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Reference on EC 2.1.1.148 - thymidylate synthase (FAD)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Myllykallio, H.; Lipowski, G.; Leduc, D.; Filee, J.; Forterre, P.; Liebl, U.
An alternative flavin-dependent mechanism for thymidylate synthesis
Science
297
105-107
2002
Borreliella burgdorferi, Campylobacter jejuni, Chlamydia sp., Dictyostelium discoideum, Helicobacter pylori (Q9ZJ93), Mycobacterium tuberculosis, Pyrococcus abyssi (Q9UZ51), Pyrococcus horikoshii, Rickettsia prowazekii, Saccharolobus solfataricus, Treponema pallidum
Manually annotated by BRENDA team
Giladi, M.; Bitan-Banin, G.; Mevarech, M.; Ortenberg, R.
Genetic evidence for a novel thymidylate synthase in the halophilic archaeon Halobacterium salinarum and in Campylobacter jejuni
FEMS Microbiol. Lett.
216
105-109
2002
Campylobacter jejuni, Halobacterium salinarum
Manually annotated by BRENDA team
Montfort, W.R.
Complementing thymidylate synthase
Structure
11
607-608
2003
Dictyostelium discoideum, Thermotoga maritima (Q9WYT0)
Manually annotated by BRENDA team
Mathews, I.I.; Deacon, A.M.; Canaves, J.M.; McMullan, D.; Lesley, S.A.; Agarwalla, S.; Kuhn, P.
Functional analysis of substrate and cofactor complex structures of a thymidylate synthase-complementing protein
Structure
11
677-690
2003
Bacillus anthracis, Borreliella burgdorferi, Campylobacter jejuni, Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Clostridium botulinum, Clostridioides difficile, Clostridium perfringens, Corynebacterium diphtheriae, Dictyostelium discoideum, Ehrlichia chaffeensis, Helicobacter pylori, Helicobacter pylori (Q9ZJ93), Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium tuberculosis variant bovis, Mycobacterium leprae, Rhodococcus sp., Rickettsia conorii, Rickettsia prowazekii, Treponema denticola, Treponema pallidum, Thermotoga maritima (Q9WYT0), Thermotoga maritima DSM 3109 (Q9WYT0)
Manually annotated by BRENDA team
Leduc, D.; Graziani, S.; Meslet-Cladiere, L.; Sodolescu, A.; Liebl, U.; Myllykallio, H.
Two distinct pathways for thymidylate (dTMP) synthesis in (hyper)thermophilic bacteria and archaea
Biochem. Soc. Trans.
32
231-235
2004
Aeropyrum pernix, Aquifex aeolicus, no activity in Methanocaldococcus jannaschii, Pyrobaculum aerophilum, Pyrococcus abyssi, Pyrococcus furiosus, Pyrococcus horikoshii, Saccharolobus solfataricus, Thermoplasma acidophilum, Thermoplasma volcanium, Thermotoga maritima, no activity in Archaeoglobus fulgidus, no activity in Methanopyrus kandleri, no activity in Methanothermobacter thermoautotrophicus, Sulfurisphaera tokodaii, no activity in Methanopyrus kandleri AV19
Manually annotated by BRENDA team
Agrawal, N.; Lesley, S.A.; Kuhn, P.; Kohen, A.
Mechanistic studies of a flavin-dependent thymidylate synthase
Biochemistry
43
10295-10301
2004
Thermotoga maritima (Q9WYT0), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9WYT0)
Manually annotated by BRENDA team
Gattis, S.G.; Palfey, B.A.
Direct observation of the participation of flavin in product formation by thyX-encoded thymidylate synthase
J. Am. Chem. Soc.
127
832-833
2005
Campylobacter jejuni
Manually annotated by BRENDA team
Liu, X.Q.; Yang, J.
Bacterial thymidylate synthase with intein, group II Intron, and distinctive ThyX motifs
J. Bacteriol.
186
6316-6319
2004
Trichodesmium erythraeum
Manually annotated by BRENDA team
Graziani, S.; Xia, Y.; Gurnon, J.R.; Van Etten, J.L.; Leduc, D.; Skouloubris, S.; Myllykallio, H.; Liebl, U.
Functional analysis of FAD-dependent thymidylate synthase ThyX from Paramecium bursaria Chlorella virus-1
J. Biol. Chem.
279
54340-54347
2004
Paramecium bursaria Chlorella virus-1
Manually annotated by BRENDA team
Leduc, D.; Graziani, S.; Lipowski, G.; Marchand, C.; Le Marechal, P.; Liebl, U.; Myllykallio, H.
Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers
Proc. Natl. Acad. Sci. USA
101
7252-7257
2004
Helicobacter pylori
Manually annotated by BRENDA team
Chernyshev, A.; Fleischmann, T.; Kohen, A.
Thymidyl biosynthesis enzymes as antibiotic targets
Appl. Microbiol. Biotechnol.
74
282-289
2007
Bacillus anthracis, Chlamydia trachomatis, Clostridium botulinum, Helicobacter pylori, Mycobacterium leprae, no activity in Homo sapiens, Pyrococcus furiosus, Rickettsia sp., Thermotoga maritima, Paramecium bursaria Chlorella virus-1, Treponema palladium, Mycobacterium tuberculosis (P9WG57), Mycobacterium tuberculosis H37Rv (P9WG57)
Manually annotated by BRENDA team
Kanai, A.; Sato, A.; Imoto, J.; Tomita, M.
Archaeal Pyrococcus furiosus thymidylate synthase 1 is an RNA-binding protein
Biochem. J.
393
373-379
2006
Pyrococcus furiosus (Q8U3C9), Pyrococcus furiosus
Manually annotated by BRENDA team
Mason, A.; Agrawal, N.; Washington, M.T.; Lesley, S.A.; Kohen, A.
A lag-phase in the reduction of flavin dependent thymidylate synthase (FDTS) revealed a mechanistic missing link
Chem. Commun. (Camb. )
16
1781-1783
2006
Thermotoga maritima
Manually annotated by BRENDA team
Graziani, S.; Bernauer, J.; Skouloubris, S.; Graille, M.; Zhou, C.Z.; Marchand, C.; Decottignies, P.; van Tilbeurgh, H.; Myllykallio, H.; Liebl, U.
Catalytic mechanism and structure of viral flavin-dependent thymidylate synthase ThyX
J. Biol. Chem.
281
24048-24057
2006
Paramecium bursaria Chlorella virus-1
Manually annotated by BRENDA team
Sampathkumar, P.; Turley, S.; Ulmer, J.E.; Rhie, H.G.; Sibley, C.H.; Hol, W.G.
Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution
J. Mol. Biol.
352
1091-1104
2005
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Sampathkumar, P.; Turley, S.; Sibley, C.H.; Hol, W.G.
NADP+ expels both the co-factor and a substrate analog from the Mycobacterium tuberculosis ThyX active site: opportunities for anti-bacterial drug design
J. Mol. Biol.
360
1-6
2006
Mycobacterium tuberculosis (P9WG57), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WG57)
Manually annotated by BRENDA team
Esra Onen, F.; Boum, Y.; Jacquement, C.; Spanedda, M.V.; Jaber, N.; Scherman, D.; Myllykallio, H.; Herscovici, J.
Design, synthesis and evaluation of potent thymidylate synthase X inhibitors
Bioorg. Med. Chem. Lett.
18
3628-3631
2008
Paramecium bursaria Chlorella virus 1 (O41156)
Manually annotated by BRENDA team
Chernyshev, A.; Fleischmann, T.; Koehn, E.M.; Lesley, S.A.; Kohen, A.
The relationships between oxidase and synthase activities of flavin dependent thymidylate synthase (FDTS)
Chem. Commun. (Camb. )
27
2861-2863
2007
Thermotoga maritima
Manually annotated by BRENDA team
Leduc, D.; Escartin, F.; Nijhout, H.F.; Reed, M.C.; Liebl, U.; Skouloubris, S.; Myllykallio, H.
Flavin-dependent thymidylate synthase ThyX activity: implications for the folate cycle in bacteria
J. Bacteriol.
189
8537-8545
2007
Rhodobacter capsulatus, Rhodobacter capsulatus MT1131
Manually annotated by BRENDA team
Hunter, J.H.; Gujjar, R.; Pang, C.K.; Rathod, P.K.
Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX
PLoS ONE
3
e2237
2008
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Wang, Z.; Chernyshev, A.; Koehn, E.M.; Manuel, T.D.; Lesley, S.A.; Kohen, A.
Oxidase activity of a flavin-dependent thymidylate synthase
FEBS J.
276
2801-2810
2009
Thermotoga maritima (Q9WYT0)
Manually annotated by BRENDA team
Ulmer, J.E.; Boum, Y.; Thouvenel, C.D.; Myllykallio, H.; Sibley, C.H.
Functional analysis of the Mycobacterium tuberculosis FAD-dependent thymidylate synthase, ThyX, reveals new amino acid residues contributing to an extended ThyX motif
J. Bacteriol.
190
2056-2064
2008
Mycobacterium tuberculosis (P9WG57), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WG57)
Manually annotated by BRENDA team
Koehn, E.M.; Fleischmann, T.; Conrad, J.A.; Palfey, B.A.; Lesley, S.A.; Mathews, I.I.; Kohen, A.
An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene
Nature
458
919-923
2009
Thermotoga maritima (Q9WYT0)
Manually annotated by BRENDA team
Escartin, F.; Skouloubris, S.; Liebl, U.; Myllykallio, H.
Flavin-dependent thymidylate synthase X limits chromosomal DNA replication
Proc. Natl. Acad. Sci. USA
105
9948-9952
2008
Helicobacter pylori, Paramecium bursaria Chlorella virus 1
Manually annotated by BRENDA team
Kan, S.C.; Liu, J.S.; Hu, H.Y.; Chang, C.M.; Lin, W.D.; Wang, W.C.; Hsu, W.H.
Biochemical characterization of two thymidylate synthases in Corynebacterium glutamicum NCHU 87078
Biochim. Biophys. Acta
1804
1751-1759
2010
no activity in Corynebacterium glutamicum strain NCHU 87078
Manually annotated by BRENDA team
Mishanina, T.V.; Koehn, E.M.; Conrad, J.A.; Palfey, B.A.; Lesley, S.A.; Kohen, A.
Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase
J. Am. Chem. Soc.
134
4442-4448
2012
Thermotoga maritima (Q9WYT0), Thermotoga maritima ATCC 43589 (Q9WYT0)
Manually annotated by BRENDA team
Zhang, X.; Zhang, J.; Guo, G.; Mao, X.; Hu, Y.; Zou, Q.
Crystal structure of a flavin-dependent thymidylate synthase from Helicobacter pylori strain 26695
Protein Pept. Lett.
19
1225-1230
2012
Helicobacter pylori
Manually annotated by BRENDA team
Wang, K.; Wang, Q.; Chen, J.; Chen, L.; Jiang, H.; Shen, X.
Crystal structure and enzymatic characterization of thymidylate synthase X from Helicobacter pylori strain SS1
Protein Sci.
20
1398-1410
2011
Helicobacter pylori (Q5UVJ4), Helicobacter pylori, Helicobacter pylori SS1 (Q5UVJ4)
Manually annotated by BRENDA team
Becker, H.F.; Djaout, K.; Lamarre, I.; Ulmer, J.E.; Schaming, D.; Balland, V.; Liebl, U.; Myllykallio, H.; Vos, M.H.
Substrate interaction dynamics and oxygen control in the active site of thymidylate synthase ThyX
Biochem. J.
459
37-45
2014
Paramecium bursaria Chlorella virus 1 (O41156)
Manually annotated by BRENDA team
Alexandrova, L.A.; Chekhov, V.O.; Shmalenyuk, E.R.; Kochetkov, S.N.; El-Asrar, R.A.; Herdewijn, P.
Synthesis and evaluation of C-5 modified 2-deoxyuridine monophosphates as inhibitors of M. tuberculosis thymidylate synthase
Bioorg. Med. Chem.
23
7131-7137
2015
Mycobacterium tuberculosis
Manually annotated by BRENDA team
Mishanina, T.V.; Corcoran, J.M.; Kohen, A.
Substrate activation in flavin-dependent thymidylate synthase
J. Am. Chem. Soc.
136
10597-10600
2014
Thermotoga maritima (Q9WYT0), Thermotoga maritima ATCC 43589 (Q9WYT0)
Manually annotated by BRENDA team
Mathews, I.I.
Flavin-dependent thymidylate synthase as a drug target for deadly microbes: mutational study and a strategy for inhibitor design
J. Bioterror Biodef.
Suppl 12
004
2013
Thermotoga maritima (Q9WYT0), Thermotoga maritima ATCC 43589 (Q9WYT0)
Manually annotated by BRENDA team
Ogawa, A.; Sampei, G.; Kawai, G.
Crystal structure of the flavin-dependent thymidylate synthase Thy1 from Thermus thermophilus with an extra C-terminal domain
Acta Crystallogr. Sect. F
75
450-455
2019
Thermus thermophilus (Q5SJB8), Thermus thermophilus, Thermus thermophilus DSM 579 (Q5SJB8)
Manually annotated by BRENDA team
Alexandrova, L.A.; Chekhov, V.O.; Shmalenyuk, E.R.; Kochetkov, S.N.; El-Asrar, R.A.; Herdewijn, P.
Synthesis and evaluation of C-5 modified 2-deoxyuridine monophosphates as inhibitors of M. tuberculosis thymidylate synthase
Bioorg. Med. Chem.
23
7131-7137
2015
Mycobacterium tuberculosis (P9WG57), Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618 (P9WG57)
Manually annotated by BRENDA team
Modranka, J.; Li, J.; Parchina, A.; Vanmeert, M.; Dumbre, S.; Salman, M.; Myllykallio, H.; Becker, H.F.; Vanhoutte, R.; Margamuljana, L.; Nguyen, H.; Abu El-Asrar, R.; Rozenski, J.; Herdewijn, P.; De Jonghe, S.; Lescrinier, E.
Synthesis and structure-activity relationship studies of benzo[b][1,4]oxazin-3(4H)-one analogues as inhibitors of mycobacterial thymidylate synthase X
ChemMedChem
14
645-662
2019
Mycobacterium tuberculosis (P9WG57), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WG57)
Manually annotated by BRENDA team
Krumova, S.; Todinova, S.; Tileva, M.; Bouzhir-Sima, L.; Vos, M.H.; Liebl, U.; Taneva, S.G.
Thermal stability and binding energetics of thymidylate synthase ThyX
Int. J. Biol. Macromol.
91
560-567
2016
Paramecium bursaria Chlorella virus 1 (O41156), Paramecium bursaria Chlorella virus 1, Thermotoga maritima (Q9WYT0), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9WYT0)
Manually annotated by BRENDA team
Luciani, R.; Saxena, P.; Surade, S.; Santucci, M.; Venturelli, A.; Borsari, C.; Marverti, G.; Ponterini, G.; Ferrari, S.; Blundell, T.L.; Costi, M.P.
Virtual screening and X-ray crystallography identify non-substrate analog inhibitors of flavin-dependent thymidylate synthase
J. Med. Chem.
59
9269-9275
2016
Thermotoga maritima (Q9WYT0), Thermotoga maritima DSM 3109 (Q9WYT0)
Manually annotated by BRENDA team
Skouloubris, S.; Djaout, K.; Lamarre, I.; Lambry, J.C.; Anger, K.; Briffotaux, J.; Liebl, U.; de Reuse, H.; Myllykallio, H.
Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones
Open Biology
5
150015
2015
Helicobacter pylori (O26061), Helicobacter pylori, Helicobacter pylori 26695 (O26061)
Manually annotated by BRENDA team