Reference on EC 2.1.1.17 - phosphatidylethanolamine N-methyltransferase
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Ridgway, N.D.; Vance, D.E.
Phosphatidylethanolamine N-methyltransferase from rat liver
Methods Enzymol.
209
366-374
1992
Rattus norvegicus
Vance, D.E.; Schneider, W.J.
Conversion of phosphatidylethanolamine to phosphatidylcholine
Methods Enzymol.
71
581-588
1981
Rattus norvegicus
Gaynor, P.M.; Carman, G.M.
Phosphatidylethanolamine methyltransferase and phospholipid methyltransferase activities from Saccharomyces cerevisiae. Enzymological and kinetic properties
Biochim. Biophys. Acta
1045
156-163
1990
Saccharomyces cerevisiae
Pajares, M.A.; Villalba, M.; Mato, J.M.
Purification of phospholipid methyltransferase from rat liver microsomal fraction
Biochem. J.
237
699-705
1986
Rattus norvegicus
McBride, K.; Furness, L.M.; Gibbons, W.A.
Lipid methyltransferase: purification and structure
Biochem. Soc. Trans.
15
924-925
1987
Rattus norvegicus
-
Fonteh, A.N.; Gibbons, W.A.
Solubilization and purification of lipid methyltransferase
Biochem. Soc. Trans.
18
266-267
1990
Rattus norvegicus
Varela, I.; Merida, I.; Pajares, M.; Villalba, M.; Mato, J.M.
Activation of partially purified rat liver lipid methyltransferase by phosphorylation
Biochem. Biophys. Res. Commun.
122
1065-1070
1984
Rattus norvegicus
Ridgway, N.D.; Vance, D.E.
Kinetic mechanism of phosphatidylethanolamine N-methyltransferase
J. Biol. Chem.
263
16864-16871
1988
Rattus norvegicus
Prasad, C.; Edwards, R.M.
Synthesis of phosphatidylcholine from phosphatidylethanolamine by at least two methyltransferases in rat pituitary extracts
J. Biol. Chem.
256
13000-13003
1981
Rattus norvegicus
-
Dudeja, P.K.; Foster, E.S.; Brasitus, T.A.
Synthesis of phosphatidylcholine by two distinct methyltransferases in rat colonic brush-border membranes: evidence for extrinsic and intrinsic membrane activities
Biochim. Biophys. Acta
875
493-500
1986
Rattus norvegicus
Ridgway, N.D.; Vance, D.E.
Purification of phosphatidylethanolamine N-methyltransferase from rat liver
J. Biol. Chem.
262
17231-17239
1987
Rattus norvegicus
Tahara, Y.; Ogawa, Y.; Sakakibara, T.; Yamada, Y.
Purification and characterization of phosphatidylethanolamine N-methyltransferase from Zymomonas mobilis
Agric. Biol. Chem.
51
1425-1430
1987
Zymomonas mobilis
-
Tahara, Y.; Ogawa, Y.; Sakakibara, T.; Yamada, Y.
Phosphatidylethanolamine N-methyltransferase from Zymomonas mobilis: purification and characterization
Agric. Biol. Chem.
50
257-259
1986
Zymomonas mobilis
-
Makishima, F.; Toyoshima, S.; Osawa, T.
Partial purification and characterization of phospholipid N-methyltransferases from murine thymocyte microsomes
Arch. Biochem. Biophys.
238
315-324
1985
Mus musculus
Morgan, T.E.
Isolation and characterization of lipid N-methyltransferase from dog lung
Biochim. Biophys. Acta
178
21-34
1969
Canis sp.
Vance, D.E.; Walkey, C.J.; Cui, Z.
Phosphatidylethanolamine N-methyltransferase from liver
Biochim. Biophys. Acta
1348
142-150
1997
Rattus norvegicus
Cui, Z.; Shen, Y.J.; Vance, D.E.
Inverse correlation between expression of phosphatidylethanolamine N-methyltransferase-2 and growth rate of perinatal rat livers
Biochim. Biophys. Acta
1346
10-16
1997
Rattus norvegicus
Nishimaki-Mogami, T.; Suzuki, K.; Takahashi, A.
The role of phosphatidylethanolamine methylation in the secretion of very low density lipoproteins by cultured rat hepatocytes: rapid inhibition of phosphatidylethanolamine methylation by bezafibrate increases the density of apolipoprotein B48-containing lipoproteins
Biochim. Biophys. Acta
1304
21-31
1996
Rattus norvegicus
Shields, D.J.; Lehner, R.; Agellon, L.B.; Vance, D.E.
Membrane topography of human phosphatidylethanolamine N-methyltransferase
J. Biol. Chem.
278
2956-2962
2003
Homo sapiens
Tessitore, L.; Dianzani, I.; Cui, Z.; Vance, D.E.
Diminished expression of phosphatidylethanolamine N-methyltransferase 2 during hepatocarcinogenesis
Biochem. J.
337
23-27
1999
Rattus norvegicus
-
Tessitore, L.; Cui, Z.; Vance, D.E.
Transient inactivation of phosphatidylethanolamine N-methyltransferase-2 and activation of cytidine triphosphate:phosphocholine cytidylyltransferase during non-neoplastic liver growth
Biochem. J.
322
151-154
1997
Rattus norvegicus
-
Waite, K.A.; Vance, D.E.
Why expression of phosphatidylethanolamine N-methyltransferase does not rescue Chinese hamster ovary cells that have an impaired CDP-choline pathway
J. Biol. Chem.
275
21197-21202
2000
Cricetulus griseus
Cui, Z.; Vance, D.E.
Expression of phosphatidylethanolamine N-methyltransferase-2 is markedly enhanced in long term choline-deficient rats
J. Biol. Chem.
271
2839-2843
1996
Rattus norvegicus
Lee, M.W.; Bakovic, M.; Vance, D.E.
Overexpression of phosphatidylethanolamine N-methyltransferase 2 in CHO-K1 cells does not attenuate the activity of the CDP-choline pathway for phosphatidylcholine biosynthesis
Biochem. J.
320
905-910
1996
Cricetulus griseus
-
Lee, E.S.Y.; Charlton, C.G.
1-Methyl-4-phenyl-pyridinium increases S-adenosyl-L-methionine dependent phospholipid methylation
Pharmacol. Biochem. Behav.
70
105-114
2001
Rattus norvegicus
Tessitore, L.; Sesca, E.; Bosco, M.; Vance, D.E.
Expression of phosphatidylethanolamine N-methyltransferase in Yoshida ascites hepatoma cells and the livers of host rats
Carcinogenesis
20
561-567
1999
Rattus norvegicus
Guan, Z.Z.; Wang, Y.N.; Xiao, K.Q.; Hu, P.S.; Liu, J.L.
Activity of phosphatidylethanolamine-N-methyltransferase in brain affected by Alzheimer's disease
Neurochem. Int.
34
41-47
1999
Homo sapiens
Kim, Y.J.; Park, H.S.; Choi, M.U.
Detection of cytosolic phosphatidylethanolamine N-methyltransferase in rat brain
J. Biochem. Mol. Biol.
31
170-176
1998
Rattus norvegicus
-
Vance, D.E.
Phosphatidylethanolamine N-methyltransferase: Unexpected findings from curiosity-driven research
Eur. J. Med. Res.
1
182-188
1996
Rattus norvegicus
Roque, M.E.; Giusto, N.M.
Phosphatidylethanolamine N-methyltransferase activity in isolated rod outer segments from bovine retina
Exp. Eye Res.
60
631-643
1995
Bos taurus
Roque, M.E.; Salvador, G.A.; Giusto, N.M.
Light activation of phosphatidylethanolamine N-methyltransferase in rod outer segments and its modulation by association states of transducin
Exp. Eye Res.
69
555-562
1999
Bos taurus
Tessitore, L.; Sesca, E.; Vance, D.E.
Inactivation of phosphatidylethanolamine N-methyltransferase-2 in aflatoxin-induced liver cancer and partial reversion of the neoplastic phenotype by PEMT transfection of hepatoma cells
Int. J. Cancer
86
362-367
2000
Rattus norvegicus
Shields, D.J.; Lingrell, S.; Agellon, L.B.; Brosnan, J.T.; Vance, D.E.
Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase
J. Biol. Chem.
280
27339-27344
2005
Mus musculus
Watkins, S.M.; Zhu, X.; Zeisel, S.H.
Phosphatidylethanolamine-N-methyltransferase activity and dietary choline regulate liver-plasma lipid flux and essential fatty acid metabolism in mice
J. Nutr.
133
3386-3391
2003
Mus musculus
Gotoh, T.; Ando, N.; Kikuchi, K.
A novel method for in vitro radiolabeling and testing enveloped viruses by phosphatidylethanolamine N-methyltransferase and host cell-specific binding
Biotechnol. Bioeng.
94
1017-1024
2006
Sus scrofa
Mueller, H.; Grande, T.; Ahlstr?m, O.; Skrede, A.
A diet rich in phosphatidylethanolamine increases plasma homocysteine in mink: a comparison with a soybean oil diet
Br. J. Nutr.
94
684-690
2005
Neogale vison
Zhu, X.; Zeisel, S.H.
Gene expression profiling in phosphatidylethanolamine N-methyltransferase knockout mice
Brain Res. Mol. Brain Res.
134
239-255
2005
Mus musculus
Igolnikov, A.C.; Green, R.M.
Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet
J. Hepatol.
44
586-592
2006
Mus musculus
Kharbanda, K.K.; Mailliard, M.E.; Baldwin, C.R.; Beckenhauer, H.C.; Sorrell, M.F.; Tuma, D.J.
Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway
J. Hepatol.
46
314-321
2007
Rattus norvegicus, Rattus norvegicus (Q08388)
Hartz, C.S.; Nieman, K.M.; Jacobs, R.L.; Vance, D.E.; Schalinske, K.L.
Hepatic phosphatidylethanolamine N-methyltransferase expression is increased in diabetic rats
J. Nutr.
136
3005-3009
2006
Rattus norvegicus
Li, Z.; Agellon, L.B.; Vance, D.E.
A role for high density lipoproteins in hepatic phosphatidylcholine homeostasis
Biochim. Biophys. Acta
1771
893-900
2007
Mus musculus
Resseguie, M.; Song, J.; Niculescu, M.D.; da Costa, K.; Randall, T.A.; Zeisel, S.H.
Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes
FASEB J.
21
2622-2632
2007
Mus musculus (Q61907), Mus musculus, Homo sapiens (Q9UBM1), Homo sapiens
Xu, X.; Gammon, M.D.; Zeisel, S.H.; Lee, Y.L.; Wetmur, J.G.; Teitelbaum, S.L.; Bradshaw, P.T.; Neugut, A.I.; Santella, R.M.; Chen, J.
Choline metabolism and risk of breast cancer in a population-based study
FASEB J.
22
2045-2052
2008
Homo sapiens (Q9UBM1)
Vance, D.E.; Li, Z.; Jacobs, R.L.
Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology
J. Biol. Chem.
282
33237-33241
2007
Mus musculus
Zhao, Y.; Su, B.; Jacobs, R.L.; Kennedy, B.; Francis, G.A.; Waddington, E.; Brosnan, J.T.; Vance, J.E.; Vance, D.E.
Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice
Arterioscler. Thromb. Vasc. Biol.
29
1349-1355
2009
Mus musculus
Jun, D.W.; Han, J.H.; Jang, E.C.; Kim, S.H.; Kim, S.H.; Jo, Y.J.; Park, Y.S.; Chae, J.D.
Polymorphisms of microsomal triglyceride transfer protein gene and phosphatidylethanolamine N-methyltransferase gene in alcoholic and nonalcoholic fatty liver disease in Koreans
Eur. J. Gastroenterol. Hepatol.
21
667-672
2009
Homo sapiens
Ivanov, A.; Nash-Barboza, S.; Hinkis, S.; Caudill, M.A.
Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted
J. Am. Diet. Assoc.
109
313-318
2009
Homo sapiens
Hacker, S.; Sohlenkamp, C.; Aktas, M.; Geiger, O.; Narberhaus, F.
Multiple phospholipid N-methyltransferases with distinct substrate specificities are encoded in Bradyrhizobium japonicum
J. Bacteriol.
190
571-580
2008
Bradyrhizobium japonicum, Bradyrhizobium japonicum USDA 110
Caudill, M.A.; Dellschaft, N.; Solis, C.; Hinkis, S.; Ivanov, A.A.; Nash-Barboza, S.; Randall, K.E.; Jackson, B.; Solomita, G.N.; Vermeylen, F.
Choline intake, plasma riboflavin, and the phosphatidylethanolamine N-methyltransferase G5465A genotype predict plasma homocysteine in folate-deplete Mexican-American men with the methylenetetrahydrofolate reductase 677TT genotype
J. Nutr.
139
727-733
2009
Homo sapiens
Li, Z.; Agellon, L.B.; Vance, D.E.
The role of phosphatidylethanolamine methyltransferase in a mouse model of intrahepatic cholestasis
Biochim. Biophys. Acta
1811
278-283
2011
Mus musculus
Morrill, G.; Kostellow, A.; Askari, A.
Progesterone modulation of transmembrane helix-helix interactions between the -subunit of Na/K-ATPase and phospholipid N-methyltransferase in the oocyte plasma membrane
BMC Struct. Biol.
10
12
2010
Lithobates pipiens
Morita, S.Y.; Ikeda, N.; Horikami, M.; Soda, K.; Ishihara, K.; Teraoka, R.; Terada, T.; Kitagawa, S.
Effects of phosphatidylethanolamine N-methyltransferase on phospholipid composition, microvillus formation and bile salt resistance in LLC-PK1 cells
FEBS J.
278
4768-4781
2011
Homo sapiens (Q9UBM1)
Aktas, M.; Gleichenhagen, J.; Stoll, R.; Narberhaus, F.
S-adenosylmethionine-binding properties of a bacterial phospholipid N-methyltransferase
J. Bacteriol.
193
3473-3481
2011
Agrobacterium tumefaciens
Cole, L.K.; Vance, D.E.
A role for Sp1 in transcriptional regulation of phosphatidylethanolamine N-methyltransferase in liver and 3T3-L1 adipocytes
J. Biol. Chem.
285
11880-11891
2010
Mus musculus
Pynn, C.J.; Henderson, N.G.; Clark, H.; Koster, G.; Bernhard, W.; Postle, A.D.
Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo
J. Lipid Res.
52
399-407
2011
Homo sapiens
Athamena, A.; Trajkovic-Bodennec, S.; Brichon, G.; Zwingelstein, G.; Bodennec, J.
Synthesis of phosphatidylcholine through phosphatidylethanolamine N-methylation in tissues of the mussel Mytilus galloprovincialis
Lipids
46
1141-1154
2011
Mytilus galloprovincialis
Kobayashi, S.; Mizuike, A.; Horiuchi, H.; Fukuda, R.; Ohta, A.
Mitochondrially-targeted bacterial phosphatidylethanolamine methyltransferase sustained phosphatidylcholine synthesis of a Saccharomyces cerevisiae DELTApem1 DELTApem2 double mutant without exogenous choline supply
Biochim. Biophys. Acta
1841
1264-1271
2014
Acetobacter aceti, Acetobacter aceti NBRC 3283
Valtolina, C.; Vaandrager, A.B.; Favier, R.P.; Robben, J.H.; Tuohetahuntila, M.; Kummeling, A.; Jeusette, I.; Rothuizen, J.
No up-regulation of the phosphatidylethanolamine N-methyltransferase pathway and choline production by sex hormones in cats
BMC Vet. Res.
11
280
2015
Felis catus (M3W4J4), Felis catus
Tajuddin, S.M.; Amaral, A.F.; Fernandez, A.F.; Chanock, S.; Silverman, D.T.; Tardon, A.; Carrato, A.; Garcia-Closas, M.; Jackson, B.P.; Torano, E.G.; Marquez, M.; Urdinguio, R.G.; Garcia-Closas, R.; Rothman, N.; Kogevinas, M.; Real, F.X.; Fraga, M.F.; Malats, N.; Malats, N.
LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk
Br. J. Cancer
110
2123-2130
2014
Homo sapiens
Danne, L.; Aktas, M.; Gleichenhagen, J.; Grund, N.; Wagner, D.; Schwalbe, H.; Hoffknecht, B.; Metzler-Nolte, N.; Narberhaus, F.
Membrane-binding mechanism of a bacterial phospholipid N-methyltransferase
Mol. Microbiol.
95
313-331
2015
Agrobacterium tumefaciens
Gao, X.; van der Veen, J.N.; Vance, J.E.; Thiesen, A.; Vance, D.E.; Jacobs, R.L.
Lack of phosphatidylethanolamine N-methyltransferase alters hepatic phospholipid composition and induces endoplasmic reticulum stress
Biochim. Biophys. Acta
1852
2689-2699
2015
Mus musculus (Q61907), Mus musculus
Presa, N.; Clugston, R.D.; Lingrell, S.; Kelly, S.E.; Merrill, A.H.; Jana, S.; Kassiri, Z.; Gomez-Munoz, A.; Vance, D.E.; Jacobs, R.L.; van der Veen, J.N.
Vitamin E alleviates non-alcoholic fatty liver disease in phosphatidylethanolamine N-methyltransferase deficient mice
Biochim. Biophys. Acta
1865
14-25
2019
Mus musculus (Q61907)
Zufferey, R.
In vitro assay to measure phosphatidylethanolamine methyltransferase activity
J. Vis. Exp.
107
e53302
2016
Leishmania sp.
Jacobs, R.L.; Jiang, H.; Kennelly, J.P.; Orlicky, D.J.; Allen, R.H.; Stabler, S.P.; Maclean, K.N.
Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria
Mol. Genet. Metab.
120
325-336
2017
Mus musculus (Q61907), Mus musculus
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