Disease on EC 2.1.1.6 - catechol O-methyltransferase
Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
22q11 Deletion Syndrome
Catechol-O-methyl transferase and expression of schizophrenia in 73 adults with 22q11 deletion syndrome.
Acquired Immunodeficiency Syndrome
Tea and circulating estrogen levels in postmenopausal Chinese women in Singapore.
Acute Kidney Injury
Pilot study of association of catechol-O-methyl transferase rs4680 genotypes with acute kidney injury and tubular stress after open heart surgery.
Adenomyosis
COMT 158G/A and CYP1B1 432C/G polymorphisms increase the risk of endometriosis and adenomyosis: a meta-analysis.
Alzheimer Disease
Apolipoprotein E epsilon4 and catechol-O-methyltransferase alleles in autopsy-proven Parkinson's disease: relationship to dementia and hallucinations.
Alzheimer Disease
Association between polymorphism of COMT gene (Val158Met) with Alzheimer's disease: An updated analysis.
Alzheimer Disease
Association between the catechol-O-methyltransferase polymorphism Val158Met and Alzheimer's disease in a Japanese population.
Alzheimer Disease
Catechol-o-methyltransferase and Alzheimer's disease: a review of biological and genetic findings.
Alzheimer Disease
Catechol-O-methyltransferase gene polymorphism is associated with risk of psychosis in Alzheimer Disease.
Alzheimer Disease
Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease.
Alzheimer Disease
Catechol-O-Methyltransferase Val158Met Polymorphism on Striatum Structural Covariance Networks in Alzheimer's Disease.
Alzheimer Disease
COMT Val158Met and PPAR? Pro12Ala polymorphisms and susceptibility to Alzheimer's disease: a meta-analysis.
Alzheimer Disease
Lack of Association Between COMT Polymorphisms and Apathy in Alzheimer's Disease.
Alzheimer Disease
Pharmacophore-based virtual screening of catechol-o-methyltransferase (COMT) inhibitors to combat Alzheimer's disease.
Amyloidosis
Transthyretin stabilization activity of the catechol-O-methyltransferase inhibitor tolcapone (SOM0226) in hereditary ATTR amyloidosis patients and asymptomatic carriers: proof-of-concept study
Anaphylaxis
[Drug hypersensitivity in patients with presumed histamine intolerance and mast cell activation disease].
Anemia, Sickle Cell
Catechol-O-methyltransferase activity in erythrocytes of pregnant women with sickle cell disease before, during, and after transfusion and partial exchange transfusion.
Anemia, Sickle Cell
Dopamine D3 receptor Ser9Gly and catechol-o-methyltransferase Val158Met polymorphisms and acute pain in sickle cell disease.
Arthralgia
Genetic Predictors of Response to Acupuncture for Aromatase Inhibitor-Associated Arthralgia Among Breast Cancer Survivors.
Asthma
[Catecholamine complex-adrenoreactive system of various subtypes in various forms of bronchial asthma in children]
Astrocytoma
Catechol-O-methyl transferase and monoamine oxidase activity in cultured rodent astrocytoma cells.
Atherosclerosis
Catechol-O-methyltransferase is dispensable for vascular protection by estradiol in mouse models of atherosclerosis and neointima formation.
Blepharoptosis
[Feeding difficulty and developmental delay for 8 months and nystagmus for 4 months in an infant].
Brain Diseases
Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression.
Brain Injuries, Traumatic
Association of COMT Val158Met Polymorphism With Delirium Risk and Outcomes After Traumatic Brain Injury.
Brain Injuries, Traumatic
Catechol-O-methyltransferase gene expression in stress-induced and non-stress induced schizophrenia.
Brain Injuries, Traumatic
Catechol-O-Methyltransferase Genotypes and Parenting Influence on Long-Term Executive Functioning After Moderate to Severe Early Childhood Traumatic Brain Injury: An Exploratory Study.
Brain Injuries, Traumatic
COMT and ANKK1 Genetics Interact With Depression to Influence Behavior Following Severe TBI: An Initial Assessment.
Brain Injuries, Traumatic
Influence of Catechol-O-methyltransferase on Executive Functioning Longitudinally After Early Childhood Traumatic Brain Injury: Preliminary Findings.
Brain Injuries, Traumatic
Traumatic brain injury stimulates hippocampal catechol-O-methyl transferase expression in microglia.
Brain Injuries, Traumatic
[Clinical and prognostic value of inflammatory genetic markers in traumatic brain injury].
Brain Neoplasms
COMT, BDNF, and DTNBP1 polymorphisms and cognitive functions in patients with brain tumors.
Breast Neoplasms
Adipose tissue PCB levels and CYP1B1 and COMT genotypes in relation to breast cancer risk in postmenopausal Danish women.
Breast Neoplasms
An association between the allele coding for a low activity variant of catechol-O-methyltransferase and the risk for breast cancer.
Breast Neoplasms
Association between polymorphisms in estrogen metabolism genes and breast cancer development in Chinese women: A prospective case-control study.
Breast Neoplasms
Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis.
Breast Neoplasms
Breast cancer risk reduction and membrane-bound catechol O-methyltransferase genetic polymorphisms.
Breast Neoplasms
Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase.
Breast Neoplasms
Catechol-O-Methyltransferase (COMT) gene polymorphism and breast cancer risk in young women.
Breast Neoplasms
Catechol-O-methyltransferase gene polymorphism and post-menopausal breast cancer risk.
Breast Neoplasms
Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression.
Breast Neoplasms
Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors.
Breast Neoplasms
Catechol-O-methyltransferase genotype modulates cancer treatment-related cognitive deficits in breast cancer survivors.
Breast Neoplasms
Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New York.
Breast Neoplasms
Catechol-O-methyltransferase polymorphism is not associated with ovarian cancer risk.
Breast Neoplasms
Catechol-O-methyltransferase Val 108/158 Met polymorphism and breast cancer risk: a case control study in Syria.
Breast Neoplasms
Catechol-O-methyltransferase Val 108/158 Met polymorphism in premenopausal breast cancer patients.
Breast Neoplasms
Catechol-O-methyltransferase Val158Met polymorphism and breast cancer risk in Asian population.
Breast Neoplasms
Catechol-O-methyltransferase Val158Met polymorphism in breast cancer risk.
Breast Neoplasms
Catechol-O-methyltransferase: characteristics, polymorphisms and role in breast cancer.
Breast Neoplasms
Catechol-O-methyltransferase: effects of the val108met polymorphism on protein turnover in human cells.
Breast Neoplasms
Comprehensive assessment of genetic variation of catechol-O-methyltransferase and breast cancer risk.
Breast Neoplasms
COMT Val158Met polymorphism and breast cancer risk: evidence from 26 case-control studies.
Breast Neoplasms
CYP17, catechol-o-methyltransferase, and glutathione transferase M1 genetic polymorphisms, lifestyle factors, and breast cancer risk in women on prince edward island.
Breast Neoplasms
Cytochrome P450 1B1 and catechol-O-methyltransferase genetic polymorphisms and breast cancer risk in Chinese women: results from the shanghai breast cancer study and a meta-analysis.
Breast Neoplasms
Cytochrome P450 1B1 gene polymorphisms and postmenopausal breast cancer risk.
Breast Neoplasms
Cytochrome P450 CYP1B1 and catechol O-methyltransferase (COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population.
Breast Neoplasms
Departure from multiplicative interaction for catechol-O-methyltransferase genotype and active/passive exposure to tobacco smoke among women with breast cancer.
Breast Neoplasms
Elucidation of the impact of P-glycoprotein and Breast Cancer Resistance Protein on the brain distribution of catechol-O-methyltransferase inhibitors.
Breast Neoplasms
Expression of cytochrome P450 1B1 and catechol-O-methyltransferase in breast tissue and their associations with breast cancer risk.
Breast Neoplasms
Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression.
Breast Neoplasms
Functional polymorphism of thymidylate synthase, but not of the COMT and IL-1B genes, is associated with breast cancer.
Breast Neoplasms
Genetic Association Between the COMT Genotype and Urinary Levels of Tea Polyphenols and Their Metabolites among Daily Green Tea Drinkers.
Breast Neoplasms
Genetic modeling of estrogen metabolism as a risk factor of hormone-dependent disorders.
Breast Neoplasms
Genetic modelling of the estrogen metabolism as a risk factor of hormone-dependent disorders.
Breast Neoplasms
Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility.
Breast Neoplasms
Genetic polymorphisms in catechol-O-methyltransferase, menopausal status, and breast cancer risk.
Breast Neoplasms
Genetic Predictors of Response to Acupuncture for Aromatase Inhibitor-Associated Arthralgia Among Breast Cancer Survivors.
Breast Neoplasms
Genetic susceptibility of catechol-O-methyltransferase polymorphism in Japanese patients with breast cancer.
Breast Neoplasms
Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk.
Breast Neoplasms
Immunoperoxidase localization of catechol-o-methyl transferase (COMT) in human breast cancer.
Breast Neoplasms
Impact of Catechol-O-Methyltransferase Val 158Met (rs4680) Polymorphism on Breast Cancer Susceptibility in Asian Population
Breast Neoplasms
Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and mucosal immune systems in breast cancer survivors.
Breast Neoplasms
Interactions between genetic polymorphism of cytochrome P450-1B1, sulfotransferase 1A1, catechol-o-methyltransferase and tobacco exposure in breast cancer risk.
Breast Neoplasms
Lack of association between catechol-O-methyltransferase Val108/158Met polymorphism and breast cancer risk: a meta-analysis of 25,627 cases and 34,222 controls.
Breast Neoplasms
Limited association between a catechol-O-methyltransferase (COMT) polymorphism and breast cancer risk in Japan.
Breast Neoplasms
Meta-analysis of genetic polymorphisms in xenobiotic metabolizing enzymes and their association with breast cancer risk.
Breast Neoplasms
Polymorphic catechol-O-methyltransferase gene, duration of estrogen exposure, and breast cancer risk: a nested case-control study in Taiwan.
Breast Neoplasms
Polymorphic catechol-O-methyltransferase gene, soy isoflavone intake and breast cancer in postmenopausal women: a case-control study.
Breast Neoplasms
Progesterone regulates catechol-O-methyl transferase gene expression in breast cancer cells: distinct effect of progesterone receptor isoforms.
Breast Neoplasms
Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs.
Breast Neoplasms
Proteomics Identification and Validation of Desmocollin-1 and Catechol-O-Methyltransferase as Proteins Associated with Breast Cancer Cell Migration and Metastasis.
Breast Neoplasms
Reduced COMT activity as a possible environmental risk factor for breast cancer. Opinion.
Breast Neoplasms
Relative imbalances in the expression of catechol-O-methyltransferase and cytochrome P450 in breast cancer tissue and their association with breast carcinoma.
Breast Neoplasms
Soluble and membrane-bound catechol-O-methyltransferase in normal and malignant mammary gland.
Breast Neoplasms
The Catechol-O-Methyltransferase Val158Met Polymorphism Contributes to the Risk of Breast Cancer in the Chinese Population: An Updated Meta-Analysis.
Breast Neoplasms
The COMT (rs165599) gene polymorphism contributes to chemotherapy-induced cognitive impairment in breast cancer patients.
Breast Neoplasms
The V108M mutation decreases the structural stability of catechol O-methyltransferase.
Breast Neoplasms
Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk factors for breast cancer.
Breast Neoplasms
Variations in COMT and NTRK2 Influence Symptom Burden in Women Undergoing Breast Cancer Treatment.
Breast Neoplasms
[Prevalence of Val158Met polymorphism in COMT gene on non-BRCA1/2 hereditary breast cancer]
Carcinogenesis
Association between the COMT Val158Met polymorphism and risk of cancer: evidence from 99 case-control studies.
Carcinogenesis
Breast cancer risk reduction and membrane-bound catechol O-methyltransferase genetic polymorphisms.
Carcinogenesis
CYP2E1 rs2031920, COMT rs4680 Polymorphisms, Cigarette Smoking, Alcohol Use and Lung Cancer Risk in a Japanese Population.
Carcinogenesis
Effects of a catechol-O-methyltransferase inhibitor on catechol estrogen-induced cellular transformation, chromosome aberrations and apoptosis in Syrian hamster embryo cells.
Carcinogenesis
Lack of association between the COMT rs4680 polymorphism and ovarian cancer risk: evidence from a meta-analysis of 3,940 individuals.
Carcinogenesis
Modulation of Estrogen Chemical Carcinogenesis by Botanical Supplements used for Postmenopausal Women's Health.
Carcinogenesis
Multiple promoters of catechol-O-methyltransferase gene are selectively inactivated by CpG hypermethylation in endometrial cancer.
Carcinogenesis
No association between germline variation in catechol-O-methyltransferase and colorectal cancer survival in postmenopausal women.
Carcinogenesis
Polymorphic catechol-O-methyltransferase gene, duration of estrogen exposure, and breast cancer risk: a nested case-control study in Taiwan.
Carcinogenesis
Polymorphic catechol-O-methyltransferase gene, soy isoflavone intake and breast cancer in postmenopausal women: a case-control study.
Carcinogenesis
Polymorphisms related to estrogen and xenobiotic metabolism in healthy Turkish women.
Carcinogenesis
Potential Impact of COMT-rs4680 G > A Gene Polymorphism in Coronary Artery Disease.
Carcinogenesis
The Catechol-O-Methyltransferase Val158Met Polymorphism Contributes to the Risk of Breast Cancer in the Chinese Population: An Updated Meta-Analysis.
Carcinogenesis
Val153Met polymorphism of catechol-O-methyltransferase and prevalence of uterine leiomyomata.
Carcinoma
Effect of testosterone and 6-hydroxydopamine treatment on the metabolism of catecholamine and 5-hydroxytryptamine in methylcholanthrene-induced prostate carcinoma of rats.
Carcinoma
Genetic polymorphisms of estrogen receptor alpha and catechol-O-methyltransferase genes in Turkish patients with familial prostate carcinoma.
Carcinoma
Genetic polymorphisms of estrogen receptor alpha, CYP19, catechol-O-methyltransferase are associated with familial prostate carcinoma risk in a Japanese population.
Carcinoma, Hepatocellular
Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form.
Carcinoma, Ovarian Epithelial
Polymorphisms of the estrogen-metabolizing genes CYP17 and catechol-O-methyltransferase and risk of epithelial ovarian cancer.
Carcinoma, Renal Cell
Polymorphisms of catechol-O-methyltransferase in men with renal cell cancer.
Cardiovascular Diseases
Association of Catechol-O-methyltransferase (COMT Val158Met) with future risk of cardiovascular disease in depressed individuals - a Swedish population-based cohort study.
Cardiovascular Diseases
Catechol-O-Methyltransferase (COMT): An Update on Its Role in Cancer, Neurological and Cardiovascular Diseases.
Cardiovascular Diseases
Effect of a natural mineral-rich water on catechol-O-methyltransferase function.
Cardiovascular Diseases
Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease.
Cardiovascular Diseases
Risk factors associated with metabolic syndrome in bipolar and schizophrenia subjects treated with antipsychotics: the role of folate pharmacogenetics.
Carpal Tunnel Syndrome
Association between the catechol-o-methyltransferase val158met polymorphism with susceptibility and severity of carpal tunnel syndrome.
Carpal Tunnel Syndrome
Catechol-O-Methyltransferase Val158Met Polymorphism is Associated with Pain and Disability, but not Widespread Pressure Pain Sensitivity, in Women with Carpal Tunnel Syndrome.
Catalepsy
The COMT inhibitor tolcapone potentiates the anticataleptic effect of Madopar in MPP(+)-lesioned mice.
catechol o-methyltransferase deficiency
Catechol-O-Methyltransferase Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II.
catechol o-methyltransferase deficiency
Delayed O-methylation of l-DOPA in MB-COMT-deficient mice after oral administration of l-DOPA and carbidopa.
catechol o-methyltransferase deficiency
Effect of S-COMT deficiency on behavior and extracellular brain dopamine concentrations in mice.
catechol o-methyltransferase deficiency
[Effect of Catechol-O-methyltransferase deficiency on reinforcing effects of cocaine (experimental study)].
Choriocarcinoma
Catechol-O-methyltransferase in rat placenta, human placenta and choriocarcinoma grown in culture.
Classical Lissencephalies and Subcortical Band Heterotopias
Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study.
Colonic Neoplasms
Cytochrome P450 17A1 and catechol O-methyltransferase polymorphisms and age at Lynch syndrome colon cancer onset in Newfoundland.
Colonic Neoplasms
Ten polymorphisms of estrogen-metabolizing genes and a family history of colon cancer--an association study of multiple gene-gene interactions.
Colorectal Neoplasms
Catechol-O-Methyltransferase Inhibits Colorectal Cancer Cell Proliferation and Invasion.
Colorectal Neoplasms
Evaluation of the Association of rs4680 COMT Polymorphism and Clinical Parameters of the Tumor in Colorectal Cancer (a Pilot Study).
Colorectal Neoplasms
Impact of catechol-O-methyltransferase gene variants on methylation status of P16 and MGMT genes and their downregulation in colorectal cancer.
Colorectal Neoplasms
Metabolic-Pathway-Oriented Screening Targeting S-Adenosyl-l-methionine Reveals the Epigenetic Remodeling Activities of Naturally Occurring Catechols.
Colorectal Neoplasms
No association between germline variation in catechol-O-methyltransferase and colorectal cancer survival in postmenopausal women.
Colorectal Neoplasms
[The expression of catechol o-methyltransferase gene in colorectal cancer]
Colorectal Neoplasms, Hereditary Nonpolyposis
Cytochrome P450 17A1 and catechol O-methyltransferase polymorphisms and age at Lynch syndrome colon cancer onset in Newfoundland.
Coronary Disease
Catechol-O-methyltransferase promoter hypomethylation is associated with the risk of coronary heart disease.
COVID-19
Warriors, Worriers, and COVID-19: An Exploratory Study of the Catechol O-Methyltransferase Val158Met Polymorphism Across Populations.
Craniocerebral Trauma
178?COMT Val158Met is Associated With Domain-Specific Cognitive Impairment Following Mild Traumatic Brain Injury.
Craniocerebral Trauma
COMT Val (158) Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury.
Deafness
A catechol-O-methyltransferase that is essential for auditory function in mice and humans.
Deglutition Disorders
Role of rs6265 BDNF polymorphisms and post-stroke dysphagia recovery-A prospective cohort study.
Delirium
Association of COMT Val158Met Polymorphism With Delirium Risk and Outcomes After Traumatic Brain Injury.
Delirium
Polymorphisms in the catechol-o-methyltransferase gene and delirium in the elderly.
Delirium
The Association Between C-Reactive Protein and Postoperative Delirium Differs by Catechol-O-Methyltransferase Genotype.
Dementia
APOE, MAPT, and COMT and Parkinson's Disease Susceptibility and Cognitive Symptom Progression.
Dementia
Apolipoprotein E epsilon4 and catechol-O-methyltransferase alleles in autopsy-proven Parkinson's disease: relationship to dementia and hallucinations.
Dementia
Association study of a functional catechol-o-methyltransferase polymorphism and cognitive function in patients with dementia.
Dementia
Association study of a functional catechol-O-methyltransferase polymorphism and executive function in elderly males without dementia.
Dementia
Catechol-o-methyltransferase gene polymorphism in dementia with Lewy bodies-related psychosis: evidence for a genetic predisposition.
Dementia
Demographic and motor features associated with the occurrence of neuropsychiatric and sleep complications of Parkinson's disease.
Dementia
Influence of COMT polymorphism in cognitive performance on dementia in community-dwelling elderly Mexican (SADEM study).
Dermatitis, Atopic
Catechol-O-methyl transferase in skin of patients with atopic dermatitis.
Diabetes Mellitus
The effects of type 1 diabetes mellitus and of tobacco smoke on dissipation of catecholamines in pulmonary endothelial cells--a non-neuronal site of uptake1.
Diabetes Mellitus
[Study on the association between catechol-O-methyltransferase gene polymorphisms and type 2 diabetes mellitus].
Diabetes Mellitus, Type 1
The effects of type 1 diabetes mellitus and of tobacco smoke on dissipation of catecholamines in pulmonary endothelial cells--a non-neuronal site of uptake1.
Diabetes Mellitus, Type 2
A case control association study of COMT gene polymorphism (I/D) with type 2 diabetes and its related factors in Pakistani Punjabi population.
Diabetes Mellitus, Type 2
[Study on the association between catechol-O-methyltransferase gene polymorphisms and type 2 diabetes mellitus].
Diabetes, Gestational
Risks of Macrosomia Associated with Catechol-O-Methyltransferase Genotypes and Genetic-Epigenetic Interactions among Children with and without Gestational Diabetes Exposure.
DiGeorge Syndrome
A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.
DiGeorge Syndrome
Association of codon 108/158 catechol-O-methyltransferase gene polymorphism with the psychiatric manifestations of velo-cardio-facial syndrome.
DiGeorge Syndrome
Association of copy number polymorphisms at the promoter and translated region of COMT with Japanese patients with schizophrenia.
DiGeorge Syndrome
Biological Effects of COMT Haplotypes and Psychosis Risk in 22q11.2 Deletion Syndrome.
DiGeorge Syndrome
Catechol-O-methyltransferase polymorphism modulates cognitive control in children with chromosome 22q11.2 deletion syndrome.
DiGeorge Syndrome
Catecholamines in patients with 22q11.2 deletion syndrome and the low-activity COMT polymorphism.
DiGeorge Syndrome
COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome.
DiGeorge Syndrome
Does dysregulation of catechol-O-methyltransferase predispose to opioid-induced hallucinations? A report of a patient with microdeletion of chromosome 22 and opioid-associated hallucinations.
DiGeorge Syndrome
Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndrome.
DiGeorge Syndrome
Exome-Wide Association Study Identified New Risk Loci for Hirschsprung's Disease.
DiGeorge Syndrome
No association found between 158 Val/Met polymorphism of the COMT gene and schizophrenia with minor physical anomalies.
DiGeorge Syndrome
No Evidence for an Effect of COMT Val158Met Genotype on Executive Function in Patients With 22q11 Deletion Syndrome.
DiGeorge Syndrome
No evidence for linkage of chromosome 22 markers to schizophrenia in southern African Bantu-speaking families.
DiGeorge Syndrome
Risk factors for the emergence of psychotic disorders in adolescents with 22q11.2 deletion syndrome.
DiGeorge Syndrome
Schizophrenia-like neurophysiological abnormalities in 22q11.2 deletion syndrome and their association to COMT and PRODH genotypes.
DiGeorge Syndrome
Separate and interacting effects within the catechol-O-methyltransferase (COMT) are associated with schizophrenia.
DiGeorge Syndrome
Stimulant treatment effectiveness, safety and risk for psychosis in individuals with 22q11.2 deletion syndrome.
DiGeorge Syndrome
The development of cognitive control in children with chromosome 22q11.2 deletion syndrome.
DiGeorge Syndrome
The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion regulation in velo-cardio-facial syndrome (22q11.2 deletion syndrome): An fMRI study.
DiGeorge Syndrome
Ultra-ultra rapid cycling bipolar disorder is associated with the low activity catecholamine-O-methyltransferase allele.
Disorders of Excessive Somnolence
Association of daytime sleepiness with COMT polymorphism in patients with parkinson disease: a pilot study.
Disorders of Excessive Somnolence
Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease.
Disorders of Excessive Somnolence
Sleep disorders in Parkinson's disease: epidemiology and management.
Down Syndrome
Catechol-o-methyltransferase activity in erythrocytes in Down's syndrome: family studies.
Down Syndrome
Erythrocyte catechol-O-methyltransferase activity: genetic analysis in nuclear families with one child affected by Down syndrome.
Drug-Related Side Effects and Adverse Reactions
Evaluation of Phenotypic and Genotypic Variations of Drug Metabolising Enzymes and Transporters in Chronic Pain Patients Facing Adverse Drug Reactions or Non-Response to Analgesics: A Retrospective Study.
Dyskinesia, Drug-Induced
The evolution of pharmacological treatment for Parkinson's disease.
Dyskinesias
Alterations in preproenkephalin and adenosine-2a receptor mRNA, but not preprotachykinin mRNA correlate with occurrence of dyskinesia in normal monkeys chronically treated with L-DOPA.
Dyskinesias
Analysis of catechol-O-methyltransferase gene mutation and identification of new pathogenic gene for paroxysmal kinesigenic dyskinesia.
Dyskinesias
Association between catechol-O-methyltransferase gene polymorphisms and wearing-off and dyskinesia in Parkinson's disease.
Dyskinesias
Association of COMT rs4680 and MAO-B rs1799836 polymorphisms with levodopa-induced dyskinesia in Parkinson's disease-a meta-analysis.
Dyskinesias
Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease.
Dyskinesias
Dopamine Reuptake Inhibitors in Parkinson's Disease: A Review of Nonhuman Primate Studies and Clinical Trials.
Dyskinesias
L-dopa induces dyskinesia in normal monkeys: behavioural and pharmacokinetic observations.
Dyskinesias
Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia.
Dyskinesias
The contribution of the MPTP-treated primate model to the development of new treatment strategies for Parkinson's disease.
Dyskinesias
The therapy of the motor symptoms in the advanced stage of Parkinson's disease.
Dyskinesias
Use of catechol-O-methyltransferase inhibition to minimize L-3,4-dihydroxyphenylalanine-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque.
Dyskinesias
[Influence of levodopa, stalevo on dyskinesia in Parkinson's disease: STRIDE-PD study].
Dystonia
Catechol-O-methyltransferase activity in cultured human skin fibroblasts from controls and patients with dystonia musculorum deformans.
Dystonia Musculorum Deformans
Catechol-O-methyltransferase activity in cultured human skin fibroblasts from controls and patients with dystonia musculorum deformans.
Encephalitis, Japanese
Entacapone, a catechol-O-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson's disease induced by Japanese encephalitis virus.
Encephalomyelitis
The blood-brain barrier-permeable catechol-O-methyltransferase inhibitor dinitrocatechol suppresses experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
The blood-brain barrier-permeable catechol-O-methyltransferase inhibitor dinitrocatechol suppresses experimental autoimmune encephalomyelitis.
Endometrial Neoplasms
Catechol-O-Methyltransferase and Cytochrome P-450 1B1 Polymorphisms and Endometrial Cancer Risk: A Meta-analysis.
Endometrial Neoplasms
Contribution of catechol-O-methyltransferase Val158Met polymorphism to endometrial cancer risk in postmenopausal women: a meta-analysis.
Endometrial Neoplasms
Cytochrome P450 1B1 and catechol-O-methyltransferase genetic polymorphisms and endometrial cancer risk in Chinese women.
Endometrial Neoplasms
Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms and endometrial cancer susceptibility.
Endometrial Neoplasms
Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: Lower levels of CYP1B1 and increased expression of S-COMT.
Endometrial Neoplasms
Hormonal imbalance in two types of endometrial cancer and genetic polymorphism of steroidogenic enzymes.
Endometrial Neoplasms
Multiple promoters of catechol-O-methyltransferase gene are selectively inactivated by CpG hypermethylation in endometrial cancer.
Endometrial Neoplasms
Progesterone-mediated regulation of catechol-O-methyl transferase expression in endometrial cancer cells.
Endometrial Neoplasms
[Polymorphism of catechol-O-methyltransferase gene in relation to the risk of endometrial cancer]
Endometrial Neoplasms
[Prognostic significance of assay of sex hormones, their receptors and enzymes involved in estrogen synthesis and metabolism in endometrial carcinoma]
Endometriosis
Aberrant endometrial DNA methylome of homeobox A10 and catechol-O-methyltransferase in endometriosis.
Endometriosis
Analysis of the relationship between COMT polymorphisms and endometriosis susceptibility.
Endometriosis
COMT 158G/A and CYP1B1 432C/G polymorphisms increase the risk of endometriosis and adenomyosis: a meta-analysis.
Endometriosis
Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: A source of excessive hydroxy-estrogens and ROS?
Endometriosis
Ten estrogen-related polymorphisms and endometriosis: a study of multiple gene-gene interactions.
Epilepsy
BDNF and COMT, but not APOE, alleles are associated with psychiatric symptoms in refractory epilepsy.
Epilepsy
Genetic Contribution of Catechol-O-methyltransferase Polymorphism in Patients with Migraine without Aura.
Essential Hypertension
Radioenzymatic assay of plasma adrenaline and noradrenaline: evidence for a catechol-O-methyltransferase (COMT) inhibiting factor associated with essential hypertension.
Essential Hypertension
[Association of catechol-O-methyltransferase Val 108/158 Met polymorphism with essential hypertension].
Fatigue Syndrome, Chronic
Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic fatigue syndrome.
Fetal Growth Retardation
Effect of Prenatal Hypoxia in Transgenic Mouse Models of Preeclampsia and Fetal Growth Restriction.
Fetal Growth Retardation
Functional maternal catechol-O-methyltransferase polymorphism and fetal growth restriction.
Fetal Growth Retardation
Sildenafil Citrate Rescues Fetal Growth in the Catechol-O-Methyl Transferase Knockout Mouse Model.
Fibromyalgia
Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study.
Fibromyalgia
Association between the COMT Val158Met polymorphism and fibromyalgia susceptibility and fibromyalgia impact questionnaire score: a meta-analysis.
Fibromyalgia
Association of Catechol-O-methyltransferase single nucleotide polymorphisms, ethnicity, and sex in a large cohort of fibromyalgia patients.
Fibromyalgia
Catechol-O-Methyl Transferase (COMT) gene haplotypes in Mexican and Spaniard patients with fibromyalgia.
Fibromyalgia
Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, but not pressure pain sensitivity, in women with fibromyalgia syndrome.
Fibromyalgia
Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism.
Fibromyalgia
Fear of pain moderates the relationship between self-reported fatigue and methionine allele of catechol-O-methyltransferase gene in patients with fibromyalgia.
Fibromyalgia
Has catechol-O-methyltransferase genotype (Val158Met) an influence on endocrine, sympathetic nervous and humoral immune systems in women with fibromyalgia syndrome?
Fibromyalgia
Meta-analysis reveals a lack of association between a common catechol-O-methyltransferase (COMT) polymorphism val(158)met and fibromyalgia.
Fibromyalgia
Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene.
Fibromyalgia
Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility.
Fibromyalgia
Significance of catechol-O-methyltransferase gene polymorphism in fibromyalgia syndrome.
Fibromyalgia
Sustained stimulation of ?2- and ?3-adrenergic receptors leads to persistent functional pain and neuroinflammation.
Fibromyalgia
The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia.
Frontotemporal Lobar Degeneration
Effect of Functional BDNF and COMT Polymorphisms on Symptoms and Regional Brain Volume in Frontotemporal Dementia and Corticobasal Syndrome.
Genetic Diseases, Inborn
Does dysregulation of catechol-O-methyltransferase predispose to opioid-induced hallucinations? A report of a patient with microdeletion of chromosome 22 and opioid-associated hallucinations.
Glioma
BDNF, COMT, and DRD2 polymorphisms and ability to return to work in adult patients with low- and high-grade glioma.
Glioma
Metabolism of catecholamines by catechol-O-methyltransferase in cells expressing recombinant catecholamine transporters.
Glossitis
Anxiety and genetic polymorphisms in catechol-O-methyltransferase (COMT) and serotonin transportation gene (5HTT) are associated with benign migratory glossitis.
Glossitis, Benign Migratory
Anxiety and genetic polymorphisms in catechol-O-methyltransferase (COMT) and serotonin transportation gene (5HTT) are associated with benign migratory glossitis.
Hallucinations
Apolipoprotein E epsilon4 and catechol-O-methyltransferase alleles in autopsy-proven Parkinson's disease: relationship to dementia and hallucinations.
Hallucinations
Does dysregulation of catechol-O-methyltransferase predispose to opioid-induced hallucinations? A report of a patient with microdeletion of chromosome 22 and opioid-associated hallucinations.
Hallucinations
Effect of tDCS on auditory hallucinations in schizophrenia: Influence of catechol-O-methyltransferase (COMT) Val158Met polymorphism.
Hallucinations
The Effect of Dopamine Antagonist Treatment on Auditory Verbal Hallucinations in Healthy Individuals Is Clearly Influenced by COMT Genotype and Accompanied by Corresponding Brain Structural and Functional Alterations: An Artificially Controlled Pilot Study.
Hearing Loss
A Comparative Study of Hearing Loss in Two Microdeletion Syndromes: Velocardiofacial (22q11.2 Deletion) and Williams (7q11.23 Deletion) Syndromes.
Hearing Loss
Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts.
Hearing Loss
[Effect of Electroacupuncture on Expression of Catechol-O-methyltransferase in the Inferior Colliculus and Auditory Cortex in Age-related Hearing Loss Guinea Pigs].
Heart Failure
Cardiac catechol O-methyltransferase and monoamine oxidase activity in congestive heart failure.
Hemochromatosis
[The polymorphism of catechol-O-methyltransferase (COMT) and hemochromatosis (HFE) genes in the radiocontaminated regions residents with different chromosome aberration frequency]
Hepatitis
[Diagnostic significance of catechol-O-methyltransferase (COMT) activity in viral hepatitis]
Hepatitis C
Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients.
Hepatitis C, Chronic
Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients.
Herpes Simplex
The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection are risk factors for cognitive impairment in bipolar disorder: additive gene-environmental effects in a complex human psychiatric disorder.
HIV Infections
The dopamine-related polymorphisms BDNF, COMT, DRD2, DRD3, and DRD4 are not linked with changes in CSF dopamine levels and frequency of HIV infection.
Huntington Disease
Monoamines and their metabolites in Huntington's disease brain: evidence for decreased catechol-O-methyltransferase activity.
Hyperalgesia
Effect of catechol-O-methyltransferase (rs4680) single-nucleotide polymorphism on opioid-induced hyperalgesia in adults with chronic pain.
Hyperhomocysteinemia
Hyperhomocysteinemia in movement disorders: Current evidence and hypotheses.
Hyperhomocysteinemia
Is the deficiency of vitamin b(12) related to oxidative stress and neurotoxicity in Parkinson's patients?
Hyperhomocysteinemia
Management of L-Dopa related hyperhomocysteinemia: catechol-O-methyltransferase (COMT) inhibitors or B vitamins? Results from a review.
Hyperhomocysteinemia
On the mechanism of homocysteine pathophysiology and pathogenesis: a unifying hypothesis.
Hyperhomocysteinemia
The controversy concerning plasma homocysteine in Parkinson disease patients treated with levodopa alone or with entacapone: effects of vitamin status.
Hypersensitivity
Catechol-O-Methyltransferase Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II.
Hypersensitivity
Catechol-O-methyltransferase genotype (Val158met) modulates cancer-related fatigue and pain sensitivity in breast cancer survivors.
Hypersensitivity
Serotonin-Induced Hypersensitivity via Inhibition of Catechol O-Methyltransferase Activity.
Hypersensitivity
[Drug hypersensitivity in patients with presumed histamine intolerance and mast cell activation disease].
Hypertension
2-Methoxyestradiol ameliorates metabolic syndrome-induced hypertension and catechol-O-methyltransferase inhibited expression and activity in rats.
Hypertension
Association of the Catechol-O-Methyl Transferase Gene Val158Met Polymorphism With Blood Pressure and Prevalence of Hypertension: Interaction With Dietary Energy Intake.
Hypertension
Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men.
Hypertension
Catechol-O-Methyltransferase Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II.
Hypertension
Catechol-O-methyltransferase: potential relationship to idiopathic hypertension.
Hypertension
COMT-catalyzed palmitic acid methyl ester biosynthesis in perivascular adipose tissue and its potential role against hypertension.
Hypertension
Dietary Magnesium Insufficiency Induces Salt-Sensitive Hypertension in Mice Associated With Reduced Kidney Catechol-O-Methyl Transferase Activity.
Hypertension
Effect of a natural mineral-rich water on catechol-O-methyltransferase function.
Hypertension
Endothelial dysfunction in gestational hypertension induced by catechol-O-methyltransferase inhibition.
Hypertension
Exclusion of the catechol-o-methyltransferase gene from genes contributing to salt-sensitive hypertension in dahl salt-sensitive rats.
Hypertension
Low catechol-O-methyltransferase activity in the brain and blood pressure regulation.
Hypertension
Model approach for stress induced steroidal hormone cascade changes in severe mental diseases.
Hypertension
Severe early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression.
Hypertension
Suppression of catechol-O-methyltransferase activity through blunting of alpha2-adrenoceptor can explain hypertension in Dahl salt-sensitive rats.
Hypertension, Pregnancy-Induced
Aromatase and estrogen 2-hydroxylase activities of human placental microsomes in pregnancy-induced hypertension.
Hypertension, Pregnancy-Induced
Dopamine in the Pathophysiology of Preeclampsia and Gestational Hypertension: Monoamine Oxidase (MAO) and Catechol-O-methyl Transferase (COMT) as Possible Mechanisms.
Hypertension, Pregnancy-Induced
Endothelial dysfunction in gestational hypertension induced by catechol-O-methyltransferase inhibition.
Hypertension, Pregnancy-Induced
Erythrocyte catechol-O-methyltransferase activity in pregnant women with pregnancy-induced hypertension.
Hyperthyroidism
Influence of hypo- and hyperthyroidism on noradrenaline metabolism in brown adipose tissue of the developing rat.
Hyperthyroidism
Lithium suppresses elevated behavioural activity and brain catecholamines in developing hyperthyroid rats.
Hypokinesia
Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson's Disease.
Hypophosphatemia, Familial
Role of Chronic Inhibition of Dopamine-Metabolizing Enzymes in the Regulation of Renal Sodium and Phosphate Excretion in the Rat Remnant Kidney.
Hypotension
Reduced membrane-bound catechol-O-methyltransferase in the liver of spontaneously hypertensive rats.
Infections
Expression of recombinant soluble and membrane-bound catechol O-methyltransferase in eukaryotic cells and identification of the respective enzymes in rat brain.
Infections
The catechol O-methyltransferase Val158Met polymorphism and herpes simplex virus type 1 infection are risk factors for cognitive impairment in bipolar disorder: additive gene-environmental effects in a complex human psychiatric disorder.
Infections
Tobacco O-methyltransferases involved in phenylpropanoid metabolism. The different caffeoyl-coenzyme A/5-hydroxyferuloyl-coenzyme A 3/5-O-methyltransferase and caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase classes have distinct substrate specificities and expression patterns.
Insulinoma
Monoamine oxidase and catechol-O-methyltransferase activity in hamster and rat insulinomas.
Intellectual Disability
Study: the lack of significant association of the catechol-O-methyl transferase (COMT) gene polymorphism in violent offenders with mental retardation.
Intervertebral Disc Degeneration
A novel catechol-O-methyltransferase variant associated with human disc degeneration.
Intervertebral Disc Degeneration
Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease.
Intervertebral Disc Degeneration
The relationship between disc degeneration, low back pain, and human pain genetics.
Irritable Bowel Syndrome
A genetic association study of single nucleotide polymorphisms in GN?3 and COMT in elderly patients with irritable bowel syndrome.
Irritable Bowel Syndrome
Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome.
Irritable Bowel Syndrome
The Relationship between the Val158Met Catechol-o-Methyltransferase (COMT) Polymorphism and Irritable Bowel Syndrome.
Ischemic Stroke
Catechol-O-methyltransferase polymorphism influences outcome after ischemic stroke: a prospective double-blind study.
Kidney Diseases
A case control association study of COMT gene polymorphism (I/D) with type 2 diabetes and its related factors in Pakistani Punjabi population.
Kidney Failure, Chronic
External and internal standards in the single-isotope derivative (radioenzymatic) measurement of plasma norepinephrine and epinephrine.
Kidney Neoplasms
Induction of nuclear catechol-O-methyltransferase by estrogens in hamster kidney: implications for estrogen-induced renal cancer.
Kidney Neoplasms
Significant association of catechol-O-methyltransferase Val158Met polymorphism with bladder cancer instead of prostate and kidney cancer.
Leiomyoma
Association study between catechol-O-methyltransferase polymorphisms and uterine leiomyomas in a Japanese population.
Leiomyoma
Catechol-o-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells.
Leiomyoma
Catechol-O-methyltransferase polymorphism is associated with increased uterine leiomyoma risk in different ethnic groups.
Leiomyoma
Catechol-O-methyltransferase Val158Met polymorphism is associated with increased risk of multiple uterine leiomyomas either positive or negative for MED12 exon 2 mutations.
Leiomyoma
Genotype distribution of estrogen receptor-alpha, catechol-O-methyltransferase, and cytochrome P450 17 gene polymorphisms in Caucasian women with uterine leiomyomas.
Leiomyoma
Green Tea Extract Inhibition of Human Leiomyoma Cell Proliferation Is Mediated via Catechol- O -Methyltransferase.
Leiomyoma
Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas.
Leiomyoma
The associations between the Val158Met in the catechol-O-methyltransferase (COMT) gene and the risk of uterine leiomyoma (ULM).
Leiomyoma
The catechol-O-methyltransferase (COMT) gene polymorphism and prevalence of uterine fibroids.
Leiomyoma
Towards non-surgical therapy for uterine fibroids: catechol-O-methyl transferase inhibitor shrinks uterine fibroid lesions in the Eker rat model.
Leiomyoma
Val153Met polymorphism of catechol-O-methyltransferase and prevalence of uterine leiomyomata.
Leiomyoma
Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase.
Lesch-Nyhan Syndrome
Monoamine oxidase and catechol-o-methyltransferase activity in cultured fibroblasts from patients with maple syrup urine disease, Lesch-Nyhan syndrome and healthy controls.
Liver Diseases
Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients.
Liver Failure
Tolcapone-related liver dysfunction: implications for use in Parkinson's disease therapy.
Liver Neoplasms
Defining the role of echinocandin catechol functional groups in the development of secondary hepatocellular carcinoma.
Liver Neoplasms
Genetic polymorphisms of steroid hormone metabolizing enzymes and risk of liver cancer in hepatitis C-infected patients.
Lung Neoplasms
Association between Catechol-O-methyltransferase rs4680 (G>A) polymorphism and lung cancer risk.
Lung Neoplasms
Association between the COMT 158 G/A polymorphism and lung cancer risk: a meta-analysis.
Lung Neoplasms
CYP2E1 rs2031920, COMT rs4680 Polymorphisms, Cigarette Smoking, Alcohol Use and Lung Cancer Risk in a Japanese Population.
Lung Neoplasms
Genetic polymorphism of catechol-O-methyltransferase modulates the association of green tea consumption and lung cancer.
Lung Neoplasms
Interaction Between Environmental Risk Factors and Catechol-O-Methyltransferase (COMT) and X-Ray Repair Cross-Complementing Protein 1 (XRCC1) Gene Polymorphisms in Risk of Lung Cancer Among Non-Smoking Chinese Women: A Case-Control Study.
Lung Neoplasms
Potentially estrogenic polychlorinated biphenyls congeners serum levels and its relation with lung cancer.
Lung Neoplasms
Synergistic inhibition of lung cancer cell lines by (-)-epigallocatechin-3-gallate in combination with clinically used nitrocatechol inhibitors of catechol-O-methyltransferase.
Lymphangioleiomyomatosis
Oestrogen metabolism in lymphangioleiomyomatosis: catechol-O-methyltransferase pathway is not involved.
Lymphatic Metastasis
Proteomics Identification and Validation of Desmocollin-1 and Catechol-O-Methyltransferase as Proteins Associated with Breast Cancer Cell Migration and Metastasis.
Lymphoma, B-Cell
Expression and cyclic variations of catechol-O-methyl transferase in human endometrial stroma.
Lymphoma, Non-Hodgkin
Polymorphisms and haplotypes in the cytochrome P450 17A1, prolactin, and catechol-O-methyltransferase genes and non-Hodgkin lymphoma risk.
Mania
Recurrence of bipolar mania is associated with catechol-O-methyltransferase Val(108/158)Met polymorphism.
Maple Syrup Urine Disease
Monoamine oxidase and catechol-o-methyltransferase activity in cultured fibroblasts from patients with maple syrup urine disease, Lesch-Nyhan syndrome and healthy controls.
Melanoma
Catechol-O-methyltransferase activity is higher in psoriasis patients and is down-regulated by narrowband ultraviolet B treatment.
Melanoma
Differences in subcellular distribution of catechol-O-methyltransferase and tyrosinase in malignant melanoma.
Melanoma
Induction of cytotoxicity in melanoma cells through inhibition of catechol-O-methyltransferase.
Melanoma
Production, circulation, and excretion of melanin-related metabolites in B16 melanoma-bearing mice.
Melanoma
Ultraviolet B radiation differentially modifies catechol-O-methyltransferase activity in keratinocytes and melanoma cells.
Melanoma, Experimental
Production, circulation, and excretion of melanin-related metabolites in B16 melanoma-bearing mice.
Memory Disorders
Association of abstinence-induced alterations in working memory function and COMT genotype in smokers.
Memory Disorders
Brain catechol-O-methyltransferase (COMT) inhibition by tolcapone counteracts recognition memory deficits in normal and chronic phencyclidine-treated rats and in COMT-Val transgenic mice.
Memory Disorders
Tolcapone, an inhibitor of catechol O-methyltransferase, counteracts memory deficits caused by bilateral cholinotoxin lesions of the basal nuclei of Meynert.
Meningioma
Barrier functions of the leptomeninges: a study of normal meninges and meningiomas in tissue culture.
Metabolic Syndrome
Detection of metabolic syndrome in schizophrenia and implications for antipsychotic therapy : is there a role for folate?
Metabolic Syndrome
Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype.
Metabolic Syndrome
The influence of metabolic syndrome, physical activity and genotype on catechol-O-methyl transferase promoter-region methylation in schizophrenia.
Migraine Disorders
Catechol-O-Methyltransferase Val158Met Polymorphism Is Associated with Anxiety, Depression, and Widespread Pressure Pain Sensitivity in Women with Chronic, but Not Episodic, Migraine.
Migraine Disorders
Genetic contribution of catechol-O-methyltransferase in hippocampal structural and functional changes of female migraine sufferers.
Migraine Disorders
Genetic Contribution of Catechol-O-methyltransferase Polymorphism in Patients with Migraine without Aura.
Migraine Disorders
Impact of a 12-week open-label placebo treatment on headache days in episodic and chronic migraine: a study protocol for a parallel-group, multicentre, randomised controlled trial.
Migraine Disorders
Look beyond Catechol-O-Methyltransferase genotype for cathecolamines derangement in migraine: the BioBIM rs4818 and rs4680 polymorphisms study.
Migraine Disorders
Significance of the catechol-O-methyltransferase gene polymorphism in migraine.
Migraine Disorders
The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study.
Migraine without Aura
Genetic Contribution of Catechol-O-methyltransferase Polymorphism in Patients with Migraine without Aura.
MPTP Poisoning
Effects of catechol-O-methyltransferase inhibition on the rates of uptake and reversibility of 6-fluoro-L-Dopa trapping in MPTP-induced parkinsonism in monkeys.
Multiple Sclerosis
Catechol-O-methyltransferase Val158Met polymorphism (rs4680) is associated with pain in multiple sclerosis.
Multiple Sclerosis
Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis.
Multiple Sclerosis
The blood-brain barrier-permeable catechol-O-methyltransferase inhibitor dinitrocatechol suppresses experimental autoimmune encephalomyelitis.
Muscle Hypotonia
[Feeding difficulty and developmental delay for 8 months and nystagmus for 4 months in an infant].
Musculoskeletal Pain
Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study.
Myalgia
Biopsychosocial influence on exercise-induced delayed onset muscle soreness at the shoulder: pain catastrophizing and catechol-o-methyltransferase (COMT) diplotype predict pain ratings.
Myalgia
Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome.
Mycetoma
Polymorphisms in catechol-O-methyltransferase and cytochrome p450 subfamily 19 genes predispose towards Madurella mycetomatis-induced mycetoma susceptibility.
Myocardial Infarction
Association between the low activity genotype of catechol-O-methyltransferase and myocardial infarction in a hypertensive population.
Myocardial Infarction
The impact of the catechol-O-methyltransferase Val158Met polymorphism on survival in the general population--the HUNT study.
Myocardial Ischemia
Contribution of catechol O-methyltransferase to the removal of accumulated interstitial catecholamines evoked by myocardial ischemia.
Narcolepsy
Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil.
Neoplasm Metastasis
Immunoperoxidase localization of catechol-o-methyl transferase (COMT) in human breast cancer.
Neoplasm Metastasis
Proteomics Identification and Validation of Desmocollin-1 and Catechol-O-Methyltransferase as Proteins Associated with Breast Cancer Cell Migration and Metastasis.
Neoplasms
Allelic and genotype frequencies of catechol-O-methyltransferase (Val158Met) and CYP2D6*10 (Pro34Ser) single nucleotide polymorphisms in the Philippines.
Neoplasms
Association of the OPRM1 and COMT genes' polymorphisms with the efficacy of morphine in Tunisian cancer patients: Impact of the high genetic heterogeneity in Tunisia?
Neoplasms
Catechol estrogen metabolites and conjugates in different regions of the prostate of Noble rats treated with 4-hydroxyestradiol: implications for estrogen-induced initiation of prostate cancer.
Neoplasms
Catechol-O-Methyltransferase (COMT): An Update on Its Role in Cancer, Neurological and Cardiovascular Diseases.
Neoplasms
Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression.
Neoplasms
Catechol-O-methyltransferase genotype modulates cancer treatment-related cognitive deficits in breast cancer survivors.
Neoplasms
Catechol-o-methyltransferase genotypes are associated with progression and biological behaviour of canine mammary tumours.
Neoplasms
Catechol-O-Methyltransferase Inhibits Colorectal Cancer Cell Proliferation and Invasion.
Neoplasms
Catechol-o-methyltransferase polymorphisms predict opioid consumption in postoperative pain.
Neoplasms
COMT and Alpha-Tocopherol Effects in Cancer Prevention: Gene-Supplement Interactions in Two Randomized Clinical Trials.
Neoplasms
Conversion of estrone to 2- and 4-hydroxyestrone by hamster kidney and liver microsomes: implications for the mechanism of estrogen-induced carcinogenesis.
Neoplasms
Detection of catechol-O-methyltransferase Val158Met polymorphism by a simple one-step tetra-primer amplification refractory mutation system-PCR.
Neoplasms
Diagnostic potential in bladder cancer of a panel of tumor markers (calreticulin, gamma -synuclein, and catechol-o-methyltransferase) identified by proteomic analysis.
Neoplasms
Effects of human blood levels of two PAH mixtures on the AHR signalling activation pathway and CYP1A1 and COMT target genes in granulosa non-tumor and granulosa tumor cell lines.
Neoplasms
Effects of the tumor inhibitor, vernolepin, and of its thioether adduct, on the activity of catechol O-methyltransferase in vitro.
Neoplasms
Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea.
Neoplasms
Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk.
Neoplasms
Evaluation of the Association of rs4680 COMT Polymorphism and Clinical Parameters of the Tumor in Colorectal Cancer (a Pilot Study).
Neoplasms
Expectation of a Decrease in Pain Affects the Prognosis of Pain in Cancer Patients: a Prospective Cohort Study of Response to Morphine.
Neoplasms
Expression changes in arrestin ? 1 and genetic variation in catechol-O-methyltransferase are biomarkers for the response to morphine treatment in cancer patients.
Neoplasms
Genetic variation and response to morphine in cancer patients: catechol-o-methyltransferase and multidrug resistance-1 gene polymorphisms are associated with central side effects.
Neoplasms
Genetic variation in catechol-O-methyltransferase (COMT) and obesity in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial.
Neoplasms
Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain.
Neoplasms
Interaction Between Environmental Risk Factors and Catechol-O-Methyltransferase (COMT) and X-Ray Repair Cross-Complementing Protein 1 (XRCC1) Gene Polymorphisms in Risk of Lung Cancer Among Non-Smoking Chinese Women: A Case-Control Study.
Neoplasms
Is bisphenol A a weak carcinogen like the natural estrogens and diethylstilbestrol?
Neoplasms
Microsomal hydroxylation of 2- and 4-fluoroestradiol to catechol metabolites and their conversion to methyl ethers: catechol estrogens as possible mediators of hormonal carcinogenesis.
Neoplasms
Multiple promoters of catechol-O-methyltransferase gene are selectively inactivated by CpG hypermethylation in endometrial cancer.
Neoplasms
Neuregulin-1 Regulates Cell Adhesion via an ErbB2/Phosphoinositide-3 Kinase/Akt-Dependent Pathway: Potential Implications for Schizophrenia and Cancer.
Neoplasms
Opioid response in paediatric cancer patients and the Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene: an Italian study on 87 cancer children and a systematic review.
Neoplasms
Plasma metanephrines are markers of pheochromocytoma produced by catechol-O-methyltransferase within tumors.
Neoplasms
Polymorphisms related to estrogen and xenobiotic metabolism in healthy Turkish women.
Neoplasms
Progesterone regulates catechol-O-methyl transferase gene expression in breast cancer cells: distinct effect of progesterone receptor isoforms.
Neoplasms
Progression of human breast cancers to the metastatic state is linked to genotypes of catechol-O-methyltransferase.
Neoplasms
Prospective replication study implicates the catechol-O-methyltransferase Val(158)Met polymorphism as a biomarker for the response to morphine in patients with cancer.
Neoplasms
Proteomics Identification and Validation of Desmocollin-1 and Catechol-O-Methyltransferase as Proteins Associated with Breast Cancer Cell Migration and Metastasis.
Neoplasms
Quercetin increased bioavailability and decreased methylation of green tea polyphenols in vitro and in vivo.
Neoplasms
Significant association of catechol-O-methyltransferase Val158Met polymorphism with bladder cancer instead of prostate and kidney cancer.
Neoplasms
Soluble and membrane-bound catechol-O-methyltransferase in normal and malignant mammary gland.
Neoplasms
The catechol-O-methyltransferase inhibitor, tolcapone, increases the bioavailability of unmethylated (-)-epigallocatechin-3-gallate in mice.
Neoplasms
The impact of Catechol-O-methyl transferase knockdown on the cell proliferation of hormone-responsive cancers.
Neoplasms
The impact of the catechol-O-methyltransferase Val158Met polymorphism on survival in the general population--the HUNT study.
Neoplasms
The role of inherited TPMT and COMT genetic variation in cisplatin-induced ototoxicity in children with cancer.
Neoplasms
The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients.
Neoplasms
Three-dimensional lung tumor segmentation from x-ray computed tomography using sparse field active models.
Neoplasms
Time-on-Task Effect During Sleep Deprivation in Healthy Young Adults Is Modulated by Dopamine Transporter Genotype.
Neoplasms
Uptake and metabolism of olive oil polyphenols in human breast cancer cells using nano-liquid chromatography coupled to electrospray ionization-time of flight-mass spectrometry.
Neoplasms
[Analysis of polymorphisms in genes of insulin receptor substrate-1 and enzymes involved in estrogen biosynthesis and metabolism among breast cancer patients with BRCA1 mutations]
Neoplasms
[Prognostic significance of assay of sex hormones, their receptors and enzymes involved in estrogen synthesis and metabolism in endometrial carcinoma]
Nervous System Diseases
Cathecol-O-methyl transferase Val158Met genotype is not a risk factor for conversion disorder.
Nervous System Diseases
Genetic modeling of estrogen metabolism as a risk factor of hormone-dependent disorders.
Nervous System Diseases
Genetic modelling of the estrogen metabolism as a risk factor of hormone-dependent disorders.
Nervous System Diseases
Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles.
Nervous System Diseases
Inhibitors of Catechol-O-Methyl Transferase in the Treatment of Neurological Disorders.
Nervous System Diseases
Liver says no: the ongoing search for safe catechol O-methyltransferase inhibitors to replace tolcapone.
Neural Tube Defects
Variants in maternal COMT and MTHFR genes and risk of neural tube defects in offspring.
Neuralgia
Catechol-O-methyltransferase polymorphism Val158Met is associated with distal neuropathic pain in HIV-associated sensory neuropathy.
Neuroblastoma
Concerted action of the cytosolic sulfotransferase, SULT1A3, and catechol-O-methyltransferase in the metabolism of dopamine in SK-N-MC human neuroblastoma cells.
Neuroblastoma
Differences in toxicity of the catechol-O-methyl transferase inhibitors, tolcapone and entacapone to cultured human neuroblastoma cells.
Neuroblastoma
Prostaglandin J2 reduces catechol-O-methyltransferase activity and enhances dopamine toxicity in neuronal cells.
Neuroblastoma
The catechol estrogen, 2-hydroxyestradiol, inhibits catechol-O-methyltransferase activity in neuroblastoma cells.
Neuroblastoma
Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells.
Neurodegenerative Diseases
Development of fed-batch profiles for efficient biosynthesis of catechol-O-methyltransferase.
Neuroinflammatory Diseases
Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis.
Obesity
Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men.
Obesity
Effect of the catechol-O-methyltransferase Val 158 Met polymorphism on theory of mind in obesity.
Obesity
Genetic variation in catechol-O-methyltransferase (COMT) and obesity in the prostate, lung, colorectal, and ovarian (PLCO) cancer screening trial.
Obesity
Mice exposed to maternal androgen excess and diet-induced obesity have altered phosphorylation of catechol-O-methyltransferase in the placenta and fetal liver.
Obesity, Abdominal
Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men.
Obesity, Maternal
Mice exposed to maternal androgen excess and diet-induced obesity have altered phosphorylation of catechol-O-methyltransferase in the placenta and fetal liver.
Obstetric Labor, Premature
Catechol-O-methyltransferase activity in red blood cells in threatened preterm labor; effect of indomethacin and nylidrin.
Osteoarthritis
Association Between Genetic Polymorphisms and Pain Sensitivity in Patients with Hip Osteoarthritis.
Ototoxicity
Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts.
Ototoxicity
TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity.
Ovarian Neoplasms
Catechol-O-methyltransferase polymorphism is not associated with ovarian cancer risk.
Ovarian Neoplasms
Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer.
Ovarian Neoplasms
Estradiol 17? and Its Metabolites Stimulate Cell Proliferation and Antagonize Ascorbic Acid-Suppressed Cell Proliferation in Human Ovarian Cancer Cells.
Ovarian Neoplasms
Investigation of Catechol-O-methyltransferase (COMT) gene Val158Met polymorphism in ovarian cancer
Ovarian Neoplasms
Lack of association between the COMT rs4680 polymorphism and ovarian cancer risk: evidence from a meta-analysis of 3,940 individuals.
Ovarian Neoplasms
Lack of associations of the COMT Val158Met polymorphism with risk of endometrial and ovarian cancer: a pooled analysis of case-control studies.
Ovarian Neoplasms
Microarray analysis of differentially expressed genes associated with human ovarian cancer.
Ovarian Neoplasms
The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity.
Overweight
Green Tea Extract and Catechol-O-Methyltransferase Genotype Modify Fasting Serum Insulin and Plasma Adiponectin Concentrations in a Randomized Controlled Trial of Overweight and Obese Postmenopausal Women.
Overweight
Green tea extract and catechol-O-methyltransferase genotype modify the post-prandial serum insulin response in a randomised trial of overweight and obese post-menopausal women.
Pancreatic Neoplasms
Catechol-O-Methyltransferase (COMT), a New Target for Pancreatic Cancer Therapy.
Pancreatitis, Chronic
Catechol-O-methyltransferase (COMT) gene variants and pain in chronic pancreatitis.
Parkinson Disease
(-)-Deprenyl treatment of patients with Parkinson's disease does not affect erythrocyte catechol-O-methyl transferase activity.
Parkinson Disease
A comparison of dopamine agonists and catechol-O-methyltransferase inhibitors in Parkinson's disease.
Parkinson Disease
A double-blind pharmacokinetic and clinical dose-response study of entacapone as an adjuvant to levodopa therapy in advanced Parkinson's disease.
Parkinson Disease
A Double-Blind, Randomized, Placebo and Active-Controlled Study of Nebicapone for the Treatment of Motor Fluctuations in Parkinson's Disease.
Parkinson Disease
A systematic review of catechol-o-methyltransferase inhibitors: efficacy and safety in clinical practice.
Parkinson Disease
A within-subject comparison of 6-[18F]fluoro-m-tyrosine and 6-[18F]fluoro-L-dopa in Parkinson's disease.
Parkinson Disease
An artificial neural network for membrane-bound catechol-O-methyltransferase biosynthesis with Pichia pastoris methanol-induced cultures.
Parkinson Disease
An HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite in human plasma.
Parkinson Disease
Antiparkinsonian Agents : Clinically Significant Drug Interactions and Adverse Effects, and Their Management.
Parkinson Disease
Apolipoprotein E (APOE), PARKIN and catechol-O-methyltransferase (COMT) genes and susceptibility to sporadic Parkinson's disease in Finland.
Parkinson Disease
Apolipoprotein E epsilon4 and catechol-O-methyltransferase alleles in autopsy-proven Parkinson's disease: relationship to dementia and hallucinations.
Parkinson Disease
Association Between Catechol-O-Methyltransferase (COMT) Gene Polymorphisms, Parkinson's Disease, and Levodopa Efficacy.
Parkinson Disease
Association between catechol-O-methyltransferase gene polymorphisms and wearing-off and dyskinesia in Parkinson's disease.
Parkinson Disease
Association of Catechol-O-Methyltransferase and monoamine oxidase B gene polymorphisms with motor complications in parkinson's disease in a Chinese population.
Parkinson Disease
Association of catechol-o-methyltransferase polymorphism (Val108/158Met) with Parkinson's disease: a meta-analysis.
Parkinson Disease
Association of COMT rs4680 and MAO-B rs1799836 polymorphisms with levodopa-induced dyskinesia in Parkinson's disease-a meta-analysis.
Parkinson Disease
Association of COMT Val158Met polymorphism with wearing-off susceptibility in Parkinson's disease.
Parkinson Disease
Association of daytime sleepiness with COMT polymorphism in patients with parkinson disease: a pilot study.
Parkinson Disease
Association of monoamine oxidase B and catechol-O-methyltransferase polymorphisms with sporadic Parkinson's disease in an Iranian population.
Parkinson Disease
Association of UDP-glucuronosyltransferase 1A9 polymorphisms with adverse reactions to catechol-O-methyltransferase inhibitors in Parkinson's disease patients.
Parkinson Disease
Beneficial effects of co-administration of catechol-O-methyltransferase inhibitors and L-dihydroxyphenylalanine in rat models of depression.
Parkinson Disease
Benserazide and carbidopa as substrates of catechol-O-methyltransferase: new mechanism of action in Parkinson's disease.
Parkinson Disease
Bimodal administration of entacapone in Parkinson's disease patients improves motor control.
Parkinson Disease
Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity.
Parkinson Disease
Bisubstrate Inhibitors of Catechol O-Methyltransferase (COMT): the Crucial Role of the Ribose Structural Unit for Inhibitor Binding Affinity.
Parkinson Disease
Boosting Drug Discovery for Parkinson's: Enhancement of the Delivery of a Monoamine Oxidase-B Inhibitor by Brain-Targeted PEGylated Polycaprolactone-Based Nanoparticles.
Parkinson Disease
Capture Compound Mass Spectrometry (CCMS) Sheds Light on the Molecular Mechanisms of Liver Toxicity of two Parkinson Drugs.
Parkinson Disease
Case-control study of dopamine transporter-1, monoamine oxidase-B, and catechol-O-methyl transferase polymorphisms in Parkinson's disease.
Parkinson Disease
Catechol O-methyltransferase inhibition and the treatment of Parkinson's disease.
Parkinson Disease
Catechol O-methyltransferase Val158Met genotype influences frontoparietal activity during planning in patients with Parkinson's disease.
Parkinson Disease
Catechol-O-methyl transferase (COMT) inhibitors in patients with Parkinson's disease: is COMT genotype a useful indicator of clinical efficacy?
Parkinson Disease
Catechol-O-methyltransferase (COMT) genetic variants are associated with cognitive decline in patients with Parkinson's disease.
Parkinson Disease
Catechol-O-methyltransferase activity: a determinant of levodopa response.
Parkinson Disease
Catechol-O-methyltransferase and monoamine oxidase B genes and susceptibility to sporadic Parkinson's disease in a Polish population.
Parkinson Disease
Catechol-O-methyltransferase genotype and susceptibility to Parkinson's disease in Japan. Short communication.
Parkinson Disease
Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons.
Parkinson Disease
Catechol-O-methyltransferase inhibition improves levodopa-associated strength increase in patients with Parkinson disease.
Parkinson Disease
Catechol-O-methyltransferase inhibitors for levodopa-induced complications in Parkinson's disease.
Parkinson Disease
Catechol-O-methyltransferase inhibitors for treatment of Parkinson's disease.
Parkinson Disease
Catechol-O-methyltransferase inhibitors in Parkinson's disease.
Parkinson Disease
Catechol-O-methyltransferase inhibitors in the management of Parkinson's disease.
Parkinson Disease
Catechol-O-methyltransferase inhibitors versus active comparators for levodopa-induced complications in Parkinson's disease.
Parkinson Disease
Catechol-O-methyltransferase inhibitors: new options for Parkinson's disease.
Parkinson Disease
Catechol-O-methyltransferase val158met and cognitive function in Parkinson's disease.
Parkinson Disease
Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease.
Parkinson Disease
Catechol-O-methyltransferase Val158Met polymorphism influences prefrontal executive function in early Parkinson's disease.
Parkinson Disease
Catechol-O-methyltransferase Val158Met polymorphism: modulation of wearing-off susceptibility in a Chinese cohort of Parkinson's disease.
Parkinson Disease
Chemical synthesis and characterization of conjugates of a novel catechol-O-methyltransferase inhibitor.
Parkinson Disease
Chronopharmacology of nebicapone, a new catechol-O-methyltransferase inhibitor.
Parkinson Disease
Clinical pharmacology review of opicapone for the treatment of Parkinson's disease.
Parkinson Disease
CNS dopamine oxidation and catechol-O-methyltransferase: importance in the etiology, pharmacotherapy, and dietary prevention of Parkinson's disease.
Parkinson Disease
Comparison of endothelial progenitor cells in Parkinson's disease patients treated with levodopa and levodopa/COMT inhibitor.
Parkinson Disease
Computation of the binding affinities of catechol-O-methyltransferase inhibitors: Multisubstate relative free energy calculations.
Parkinson Disease
COMT gene and risk for Parkinson's disease: a systematic review and meta-analysis.
Parkinson Disease
COMT inhibition with tolcapone does not affect carbidopa pharmacokinetics in parkinsonian patients in levodopa/carbidopa (Sinemet).
Parkinson Disease
COMT Val158Met polymorphism and Parkinson's disease risk: a pooled analysis in different populations.
Parkinson Disease
COMT-inhibition increases serum levels of dihydroxyphenylacetic acid (DOPAC) in patients with advanced Parkinson's disease.
Parkinson Disease
Correction to: Remarkable clinical responses of non-fluctuating Parkinson's disease (PD) after alternating catechol O-methyltransferase inhibitors: case series switching from entacapone 200 ~ 300 mg/day to opicapone 25 mg/day.
Parkinson Disease
Cost-effectiveness of opicapone and entacapone in reducing OFF-time in Parkinson's disease patients treated with levodopa/carbidopa.
Parkinson Disease
Crystal Structure of Catechol O-Methyltransferase Complexed with Nitecapone.
Parkinson Disease
Crystallization and preliminary X-ray diffraction studies of a catechol-O-methyltransferase/inhibitor complex.
Parkinson Disease
Current and experimental treatments of Parkinson disease: A guide for neuroscientists.
Parkinson Disease
Daytime sleepiness and the COMT val158met polymorphism in patients with Parkinson disease.
Parkinson Disease
Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson's disease.
Parkinson Disease
Detection of response to COMT inhibition in FDOPA PET in advanced Parkinson's disease requires prolonged imaging.
Parkinson Disease
Development of a gas chromatographic/mass spectrometric method to quantify R(-)-apomorphine, R(-)-apocodeine and R(-)-norapomorphine in human plasma and urine.
Parkinson Disease
Development of a liquid chromatography assay for the determination of opicapone and BIA 9-1079 in rat matrices.
Parkinson Disease
Development of a physiologically based pharmacokinetic/pharmacodynamic model to identify mechanisms contributing to entacapone low bioavailability.
Parkinson Disease
Development of fed-batch profiles for efficient biosynthesis of catechol-O-methyltransferase.
Parkinson Disease
Differences in toxicity of the catechol-O-methyl transferase inhibitors, tolcapone and entacapone to cultured human neuroblastoma cells.
Parkinson Disease
Different modes of action of catecholamine-O-methyltransferase inhibitors entacapone and tolcapone on adenylyl cyclase activity in vitro.
Parkinson Disease
Double-blind, placebo-controlled study of entacapone in levodopa-treated patients with stable Parkinson disease.
Parkinson Disease
Effect of 3 Single-Dose Regimens of Opicapone on Levodopa Pharmacokinetics, Catechol-O-Methyltransferase Activity and Motor Response in Patients With Parkinson Disease.
Parkinson Disease
Effect of catechol-O-methyltransferase inhibition on brain uptake of [18F]fluorodopa: implications for compartmental modelling and clinical usefulness.
Parkinson Disease
Effect of entacapone on colon motility and ion transport in a rat model of Parkinson's disease.
Parkinson Disease
Effect of entacapone, a COMT inhibitor, on clinical disability and levodopa metabolism in parkinsonian patients.
Parkinson Disease
Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with levodopa in patients with Parkinson's disease.
Parkinson Disease
Effect of moderate liver impairment on the pharmacokinetics of opicapone.
Parkinson Disease
Effect of opicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity and motor fluctuations in patients with Parkinson's disease.
Parkinson Disease
Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells.
Parkinson Disease
Effect of tolcapone on plasma and striatal apomorphine disposition in rats.
Parkinson Disease
Effect of tolcapone on plasma levodopa concentrations after coadministration with levodopa/carbidopa to healthy volunteers.
Parkinson Disease
Effects of 3-O-Methyldopa, L-3,4-Dihydroxyphenylalanine Metabolite, on Locomotor Activity and Dopamine Turnover in Rats.
Parkinson Disease
Effects of Active-Site Modification and Quaternary Structure on the Regioselectivity of Catechol-O-Methyltransferase.
Parkinson Disease
Effects of nebicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity, and motor fluctuations in patients with Parkinson disease.
Parkinson Disease
Effects of the catechol-O-methyltransferase inhibitor tolcapone in Parkinson's disease: correlations between concentrations of dopaminergic substances in the plasma and cerebrospinal fluid and clinical improvement.
Parkinson Disease
Effects of tolcapone in Parkinson's patients taking L-dihydroxyphenylalanine/carbidopa and selegiline.
Parkinson Disease
Effects of tolcapone on working memory and brain activity in abstinent smokers: A proof-of-concept study.
Parkinson Disease
Effects of tolcapone, a catechol-O-methyltransferase inhibitor, and Sinemet on intestinal electrolyte and fluid transport in conscious dogs.
Parkinson Disease
Effects of tolcapone, a catechol-O-methyltransferase inhibitor, on motor symptoms and pharmacokinetics of levodopa in patients with Parkinson's disease.
Parkinson Disease
Efficacy and safety of entacapone in Parkinson's disease patients with suboptimal levodopa response: a 6-month randomized placebo-controlled double-blind study in Germany and Austria (Celomen study).
Parkinson Disease
Elevated plasma homocysteine levels in patients treated with levodopa: association with vascular disease.
Parkinson Disease
Elucidating Differences in the Hepatotoxic Potential of Tolcapone and Entacapone With DILIsym(®), a Mechanistic Model of Drug-Induced Liver Injury.
Parkinson Disease
Endothelial dysfunction and hyperhomocysteinemia in Parkinson's disease: flow-mediated dilation study.
Parkinson Disease
Entacapone detection by a GOQDs-molecularly imprinted silica fluorescent chemical nanosensor.
Parkinson Disease
Entacapone in combination with standard or controlled-release levodopa/carbidopa: a clinical and pharmacokinetic study in patients with Parkinson's disease.
Parkinson Disease
Entacapone increases levodopa exposure and reduces plasma levodopa variability when used with Sinemet CR.
Parkinson Disease
Entacapone is beneficial in both fluctuating and non-fluctuating patients with Parkinson's disease: a randomised, placebo controlled, double blind, six month study.
Parkinson Disease
Entacapone Treatment Modulates Hippocampal Proteins Related to Synaptic Vehicle Trafficking.
Parkinson Disease
Entacapone, a catechol-O-methyltransferase inhibitor for treating Parkinson's disease: review and current status.
Parkinson Disease
Entacapone, a catechol-O-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson's disease induced by Japanese encephalitis virus.
Parkinson Disease
Entacapone, a novel catechol-O-methyltransferase inhibitor for Parkinson's disease, does not impair mitochondrial energy production.
Parkinson Disease
Entacapone: a catechol-O-methyltransferase inhibitor for the adjunctive treatment of Parkinson's disease.
Parkinson Disease
Erythrocytes catechol-o-methyl transferase activity is up-regulated after a 3-month treatment by entacapone in parkinsonian patients.
Parkinson Disease
Evaluation of opicapone on cardiac repolarization in a thorough QT/QTc study.
Parkinson Disease
Evidence-based efficacy comparison of tolcapone and entacapone as adjunctive therapy in Parkinson's disease.
Parkinson Disease
Expression of catechol-O-methyltransferase in the brain and periphery of normal and MPTP-treated common marmosets.
Parkinson Disease
Favorable effect of catechol-O-methyltransferase inhibition by OR-462 in experimental models of Parkinson's disease.
Parkinson Disease
Fewer fluctuations, higher maximum concentration and better motor response of levodopa with catechol-O-methyltransferase inhibition.
Parkinson Disease
G/A1947 polymorphism in catechol-O-methyltransferase (COMT) gene in Parkinson's disease.
Parkinson Disease
Gene polymorphisms and motor levodopa-induced complications in Parkinson's disease.
Parkinson Disease
Genetic modeling of estrogen metabolism as a risk factor of hormone-dependent disorders.
Parkinson Disease
Genetic modelling of the estrogen metabolism as a risk factor of hormone-dependent disorders.
Parkinson Disease
Genetic polymorphism of catechol-O-methyltransferase and levodopa pharmacokinetic-pharmacodynamic pattern in patients with Parkinson's disease.
Parkinson Disease
Genetic variations in catechol-O-methyltransferase gene are associated with levodopa response variability in Chinese patients with Parkinson's disease.
Parkinson Disease
Genotypes of catechol-O-methyltransferase and response to levodopa treatment in patients with Parkinson's disease.
Parkinson Disease
Heart rate variability in Parkinson's disease patients treated with tolcapone.
Parkinson Disease
Hepatotoxic profile of catechol-O-methyltransferase inhibitors in Parkinson's disease.
Parkinson Disease
High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson's disease.
Parkinson Disease
Identification of metabolite profiles of the catechol-O-methyl transferase inhibitor tolcapone in rat urine using LC/MS-based metabonomics analysis.
Parkinson Disease
Identification of Potential Off-target Toxicity Liabilities of Catechol-O-methyltransferase Inhibitors by Differential Competition Capture Compound Mass Spectrometry.
Parkinson Disease
Impact of Gastric Emptying on Levodopa Pharmacokinetics in Parkinson Disease Patients.
Parkinson Disease
In silico discovery and evaluation of phytochemicals binding mechanism against human catechol-O-methyltransferase as a putative bioenhancer of L-DOPA therapy in Parkinson disease.
Parkinson Disease
In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity.
Parkinson Disease
Increased catechol-O-methyltransferase activity and protein expression in OX-42-positive cells in the substantia nigra after lipopolysaccharide microinfusion.
Parkinson Disease
Influence of Single Nucleotide Polymorphisms in COMT , MAO-A and BDNF Genes on Dyskinesias and Levodopa Use in Parkinson's Disease.
Parkinson Disease
Inhibition of catechol-o-methyltransferase (COMT) by myricetin, dihydromyricetin, and myricitrin.
Parkinson Disease
Inhibition of catechol-O-methyltransferase contributes to more stable levodopa plasma levels.
Parkinson Disease
Inhibition of catechol-O-methyltransferase modifies acute homocysteine rise during repeated levodopa application in patients with Parkinson's disease.
Parkinson Disease
Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson's Disease.
Parkinson Disease
Interventions to achieve tonic exposure to levodopa: delaying or preventing the onset of motor complications
Parkinson Disease
Introductory remarks: Catechol-O-methyltransferase inhibition--an innovative approach to enhance L-dopa therapy in Parkinson's disease with dual enzyme inhibition.
Parkinson Disease
Levodopa + carbidopa + entacapone. Entacapone: a second look: new preparations. Parkinson's disease: a modest effect.
Parkinson Disease
Levodopa therapy with entacapone in daily clinical practice: results of a post-marketing surveillance study.
Parkinson Disease
Levodopa-related cysteinyl-glycine and cysteine reduction with and without catechol-O-methyltransferase inhibition in Parkinson's disease patients.
Parkinson Disease
Liver says no: the ongoing search for safe catechol O-methyltransferase inhibitors to replace tolcapone.
Parkinson Disease
Long-term efficacy of opicapone in fluctuating Parkinson's disease patients: A pooled-analysis of data from two Phase 3 clinical trials and their open-label extensions.
Parkinson Disease
Management for motor and non-motor complications in late Parkinson's disease.
Parkinson Disease
Medical management of levodopa-associated motor complications in patients with Parkinson's disease.
Parkinson Disease
Membrane bound COMT isoform is an interfacial enzyme: general mechanism and new drug design paradigm.
Parkinson Disease
Meta-analysis of polymorphism of the catechol-O-methyltransferase gene in relation to the etiology of Parkinson's disease in Japan.
Parkinson Disease
Meta-Analysis of the Effects of the Catechol-O-Methyltransferase Val158/108Met Polymorphism on Parkinson's Disease Susceptibility and Cognitive Dysfunction.
Parkinson Disease
Micellar electrokinetic capillary chromatography method for direct determination of glucuronides of entacapone and its (Z)-isomer in human urine.
Parkinson Disease
Molecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitors.
Parkinson Disease
Monoamine oxidase B rs1799836 G allele polymorphism is a risk factor for early development of levodopa-induced dyskinesia in Parkinson's disease.
Parkinson Disease
More than an "inverted-U"? An exploratory study of the association between the catechol-o-methyltransferase gene polymorphism and executive functions in Parkinson's disease.
Parkinson Disease
New, selective catechol-O-methyltransferase inhibitors as therapeutic agents in Parkinson's disease.
Parkinson Disease
Nitrocatechol Derivatives of Chalcone as Inhibitors of Monoamine Oxidase and Catechol-O-Methyltransferase.
Parkinson Disease
No association between Parkinson's disease and low-activity alleles of catechol O-methyltransferase.
Parkinson Disease
No change of brain extracellular catecholamine levels after acute catechol-O-methyltransferase inhibition: a microdialysis study in anaesthetized rats.
Parkinson Disease
No significance of the COMT val158met polymorphism in restless legs syndrome.
Parkinson Disease
Noninvasive options for 'wearing-off' in Parkinson's disease: a clinical consensus from a panel of UK Parkinson's disease specialists.
Parkinson Disease
Open study of the catechol-O-methyltransferase inhibitor tolcapone in major depressive disorder.
Parkinson Disease
Opicapone (Ongentys): A New COMT Inhibitor for the Treatment of Parkinson's Disease.
Parkinson Disease
Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor Fluctuations: A Randomized Clinical Trial.
Parkinson Disease
Opicapone enhances the reversal of MPTP-induced Parkinson-like syndrome by levodopa in cynomolgus monkeys.
Parkinson Disease
Opicapone for the treatment of Parkinson's disease: A review of a new licensed medicine.
Parkinson Disease
Parkinson's Disease and Its Management: Part 3: Nondopaminergic and Nonpharmacological Treatment Options.
Parkinson Disease
Peripheral and central inhibitors of catechol-O-methyl transferase: effects on liver and brain COMT activity and L-DOPA metabolism.
Parkinson Disease
Perspectives in the treatment of Parkinson's disease: COMT inhibitors open up new treatment strategies.
Parkinson Disease
Pharmacokinetic characteristics of agents applied in the treatment of Parkinson's disease.
Parkinson Disease
Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/benserazide.
Parkinson Disease
Pharmacokinetics of Opicapone and Its Metabolites in Healthy White and Chinese Subjects.
Parkinson Disease
Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration: A comparative study in the rat.
Parkinson Disease
Pharmacokinetics of oral entacapone after frequent multiple dosing and effects on levodopa disposition.
Parkinson Disease
Pharmacokinetics, pharmacodynamics, and tolerability of tolcapone: a review of early studies in volunteers.
Parkinson Disease
Pharmacologic treatment of advanced Parkinson's disease: A meta-analysis of COMT inhibitors and MAO-B inhibitors.
Parkinson Disease
Pharmacological profile of opicapone, a third-generation nitrocatechol catechol-O-methyl transferase inhibitor, in the rat.
Parkinson Disease
Prospecting for new catechol-O-methyltransferase (COMT) inhibitors as a potential treatment for Parkinson's disease: a study by molecular dynamics and structure-based virtual screening.
Parkinson Disease
Quality of life in Parkinson's disease patients following adjunctive tolcapone therapy: results of an open-label, multicenter, community-based trial.
Parkinson Disease
Recovery of biological active catechol-O-methyltransferase isoforms from Q-sepharose.
Parkinson Disease
Reduction of circulating 3-O-methyldopa by inhibition of catechol-O-methyltransferase with OR-611 and OR-462 in cynomolgus monkeys: implications for the treatment of Parkinson's disease.
Parkinson Disease
Remarkable clinical responses of non-fluctuating Parkinson's disease (PD) after alternating catechol O-methyltransferase inhibitors: case series switching from entacapone 200?~?300 mg/day to opicapone 25 mg/day.
Parkinson Disease
Role of catechol-O-methyltransferase (COMT)-dependent processes in Parkinson's disease and L-DOPA treatment.
Parkinson Disease
Roles of functional catechol-O-methyltransferase genotypes in Chinese patients with Parkinson's disease.
Parkinson Disease
Safety and efficacy of tolcapone in Parkinson's disease: systematic review.
Parkinson Disease
Safety of entacapone and apomorphine coadministration in levodopa-treated Parkinson's disease patients: pharmacokinetic and pharmacodynamic results of a multicenter, double-blind, placebo-controlled, cross-over study.
Parkinson Disease
Separation of the glucuronides of entacapone and its (Z)-isomer in urine by micellar electrokinetic capillary chromatography.
Parkinson Disease
Simultaneous MAO-B and COMT inhibition in L-Dopa-treated patients with Parkinson's disease.
Parkinson Disease
Structure-based drug design: exploring the proper filling of apolar pockets at enzyme active sites.
Parkinson Disease
Synthesis and in-vitro/in-vivo evaluation of orally administered entacapone prodrugs.
Parkinson Disease
The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications.
Parkinson Disease
The catechol-O-methyltransferase (COMT) inhibitor entacapone enhances the pharmacokinetic and clinical response to Sinemet CR in Parkinson's disease.
Parkinson Disease
The catechol-O-methyltransferase and monoamine oxidase B polymorphisms and levodopa therapy in the Iranian patients with sporadic Parkinson's disease.
Parkinson Disease
The catechol-O-methyltransferase Val158Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson's disease: a PET study.
Parkinson Disease
The COMT Val158Met polymorphism as an associated risk factor for Parkinson's disease in Asian rather than Caucasian populations.
Parkinson Disease
The controversy concerning plasma homocysteine in Parkinson disease patients treated with levodopa alone or with entacapone: effects of vitamin status.
Parkinson Disease
The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort.
Parkinson Disease
The effect of catechol-O-methyltransferase inhibition with entacapone on cardiovascular autonomic responses in L-Dopa-treated patients with Parkinson's disease.
Parkinson Disease
The effect of entacapone on levodopa rate of absorption and latency to motor response in patients with Parkinson disease.
Parkinson Disease
The effect of monoamine oxidase B (MAOB) and catechol-O-methyltransferase (COMT) polymorphisms on levodopa therapy in patients with sporadic Parkinson's disease.
Parkinson Disease
The influence of levodopa and the COMT inhibitor on serum vitamin B12 and folate levels in Parkinson's disease patients.
Parkinson Disease
The inhibition of catechol O-methyltransferase and monoamine oxidase by tetralone and indanone derivatives substituted with the nitrocatechol moiety.
Parkinson Disease
The preclinical discovery and development of opicapone for the treatment of Parkinson's disease.
Parkinson Disease
The relationship between COMT genotype and the clinical effectiveness of tolcapone, a COMT inhibitor, in patients with Parkinson's disease.
Parkinson Disease
The relevance of preclinical studies for the treatment of Parkinson's disease.
Parkinson Disease
The val(158)met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease.
Parkinson Disease
Tolcapone addition improves Parkinson's disease associated nonmotor symptoms.
Parkinson Disease
Tolcapone, a selective catechol-O-methyltransferase inhibitor for treatment of Parkinson's disease.
Parkinson Disease
Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism.
Parkinson Disease
Val158Met polymorphism of COMT gene and Parkinson's disease risk in Asians.
Parkinson Disease
[A comparative study of efficacy of dopamine receptors agonists and catechol-O-methyltransferase in the treatment of late stages of Parkinson's disease]
Parkinson Disease
[Entacapone++ : a new catechol-O-methyltransferase inhibitor which improves the response to levodopa in patients with Parkinson disease and fluctuating motor function]
Parkinson Disease
[Polymorphisms of catechol-O-methyltransferase and monoamine oxidase B genes among Chinese patients with Parkinson's disease].
Parkinson Disease
[Recent progress in development of psychotropic drugs (3)--Antiparkinsonian agents applied in the treatment of Parkinson's disease or are under investigation for patients or model animals]
Parkinson Disease
[Role of gene polymorphism of catechol-O-methyltransferase (COMT), monoamine oxidase B (MAOB), cytochrome P450 2D6 (CYP2D6) and N-acetyltransferase 2 (NAT2) in pathogenesis of Parkinson's disease]
Parkinsonian Disorders
Clinical, pharmacokinetic, and pharmacodynamic effects of tolcapone withdrawal in levodopa-treated patients with parkinsonism.
Parkinsonian Disorders
Fracture risk associated with parkinsonism and anti-Parkinson drugs.
Parkinsonian Disorders
Naloxone-responsive acute dystonia and parkinsonism following general anaesthesia.
Parkinsonian Disorders
Tolcapone in stable Parkinson's disease: efficacy and safety of long-term treatment. The Tolcapone Stable Study Group.
Parkinsonian Disorders
Tolcapone in stable Parkinson's disease: efficacy and safety of long-term treatment. Tolcapone Stable Study Group.
Pharyngeal Neoplasms
Genetic and Proteinic Linkage of MAO and COMT with Oral Potentially Malignant Disorders and Cancers of the Oral Cavity and Pharynx.
Pheochromocytoma
Metabolism and storage of catecholamines in rats with pheochromocytoma implants.
Pheochromocytoma
Monoamine oxidase a down-regulation contributes to high metanephrine concentration in pheochromocytoma.
Pheochromocytoma
Plasma metanephrines are markers of pheochromocytoma produced by catechol-O-methyltransferase within tumors.
Polycystic Ovary Syndrome
Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome.
Polycystic Ovary Syndrome
Regulation of catechol O-methyltransferase expression in granulosa cells: a potential role for follicular arrest in polycystic ovary syndrome.
Polyneuropathies
Impact of serotonin transporter and catechol-O-methyl transferase genes polymorphism on gastrointestinal dysfunction in Swedish and Japanese familial amyloidotic polyneuropathy patients.
Pre-Eclampsia
2-Methoxyoestradiol levels and placental catechol-O-methyltransferase expression in patients with late-onset preeclampsia.
Pre-Eclampsia
A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2).
Pre-Eclampsia
Association between COMT Val158Met polymorphism and preeclampsia in the Chinese Han population.
Pre-Eclampsia
Association between Val158Met functional polymorphism in the COMT gene and risk of preeclampsia in a Chinese population.
Pre-Eclampsia
Catechol-O-Methyltransferase Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II.
Pre-Eclampsia
Catechol-O-methyltransferase Gene Polymorphism (Val158Met) and Development of Pre-eclampsia.
Pre-Eclampsia
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia.
Pre-Eclampsia
Dopamine in the Pathophysiology of Preeclampsia and Gestational Hypertension: Monoamine Oxidase (MAO) and Catechol-O-methyl Transferase (COMT) as Possible Mechanisms.
Pre-Eclampsia
Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.
Pre-Eclampsia
Fetal Val108/158Met catechol-O-methyltransferase (COMT) polymorphism and placental COMT activity are associated with the development of preeclampsia.
Pre-Eclampsia
Genetic polymorphism of catechol-O-methyltransferase and cytochrome P450c17? in preeclampsia.
Pre-Eclampsia
Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of pre-eclampsia.
Pre-Eclampsia
Low catechol-O-methyltransferase and 2-methoxyestradiol in preeclampsia: more than a unifying hypothesis.
Pre-Eclampsia
Orchestrating the organizers: catechol-o-methyltransferase and endothelial nitric oxide synthase stress in preeclampsia.
Pre-Eclampsia
Promoter hypomethylation of COMT in human placenta is not associated with the development of pre-eclampsia.
Pre-Eclampsia
Protective Role of Maternal P.VAL158MET Catechol-O-Methyltransferase Polymorphism against Early-Onset Preeclampsia and its Complications.
Pre-Eclampsia
Severe early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression.
Pre-Eclampsia
Sildenafil Citrate Rescues Fetal Growth in the Catechol-O-Methyl Transferase Knockout Mouse Model.
Pre-Eclampsia
VAL158MET catechol O-methyltransferase polymorphism contributes to the development of preeclampsia.
Pre-Eclampsia
[Serum unconjugated 2-hydroxyestrone and erythrocyte catechol-O-methyltransferase activity in pregnancy toxemia]
Premature Birth
A Single-Nucleotide Polymorphism in the Fetal Catechol-O-methyltransferase Gene is Associated With Spontaneous Preterm Birth in African Americans.
Premature Birth
Treatment with an inhibitor of catechol-O-methyltransferase activity reduces preterm birth and impedes cervical resistance to stretch in pregnant rats.
Premature Ejaculation
Preliminary Evidence for an Association Between Variants of the Catechol-O-Methyltransferase (COMT) Gene and Premature Ejaculation.
Prolactinoma
Erythrocyte catechol-O-methyltransferase, platelet monoamine oxidase, and platelet phenol sulfotransferase activities in patients with prolactin-secreting pituitary adenomas.
Prostatic Hyperplasia
Association of catechol-o-methyl transferase gene polymorphism with prostate cancer and benign prostatic hyperplasia.
Prostatic Hyperplasia
Catechol-O-methyltransferase gene polymorphisms in benign prostatic hyperplasia and sporadic prostate cancer.
Prostatic Neoplasms
Association of catechol-o-methyl transferase gene polymorphism with prostate cancer and benign prostatic hyperplasia.
Prostatic Neoplasms
Catechol-O-methyltransferase gene polymorphisms in benign prostatic hyperplasia and sporadic prostate cancer.
Prostatic Neoplasms
Entacapone and Prostate Cancer Risk in Patients With Parkinson's Disease.
Prostatic Neoplasms
Green tea polyphenols and metabolites in prostatectomy tissue: implications for cancer prevention.
Prostatic Neoplasms
Lack of Association between COMT Val158Met Polymorphism and Prostate Cancer Susceptibility.
Prostatic Neoplasms
No association between COMT Val158Met polymorphism and prostate cancer risk: a meta-analysis.
Prostatic Neoplasms
Quercetin increased the antiproliferative activity of green tea polyphenol (-)-epigallocatechin gallate in prostate cancer cells.
Prostatic Neoplasms
The l58Val/Met polymorphism of catechol-O-methyl transferase gene and prostate cancer risk: a meta-analysis.
Prostatic Neoplasms
The Val158Met polymorphism of the catechol-O-methyltransferase gene is associated with the PSA-progression-free survival in prostate cancer patients treated with estramustine phosphate.
Prostatic Neoplasms
The Val158Met polymorphism of the catechol-O-methyltransferase gene is not associated with the risk of sporadic or latent prostate cancer in Japanese men.
Proteinuria
Severe early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression.
Psoriasis
Catechol-O-methyltransferase activity in psoriasis patients treated with psoralen plus ultraviolet A therapy.
Psoriasis
Catechol-O-methyltransferase activity is higher in psoriasis patients and is down-regulated by narrowband ultraviolet B treatment.
Psoriasis
Polymorphism of the catechol-O-methyltransferase gene in Han Chinese patients with psoriasis vulgaris.
Rectal Neoplasms
Cytochrome P450 17A1 and catechol O-methyltransferase polymorphisms and age at Lynch syndrome colon cancer onset in Newfoundland.
Renal Insufficiency
Red blood cell catechol-o-methyl transferase, plasma catecholamines and renin in renal failure.
Respiratory Insufficiency
Severe and persistent morphine-induced respiratory depression associated with ATP-Binding Cassette Subfamily B Member 1 and catechol-O-methyltransferase genetic defects: A case report.
Seizures
Catechol-O-methyl transferase and monoamine oxidase activities in brains of mice susceptible and resistant to audiogenic seizures.
Seizures
Monoamine metabolites, iron induced seizures, and the anticonvulsant effect of tannins.
Seizures
The time course of brain and blood catecholamines, catechol O-methyltransferase, and amino acids in rats convulsed by oxygen at high pressure.
Shoulder Pain
Biopsychosocial influence on exercise-induced delayed onset muscle soreness at the shoulder: pain catastrophizing and catechol-o-methyltransferase (COMT) diplotype predict pain ratings.
Shoulder Pain
Evidence for a biopsychosocial influence on shoulder pain: pain catastrophizing and catechol-O-methyltransferase (COMT) diplotype predict clinical pain ratings.
Shoulder Pain
Sensory and Psychological Factors Predict Exercise-Induced Shoulder Injury Responses in a High-Risk Phenotype Cohort.
Shwartzman Phenomenon
Sensitization to the generalized Shwartzman reaction by catechol-O-methyltransferase inhibitors.
Sleep Deprivation
Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism.
Sleep Deprivation
Catechol-O-methyltransferase (COMT) genotype affects cognitive control during total sleep deprivation.
Starvation
Effect of starvation and pattern of feeding upon activities of enzymes catechol-O-methyltransferase and monoamine oxidase in heart and liver of developing rats.
Starvation
Influence of progressive starvation upon brain and adrenal monoaminergic activity in developing rats of two different ages.
Stroke
Association between genetic variation in the dopamine system and motor recovery after stroke.
Stroke
Genetic polymorphisms for BDNF, COMT, and APOE do not affect gait or ankle motor control in chronic stroke: A preliminary cross-sectional study.
Tardive Dyskinesia
Negative association between Catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and persistent tardive dyskinesia in schizophrenia.
Tardive Dyskinesia
Tardive dyskinesia is not associated with the polymorphisms of 5-HT2A receptor gene, serotonin transporter gene and catechol-o-methyltransferase gene.
Tardive Dyskinesia
The association between COMT Val158Met gene polymorphism and antipsychotic-induced tardive dyskinesia risk.
Tardive Dyskinesia
Val158Met polymorphism in the catechol-O-methyltransferase (COMT) gene is not associated with tardive dyskinesia in schizophrenia.
Temporomandibular Joint Disorders
Assessing potential functionality of catechol-O-methyltransferase (COMT) polymorphisms associated with pain sensitivity and temporomandibular joint disorders.
Temporomandibular Joint Disorders
Catechol-O-Methyltransferase (COMT) Gene Polymorphisms as Risk Factor in Temporomandibular Disorders Patients From Southern Italy.
Temporomandibular Joint Disorders
Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study.
Temporomandibular Joint Disorders
Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain.
Temporomandibular Joint Disorders
Evaluation of genetic risk related to catechol-O-methyltransferase (COMT) and ?2-adrenergic receptor (ADRB2) activity in different diagnostic subgroups of temporomandibular disorder in Brazilian patients.
Temporomandibular Joint Disorders
Genetic Polymorphisms of Catechol-O-Methyltransferase: Association with Temporomandibular Disorders and Postoperative Pain.
Temporomandibular Joint Disorders
Sustained stimulation of ?2- and ?3-adrenergic receptors leads to persistent functional pain and neuroinflammation.
Temporomandibular Joint Disorders
The association of genetic polymorphisms in serotonin transporter and catechol-O-methyltransferase on temporomandibular disorders and anxiety in adolescents.
Temporomandibular Joint Disorders
The effect of catechol-O-methyltransferase polymorphisms on pain is modified by depressive symptoms.
Tension-Type Headache
Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated with Widespread Pressure Pain Sensitivity and Depression in Women with Chronic, but not Episodic, Tension Type Headache.
Tension-Type Headache
Genetic Contribution of Catechol-O-Methyltransferase Polymorphism (Val158met) in Children with Chronic Tension Type Headache.
Tourette Syndrome
Association of Catechol-O-methyltransferase val/met polymorphism with cognitive function in Gilles de la Tourette syndrome patients.
Tourette Syndrome
Monoamine oxidase and catechol-O-methyltransferase activities in cultured fibroblasts and blood cells from children with autism and the Gilles de la Tourette syndrome.
Tourette Syndrome
No significant association between Catechol-O-methyl transferase (COMT) -287A/G gene polymorphism and Tourette's syndrome in family-based association study in Chinese Han population.
Tourette Syndrome
Retraction Note to: Association of Catechol-O-methyltransferase val/met polymorphism with cognitive function in Gilles de la Tourette syndrome patients.
Tremor
Interactions of COMT and ALDH2 Genetic Polymorphisms on Symptoms of Parkinson's Disease.
Trigeminal Neuralgia
Polymorphisms of Nav1.6 sodium channel, Brain-derived Neurotrophic Factor, Catechol-O-methyltransferase and Guanosine Triphosphate Cyclohydrolase 1 genes in trigeminal neuralgia.
Triple Negative Breast Neoplasms
Proteomics Identification and Validation of Desmocollin-1 and Catechol-O-Methyltransferase as Proteins Associated with Breast Cancer Cell Migration and Metastasis.
Urinary Bladder Neoplasms
Associations differ by sex for catechol-O-methyltransferase genotypes and bladder cancer risk in South Egypt.
Urinary Bladder Neoplasms
Diagnostic potential in bladder cancer of a panel of tumor markers (calreticulin, gamma -synuclein, and catechol-o-methyltransferase) identified by proteomic analysis.
Urinary Bladder Neoplasms
Significant association of catechol-O-methyltransferase Val158Met polymorphism with bladder cancer instead of prostate and kidney cancer.
Urinary Incontinence
A Nationwide Survey of Parkinson's Disease Medicines Availability and Affordability in Nigeria.
Uterine Cervical Neoplasms
Analysis of CYP1A1 and COMT polymorphisms in women with cervical cancer.
Vascular Diseases
Vascular Health and Genetic Risk Affect Mild Cognitive Impairment Status and 4-Year Stability: Evidence From the Victoria Longitudinal Study.
Velopharyngeal Insufficiency
Olfactory deficits and psychosis-spectrum symptoms in 22q11.2 deletion syndrome.
Venous Thrombosis
Catechol-O-methyltransferase genotype is associated with plasma total homocysteine levels and may increase venous thrombosis risk.
Ventricular Fibrillation
A new model of ventricular fibrillation induced by isoprenaline and catechol-O-methyl transferase inhibitor at a high perfusion temperature in isolated rat hearts.
Virus Diseases
Tobacco O-methyltransferases involved in phenylpropanoid metabolism. The different caffeoyl-coenzyme A/5-hydroxyferuloyl-coenzyme A 3/5-O-methyltransferase and caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase classes have distinct substrate specificities and expression patterns.
Vitiligo
A functional single-nucleotide polymorphism in the catechol-O-methyltransferase gene alter vitiligo risk in a Chinese population.
Vitiligo
Analysis of oxidative stress status, catalase and catechol-O-methyltransferase polymorphisms in Egyptian vitiligo patients.
Vulvodynia
Catechol-O-methyltransferase gene polymorphism and vulvar pain in women with vulvodynia.
Wolfram Syndrome
Multicentre Italian family-based association study on tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders.
Xeroderma Pigmentosum
Impact of Occupational Exposures and Genetic Polymorphisms on Recurrence and Progression of Non-Muscle-Invasive Bladder Cancer.
html completed