Reference on EC 2.1.1.137 - arsenite methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wildfang, E.; Zakharyan, R.A.; Aposhian, H.V.
Enzymatic methylation of arsenic compounds. VI. Characterization of hamster liver arsenite and methylarsonic acid methyltransferase activities in vitro
Toxicol. Appl. Pharmacol.
152
366-375
1998
Cricetinae
Healey, S.M.; Casarez, E.A.; Ayalo-Fierro, F.; Aposhian, H.V.
Enzymatic methylation of arsenic compoundes. Arsenite methyltransferase activity in tissues of mice
Toxicol. Appl. Pharmacol.
148
65-70
1998
Mus musculus
Healy S.M.; Zakharyan, R.A.; Aposhian, H.V.
Enzymatic methylation of arsenic compounds. VI. In vitro and in vivo deficiency of the methylation of arsenite and monomethylarsonic acid in the guinea pig
Mutat. Res.
386
229-239
1997
no activity in Cavia porcellus
Zakharyan, R.A.; Wildfang, E.; Aposhian, H.V.
Enzymatic methylation of arsenic compoundes. The marmoset and tamarin, but not the rhesus monkeys are deficient in methyltransferases that methylate inorganic compounds
Toxicol. Appl. Pharmacol.
140
77-84
1996
Oryctolagus cuniculus, Macaca mulatta, no activity in Callithrix jacchus, no activity in Saguinus oedipus
Zakharyan, R.; Wu, Y.; Bogdan, G.M.; Aposhian, H.V.
Enzymatic methylation of arsenic compounds: assay, partial purification, and properties of arsenite methyltransferase and monomethylarsonic acid methyltransferase of rabbit liver
Chem. Res. Toxicol.
8
1029-1038
1995
Oryctolagus cuniculus
Hayakawa, T.; Kobayashi, Y.; Cui, X.; Hirano, S.
A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19
Arch. Toxicol.
79
183-191
2005
Homo sapiens
Walton, F.S.; Waters, S.B.; Jolley, S.L.; LeCluyse, E.L.; Thomas, D.J.; Styblo, M.
Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes
Chem. Res. Toxicol.
16
261-265
2003
Homo sapiens, Rattus norvegicus
Waters, S.B.; Devesa, V.; Fricke, M.W.; Creed, J.T.; Styblo, M.; Thomas, D.J.
Glutathione modulates recombinant rat arsenic (+3 oxidation state) methyltransferase-catalyzed formation of trimethylarsine oxide and trimethylarsine
Chem. Res. Toxicol.
17
1621-1629
2004
Rattus norvegicus (Q8VHT6)
Lin, S.; Shi, Q.; Nix, F.B.; Styblo, M.; Beck, M.A.; Herbin-Davis, K.M.; Hall, L.L.; Simeonsson, J.B.; Thomas, D.J.
A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol
J. Biol. Chem.
277
10795-10803
2002
Rattus norvegicus (Q8VHT6), Homo sapiens (Q9HBK9), Homo sapiens
Wildfang, E.; Radabaugh, T.R.; Vasken Aposhian, H.
Enzymatic methylation of arsenic compounds. IX. Liver arsenite methyltransferase and arsenate reductase activities in primates
Toxicology
168
213-221
2001
Macaca fascicularis, Macaca mulatta, Macaca nemestrina, no activity in Aotus sp., no activity in Callithrix jacchus, no activity in Cheirogaleus medius, no activity in Daubentonia madagascariensis, no activity in Galago senegalensis, no activity in Gorilla gorilla, no activity in Lemur catta, no activity in Nycticebus coucang, no activity in Pan troglodytes, no activity in Papio cynocephalus, no activity in Pongo pygmaeus, no activity in Propithecus verreauxi, no activity in Saguinus oedipus, Saimiri sp.
Drobna, Z.; Xing, W.; Thomas, D.J.; Styblo, M.
shRNA silencing of AS3MT expression minimizes arsenic methylation capacity of HepG2 cells
Chem. Res. Toxicol.
19
894-898
2006
Homo sapiens
Thomas, D.J.; Li, J.; Waters, S.B.; Xing, W.; Adair, B.M.; Drobna, Z.; Devesa, V.; Styblo, M.
Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals
Exp. Biol. Med.
232
3-13
2007
Bos taurus, Bos taurus (Q58DQ0), Gallus gallus, Ciona intestinalis, Mus musculus, no activity in Caenorhabditis elegans, no activity in Drosophila melanogaster, Oncorhynchus mykiss, Pan troglodytes, Rattus norvegicus, Rattus norvegicus (Q8VHT6), Rhodopseudomonas palustris, Strongylocentrotus purpuratus, Homo sapiens (Q9HBK9)
Wood, T.C.; Salavagionne, O.E.; Mukherjee, B.; Wang, L.; Klumpp, A.F.; Thomae, B.A.; Eckloff, B.W.; Schaid, D.J.; Wieben, E.D.; Weinshilboum, R.M.
Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies
J. Biol. Chem.
281
7364-7373
2006
Homo sapiens
Qin, J.; Rosen, B.P.; Zhang, Y.; Wang, G.; Franke, S.; Rensing, C.
Arsenic detoxification and evolution of trimethylarsine gas by a microbial arsenite S-adenosylmethionine methyltransferase
Proc. Natl. Acad. Sci. USA
103
2075-2080
2006
Rhodopseudomonas palustris, Rhodopseudomonas palustris CGA009
Drobna, Z.; Waters, S.B.; Devesa, V.; Harmon, A.W.; Thomas, D.J.; Styblo, M.
Metabolism and toxicity of arsenic in human urothelial cells expressing rat arsenic (+3 oxidation state)-methyltransferase
Toxicol. Appl. Pharmacol.
207
147-159
2005
Rattus norvegicus
John, J.P.; Oh, J.E.; Pollak, A.; Lubec, G.
Identification and characterisation of arsenite (+3 oxidation state) methyltransferase (AS3MT) in mouse neuroblastoma cell line N1E-115
Amino Acids
35
355-358
2008
Mus musculus (Q91WU5), Mus musculus
De Chaudhuri, S.; Ghosh, P.; Sarma, N.; Majumdar, P.; Sau, T.J.; Basu, S.; Roychoudhury, S.; Ray, K.; Giri, A.K.
Genetic variants associated with arsenic susceptibility: study of purine nucleoside phosphorylase, arsenic (+3) methyltransferase, and glutathione s-transferase omega genes
Environ. Health Perspect.
116
501-505
2008
Homo sapiens (Q9HBK9)
Yuan, C.; Lu, X.; Qin, J.; Rosen, B.P.; Le, X.C.
Volatile arsenic species released from Escherichia coli expressing the AsIII S-adenosylmethionine methyltransferase gene
Environ. Sci. Technol.
42
3201-3206
2008
Rhodopseudomonas palustris
Fujihara, J.; Soejima, M.; Koda, Y.; Kunito, T.; Takeshita, H.
Asian specific low mutation frequencies of the M287T polymorphism in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene
Mutat. Res.
654
158-161
2008
Homo sapiens (Q9HBK9), Homo sapiens
Fujihara, J.; Kunito, T.; Agusa, T.; Yasuda, T.; Iida, R.; Fujii, Y.; Takeshita, H.
Population differences in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method
Toxicol. Appl. Pharmacol.
225
251-254
2007
Homo sapiens (Q9HBK9), Homo sapiens
Fujihara, J.; Yasuda, T.; Kato, H.; Yuasa, I.; Panduro, A.; Kunito, T.; Takeshita, H.
Genetic variants associated with arsenic metabolism within human arsenic (+3 oxidation state) methyltransferase show wide variation across multiple populations
Arch. Toxicol.
85
119-125
2011
Homo sapiens
Sumi, D.; Fukushima, K.; Miyataka, H.; Himeno, S.
Alternative splicing variants of human arsenic (+3 oxidation state) methyltransferase
Biochem. Biophys. Res. Commun.
415
48-53
2011
Homo sapiens
Marapakala, K.; Qin, J.; Rosen, B.P.
Identification of catalytic residues in the As(III) S-adenosylmethionine methyltransferase
Biochemistry
51
944-951
2012
Cyanidioschyzon sp.
Song, X.; Geng, Z.; Li, X.; Hu, X.; Bian, N.; Zhang, X.; Wang, Z.
New insights into the mechanism of arsenite methylation with the recombinant human arsenic (+3) methyltransferase (hAS3MT)
Biochimie
92
1397-1406
2010
Homo sapiens
Song, X.; Geng, Z.; Li, X.; Zhao, Q.; Hu, X.; Zhang, X.; Wang, Z.
Functional and structural evaluation of cysteine residues in the human arsenic (+3 oxidation state) methyltransferase (hAS3MT)
Biochimie
93
369-375
2011
Homo sapiens
Hamdi, M.; Yoshinaga, M.; Packianathan, C.; Qin, J.; Hallauer, J.; McDermott, J.R.; Yang, H.C.; Tsai, K.J.; Liu, Z.
Identification of an S-adenosylmethionine (SAM) dependent arsenic methyltransferase in Danio rerio
Toxicol. Appl. Pharmacol.
262
185-193
2012
Danio rerio
Ding, L.; Saunders, R.J.; Drobna, Z.; Walton, F.S.; Xun, P.; Thomas, D.J.; Styblo, M.
Methylation of arsenic by recombinant human wild-type arsenic (+3 oxidation state) methyltransferase and its methionine 287 threonine (M287T) polymorph: Role of glutathione
Toxicol. Appl. Pharmacol.
264
121-130
2012
Homo sapiens
Zhang, J.; Cao, T.; Tang, Z.; Shen, Q.; Rosen, B.P.; Zhao, F.J.
Arsenic methylation and volatilization by arsenite S-adenosylmethionine methyltransferase in Pseudomonas alcaligenes NBRC14159
Appl. Environ. Microbiol.
81
2852-2860
2015
Pseudomonas alcaligenes (U2ZU49), Pseudomonas alcaligenes, Pseudomonas alcaligenes NBRC 14159 (U2ZU49)
Ye, J.; Chang, Y.; Yan, Y.; Xiong, J.; Xue, X.M.; Yuan, D.; Sun, G.X.; Zhu, Y.G.; Miao, W.
Identification and characterization of the arsenite methyltransferase from a protozoan, Tetrahymena pyriformis
Aquat. Toxicol.
149
50-57
2014
Tetrahymena pyriformis
Ajees, A.A.; Marapakala, K.; Packianathan, C.; Sankaran, B.; Rosen, B.P.
Structure of an As(III) S-adenosylmethionine methyltransferase: insights into the mechanism of arsenic biotransformation
Biochemistry
51
5476-5485
2012
Cyanidioschyzon sp. (C0JV69)
Li, X.; Geng, Z.; Chang, J.; Song, X.; Wang, Z.
Mutational analysis of residues in human arsenic (III) methyltransferase (hAS3MT) belonging to 5 A around S-adenosylmethionine (SAM)
Biochimie
107 Pt B
396-405
2014
Homo sapiens (Q9HBK9), Homo sapiens
Sumi, D.; Himeno, S.
Role of arsenic (+3 oxidation state) methyltransferase in arsenic metabolism and toxicity
Biol. Pharm. Bull.
35
1870-1875
2012
Homo sapiens (Q9HBK9)
Wang, P.P.; Sun, G.X.; Zhu, Y.G.
Identification and characterization of arsenite methyltransferase from an archaeon, Methanosarcina acetivorans C2A
Environ. Sci. Technol.
48
12706-12713
2014
Methanosarcina acetivorans
Li, X.; Geng, Z.; Wang, S.; Song, X.; Hu, X.; Wang, Z.
Functional evaluation of Asp76, 84, 102 and 150 in human arsenic(III) methyltransferase (hAS3MT) interacting with S-adenosylmethionine
FEBS Lett.
587
2232-2240
2013
Homo sapiens (Q9HBK9), Homo sapiens
Wang, P.P.; Bao, P.; Sun, G.X.
Identification and catalytic residues of the arsenite methyltransferase from a sulfate-reducing bacterium, Clostridium sp. BXM
FEMS Microbiol. Lett.
362(4)
1-8
2015
Clostridium sp. (A0A0D3MJQ5), Clostridium sp. BXM (A0A0D3MJQ5)
Huang, L.; Yu, F.; Xu, C.; Tang, L.; He, J.
Crystallization and preliminary X-ray crystallographic analysis of the arsenic (III) S-adenosylmethionine methyltransferase from Rhodopseudanonas palustris
He Jishu Nuclear Techniques
35
326-330
2012
Rhodopseudomonas palustris
-
Wang, S.; Li, X.; Song, X.; Geng, Z.; Hu, X.; Wang, Z.
Rapid equilibrium kinetic analysis of arsenite methylation catalyzed by recombinant human arsenic (+3 oxidation state) methyltransferase (hAS3MT)
J. Biol. Chem.
287
38790-38799
2012
Homo sapiens (Q9HBK9), Homo sapiens
Wang, S.; Geng, Z.; Shi, N.; Li, X.; Wang, Z.
The functions of crucial cysteine residues in the arsenite methylation catalyzed by recombinant human arsenic (III) methyltransferase
PLoS ONE
9
e110924
2014
Homo sapiens (Q9HBK9), Homo sapiens
Tokumoto, M.; Kutsukake, N.; Yamanishi, E.; Katsuta, D.; Anan, Y.; Ogra, Y.
Arsenic (+3 oxidation state) methyltransferase is a specific but replaceable factor against arsenic toxicity
Toxicol. Rep.
1
589-595
2014
Homo sapiens (Q9HBK9)
Marapakala, K.; Packianathan, C.; Ajees, A.A.; Dheeman, D.S.; Sankaran, B.; Kandavelu, P.; Rosen, B.P.
A disulfide-bond cascade mechanism for arsenic(III) S-adenosylmethionine methyltransferase
Acta Crystallogr. Sect. D
71
505-515
2015
Cyanidioschyzon sp. 5508 (C0JV69)
Huang, K.; Chen, C.; Shen, Q.; Rosen, B.P.; Zhao, F.J.
Genetically engineering Bacillus subtilis with a heat-resistant arsenite methyltransferase for bioremediation of arsenic-contaminated organic waste
Appl. Environ. Microbiol.
81
6718-6724
2015
Cyanidioschyzon sp. 5508 (C0JV69)
Sumi, D.; Takeda, C.; Yasuoka, D.; Himeno, S.
Hydrogen peroxide triggers a novel alternative splicing of arsenic (+3 oxidation state) methyltransferase gene
Biochem. Biophys. Res. Commun.
480
18-22
2016
Homo sapiens (Q9HBK9), Homo sapiens
Guo, Y.; Xue, X.; Yan, Y.; Zhu, Y.; Yang, G.; Ye, J.
Arsenic methylation by an arsenite S-adenosylmethionine methyltransferase from Spirulina platensis
J. Environ. Sci. (China)
49
162-168
2016
Arthrospira platensis
Maimaitiyiming, Y.; Wang, C.; Xu, S.; Islam, K.; Chen, Y.J.; Yang, C.; Wang, Q.Q.; Naranmandura, H.
Role of arsenic (+3 oxidation state) methyltransferase in arsenic mediated APL treatment an in vitro investigation
Metallomics
10
828-837
2018
Homo sapiens (Q9HBK9), Homo sapiens
Huang, K.; Xu, Y.; Packianathan, C.; Gao, F.; Chen, C.; Zhang, J.; Shen, Q.; Rosen, B.P.; Zhao, F.J.
Arsenic methylation by a novel ArsM As(III) S-adenosylmethionine methyltransferase that requires only two conserved cysteine residues
Mol. Microbiol.
107
265-276
2018
Bacillus sp. CX-1 (A0A2P1M875)
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