Information on EC 2.1.1.227 - 16S rRNA (cytidine1409-2'-O)-methyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.1.1.227
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RECOMMENDED NAME
GeneOntology No.
16S rRNA (cytidine1409-2'-O)-methyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + cytidine1409 in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
show the reaction diagram
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:16S rRNA (cytidine1409-2'-O)-methyltransferase
The bifunctional enzyme from Mycobacterium tuberculosis 2'-O-methylates cytidine1409 in helix 44 of 16S rRNA and cytidine1920 in helix 69 of 23S rRNA (cf. EC 2.1.1.226, 23S rRNA (cytidine1920-2'-O)-methyltransferase).
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene tlyA
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Manually annotated by BRENDA team
gene tlyA
UniProt
Manually annotated by BRENDA team
gene tlyA
UniProt
Manually annotated by BRENDA team
no activity in Escherichia coli
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Manually annotated by BRENDA team
gene tlyA
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Manually annotated by BRENDA team
gene tlyA
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + cytidine1409 in 16S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
show the reaction diagram
S-adenosyl-L-methionine + cytidine1409 in 30S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 30S rRNA
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + cytidine1409 in 16S rRNA
S-adenosyl-L-homocysteine + 2'-O-methylcytidine1409 in 16S rRNA
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
S-adenosyl-L-methionine
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
recombinant C-terminally His-tagged enzyme from Escherichia coli
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression of recombinant tlyA in Escherichia coli markedly increases susceptibility to the drugs capreomycin and viomycin
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gene tlyA, DNA and amino acid sequence determination, analysis and comparison, expression in Escherichia coli strain DH1
gene tlyA, recombinant expression of C-terminally His-tagged enzyme in Escherichia coli
Show AA Sequence (157 entries)
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