Information on EC 2.1.1.299 - protein N-terminal monomethyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.1.1.299
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RECOMMENDED NAME
GeneOntology No.
protein N-terminal monomethyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + N-terminal-(A,P,S)PK-[protein] = S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-(A,P,S)PK-[protein]
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:N-terminal-(A,P,S)PK-[protein] monomethyltransferase
This enzyme methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys after the initiator L-methionine is cleaved. In contrast to EC 2.1.1.244, protein N-terminal methyltransferase, the protein only adds one methyl group to the N-terminal.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + N-terminal-Ala-Pro-Lys-[protein]
S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-Ala-Pro-Lys-[protein]
show the reaction diagram
S-adenosyl-L-methionine + N-terminal-Pro-Pro-Lys-[protein]
S-adenosyl-L-homocysteine + N-terminal-N-methyl-Pro-Pro-Lys-[protein]
show the reaction diagram
S-adenosyl-L-methionine + N-terminal-Ser-Pro-Lys-[protein]
S-adenosyl-L-homocysteine + N-terminal-N-methyl-Ser-Pro-Lys-[protein]
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + N-terminal-Ala-Pro-Lys-[protein]
S-adenosyl-L-homocysteine + N-terminal-N-methyl-N-Ala-Pro-Lys-[protein]
show the reaction diagram
S-adenosyl-L-methionine + N-terminal-Pro-Pro-Lys-[protein]
S-adenosyl-L-homocysteine + N-terminal-N-methyl-Pro-Pro-Lys-[protein]
show the reaction diagram
S-adenosyl-L-methionine + N-terminal-Ser-Pro-Lys-[protein]
S-adenosyl-L-homocysteine + N-terminal-N-methyl-Ser-Pro-Lys-[protein]
show the reaction diagram
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
assay at
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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NRMT2 mRNA is enriched in the liver and in the skeletal muscle. Expressed at fairly low levels in all tissues examined
Manually annotated by BRENDA team
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NRMT2 mRNA is enriched in the liver and in the skeletal muscle. Expressed at fairly low levels in all tissues examined
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
PDB
SCOP
CATH
ORGANISM
UNIPROT
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressio in HeLa cells
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