M.; Suzuki, M.; Kondo, Y.; Wakabayashi, T.
Correlation between quantified promoter methylation and enzymatic activity of O6-methylguanine-DNA methyltransferase in glioblastomas
Tumour Biol.
33
373-381
2012
Homo sapiens
Perugino, G.; Miggiano, R.; Serpe, M.; Vettone, A.; Valenti, A.; Lahiri, S.; Rossi, F.; Rossi, M.; Rizzi, M.; Ciaramella, M.
Structure-function relationships governing activity and stability of a DNA alkylation damage repair thermostable protein
Nucleic Acids Res.
43
8801-8816
2015
Saccharolobus solfataricus (Q97VW7), Saccharolobus solfataricus P2 (Q97VW7)
Thirumal Kumar, D.; Mendonca, E.; Priyadharshini Christy, J.; George Priya Doss, C.; Zayed, H.
A computational model to predict the structural and functional consequences of missense mutations in O6-methylguanine DNA methyltransferase
Adv. Protein Chem. Struct. Biol.
115
351-369
2019
Homo sapiens (P16455)
Girot, P.; Dumars, C.; Mosnier, J.F.; Muzellec, L.; Senellart, H.; Foubert, F.; Caroli-Bosc, F.X.; Cauchin, E.; Regenet, N.; Matysiak-Budnik, T.; Touchefeu, Y.
Short article Evaluation of O6-methylguanine-DNA methyltransferase as a predicting factor of response to temozolomide-based chemotherapy in well-differentiated metastatic pancreatic neuroendocrine tumors
Eur. J. Gastroenterol. Hepatol.
29
826-830
2017
Homo sapiens (P16455), Homo sapiens
Cabrini, G.; Fabbri, E.; Lo Nigro, C.; Dechecchi, M.C.; Gambari, R.
Regulation of expression of O6-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review)
Int. J. Oncol.
47
417-428
2015
Homo sapiens
Kurimoto, T.; Kondo, A.; Ogino, I.; Fujimura, J.; Arakawa, A.; Arai, H.; Shimizu, T.
Effect of O6-methylguanine-DNA methyltransferase methylation in medulloblastoma
Mol. Clin. Oncol.
7
1107-1111
2017
Homo sapiens (P16455)
Zhao, Y.; Xiao, Z.; Chen, W.; Yang, J.; Li, T.; Fan, B.
Disulfiram sensitizes pituitary adenoma cells to temozolomide by regulating O6-methylguanine-DNA methyltransferase expression
Mol. Med. Rep.
12
2313-2322
2015
Homo sapiens
Chikan, N.A.; Bukhari, S.; Shabir, N.; Amin, A.; Shafi, S.; Qadri, R.A.; Patel, T.N.
Atomic insight into the altered O6-methylguanine-DNA methyltransferase protein architecture in gastric cancer
PLoS ONE
10
e0127741
2015
Homo sapiens (P16455), Homo sapiens
Franceschi, E.; Tosoni, A.; Minichillo, S.; Depenni, R.; Paccapelo, A.; Bartolini, S.; Michiara, M.; Pavesi, G.; Urbini, B.; Crisi, G.; Cavallo, M.A.; Tosatto, L.; Dazzi, C.; Biasini, C.; Pasini, G.; Balestrini, D.; Zanelli, F.; Ramponi, V.; Fioravanti, A.; Giombelli, E.; De Biase, D.; Baruzzi, A.
The prognostic roles of gender and O6-methylguanine-DNA methyltransferase methylation status in glioblastoma patients The female power
World Neurosurg.
112
e342-e347
2018
Homo sapiens
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