Information on EC 2.1.1.288 - aklanonic acid methyltransferase

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The expected taxonomic range for this enzyme is: Streptomyces sp.

EC NUMBER
COMMENTARY hide
2.1.1.288
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RECOMMENDED NAME
GeneOntology No.
aklanonic acid methyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + aklanonate = S-adenosyl-L-homocysteine + methyl aklanonate
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
aclacinomycin biosynthesis
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Biosynthesis of antibiotics
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Biosynthesis of type II polyketide products
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daunorubicin biosynthesis
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aclacinomycin biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:aklanonate O-methyltransferase
The enzyme from the Gram-positive bacterium Streptomyces sp. C5 is involved in the biosynthesis of the anthracycline daunorubicin.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the enzyme is involved in the biosynthesis of the anthracycline daunorubicin
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + aklanonate
S-adenosyl-L-homocysteine + methyl aklanonate
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + aklanonate
S-adenosyl-L-homocysteine + methyl aklanonate
show the reaction diagram
Q55214
the enzyme is involved in daunomycin biosynthesis
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?
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
24000
2 * 24000, SDS-PAGE
24319
2 * 24319, SDS-PAGE
48000
gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodimer
2 * 24000, SDS-PAGE; 2 * 24319, SDS-PAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
the dauC gene, encoding aklanonic acid methyltransferase, complements dauC-blocked mutants of Streptomyces sp. strain C5, restores in vitro aklanonic acid methyltransferase activities to the mutant strains, and confers in vitro aklanonic acid methyltransferase activity on Streptomyces lividans