Information on EC 2.1.1.44 - L-histidine Nalpha-methyltransferase

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The expected taxonomic range for this enzyme is: Neurospora crassa

EC NUMBER
COMMENTARY hide
2.1.1.44
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RECOMMENDED NAME
GeneOntology No.
L-histidine Nalpha-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3 S-adenosyl-L-methionine + L-histidine = 3 S-adenosyl-L-homocysteine + hercynine
show the reaction diagram
overall reaction
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S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + Nalpha-methyl-L-histidine
show the reaction diagram
(1a)
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S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + hercynine
show the reaction diagram
(1c)
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S-adenosyl-L-methionine + Nalpha-methyl-L-histidine = S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine
show the reaction diagram
(1b)
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
ergothioneine biosynthesis I (bacteria)
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ergothioneine biosynthesis II (fungi)
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Histidine metabolism
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NIL
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine Nalpha-methyltransferase
Part of the biosynthetic pathway of ergothioneine.
CAS REGISTRY NUMBER
COMMENTARY hide
62213-53-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + histidine
S-adenosyl-L-homocysteine + Nalpha-methylhistidine
show the reaction diagram
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-
-
-
?
S-adenosyl-L-methionine + methylhistidine
S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine
show the reaction diagram
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-
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-
?
S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine
S-adenosyl-L-homocysteine + Nalpha,Nalpha,Nalpha-trimethyl-L-histidine
show the reaction diagram
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-
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?
S-adenosyl-L-methionine + Nalpha-methylhistidine
S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine
show the reaction diagram
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?
additional information
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conversion of histidine to hercynine is mediated either by one enzyme or by two or three enzymes with chemical and physical properties so similar that common methods of protein fractionation fail to effect any separation
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + histidine
S-adenosyl-L-homocysteine + Nalpha-methylhistidine
show the reaction diagram
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-
-
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?
S-adenosyl-L-methionine + methylhistidine
S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine
show the reaction diagram
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?
S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine
S-adenosyl-L-homocysteine + Nalpha,Nalpha,Nalpha-trimethyl-L-histidine
show the reaction diagram
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?
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
hercynine
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histidine
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inhibits reaction with dimethylhistidine
Imidazolepropionate
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methylhistidine
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inhibits reaction with dimethylhistidine
S-adenosyl-L-homocysteine
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8 - 8.5
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histidine
8.5 - 9
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dimethylhistidine
9 - 9.5
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methylhistidine
PDB
SCOP
CATH
ORGANISM
UNIPROT
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
270000 - 300000
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gel filtration
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Show AA Sequence (952 entries)
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