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5-methyl-5,6,7,8-tetrahydropteroylheptaglutamate + homocysteine
?
-
-
-
-
?
5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate + L-homocysteine
?
5-methyl-5,6,7,8-tetrahydropteroyltriglutamate + L-homocysteine
?
-
-
-
-
?
5-methyltetrahydrofolate + 2-mercaptoethanol
S-methylmercaptoethanol + tetrahydrofolate
-
-
-
?
5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
N5-methyltetrahydropteroylheptaglutamate + L-homocysteine
tetrahydropteroylheptaglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
N5-methyltetrahydropteroylpentaglutamate + L-homocysteine
tetrahydropteroylpentaglutamate + L-methionine
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
S-adenosyl-L-methionine + L-homocysteine
methionine + S-adenosyl-L-homocysteine
-
-
-
?
S-adenosyl-L-methionine + L-selenohomocysteine
selenomethionine + S-adenosyl-L-homocysteine
-
-
-
?
S-adenosyl-L-methionine + tetrahydrofolate
5-methyltetrahydrofolate + S-adenosyl-L-homocysteine
-
-
-
?
additional information
?
-
5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate + L-homocysteine
?
-
-
-
-
?
5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate + L-homocysteine
?
-
-
-
-
?
5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
homocysteine increases methionine synthase mRNA level
-
-
?
5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
gene expression is induced by light, but more strongly induced under salt, drought and cold stresses and by treatment with ABA or H2O2
-
-
?
5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
methionine biosynthesis
-
-
?
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
transcription is not regulated by Met, but is enhanced by homocysteine and repressed by choline and betaine. Synthesis of the enzyme is also regulated posttranscriptionally
-
-
?
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
?
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
N5-methyltetrahydrofolate + L-homocysteine
tetrahydrofolate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
Ochromonas malhamensis
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylmonoglutamate + L-homocysteine
tetrahydropteroylmonoglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylpentaglutamate + L-homocysteine
tetrahydropteroylpentaglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroylpentaglutamate + L-homocysteine
tetrahydropteroylpentaglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
Ochromonas malhamensis
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
?
N5-methyltetrahydropteroyltriglutamate + L-homocysteine
tetrahydropteroyltriglutamate + L-methionine
-
-
-
-
?
additional information
?
-
-
binding of the folate substrate
-
-
?
additional information
?
-
-
S-adenosylhomocysteine replaces homocysteine as methyl acceptor to a limited extent
-
-
?
additional information
?
-
the activation barrier for the reductive elimination reaction (24.4 kcal per mol) is almost four times higher than that for the SN2 reaction (7.3 kcal per mol). This energy demand is rooted in the structural distortion of the corrin ring that is induced en route to the formation of the triangular transition state. The reductive elimination reaction demands the syn accommodation of the methyl group and the substrate over the upper face of the corrin ring, which also accounts for the high energy demand of the reaction. Therefore the reductive elimination pathway for MetH-catalyzed methyl transfer cannot be considered as one of the possible mechanistic routes
-
-
?
additional information
?
-
-
S-adenosylhomocysteine replaces homocysteine as methyl acceptor to a limited extent
-
-
?
additional information
?
-
-
binding of the folate substrate
-
-
?
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Kolhouse, J.F.; Allen, R.H.
Recognition of two intracellular cobalamin binding proteins and their identification as methylmalonyl-CoA mutase and methionine synthetase
Proc. Natl. Acad. Sci. USA
74
921-925
1977
Oryctolagus cuniculus
brenda
Buchanan, J.M.
Methionine biosynthesis (hog liver)
Methods Enzymol.
17B
371-378
1971
Sus scrofa
-
brenda
Cheng, F.W.; Shane, B.; Stokstad, E.L.R.
Pentaglutamate derivatives of folate as substrates for rat liver tetrahydropteroylglutamate methyltransferase and 5,10-methylenetetrahydrofolate reductase
Can. J. Biochem.
53
1020-1027
1975
Rattus norvegicus
-
brenda
Guest, J.R.; Friedman, S.; Foster, M.A.; Tejerina, G.; Woods, D.D.
Transfer of the methyl group from N5-methyltetrahydrofolates to homocysteine in Escherichia coli
Biochem. J.
92
497-504
1964
Escherichia coli, Escherichia coli B / ATCC 11303
brenda
Loughlin, R.E.; Elford, H.L.; Buchanan, J.M.
Enzymatic synthesis of the methyl group of methionine
J. Biol. Chem.
239
2888-2895
1964
Sus scrofa
brenda
Foster, M.A.; Dilworth, M.J.; Woods, D.D.
Cobalamin and the synthesis of methionine by Escherichia coli
Nature
201
39-42
1964
Escherichia coli
brenda
Gonzalez, J.C.; Banerjee, R.V.; Huang, S.; Sumner, J.S.; Matthews, R.G.
Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli: two solutions to the same chemical problem
Biochemistry
31
6045-6056
1992
Escherichia coli
brenda
Luschinsky, C.L.; Drummond, J.T.; Matthews, R.G.; Ludwig, M.L.
Crystallization and preliminary X-ray diffraction studies of the cobalamin-binding domain of methionine synthase from Escherichia coli
J. Mol. Biol.
225
557-560
1992
Escherichia coli
brenda
Magnum, J.H.; Steuart, B.W.; North, J.A.
The isolation of N5-methyltetrahydrofolate-homocysteine transmethylase from bovine brain
Arch. Biochem. Biophys.
148
63-69
1972
Bos taurus
brenda
Taylor, R.T.; Hanna, M.L.
Escherichia coli B N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase: binding of the folate substrate to the enzyme
Arch. Biochem. Biophys.
151
401-413
1972
Escherichia coli, Escherichia coli B / ATCC 11303
brenda
Rudiger, H.
On the cation sensibility of the vitamin B12-dependent methionine synthetase (5-methyltetrahydrofolate-homocysteine-methyltransferase from Escherichia coli)
FEBS Lett.
35
295-298
1973
Escherichia coli
brenda
Mangum, J.H.; North, J.A.
Isolation of a cobalamin containing 5-methyltetrahydrofolate-homocysteine transmethylase from mammalian kidney
Biochemistry
10
3765-3769
1971
Sus scrofa
brenda
Taylor, R.T.
Escherichia coli B N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase: gel-filtration behavior of apoenzyme and holoenzymes
Biochim. Biophys. Acta
242
355-364
1971
Escherichia coli, Escherichia coli B / ATCC 11303
brenda
Frasca, V.; Banerjee, R.V.; Dunham, W.R.; Sands, R.; Matthews, R.G.
Cobalamin-dependent methionine synthase from Escherichia coli B: Electron paramagnetic resonance spectra of the inactive form and the active methylated form of the enzyme
Biochemistry
27
8458-8465
1988
Escherichia coli
brenda
Taylor, R.T.; Weissbach, H.
N5-Methyltetrahydrofolate-homocysteine methyltransferases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
12
121-165
1973
Klebsiella aerogenes, Bos taurus, Gallus gallus, Auxenochlorella pyrenoidosa, Escherichia coli, Homo sapiens, Ochromonas malhamensis, Rattus norvegicus, Cereibacter sphaeroides, Salmonella enterica subsp. enterica serovar Typhimurium, Sus scrofa
-
brenda
Sato, K.; Hiei, E.; Shimizu, S.
Affinity chromatography of N5-methyltetrahydrofolate-homocysteine methyltransferase on a cobalamin-Sepharose
FEBS Lett.
85
73-76
1978
Escherichia coli
brenda
Grabau, W.; Rudiger, H.
Purification and properties of the tetrahydropteroylglutamate methyltransferase from green beans (Phaseolus vulgaris)
Hoppe-Seyler's Z. Physiol. Chem.
358
695-698
1977
Phaseolus vulgaris
brenda
Kageyama, M.; Perlman, D.
Inhibition of N5-methyltetrahodrofolate-homocysteine transmethylase by a vitamin B12-antimetabolite
Biochem. Biophys. Res. Commun.
76
420-423
1977
Escherichia coli, Escherichia coli B / ATCC 11303
brenda
Taylor, R.T.; Weissbach, H.
N5-Methytetrahydrofolate-homocysteine (vitamin B12) methyltransferase (Escherichia coli B)
Methods Enzymol.
17B
379-388
1971
Escherichia coli, Escherichia coli B / ATCC 11303
-
brenda
Lucchini, G.; Piazza, I.; Biachetti, R.
B12-dependent methyl-H4-Folate homocysteine methyltransferase in Euglena gracilis
Plant Sci. Lett.
36
177-179
1984
Euglena gracilis
-
brenda
Sauer, H.
Methionine synthase
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
3
304-311
1983
Escherichia coli, Homo sapiens
-
brenda
Ohmori, H.; Fukui, S.
Vitamin B12-dependent methionine synthetase in photosynthetic bacteria: Partial purification and properties
Agric. Biol. Chem.
38
1317-1324
1974
Chromatium sp., Rhodospirillum rubrum, Chromatium sp. D
-
brenda
Fujii, K.; Huennekens, F.M.
Activation of methionine synthetase by a reduced triphosphopyridine nucleotide-dependent flavoprotein system
J. Biol. Chem.
249
6745-6753
1974
Escherichia coli
brenda
Coward, J.K.; Chello, P.L.; Cashmore, A.R.; Parameswaran, K.N.; DeAngelis, L.M.; Bertiono, J.R.
5-methyl-5,6,7,8-tetrahydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with methionine synthetase from bovine brain
Biochemistry
14
1548-1552
1975
Bos taurus
brenda
Kolhouse, J.F.; Utley, C.; Stabler, S.P.; Allen, R.H.
Mechanism of conversion of human apo- to holomethionine synthase by various forms of cobalamin
J. Biol. Chem.
266
23010-23015
1991
Escherichia coli, Homo sapiens, Rattus norvegicus, Escherichia coli B / ATCC 11303
brenda
Beck, W.S.; Thorndike, J.
Differences in coenzyme specificity of the N5-methyltetrahydrofolate-homocysteine methyltransferases of various species: implications for corrin binding loci
Biochem. Biophys. Res. Commun.
120
74-80
1984
Escherichia coli, Homo sapiens, Propionibacterium freudenreichii subsp. shermanii, Rattus norvegicus
brenda
Utley, C.S.; Marcell, P.D.; Allen, R.H.; Antony, A.C.; Kolhouse, J.F.
Isolation and characterization of methionine synthetase from human placenta
J. Biol. Chem.
260
13656-13665
1985
Homo sapiens
brenda
Paessens, A.; Rudiger, H.
Purification and chemical characterization of the vitamin-B12-dependent 5-methyltetrahydrofolate: homocysteine methyltransferase from Escherichia coli B
Eur. J. Biochem.
112
47-51
1980
Escherichia coli, Homo sapiens, Escherichia coli B / ATCC 11303
brenda
Matthews, R.G.
Cobalamin-dependent methyltransferases
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34
681-689
2001
Escherichia coli
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Extremely low activity of methionine synthase in vitamin B-12-deficient rats may be related to effects on coenzyme stabilization rather than to changes in coenzyme induction
J. Nutr.
130
1894-1900
2000
Rattus norvegicus
brenda
Jarrett, J.T.; Goulding, C.W.; Fluhr, K.; Huang, S.; Matthews, R.G.
Purification and assay of cobalamin-dependent methionine synthase from Escherichia coli
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281
196-213
1997
Escherichia coli
brenda
Chen, Z.; Crippen, K.; Gulati, S.; Banerjee, R.
Purification and kinetic mechanism of a mammalian methionine synthase from pig liver
J. Biol. Chem.
269
27193-27197
1994
Sus scrofa
brenda
Bandarian, V.; Matthews, R.G.
Quantitation of rate enhancements attained by the binding of cobalamin to methionine synthase
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40
5056-5064
2001
Escherichia coli
brenda
Hall, D.A.; Jordan-Starck, T.C.; Loo, R.O.; Ludwig, M.L.; Matthews, R.G.
Interaction of flavodoxin with cobalamin-dependent methionine synthase
Biochemistry
39
10711-10719
2000
Escherichia coli (P13009), Escherichia coli
brenda
Hall, D.A.; Vander Kooi, C.W.; Stasik, C.N.; Stevens, S.Y.; Zuiderweg, E.R.P.; Matthews, R.G.
Mapping the interactions between flavodoxin and its physiological partners flavodoxin reductase and cobalamin-dependent methionine synthase
Proc. Natl. Acad. Sci. USA
98
9521-9526
2001
Escherichia coli
brenda
Kenyon, S.H.; Nicolaou, A.; Ast, T.; Gibbons, W.A.
Stimulation in vitro of vitamin B12-dependent methionine synthase by polyamines
Biochem. J.
316
661-665
1996
Rattus norvegicus
-
brenda
Jarrett, J.T.; Huang, S.; Matthews, R.G.
Methionine synthase exists in two distinct conformations that differ in reactivity toward methyltetrahydrofolate, adenosylmethionine, and flavodoxin
Biochemistry
37
5372-5382
1998
Escherichia coli
brenda
Goulding, C.W.; Matthews, R.G.
Cobalamin-dependent methionine synthase from Escherichia coli: Involvement of zinc in homocysteine activation
Biochemistry
36
15749-15757
1997
Escherichia coli
brenda
Yamada, K.; Yamada, S.; Tobimatsu, T.; Torava, T.
Heterologous high level expression, purification, and enzymological properties of recombinant rat cobalamin-dependent methionine synthase
J. Biol. Chem.
274
35571-35576
1999
Rattus norvegicus
brenda
Goulding, C.W.; Postigo, D.; Matthews, R.G.
Cobalamin-dependent methionine synthase is a modular protein with distinct regions for binding homocysteine, methyltetrahydrofolate, cobalamin, and adenosylmethionine
Biochemistry
36
8082-8091
1997
Escherichia coli (P13009)
brenda
Gulati, S.; Brody, L.C.; Banerjee, R.
Posttranscriptional regulation of mammalian methionine synthase by B12
Biochem. Biophys. Res. Commun.
259
436-442
1999
Chlorocebus aethiops, Homo sapiens
brenda
Drummond, J.T.; Matthews, R.G.
Nitrous oxide degradation by cobalamin-dependent methionine synthase: characterization of the reactants and products in the inactivation reaction
Biochemistry
33
3732-3741
1994
Escherichia coli
brenda
Kenyon, S.H.; Waterfield, C.J.; Timbrell, J.A.; Nicolaou, A.
Methionine synthase activity and sulphur amino acid levels in the rat liver tumour cells HTC and Phi-1
Biochem. Pharmacol.
63
381-391
2002
Rattus norvegicus
brenda
Huang, L.; Zhang, J.; Hayakawa, T.; Tsuge, H.
Assays of methylenetetrahydrofolate reductase and methionine synthase activities by monitoring 5-methyltetrahydrofolate and tetrahydrofolate using high-performance liquid chromatography with fluorescence detection
Anal. Biochem.
299
253-259
2001
Bos taurus, Gallus gallus, Myzopsetta ferruginea, Scombridae, Rattus norvegicus, Sus scrofa
brenda
Isegawa, Y.; Watanabe, F.; Kitaoka, S.; Nakano, Y.
Subcellular distribution of cobalamin-dependent methionine synthase in Euglena gracilis Z
Phytochemistry
35
59-61
1994
Euglena gracilis
-
brenda
Zhou, Z.S.; Smith, A.E.; Matthews, R.G.
L-Selenohomocysteine: One-step synthesis from L-selenomethionine and kinetic analysis as substrate for methionine synthases
Bioorg. Med. Chem. Lett.
10
2471-2475
2000
Escherichia coli
brenda
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characterization of the zinc sites in cobalamin-independent and cobalamin-dependent methionine synthase using zinc and selenium X-ray absorption spectroscopy
Biochemistry
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Escherichia coli
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Bannerjee, R.V.; Harder, S.R.; Ragsdale, S.W.; Matthews, R.G.
Mechanism of reductive activation of cobalamin-dependent methionine synthase: An electron paramagnetic resonance spectroelectrochemical study
Biochemistry
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Escherichia coli
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Kacprzak, M.M.; Lewandowska, I.; Matthews, R.G.; Paszewski, A.
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Aspergillus nidulans
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Homo sapiens
brenda
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Nat. Struct. Biol.
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Escherichia coli (P13009), Escherichia coli
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Characterization of the salt-inducible methionine synthase from barley leaves
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Hordeum vulgare
brenda
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Structures of the N-terminal modules imply large domain motions during catalysis by methionine synthase
Proc. Natl. Acad. Sci. USA
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Thermotoga maritima
brenda
Sarbia, M.; Stahl, M.; von Weyhern, C.; Weirich, G.; Puehringer-Oppermann, F.
The prognostic significance of genetic polymorphisms (methylenetetrahydrofolate reductase C677T, methionine synthase A2756G, thymidilate synthase tandem repeat polymorphism) in multimodally treated oesophageal squamous cell carcinoma
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Homo sapiens
brenda
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Rattus norvegicus
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Homo sapiens
brenda
Oltean, S.; Banerjee, R.
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Homo sapiens
brenda
Yamada, K.; Gravel, R.A.; Toraya, T.; Matthews, R.G.
Human methionine synthase reductase is a molecular chaperone for human methionine synthase
Proc. Natl. Acad. Sci. USA
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2006
Homo sapiens
brenda
Tang, C.; Zhang, Z.; Xu, B.; Li, M.; Liu, J.; Cui, J.
Two newly synthesized 5-methyltetrahydrofolate-like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1/S phase and apoptosis in vitro
Anticancer Drugs
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2008
Homo sapiens
brenda
Roeder, S.; Dreschler, K.; Wirtz, M.; Cristescu, S.M.; van Harren, F.J.; Hell, R.; Piechulla, B.
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Nicotiana suaveolens
brenda
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Kinetic analysis of site-directed mutants of methionine synthase from Candida albicans
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Candida albicans
brenda
Naushad, S.; Jain Jamal, M.; Prasad, C.; Rama Devi, A.
Relationship between methionine synthase, methionine synthase reductase genetic polymorphisms and deep vein thrombosis among South Indians
Clin. Chem. Lab. Med.
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Homo sapiens
brenda
Bera, S.; Wallimann, T.; Ray, S.; Ray, M.
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Mus musculus
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Wolthers, K.R.; Scrutton, N.S.
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FEBS J.
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Homo sapiens
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Spectroscopic study of the cobalamin-dependent methionine synthase in the activation conformation: effects of the Y1139 residue and S-adenosylmethionine on the B12 cofactor
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Escherichia coli
brenda
Brosnan, J.T.; Wijekoon, E.P.; Warford-Woolgar, L.; Trottier, N.L.; Brosnan, M.E.; Brunton, J.A.; Bertolo, R.F.
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Sus scrofa
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Proc. Natl. Acad. Sci. USA
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2008
Thermotoga maritima
brenda
Datta, S.; Koutmos, M.; Pattridge, K.A.; Ludwig, M.L.; Matthews, R.G.
A disulfide-stabilized conformer of methionine synthase reveals an unexpected role for the histidine ligand of the cobalamin cofactor
Proc. Natl. Acad. Sci. USA
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Escherichia coli (P13009), Escherichia coli
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Koutmos, M.; Datta, S.; Pattridge, K.A.; Smith, J.L.; Matthews, R.G.
Insights into the reactivation of cobalamin-dependent methionine synthase
Proc. Natl. Acad. Sci. USA
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Escherichia coli (P13009)
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Wang, Y.C.; Chen, Y.M.; Lin, Y.J.; Liu, S.P.; Chiang, E.P.
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Mus musculus
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Elshihawy, H.; Helal, M.A.; Said, M.; Hammad, M.A.
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Bioorg. Med. Chem.
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Rattus norvegicus (Q9Z2Q4)
brenda
Hayashi, T.; Morita, Y.; Mizohata, E.; Oohora, K.; Ohbayashi, J.; Inoue, T.; Hisaeda, Y.
Co(II)/Co(I) reduction-induced axial histidine-flipping in myoglobin reconstituted with a cobalt tetradehydrocorrin as a methionine synthase model
Chem. Commun. (Camb. )
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synthetic construct
brenda
Deng, X.; Guo, Y.; Tian, C.; Liu, J.; Wang, X.; Zhang, Z.
Design, synthesis and activities of aziridine derivatives of N5-methyltetrahydrofolate against methionine synthase
Chem. Res. Chin. Univ.
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Homo sapiens
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brenda
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Interaction between methionine synthase isoforms and MMACHC: characterization in cblG-variant, cblG and cblC inherited causes of megaloblastic anaemia
Hum. Mol. Genet.
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Homo sapiens
brenda
Kozlowski, P.M.; Kamachi, T.; Kumar, M.; Yoshizawa, K.
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Escherichia coli (P13009)
brenda
Kumar, N.; Kozlowski, P.M.
Mechanistic insights for formation of an organometallic Co-C bond in the methyl transfer reaction catalyzed by methionine synthase
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Thermotoga maritima (Q9WYA5), Thermotoga maritima ATCC 43589 (Q9WYA5)
brenda
Bassila, C.; Ghemrawi, R.; Flayac, J.; Froese, D.S.; Baumgartner, M.R.; Gueant, J.L.; Coelho, D.
Methionine synthase and methionine synthase reductase interact with MMACHC and with MMADHC
Biochim. Biophys. Acta
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103-112
2017
Homo sapiens (Q99707)
brenda
Ellis, K.A.; Cohen, N.R.; Moreno, C.; Marchetti, A.
Cobalamin-independent methionine synthase distribution and influence on vitamin B12 growth requirements in marine diatoms
Protist
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32-47
2017
Pseudo-nitzschia granii (A0A088GF04)
brenda