Information on EC 2.1.1.130 - precorrin-2 C20-methyltransferase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
2.1.1.130
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RECOMMENDED NAME
GeneOntology No.
precorrin-2 C20-methyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + precorrin-3A
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)
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Metabolic pathways
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Porphyrin and chlorophyll metabolism
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vitamin B12 metabolism
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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:precorrin-4 C20-methyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
131554-12-6
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132053-02-2
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132053-02-2
methyltransferase, precorrin 2- (Pseudomonas denitrificans clone pXL151)
150474-70-7
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150474-70-7
protein (Salmonella typhimurium clone pJO26 gene cbiL reduced) /genBank L12006-derived protein, methyltransferase, precorrin 2- (Salmonella typhimurium strain LT2 gene cbiL isoenzyme)
181968-95-6
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181968-95-6
methyltransferase, precorrin 2 (Methanococcus jannaschii gene MJ0771) /genBank U67522-derived protein GI 1499591
198502-83-9
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198502-83-9
methyltransferase, precorrin 2- (Methanobacterium thermoautotrophicum strain DELTAH gene MTH1348) /genBank AE000898-derived protein GI 2622455
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + cobalt-precorrin-2
S-adenosyl-L-homocysteine + cobalt-precorrin-3A
show the reaction diagram
S-adenosyl-L-methionine + precorrin-2
?
show the reaction diagram
S-adenosyl-L-methionine + precorrin-2
S-adenosyl-L-homocysteine + precorrin-3A
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + cobalt-precorrin-2
S-adenosyl-L-homocysteine + cobalt-precorrin-3A
show the reaction diagram
S-adenosyl-L-methionine + precorrin-2
?
show the reaction diagram
additional information
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
S-adenosyl-L-methionine
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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PDB
SCOP
CATH
ORGANISM
UNIPROT
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25895
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2 * 25895, calculation from nucleotide sequence
53000
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gel filtration
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 26000, SDS-PAGE
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
gene cbiL, DNA and amino acid sequence determination and analysis, genetic organization, co-overexpression of enzymes and reconstruction of the anaerobic cobalamin biosynthetic pathway in Escherichia coli in a construct comprising several genes, overview
ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthesis
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preparative multi-enzyme synthesis of precorrin-3A
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